Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/18968 |
Resumo: | Acetylcholine deficiency is a neurochemical characteristic of patients with clinical diagnosis of Alzheimer´s disease. Substances that inhibit the enzyme acetylcholinesterase, increasing levels of acetylcholine in the brain, are a promising form of treatment. Studies relate the use of omega-3 fatty acids in the treatment and prevention of Alzheimer's disease. The Northeast Region of Brazil has an enormous biological diversity and a wide variety of fish species. In this work, the oils of eleven species of marine fish found on the coast of Ceará, Brazil, were analyzed in relation to the fatty acid profile and the inhibitory activity of the enzyme acetylcholinesterase. Total lipids were extracted from fish samples by Folch metodology. The lipid extracts of the fish and industrialized fish oil, used for comparison, were esterified and fatty acid profiles were analyzed. The acetylcholinesterase inhibitory activity was measured quantitatively. The oils presented a high percentage of saturated fatty acids, which is a general characteristic of tropical fish. Oleic acid was the highest monounsaturated fatty acid. Oils of Scomberomorus cavalla, Lutjanus synagris and Haemulon plumieri presented expressive percentages of polyunsaturated fatty acids and the most potent anticholinesterase activities. This research showed the oils of S. cavalla, L. synagris and H. plumieri may be promising functional food products of active fatty acids as new therapies to treatment or prevention of Alzheimer's disease. The expressive concentration of unsaturated and polyunsaturated fatty acids together with their relevant anticholinesterase activity are characteristics of the importance of these fish oils. |
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Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast Perfil de ácidos grasos y actividad anticolinesterasa de los lípidos de pescado del Noreste de BrasilPerfil de ácidos graxos e atividade anticolinesterásica de lipídios de peixes do Nordeste do BrasilPeixes marinhosComposição de ácidos graxosÁcidos graxos poli-insaturadosAcetilcolinesteraseDoença de Alzheimer.Marine fishFatty acids compositionPolyunsaturated fatty acidsAcetylcholinesterasAlzheimer's disease.Pescado marinoComposición de ácidos grasosÁcidos grasos poliinsaturadosAcetilcolinesterasaEnfermedad de Alzheimer.Acetylcholine deficiency is a neurochemical characteristic of patients with clinical diagnosis of Alzheimer´s disease. Substances that inhibit the enzyme acetylcholinesterase, increasing levels of acetylcholine in the brain, are a promising form of treatment. Studies relate the use of omega-3 fatty acids in the treatment and prevention of Alzheimer's disease. The Northeast Region of Brazil has an enormous biological diversity and a wide variety of fish species. In this work, the oils of eleven species of marine fish found on the coast of Ceará, Brazil, were analyzed in relation to the fatty acid profile and the inhibitory activity of the enzyme acetylcholinesterase. Total lipids were extracted from fish samples by Folch metodology. The lipid extracts of the fish and industrialized fish oil, used for comparison, were esterified and fatty acid profiles were analyzed. The acetylcholinesterase inhibitory activity was measured quantitatively. The oils presented a high percentage of saturated fatty acids, which is a general characteristic of tropical fish. Oleic acid was the highest monounsaturated fatty acid. Oils of Scomberomorus cavalla, Lutjanus synagris and Haemulon plumieri presented expressive percentages of polyunsaturated fatty acids and the most potent anticholinesterase activities. This research showed the oils of S. cavalla, L. synagris and H. plumieri may be promising functional food products of active fatty acids as new therapies to treatment or prevention of Alzheimer's disease. The expressive concentration of unsaturated and polyunsaturated fatty acids together with their relevant anticholinesterase activity are characteristics of the importance of these fish oils.A deficiência da acetilcolina é uma característica neuroquímica de pacientes com diagnóstico clínico da doença de Alzheimer. As substâncias que inibem a enzima acetilcolinesterase, aumentando os níveis de acetilcolina no cérebro, são uma forma promissora de tratamento. Estudos relacionam o uso de