The effect of antioneoplastic agents on the periodontium: a narrative literature review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/32408 |
Resumo: | Objective: The aim of this study is to describe a narrative review about the effects of chemotherapeutics agents on periodontium and emphasize the clinical importance of dentists during multidisciplinary therapy in cancer patients. Methods: A exploratory research process was performed in the electronic databases Pubmed/Medline, Embase, Scopus and Scielo, using search terms: “chemotherapy and periodontitis”, “chemotherapy and gingivitis” and “chemotherapy and periodontal disease”, and it was considered articles published until june 2022. Results and discussion: Chemotherapeutic agents do no act on specific cells, they affect rapidly proliferating cells and cause cytotoxicity to connective tissue cells. Therefore, chemotherapeutic agents causes destruction of the junctional epithelium and exacerbates the inflammatory process of the gingival connective tissue. Once periodontitis that occurs by the interaction between bacterial plaque and the host is located, chemotherapeutic agents aggravates its progression. In addition, chemotherapy drugs can affect periodontal tissues indirectly by xerostomia and increasing the amount of bacteria in the mouth. Periodontal diseases are risk factors for systemic diseases such as: cardiovascular diseases, respiratory diseases, diabetes, Alzheimer's disease and adverse pregnancy outcomes and it is up to the dentist of multidisciplinary team to monitor and identify possible risks in the oral treatment of cancer patients. Within the limits of the this literature review, it can be concluded that periodontal tissues are harmzed by chemotherapy and prevention measures or forms of treatment must be taken into account by the dentists of the multidisciplinary oncology team. |
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The effect of antioneoplastic agents on the periodontium: a narrative literature reviewEl efecto de los agentes antineoplásicos en el periodoncio: una revisión narrativa de la literaturaO efeito dos agentes quimioterápicos sobre o periodonto: revisão narrativa de literaturaAntineoplastic agentsPeriodontal diseasesGingivitisPeriodontitisAlveolar bone loss.Agentes antineoplásicosEnfermedades periodontalesGingivitisPeriodontitisPérdida de hueso alveolar.Agentes antineoplásicosDoenças periodontaisGengivitePeriodontitePerda do osso alveolar.Objective: The aim of this study is to describe a narrative review about the effects of chemotherapeutics agents on periodontium and emphasize the clinical importance of dentists during multidisciplinary therapy in cancer patients. Methods: A exploratory research process was performed in the electronic databases Pubmed/Medline, Embase, Scopus and Scielo, using search terms: “chemotherapy and periodontitis”, “chemotherapy and gingivitis” and “chemotherapy and periodontal disease”, and it was considered articles published until june 2022. Results and discussion: Chemotherapeutic agents do no act on specific cells, they affect rapidly proliferating cells and cause cytotoxicity to connective tissue cells. Therefore, chemotherapeutic agents causes destruction of the junctional epithelium and exacerbates the inflammatory process of the gingival connective tissue. Once periodontitis that occurs by the interaction between bacterial plaque and the host is located, chemotherapeutic agents aggravates its progression. In addition, chemotherapy drugs can affect periodontal tissues indirectly by xerostomia and increasing the amount of bacteria in the mouth. Periodontal diseases are risk factors for systemic diseases such as: cardiovascular diseases, respiratory diseases, diabetes, Alzheimer's disease and adverse pregnancy outcomes and it is up to the dentist of multidisciplinary team to monitor and identify possible risks in the oral treatment of cancer patients. Within the limits of the this literature review, it can be concluded that periodontal tissues are harmzed by chemotherapy and prevention measures or forms of treatment must be taken into account by the dentists of the multidisciplinary oncology team.Objetivo: El objetivo de este trabajo es describir una revisión narrativa de la literatura sobre los efectos de los agentes antineoplásicos en el periodoncio y enfatizar la importancia clínica de los cirujanos dentistas durante la terapia multidisciplinaria en pacientes con cáncer. Metodología: Se realizó una búsqueda bibliográfica exploratoria en las bases de datos electrónicas Pubmed/Medline, Embase, Scopus y Scielo, utilizando los términos de búsqueda “quimioterapia and periodontitis”, “quimioterapia and gingivitis” y “quimioterapia