Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast

Detalhes bibliográficos
Autor(a) principal: Moura, Séfura Maria Assis
Data de Publicação: 2021
Outros Autores: Morais, Selene Maia de, Carioca, José Osvaldo Beserra, Rodrigues, Ana Livya Moreira, Alves, Daniela Ribeiro, Silva , Francisco Felipe Maia da, Silva, Ana Carolina Silva e, Amaral , Sheyla Maria Barreto, Silva, Ysabele Yngrydh Valente
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/18968
Resumo: Acetylcholine deficiency is a neurochemical characteristic of patients with clinical diagnosis of Alzheimer´s disease. Substances that inhibit the enzyme acetylcholinesterase, increasing levels of acetylcholine in the brain, are a promising form of treatment. Studies relate the use of omega-3 fatty acids in the treatment and prevention of Alzheimer's disease. The Northeast Region of Brazil has an enormous biological diversity and a wide variety of fish species. In this work, the oils of eleven species of marine fish found on the coast of Ceará, Brazil, were analyzed in relation to the fatty acid profile and the inhibitory activity of the enzyme acetylcholinesterase. Total lipids were extracted from fish samples by Folch metodology. The lipid extracts of the fish and industrialized fish oil, used for comparison, were esterified and fatty acid profiles were analyzed. The acetylcholinesterase inhibitory activity was measured quantitatively. The oils presented a high percentage of saturated fatty acids, which is a general characteristic of tropical fish. Oleic acid was the highest monounsaturated fatty acid. Oils of Scomberomorus cavalla, Lutjanus synagris and Haemulon plumieri presented expressive percentages of polyunsaturated fatty acids and the most potent anticholinesterase activities. This research showed the oils of S. cavalla, L. synagris and H. plumieri may be promising functional food products of active fatty acids as new therapies to treatment or prevention of Alzheimer's disease. The expressive concentration of unsaturated and polyunsaturated fatty acids together with their relevant anticholinesterase activity are characteristics of the importance of these fish oils.
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spelling Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast Perfil de ácidos grasos y actividad anticolinesterasa de los lípidos de pescado del Noreste de BrasilPerfil de ácidos graxos e atividade anticolinesterásica de lipídios de peixes do Nordeste do BrasilPeixes marinhosComposição de ácidos graxosÁcidos graxos poli-insaturadosAcetilcolinesteraseDoença de Alzheimer.Marine fishFatty acids compositionPolyunsaturated fatty acidsAcetylcholinesterasAlzheimer's disease.Pescado marinoComposición de ácidos grasosÁcidos grasos poliinsaturadosAcetilcolinesterasaEnfermedad de Alzheimer.Acetylcholine deficiency is a neurochemical characteristic of patients with clinical diagnosis of Alzheimer´s disease. Substances that inhibit the enzyme acetylcholinesterase, increasing levels of acetylcholine in the brain, are a promising form of treatment. Studies relate the use of omega-3 fatty acids in the treatment and prevention of Alzheimer's disease. The Northeast Region of Brazil has an enormous biological diversity and a wide variety of fish species. In this work, the oils of eleven species of marine fish found on the coast of Ceará, Brazil, were analyzed in relation to the fatty acid profile and the inhibitory activity of the enzyme acetylcholinesterase. Total lipids were extracted from fish samples by Folch metodology. The lipid extracts of the fish and industrialized fish oil, used for comparison, were esterified and fatty acid profiles were analyzed. The acetylcholinesterase inhibitory activity was measured quantitatively. The oils presented a high percentage of saturated fatty acids, which is a general characteristic of tropical fish. Oleic acid was the highest monounsaturated fatty acid. Oils of Scomberomorus cavalla, Lutjanus synagris and Haemulon plumieri presented expressive percentages of polyunsaturated fatty acids and the most potent anticholinesterase activities. This research showed the oils of S. cavalla, L. synagris and H. plumieri may be promising functional food products of active fatty acids as new therapies to treatment or prevention of Alzheimer's disease. The expressive concentration of unsaturated and polyunsaturated fatty acids together with their relevant anticholinesterase activity are characteristics of the importance of these fish oils.A deficiência da acetilcolina é uma característica neuroquímica de pacientes