Effect of jaboticaba and pequi extracts on gene expression of antioxidant enzymes in C2C12 mouse muscle cells
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/18864 |
Resumo: | Jaboticaba and pequi fruits contain bioactive compounds, such as polyphenols, which present antioxidant actions; however, the molecular mechanisms by which these effects are achieved are not fully elucidated. In the present study, mouse muscle cells (C2C12), induced or not by oxidative stress with hydrogen peroxide (H2O2), were treated with jaboticaba peel extract (JPE) and pequi aqueous extract (PAE) in order to evaluate their influence on expression of the following antioxidant enzymes: catalase (CAT), superoxide dismutase (SOD), glutathione s-transferase (GST) and glutathione peroxidase 1 (GPX1). Treatments with JPE (150 µg gallic acid equivalents mL-1 extract) and PAE (30 µg GAE mL-1 extract) increased CAT and GST mRNAs expression in muscle cells. In cells induced by oxidative stress with addition of H2O2, peroxide detoxification action attributed to the GST enzyme was verified. The extracts beneficial effects may be due to the synergistic activities of their various phenolic compounds and other constituents. |
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Effect of jaboticaba and pequi extracts on gene expression of antioxidant enzymes in C2C12 mouse muscle cellsEfecto de los extractos de jaboticaba y pequi sobre la expresión génica de enzimas antioxidantes en células musculares de ratón C2C12Efeito dos extratos de jabuticaba e pequi na expressão gênica de enzimas antioxidantes em células musculares C2C12 de camundongos Antioxidant actionMessenger RNAPhenolic compoundsPlant extractsOxidative stressCytotoxicity.Acción antioxidanteARN mensajeroCompuestos fenólicosExtractos de plantasEstrés oxidativoCitotoxicidad.Ação antioxidanteRNA mensageiroCompostos fenólicosExtratos vegetaisEstresse oxidativoCitotoxicidade.Jaboticaba and pequi fruits contain bioactive compounds, such as polyphenols, which present antioxidant actions; however, the molecular mechanisms by which these effects are achieved are not fully elucidated. In the present study, mouse muscle cells (C2C12), induced or not by oxidative stress with hydrogen peroxide (H2O2), were treated with jaboticaba peel extract (JPE) and pequi aqueous extract (PAE) in order to evaluate their influence on expression of the following antioxidant enzymes: catalase (CAT), superoxide dismutase (SOD), glutathione s-transferase (GST) and glutathione peroxidase 1 (GPX1). Treatments with JPE (150 µg gallic acid equivalents mL-1 extract) and PAE (30 µg GAE mL-1 extract) increased CAT and GST mRNAs expression in muscle cells. In cells induced by oxidative stress with addition of H2O2, peroxide detoxification action attributed to the GST enzyme was verified. The extracts beneficial effects may be due to the synergistic activities of their various phenolic compounds and other constituents.Los frutos de jaboticaba y pequi contienen compuestos bioactivos, como polifenoles, que presentan acciones antioxidantes; sin embargo, los mecanismos moleculares mediante los cuales se logran estos efectos no están completamente aclarados. En el presente estudio, células de músculo de ratón (C2C12), inducidas o no por estrés oxidativo con peróxido de hidrógeno (H2O2), fueron tratadas con extracto de piel de jaboticaba (JPE) y extracto acuoso de pequi (PAE) para evaluar su influencia en la expresión de las siguientes enzimas antioxidantes: catalasa (CAT), superóxido dismutasa (SOD), glutatión s-transferasa (GST) y glutatión peroxidasa 1 (GPX1). Los tratamientos con JPE (150 µg equivalente de ácido gálico mL-1 extracto) y PAE (30 µg GAE mL-1 extracto) aumentaron la expresión de ARNm de CAT y GST en las células musculares. En células inducidas por estrés oxidativo con adición de H2O2, se verificó la acción de desintoxicación del peróxido atribuida a la enzima GST. Los efectos beneficiosos de los extractos pueden deberse a las actividades sinérgicas de sus diversos compuestos fenólicos y otros constituyentes.Frutos de jabuticaba e pequi contêm compostos bioativos, como polifenóis, que apresentam ação antioxidante; entretanto, os mecanismos moleculares pelos quais esses efeitos são alcançados não estão totalmente elucidados. No presente estudo, células musculares de camundongo (C2C12), induzidas ou não por estresse oxidativo com peróxido de hidrogênio (H2O2), foram tratadas com extrato de casca de jabuticaba (JPE) e extrato aquoso de pequi (PAE) para avaliar sua influência na expressão das seguintes enzimas antioxidantes: catalase (CAT), superóxido dismutase (SOD), glutationa s-transferase (GST) e glutationa peroxidase 1 (GPX1). Os tratamentos com JPE (150 µg equivalentes de ácido gálico mL-1 extrato) e PAE (30 µg GAE mL-1 extrato) aumentaram a expressão de mRNAs de CAT e GST em células musculares. Em células induzidas por estresse oxidativo com adição de H2O2, verificou-se a ação de desintoxicação do peróxido atribuída à enzima GST. Os efeitos benéficos dos extratos podem ser devido às atividades sinérgicas de seus diversos compostos fenólicos e outros constituintes.Research, Society and Development2021-08-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1886410.33448/rsd-v10i10.18864Research, Society and Development; Vol. 10 No. 10; e375101018864Research, Society and Development; Vol. 10 Núm. 