ácidos graxos ômega-3 no tratamento e prevenção da doença. Neste trabalho, os óleos de onze espécies de peixes marinhos encontrados no litoral do Ceará, Brasil, foram analisados em relação ao perfil de ácidos graxos e à atividade inibitória da enzima acetilcolinesterase. Os lipídios totais foram extraídos das amostras de peixes pela metodologia de Folch. Os extratos lipídicos dos peixes e o óleo de peixe industrializado, usado para comparação, foram esterificados e os perfis de ácidos graxos analisados. A atividade inibitória da acetilcolinesterase foi medida quantitativamente. Os óleos apresentaram elevados percentuais de ácidos graxos saturados, característica dos peixes de águas tropicais. O ácido oléico representou o ácido graxo monoinsaturado em maior proporção. Os óleos de Scomberomorus cavalla, Lutjanus synagris e Haemulon plumieri apresentaram percentuais expressivos de ácidos graxos poli-insaturados, assim como as mais potentes atividades anticolinesterásicas. Dessa forma, a pesquisa demonstrou a importância dos óleos de S. cavalla, L. synagris e H. plumieri, como alimentos funcionais ricos em ácidos graxos ativos, e que podem ser utilizados em novas terapias para o tratamento ou prevenção da doença de Alzheimer.A deficiência da acetilcolina é uma característica neuroquímica de pacientes com diagnóstico clínico da doença de Alzheimer. As substâncias que inibem a enzima acetilcolinesterase, aumentando os níveis de acetilcolina no cérebro, são uma forma promissora de tratamento. Estudos relacionam o uso de ácidos graxos ômega-3 no tratamento e prevenção da doença. Neste trabalho, os óleos de onze espécies de peixes marinhos encontrados no litoral do Ceará, Brasil, foram analisados em relação ao perfil de ácidos graxos e à atividade inibitória da enzima acetilcolinesterase. Os lipídios totais foram extraídos das amostras de peixes pela metodologia de Folch. Os extratos lipídicos dos peixes e o óleo de peixe industrializado, usado para comparação, foram esterificados e os perfis de ácidos graxos analisados. A atividade inibitória da acetilcolinesterase foi medida quantitativamente. Os óleos apresentaram elevados percentuais de ácidos graxos saturados, característica dos peixes de águas tropicais. O ácido oléico representou o ácido graxo monoinsaturado em maior proporção. Os óleos de Scomberomorus cavalla, Lutjanus synagris e Haemulon plumieri apresentaram percentuais expressivos de ácidos graxos poli-insaturados, assim como as mais potentes atividades anticolinesterásicas. Dessa forma, a pesquisa demonstrou a importância dos óleos de S. cavalla, L. synagris e H. plumieri, como alimentos funcionais ricos em ácidos graxos ativos, e que podem ser utilizados em novas terapias para o tratamento ou prevenção da doença de Alzheimer.Research, Society and Development2021-08-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1896810.33448/rsd-v10i10.18968Research, Society and Development; Vol. 10 No. 10; e450101018968Research, Society and Development; Vol. 10 Núm. 10; e450101018968Research, Society and Development; v. 10 n. 10; e4501010189682525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/18968/17013Copyright (c) 2021 Séfura Maria Assis Moura; Selene Maia de Morais; José Osvaldo Beserra Carioca; Ana Livya Moreira Rodrigues; Daniela Ribeiro Alves; Francisco Felipe Maia da Silva ; Ana Carolina Silva e Silva; Sheyla Maria Barreto Amaral ; Ysabele Yngrydh Valente Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMoura, Séfura Maria AssisMorais, Selene Maia deCarioca, José Osvaldo BeserraRodrigues, Ana Livya MoreiraAlves, Daniela RibeiroSilva , Francisco Felipe Maia daSilva, Ana Carolina Silva eAmaral , Sheyla Maria BarretoSilva, Ysabele Yngrydh Valente2021-10-02T21:49:16Zoai:ojs.pkp.sfu.ca:article/18968Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:58.398732Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast Perfil de ácidos grasos y actividad anticolinesterasa de los lípidos de pescado del Noreste de Brasil Perfil de ácidos graxos e atividade anticolinesterásica de lipídios de peixes do Nordeste do Brasil |
title |
Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast |
spellingShingle |
Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast Moura, Séfura Maria Assis Peixes marinhos Composição de ácidos graxos Ácidos graxos poli-insaturados Acetilcolinesterase Doença de Alzheimer. Marine fish Fatty acids composition Polyunsaturated fatty acids Acetylcholinesteras Alzheimer's disease. Pescado marino Composición de ácidos grasos Ácidos grasos poliinsaturados Acetilcolinesterasa Enfermedad de Alzheimer. |