and periodontal disease”, considerándose los artículos publicados hasta junio de 2022. Resultados y discusión: Los quimioterapéuticos no actúan sobre células específicas, afectan las células que proliferan rápidamente y causan citotoxicidad en varias células del tejido conectivo. De esta forma, los quimioterápicos provocan la destrucción del epitelio de unión y exacerban el proceso inflamatorio del tejido conectivo gingival. Cuando aparece la periodontitis que se produce por la interacción entre la placa bacteriana y el huésped, los agentes antineoplásicos empeoran su progresión. Además, los medicamentos de quimioterapia pueden afectar indirectamente los tejidos periodontales al causar xerostomía y aumentar la cantidad de bacterias en la boca. Las enfermedades periodontales son factores de riesgo para enfermedades sistémicas como: enfermedades cardiovasculares, enfermedades del tracto respiratorio, diabetes, enfermedad de Alzheimer y resultados adversos del embarazo, y corresponde al cirujano dentista en el equipo multidisciplinario monitorear y identificar posibles riesgos en el tratamiento oral de pacientes con cáncer. Conclusión: Dentro de los límites de la presente revisión bibliográfica, se puede concluir que los tejidos periodontales son atacados por el uso de quimioterapia y las medidas de prevención y formas de tratamiento deben ser tenidas en cuenta por el cirujano dentista del equipo oncológico multidisciplinarioObjetivo: O objetivo deste trabalho é descrever uma revisão narrativa de literatura sobre os efeitos dos agentes quimioterápicos no periodonto e salientar sobre a importância clínica dos cirurgiões dentistas durante a terapia multidisciplinar em pacientes oncológicos. Metodologia: Uma pesquisa bibliográfica exploratória foi realizada nas bases de dados eletrônicas Pubmed/Medline, Embase, Scopus e Scielo, utilizando os termos de busca “chemotherapy and periodontitis”, “chemotherapy and gingivitis” e “chemotherapy and periodontal disease”, sendo considerado os artigos publicados até junho de 2022. Resultados e discussão: Os quimioterápicos não atuam sobre células específicas, eles afetam células de rápida proliferação celular e causam citotoxicidade várias células do tecido conjuntivo. Desta forma, os quimioterápicos causam destruição do epitélio juncional e exacerbam o processo inflamatório do tecido conjuntivo gengival. Quando a periodontite que ocorre pela interação placa bacteriana e o hospedeiro se instala, os quimioterápicos agravam sua progressão. Além disso, quimioterápicos podem afetar os tecidos periodontais de maneira indireta por causar xerostomia e aumentar a quantidade de bactérias da boca. As doenças periodontais são fatores de risco para doenças sistêmicas como: doenças cardiovasculares, doenças do trato respiratório, diabetes, doença de Alzheimer e resultados adversos da gravidez e cabe ao cirurgião dentista da equipe multidisciplinar acompanhar e identificar possíveis riscos no tratamento bucal de pacientes oncológicos. Conclusão: Dentro dos limites da presente revisão de literatura, pode-se concluir que os tecidos periodontais são agredidos pela utilização dos quimioterápicos e medidas de prevenção ou formas de tratamento devem ser levadas em consideração pelo cirurgião dentista da equipe multidisciplinar oncológica. Research, Society and Development2022-07-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3240810.33448/rsd-v11i10.32408Research, Society and Development; Vol. 11 No. 10; e147111032408Research, Society and Development; Vol. 11 Núm. 10; e147111032408Research, Society and Development; v. 11 n. 10; e1471110324082525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/32408/27634Copyright (c) 2022 David Jonathan Rodrigues Gusman; Priscila Arisa Sasaki; Paula Lazilha Faleiros; Patricia Monteiro Seraphim; Christine Men Martins; Bruna Millena da Silva; Amanda Munarolo Piacenza de Oliveira; Eder da Silva Dolens; Juliano Milanezi de Almeidahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGusman, David Jonathan Rodrigues Sasaki, Priscila Arisa Faleiros, Paula LazilhaSeraphim, Patricia Monteiro Martins, Christine Men Silva, Bruna Millena da Oliveira, Amanda Munarolo Piacenza de Dolens, Eder da Silva Almeida, Juliano Milanezi de 2022-08-12T22:23:03Zoai:ojs.pkp.sfu.ca:article/32408Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:48:25.692332Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
The effect of antioneoplastic agents on the periodontium: a narrative literature review El efecto de los agentes antineoplásicos en el periodoncio: una revisión narrativa de la literatura O efeito dos agentes quimioterápicos sobre o periodonto: revisão narrativa de literatura |
title |
