Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats

Detalhes bibliográficos
Autor(a) principal: Ueda, Rose Meire Riçato
Data de Publicação: 2021
Outros Autores: Souza, Verena Miranda de, Magalhães, Letícia Rocha, Giuffrida, Rogério, Nai, Gisele Alborghetti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/11695
Resumo: The described neurological symptoms associated with pesticide exposure include memory and concentration problems. Most experimental studies of the association between dichlorophenoxyacetic acid (2,4-D) and neurotoxicity have focused on brain development, and few have been conducted in adult animals. The aim of this study was to assess whether chronic oral or inhalation exposure to 2,4-D affects object recognition memory in adult rats. Forty albino Wistar rats were used and distributed into 4 groups (n = 10): I: animals nebulized with distilled water; O: animals receiving feed treated with nebulized distilled water; DI: animals nebulized with 9.28 x 10-3 grams of active ingredient per hectare (g.a.i./ha) of 2,4-D; and DO: animals receiving feed treated with 9.28 x 10-3 g.a.i./ha of nebulized 2,4-D. The animals were exposed for 6 months. To assess recognition memory, the object recognition test was used. Compared to control animals, animals exposed to 2,4-D spent less time exploring objects (p <0.05) and obtained an object recognition index score of -1. Route of exposure to 2,4-D had an effect only on the time spent exploring objects, which was shorter in animals exposed orally. Chronic exposure to a high concentration of 2,4-D alters the ability of adult animals to recognize objects.
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spelling Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult ratsAlteración de la memoria de reconocimiento de objetos tras la exposición crónica al ácido diclorofenoxiacético (2,4-D) en ratas adultasAlteração da memória de reconhecimento de objetos após exposição crônica ao ácido diclorofenoxiacético (2,4-D) em ratos adultosAgroquímicosHerbicidasTrastornos de la memoriaPruebas neuropsicológicasCebado de repetición.AgrochemicalsHerbicidesMemory disordersNeuropsychological testsRepetition priming.AgroquímicosHerbicidasDistúrbios de memóriaTestes neuropsicológicosPriming de repetição.The described neurological symptoms associated with pesticide exposure include memory and concentration problems. Most experimental studies of the association between dichlorophenoxyacetic acid (2,4-D) and neurotoxicity have focused on brain development, and few have been conducted in adult animals. The aim of this study was to assess whether chronic oral or inhalation exposure to 2,4-D affects object recognition memory in adult rats. Forty albino Wistar rats were used and distributed into 4 groups (n = 10): I: animals nebulized with distilled water; O: animals receiving feed treated with nebulized distilled water; DI: animals nebulized with 9.28 x 10-3 grams of active ingredient per hectare (g.a.i./ha) of 2,4-D; and DO: animals receiving feed treated with 9.28 x 10-3 g.a.i./ha of nebulized 2,4-D. The animals were exposed for 6 months. To assess recognition memory, the object recognition test was used. Compared to control animals, animals exposed to 2,4-D spent less time exploring objects (p <0.05) and obtained an object recognition index score of -1. Route of exposure to 2,4-D had an effect only on the time spent exploring objects, which was shorter in animals exposed orally. Chronic exposure to a high concentration of 2,4-D alters the ability of adult animals to recognize objects.Los síntomas neurológicos descritos asociados con la exposición a pesticidas incluyen problemas de memoria y concentración. La mayoría de los estudios experimentales de la asociación entre ácido diclorofenoxiacético (2,4-D) y neurotoxicidad se han centrado en el desarrollo del cerebro y pocos se han realizado en animales adultos. El objetivo de este estudio fue evaluar si la exposición crónica por vía oral o por inhalación al 2,4-D afecta la memoria de reconocimiento de objetos en ratas adultas. Se utilizaron cuarenta ratas albinas Wistar y se distribuyeron en 4 grupos (n = 10): I: animales nebulizados con agua destilada; O: animales que reciben alimento tratado con agua destilada nebulizada; DI: animales nebulizados con 9,28 x 10-3 gramos de ingrediente activo por hectárea (g.i.a./ha) de 2,4-D; y DO: animales que reciben alimento tratado con 9.28 x 10-3 g.i.a./ha de 2,4-D nebulizado. Los animales estuvieron expuestos durante 6 meses. Para evaluar la memoria de reconocimiento se utilizó la prueba de reconocimiento de objetos. En comparación con los animales de control, los animales expuestos a 2,4-D pasaron menos tiempo explorando objetos (p <0,05) y obtuvieron una puntuación de índice de reconocimiento de objetos de -1. La ruta de exposición al 2,4-D tuvo efecto solo en el tiempo dedicado a explorar objetos, que fue más corto en los animales expuestos por vía oral. La exposición crónica a una alta concentración de 2,4-D altera la capacidad de los animales adultos para reconocer objetos.Os sintomas neurológicos descritos associados à exposição a pesticidas incluem problemas de memória e concentração. A maioria dos estudos experimentais da associação entre ácido diclorofenoxiacético (2,4-D) e neurotoxicidade enfocou o desenvolvimento do cérebro, e poucos foram conduzidos em animais adultos. O objetivo deste estudo foi avaliar se a exposição oral crônica ou inalatória ao 2,4-D afeta a memória de reconhecimento de objetos em ratos adultos. Foram utilizados 40 ratos albinos Wistar, distribuídos em 4 grupos (n = 10): I: animais nebulizados