10; e375101018864Research, Society and Development; v. 10 n. 10; e3751010188642525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/18864/16932Copyright (c) 2021 Patrícia Rodrigues Ferreira; Flávia de Abreu Pinheiro; Marcio de Souza Duarte; Walmir da Silva; Natália Rodrigues dos Reis; Daniele Botelho Diniz Marques; Daniel Silva Sena Bastos; Edimar Aparecida Filomeno Fonteshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFerreira, Patrícia RodriguesPinheiro, Flávia de Abreu Duarte, Marcio de Souza Silva, Walmir da Reis, Natália Rodrigues dos Marques, Daniele Botelho DinizBastos, Daniel Silva SenaFontes, Edimar Aparecida Filomeno2021-10-02T21:49:16Zoai:ojs.pkp.sfu.ca:article/18864Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:53.981355Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Effect of jaboticaba and pequi extracts on gene expression of antioxidant enzymes in C2C12 mouse muscle cells Efecto de los extractos de jaboticaba y pequi sobre la expresión génica de enzimas antioxidantes en células musculares de ratón C2C12 Efeito dos extratos de jabuticaba e pequi na expressão gênica de enzimas antioxidantes em células musculares C2C12 de camundongos |
title |
Effect of jaboticaba and pequi extracts on gene expression of antioxidant enzymes in C2C12 mouse muscle cells |
spellingShingle |
Effect of jaboticaba and pequi extracts on gene expression of antioxidant enzymes in C2C12 mouse muscle cells Ferreira, Patrícia Rodrigues Antioxidant action Messenger RNA Phenolic compounds Plant extracts Oxidative stress Cytotoxicity. Acción antioxidante ARN mensajero Compuestos fenólicos Extractos de plantas Estrés oxidativo Citotoxicidad. Ação antioxidante RNA mensageiro Compostos fenólicos Extratos vegetais Estresse oxidativo Citotoxicidade. |
title_short |
Effect of jaboticaba and pequi extracts on gene expression of antioxidant enzymes in C2C12 mouse muscle cells |
title_full |
Effect of jaboticaba and pequi extracts on gene expression of antioxidant enzymes in C2C12 mouse muscle cells |
title_fullStr |
Effect of jaboticaba and pequi extracts on gene expression of antioxidant enzymes in C2C12 mouse muscle cells |
title_full_unstemmed |
Effect of jaboticaba and pequi extracts on gene expression of antioxidant enzymes in C2C12 mouse muscle cells |
title_sort |
Effect of jaboticaba and pequi extracts on gene expression of antioxidant enzymes in C2C12 mouse muscle cells |
author |
Ferreira, Patrícia Rodrigues |
author_facet |
Ferreira, Patrícia Rodrigues Pinheiro, Flávia de Abreu Duarte, Marcio de Souza Silva, Walmir da Reis, Natália Rodrigues dos Marques, Daniele Botelho Diniz Bastos, Daniel Silva Sena Fontes, Edimar Aparecida Filomeno |
author_role |
author |
author2 |
Pinheiro, Flávia de Abreu Duarte, Marcio de Souza Silva, Walmir da Reis, Natália Rodrigues dos Marques, Daniele Botelho Diniz Bastos, Daniel Silva Sena Fontes, Edimar Aparecida Filomeno |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Patrícia Rodrigues Pinheiro, Flávia de Abreu Duarte, Marcio de Souza Silva, Walmir da Reis, Natália Rodrigues dos Marques, Daniele Botelho Diniz Bastos, Daniel Silva Sena Fontes, Edimar Aparecida Filomeno |
dc.subject.por.fl_str_mv |
Antioxidant action Messenger RNA Phenolic compounds Plant extracts Oxidative stress Cytotoxicity. Acción antioxidante ARN mensajero Compuestos fenólicos Extractos de plantas Estrés oxidativo Citotoxicidad. Ação antioxidante RNA mensageiro Compostos fenólicos Extratos vegetais Estresse oxidativo Citotoxicidade. |
topic |
Antioxidant action Messenger RNA Phenolic compounds Plant extracts Oxidative stress Cytotoxicity. Acción antioxidante ARN mensajero Compuestos fenólicos Extractos de plantas Estrés oxidativo Citotoxicidad. Ação antioxidante RNA mensageiro Compostos fenólicos Extratos vegetais Estresse oxidativo Citotoxicidade. |
description |
Jaboticaba and pequi fruits contain bioactive compounds, such as polyphenols, which present antioxidant actions; however, the molecular mechanisms by which these effects are achieved are not fully elucidated. In the present study, mouse muscle cells (C2C12), induced or not by oxidative stress with hydrogen peroxide (H2O2), were treated with jaboticaba peel extract (JPE) and pequi aqueous extract (PAE) in order to evaluate their influence on expression of the following antioxidant enzymes: catalase (CAT), superoxide dismutase (SOD), glutathione s-transferase (GST) and glutathione peroxidase 1 (GPX1). Treatments with JPE (150 µg gallic acid equivalents mL-1 extract) and PAE (30 µg GAE mL-1 extract) increased CAT and GST mRNAs expression in muscle cells. In cells induced by oxidative stress with addition of H2O2, peroxide detoxification action attributed to the GST enzyme was verified. The extracts beneficial effects may be due to the synergistic activities of their various phenolic compounds and other constituents. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18864 10.33448/rsd-v10i10.18864 |
url |
https://rsdjournal.org/index.php/rsd/article/view/18864 |
identifier_str_mv |
10.33448/rsd-v10i10.18864 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18864/16932 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 10; e375101018864 Research, Society and Development; Vol. 10 Núm. 10; e375101018864 Research, Society and Development; v. 10 n. 10; e375101018864 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052686088011776 |