com diagnóstico clínico da doença de Alzheimer. As substâncias que inibem a enzima acetilcolinesterase, aumentando os níveis de acetilcolina no cérebro, são uma forma promissora de tratamento. Estudos relacionam o uso de ácidos graxos ômega-3 no tratamento e prevenção da doença. Neste trabalho, os óleos de onze espécies de peixes marinhos encontrados no litoral do Ceará, Brasil, foram analisados em relação ao perfil de ácidos graxos e à atividade inibitória da enzima acetilcolinesterase. Os lipídios totais foram extraídos das amostras de peixes pela metodologia de Folch. Os extratos lipídicos dos peixes e o óleo de peixe industrializado, usado para comparação, foram esterificados e os perfis de ácidos graxos analisados. A atividade inibitória da acetilcolinesterase foi medida quantitativamente. Os óleos apresentaram elevados percentuais de ácidos graxos saturados, característica dos peixes de águas tropicais. O ácido oléico representou o ácido graxo monoinsaturado em maior proporção. Os óleos de Scomberomorus cavalla, Lutjanus synagris e Haemulon plumieri apresentaram percentuais expressivos de ácidos graxos poli-insaturados, assim como as mais potentes atividades anticolinesterásicas. Dessa forma, a pesquisa demonstrou a importância dos óleos de S. cavalla, L. synagris e H. plumieri, como alimentos funcionais ricos em ácidos graxos ativos, e que podem ser utilizados em novas terapias para o tratamento ou prevenção da doença de Alzheimer.A deficiência da acetilcolina é uma característica neuroquímica de pacientes com diagnóstico clínico da doença de Alzheimer. As substâncias que inibem a enzima acetilcolinesterase, aumentando os níveis de acetilcolina no cérebro, são uma forma promissora de tratamento. Estudos relacionam o uso de ácidos graxos ômega-3 no tratamento e prevenção da doença. Neste trabalho, os óleos de onze espécies de peixes marinhos encontrados no litoral do Ceará, Brasil, foram analisados em relação ao perfil de ácidos graxos e à atividade inibitória da enzima acetilcolinesterase. Os lipídios totais foram extraídos das amostras de peixes pela metodologia de Folch. Os extratos lipídicos dos peixes e o óleo de peixe industrializado, usado para comparação, foram esterificados e os perfis de ácidos graxos analisados. A atividade inibitória da acetilcolinesterase foi medida quantitativamente. Os óleos apresentaram elevados percentuais de ácidos graxos saturados, característica dos peixes de águas tropicais. O ácido oléico representou o ácido graxo monoinsaturado em maior proporção. Os óleos de Scomberomorus cavalla, Lutjanus synagris e Haemulon plumieri apresentaram percentuais expressivos de ácidos graxos poli-insaturados, assim como as mais potentes atividades anticolinesterásicas. Dessa forma, a pesquisa demonstrou a importância dos óleos de S. cavalla, L. synagris e H. plumieri, como alimentos funcionais ricos em ácidos graxos ativos, e que podem ser utilizados em novas terapias para o tratamento ou prevenção da doença de Alzheimer.Research, Society and Development2021-08-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1896810.33448/rsd-v10i10.18968Research, Society and Development; Vol. 10 No. 10; e450101018968Research, Society and Development; Vol. 10 Núm. 10; e450101018968Research, Society and Development; v. 10 n. 10; e4501010189682525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/18968/17013Copyright (c) 2021 Séfura Maria Assis Moura; Selene Maia de Morais; José Osvaldo Beserra Carioca; Ana Livya Moreira Rodrigues; Daniela Ribeiro Alves; Francisco Felipe Maia da Silva ; Ana Carolina Silva e Silva; Sheyla Maria Barreto Amaral ; Ysabele Yngrydh Valente Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMoura, Séfura Maria AssisMorais, Selene Maia deCarioca, José Osvaldo BeserraRodrigues, Ana Livya MoreiraAlves, Daniela RibeiroSilva , Francisco Felipe Maia daSilva, Ana Carolina Silva eAmaral , Sheyla Maria BarretoSilva, Ysabele Yngrydh Valente2021-10-02T21:49:16Zoai:ojs.pkp.sfu.ca:article/18968Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:58.398732Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast
Perfil de ácidos grasos y actividad anticolinesterasa de los lípidos de pescado del Noreste de Brasil
Perfil de ácidos graxos e atividade anticolinesterásica de lipídios de peixes do Nordeste do Brasil
title Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast
spellingShingle Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast
Moura, Séfura Maria Assis
Peixes marinhos
Composição de ácidos graxos
Ácidos graxos poli-insaturados
Acetilcolinesterase
Doença de Alzheimer.