com água destilada; O: animais recebendo ração tratada com água destilada nebulizada; DI: animais nebulizados com 9,28 x 10-3 gramas de ingrediente ativo por hectare (g.a.i./ha) de 2,4-D; e DO: animais que receberam ração tratada com 9,28 x 10-3 g.a.i./ha de 2,4-D nebulizado. Os animais ficaram expostos por 6 meses. Para avaliar a memória de reconhecimento, foi utilizado o teste de reconhecimento de objetos. Em comparação com os animais controle, os animais expostos ao 2,4-D gastaram menos tempo explorando objetos (p <0,05) e obtiveram um índice de reconhecimento de objeto de -1. A rota de exposição ao 2,4-D afetou apenas o tempo despendido na exploração de objetos, sendo menor nos animais expostos por via oral. A exposição crônica a uma alta concentração de 2,4-D altera a capacidade dos animais adultos de reconhecer objetos.Research, Society and Development2021-01-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1169510.33448/rsd-v10i1.11695Research, Society and Development; Vol. 10 No. 1; e23310111695Research, Society and Development; Vol. 10 Núm. 1; e23310111695Research, Society and Development; v. 10 n. 1; e233101116952525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/11695/10448Copyright (c) 2021 Rose Meire Riçato Ueda; Verena Miranda de Souza; Letícia Rocha Magalhães; Rogério Giuffrida; Gisele Alborghetti Naihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessUeda, Rose Meire Riçato Souza, Verena Miranda deMagalhães, Letícia Rocha Giuffrida, Rogério Nai, Gisele Alborghetti 2021-02-20T21:19:23Zoai:ojs.pkp.sfu.ca:article/11695Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:26.824307Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats
Alteración de la memoria de reconocimiento de objetos tras la exposición crónica al ácido diclorofenoxiacético (2,4-D) en ratas adultas
Alteração da memória de reconhecimento de objetos após exposição crônica ao ácido diclorofenoxiacético (2,4-D) em ratos adultos
title Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats
spellingShingle Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats
Ueda, Rose Meire Riçato
Agroquímicos
Herbicidas
Trastornos de la memoria
Pruebas neuropsicológicas
Cebado de repetición.
Agrochemicals
Herbicides
Memory disorders
Neuropsychological tests
Repetition priming.
Agroquímicos
Herbicidas
Distúrbios de memória
Testes neuropsicológicos
Priming de repetição.
title_short Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats
title_full Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats
title_fullStr Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats
title_full_unstemmed Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats
title_sort Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats
author Ueda, Rose Meire Riçato
author_facet Ueda, Rose Meire Riçato
Souza, Verena Miranda de
Magalhães, Letícia Rocha
Giuffrida, Rogério
Nai, Gisele Alborghetti
author_role author
author2 Souza, Verena Miranda de
Magalhães, Letícia Rocha
Giuffrida, Rogério
Nai, Gisele Alborghetti
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ueda, Rose Meire Riçato
Souza, Verena Miranda de
Magalhães, Letícia Rocha
Giuffrida, Rogério
Nai, Gisele Alborghetti
dc.subject.por.fl_str_mv Agroquímicos
Herbicidas
Trastornos de la memoria
Pruebas neuropsicológicas
Cebado de repetición.
Agrochemicals
Herbicides
Memory disorders
Neuropsychological tests
Repetition priming.
Agroquímicos
Herbicidas
Distúrbios de memória
Testes neuropsicológicos
Priming de repetição.
topic Agroquímicos
Herbicidas
Trastornos de la memoria
Pruebas neuropsicológicas
Cebado de repetición.
Agrochemicals
Herbicides
Memory disorders
Neuropsychological tests
Repetition priming.
Agroquímicos
Herbicidas
Distúrbios de memória
Testes neuropsicológicos
Priming de repetição.
description The described neurological symptoms associated with pesticide exposure include memory and concentration problems. Most experimental studies of the association between dichlorophenoxyacetic acid (2,4-D) and neurotoxicity have focused on brain development, and few have been conducted in adult animals. The aim of this study was to assess whether chronic oral or inhalation exposure to 2,4-D affects object recognition memory in adult rats. Forty albino Wistar rats were used and distributed into 4 groups (n = 10): I: animals nebulized with distilled water; O: animals receiving feed treated with nebulized distilled water; DI: animals nebulized with 9.28 x 10-3 grams of active ingredient per hectare (g.a.i./ha) of 2,4-D; and DO: animals receiving feed treated with 9.28 x 10-3 g.a.i./ha of nebulized 2,4-D. The animals were exposed for 6 months. To assess recognition memory, the object recognition test was used. Compared to control animals, animals exposed to 2,4-D spent less time exploring objects (p <0.05) and obtained an object recognition index score of -1. Route of exposure to 2,4-D had an effect only on the time spent exploring objects, which was shorter in animals exposed orally. Chronic exposure to a high concentration of 2,4-D alters the ability of adult animals to recognize objects.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11695
10.33448/rsd-v10i1.11695
url https://rsdjournal.org/index.php/rsd/article/view/11695
identifier_str_mv 10.33448/rsd-v10i1.11695
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11695/10448
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 1; e23310111695
Research, Society and Development; Vol. 10 Núm. 1; e23310111695
Research, Society and Development; v. 10 n. 1; e23310111695
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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