title_short |
Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast |
title_full |
Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast |
title_fullStr |
Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast |
title_full_unstemmed |
Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast |
title_sort |
Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast |
author |
Moura, Séfura Maria Assis |
author_facet |
Moura, Séfura Maria Assis Morais, Selene Maia de Carioca, José Osvaldo Beserra Rodrigues, Ana Livya Moreira Alves, Daniela Ribeiro Silva , Francisco Felipe Maia da Silva, Ana Carolina Silva e Amaral , Sheyla Maria Barreto Silva, Ysabele Yngrydh Valente |
author_role |
author |
author2 |
Morais, Selene Maia de Carioca, José Osvaldo Beserra Rodrigues, Ana Livya Moreira Alves, Daniela Ribeiro Silva , Francisco Felipe Maia da Silva, Ana Carolina Silva e Amaral , Sheyla Maria Barreto Silva, Ysabele Yngrydh Valente |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Moura, Séfura Maria Assis Morais, Selene Maia de Carioca, José Osvaldo Beserra Rodrigues, Ana Livya Moreira Alves, Daniela Ribeiro Silva , Francisco Felipe Maia da Silva, Ana Carolina Silva e Amaral , Sheyla Maria Barreto Silva, Ysabele Yngrydh Valente |
dc.subject.por.fl_str_mv |
Peixes marinhos Composição de ácidos graxos Ácidos graxos poli-insaturados Acetilcolinesterase Doença de Alzheimer. Marine fish Fatty acids composition Polyunsaturated fatty acids Acetylcholinesteras Alzheimer's disease. Pescado marino Composición de ácidos grasos Ácidos grasos poliinsaturados Acetilcolinesterasa Enfermedad de Alzheimer. |
topic |
Peixes marinhos Composição de ácidos graxos Ácidos graxos poli-insaturados Acetilcolinesterase Doença de Alzheimer. Marine fish Fatty acids composition Polyunsaturated fatty acids Acetylcholinesteras Alzheimer's disease. Pescado marino Composición de ácidos grasos Ácidos grasos poliinsaturados Acetilcolinesterasa Enfermedad de Alzheimer. |
description |
Acetylcholine deficiency is a neurochemical characteristic of patients with clinical diagnosis of Alzheimer´s disease. Substances that inhibit the enzyme acetylcholinesterase, increasing levels of acetylcholine in the brain, are a promising form of treatment. Studies relate the use of omega-3 fatty acids in the treatment and prevention of Alzheimer's disease. The Northeast Region of Brazil has an enormous biological diversity and a wide variety of fish species. In this work, the oils of eleven species of marine fish found on the coast of Ceará, Brazil, were analyzed in relation to the fatty acid profile and the inhibitory activity of the enzyme acetylcholinesterase. Total lipids were extracted from fish samples by Folch metodology. The lipid extracts of the fish and industrialized fish oil, used for comparison, were esterified and fatty acid profiles were analyzed. The acetylcholinesterase inhibitory activity was measured quantitatively. The oils presented a high percentage of saturated fatty acids, which is a general characteristic of tropical fish. Oleic acid was the highest monounsaturated fatty acid. Oils of Scomberomorus cavalla, Lutjanus synagris and Haemulon plumieri presented expressive percentages of polyunsaturated fatty acids and the most potent anticholinesterase activities. This research showed the oils of S. cavalla, L. synagris and H. plumieri may be promising functional food products of active fatty acids as new therapies to treatment or prevention of Alzheimer's disease. The expressive concentration of unsaturated and polyunsaturated fatty acids together with their relevant anticholinesterase activity are characteristics of the importance of these fish oils. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18968 10.33448/rsd-v10i10.18968 |
url |
https://rsdjournal.org/index.php/rsd/article/view/18968 |
identifier_str_mv |
10.33448/rsd-v10i10.18968 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18968/17013 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 10; e450101018968 Research, Society and Development; Vol. 10 Núm. 10; e450101018968 Research, Society and Development; v. 10 n. 10; e450101018968 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052818701418496 |