Marine fish
Fatty acids composition
Polyunsaturated fatty acids
Acetylcholinesteras
Alzheimer's disease.
Pescado marino
Composición de ácidos grasos
Ácidos grasos poliinsaturados
Acetilcolinesterasa
Enfermedad de Alzheimer.
title_short Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast
title_full Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast
title_fullStr Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast
title_full_unstemmed Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast
title_sort Fatty acids profile and anticholinesterase activity of fish lipids from Brazilian Northeast
author Moura, Séfura Maria Assis
author_facet Moura, Séfura Maria Assis
Morais, Selene Maia de
Carioca, José Osvaldo Beserra
Rodrigues, Ana Livya Moreira
Alves, Daniela Ribeiro
Silva , Francisco Felipe Maia da
Silva, Ana Carolina Silva e
Amaral , Sheyla Maria Barreto
Silva, Ysabele Yngrydh Valente
author_role author
author2 Morais, Selene Maia de
Carioca, José Osvaldo Beserra
Rodrigues, Ana Livya Moreira
Alves, Daniela Ribeiro
Silva , Francisco Felipe Maia da
Silva, Ana Carolina Silva e
Amaral , Sheyla Maria Barreto
Silva, Ysabele Yngrydh Valente
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moura, Séfura Maria Assis
Morais, Selene Maia de
Carioca, José Osvaldo Beserra
Rodrigues, Ana Livya Moreira
Alves, Daniela Ribeiro
Silva , Francisco Felipe Maia da
Silva, Ana Carolina Silva e
Amaral , Sheyla Maria Barreto
Silva, Ysabele Yngrydh Valente
dc.subject.por.fl_str_mv Peixes marinhos
Composição de ácidos graxos
Ácidos graxos poli-insaturados
Acetilcolinesterase
Doença de Alzheimer.
Marine fish
Fatty acids composition
Polyunsaturated fatty acids
Acetylcholinesteras
Alzheimer's disease.
Pescado marino
Composición de ácidos grasos
Ácidos grasos poliinsaturados
Acetilcolinesterasa
Enfermedad de Alzheimer.
topic Peixes marinhos
Composição de ácidos graxos
Ácidos graxos poli-insaturados
Acetilcolinesterase
Doença de Alzheimer.
Marine fish
Fatty acids composition
Polyunsaturated fatty acids
Acetylcholinesteras
Alzheimer's disease.
Pescado marino
Composición de ácidos grasos
Ácidos grasos poliinsaturados
Acetilcolinesterasa
Enfermedad de Alzheimer.
description Acetylcholine deficiency is a neurochemical characteristic of patients with clinical diagnosis of Alzheimer´s disease. Substances that inhibit the enzyme acetylcholinesterase, increasing levels of acetylcholine in the brain, are a promising form of treatment. Studies relate the use of omega-3 fatty acids in the treatment and prevention of Alzheimer's disease. The Northeast Region of Brazil has an enormous biological diversity and a wide variety of fish species. In this work, the oils of eleven species of marine fish found on the coast of Ceará, Brazil, were analyzed in relation to the fatty acid profile and the inhibitory activity of the enzyme acetylcholinesterase. Total lipids were extracted from fish samples by Folch metodology. The lipid extracts of the fish and industrialized fish oil, used for comparison, were esterified and fatty acid profiles were analyzed. The acetylcholinesterase inhibitory activity was measured quantitatively. The oils presented a high percentage of saturated fatty acids, which is a general characteristic of tropical fish. Oleic acid was the highest monounsaturated fatty acid. Oils of Scomberomorus cavalla, Lutjanus synagris and Haemulon plumieri presented expressive percentages of polyunsaturated fatty acids and the most potent anticholinesterase activities. This research showed the oils of S. cavalla, L. synagris and H. plumieri may be promising functional food products of active fatty acids as new therapies to treatment or prevention of Alzheimer's disease. The expressive concentration of unsaturated and polyunsaturated fatty acids together with their relevant anticholinesterase activity are characteristics of the importance of these fish oils.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/18968
10.33448/rsd-v10i10.18968
url https://rsdjournal.org/index.php/rsd/article/view/18968
identifier_str_mv 10.33448/rsd-v10i10.18968
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/18968/17013
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 10; e450101018968
Research, Society and Development; Vol. 10 Núm. 10; e450101018968
Research, Society and Development; v. 10 n. 10; e450101018968
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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