The effect of antioneoplastic agents on the periodontium: a narrative literature review |
spellingShingle |
The effect of antioneoplastic agents on the periodontium: a narrative literature review Gusman, David Jonathan Rodrigues Antineoplastic agents Periodontal diseases Gingivitis Periodontitis Alveolar bone loss. Agentes antineoplásicos Enfermedades periodontales Gingivitis Periodontitis Pérdida de hueso alveolar. Agentes antineoplásicos Doenças periodontais Gengivite Periodontite Perda do osso alveolar. |
title_short |
The effect of antioneoplastic agents on the periodontium: a narrative literature review |
title_full |
The effect of antioneoplastic agents on the periodontium: a narrative literature review |
title_fullStr |
The effect of antioneoplastic agents on the periodontium: a narrative literature review |
title_full_unstemmed |
The effect of antioneoplastic agents on the periodontium: a narrative literature review |
title_sort |
The effect of antioneoplastic agents on the periodontium: a narrative literature review |
author |
Gusman, David Jonathan Rodrigues |
author_facet |
Gusman, David Jonathan Rodrigues Sasaki, Priscila Arisa Faleiros, Paula Lazilha Seraphim, Patricia Monteiro Martins, Christine Men Silva, Bruna Millena da Oliveira, Amanda Munarolo Piacenza de Dolens, Eder da Silva Almeida, Juliano Milanezi de |
author_role |
author |
author2 |
Sasaki, Priscila Arisa Faleiros, Paula Lazilha Seraphim, Patricia Monteiro Martins, Christine Men Silva, Bruna Millena da Oliveira, Amanda Munarolo Piacenza de Dolens, Eder da Silva Almeida, Juliano Milanezi de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gusman, David Jonathan Rodrigues Sasaki, Priscila Arisa Faleiros, Paula Lazilha Seraphim, Patricia Monteiro Martins, Christine Men Silva, Bruna Millena da Oliveira, Amanda Munarolo Piacenza de Dolens, Eder da Silva Almeida, Juliano Milanezi de |
dc.subject.por.fl_str_mv |
Antineoplastic agents Periodontal diseases Gingivitis Periodontitis Alveolar bone loss. Agentes antineoplásicos Enfermedades periodontales Gingivitis Periodontitis Pérdida de hueso alveolar. Agentes antineoplásicos Doenças periodontais Gengivite Periodontite Perda do osso alveolar. |
topic |
Antineoplastic agents Periodontal diseases Gingivitis Periodontitis Alveolar bone loss. Agentes antineoplásicos Enfermedades periodontales Gingivitis Periodontitis Pérdida de hueso alveolar. Agentes antineoplásicos Doenças periodontais Gengivite Periodontite Perda do osso alveolar. |
description |
Objective: The aim of this study is to describe a narrative review about the effects of chemotherapeutics agents on periodontium and emphasize the clinical importance of dentists during multidisciplinary therapy in cancer patients. Methods: A exploratory research process was performed in the electronic databases Pubmed/Medline, Embase, Scopus and Scielo, using search terms: “chemotherapy and periodontitis”, “chemotherapy and gingivitis” and “chemotherapy and periodontal disease”, and it was considered articles published until june 2022. Results and discussion: Chemotherapeutic agents do no act on specific cells, they affect rapidly proliferating cells and cause cytotoxicity to connective tissue cells. Therefore, chemotherapeutic agents causes destruction of the junctional epithelium and exacerbates the inflammatory process of the gingival connective tissue. Once periodontitis that occurs by the interaction between bacterial plaque and the host is located, chemotherapeutic agents aggravates its progression. In addition, chemotherapy drugs can affect periodontal tissues indirectly by xerostomia and increasing the amount of bacteria in the mouth. Periodontal diseases are risk factors for systemic diseases such as: cardiovascular diseases, respiratory diseases, diabetes, Alzheimer's disease and adverse pregnancy outcomes and it is up to the dentist of multidisciplinary team to monitor and identify possible risks in the oral treatment of cancer patients. Within the limits of the this literature review, it can be concluded that periodontal tissues are harmzed by chemotherapy and prevention measures or forms of treatment must be taken into account by the dentists of the multidisciplinary oncology team. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/32408 10.33448/rsd-v11i10.32408 |
url |
https://rsdjournal.org/index.php/rsd/article/view/32408 |
identifier_str_mv |
10.33448/rsd-v11i10.32408 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/32408/27634 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 10; e147111032408 Research, Society and Development; Vol. 11 Núm. 10; e147111032408 Research, Society and Development; v. 11 n. 10; e147111032408 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052718341160960 |