Biomolecules present in tick saliva with pharmacological potential: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/40453 |
Resumo: | Knowing that ticks have bioactive molecules in their saliva which modulate hemostatic and immunomodulatory activities in humans, we carried out a systematic search for biomolecules present in tick saliva with great pharmacological potential. We evaluated studies published in the last ten years. Following the recommendations of the Prisma tool, primary and secondary studies of a systematic nature were selected, with no language or country restriction. Studies that included arthropods other than ticks and studies in which the use of saliva had no pharmacological application were excluded. For searches, we used the following databases: MEDLINE®/PubMed®, Web of Science, LILACS, EMBASE, Cochrane and SCOPUS. The methodological quality was performed using the tools available in Joanna Briggs, always with two or more independent evaluators. The generated data were tabulated and summarized through qualitative narrative analysis. The methodology selected 19 articles that met the eligibility criteria. The saliva of hard ticks, found in the Americas, is more promising when used in experimental studies with human cells. The elucidation of the biomolecules was possible, with evasin and serpine being the biomolecules with the most evident pharmacological potential for anti-inflammatory action. In the selected studies, we found only experimental studies, with no pre-clinical or clinical studies, making methodological qualification difficult; in some studies, with the biomolecule Evasin and Serpin, the need for elucidation of these biomolecules in question was suggested. Thus, we found evidence that the saliva of American hard ticks is the most studied for pharmacological applications of anti-inflammatory and immunomodulatory action. |
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Biomolecules present in tick saliva with pharmacological potential: a systematic reviewBiomoléculas presentes en la saliva de garrapatas con potencial farmacológico: una revisión sistemáticaBiomoléculas presentes na saliva do carrapato com potencial farmacológico: uma revisão sistemáticaSalivaCarrapatoPotencial farmacológicoBiomoléculas salivares.SalivaGarrapataPotencial farmacológicoBiomoléculas salivales.SalivaTickPharmacological potentialSalivary biomolecules.Knowing that ticks have bioactive molecules in their saliva which modulate hemostatic and immunomodulatory activities in humans, we carried out a systematic search for biomolecules present in tick saliva with great pharmacological potential. We evaluated studies published in the last ten years. Following the recommendations of the Prisma tool, primary and secondary studies of a systematic nature were selected, with no language or country restriction. Studies that included arthropods other than ticks and studies in which the use of saliva had no pharmacological application were excluded. For searches, we used the following databases: MEDLINE®/PubMed®, Web of Science, LILACS, EMBASE, Cochrane and SCOPUS. The methodological quality was performed using the tools available in Joanna Briggs, always with two or more independent evaluators. The generated data were tabulated and summarized through qualitative narrative analysis. The methodology selected 19 articles that met the eligibility criteria. The saliva of hard ticks, found in the Americas, is more promising when used in experimental studies with human cells. The elucidation of the biomolecules was possible, with evasin and serpine being the biomolecules with the most evident pharmacological potential for anti-inflammatory action. In the selected studies, we found only experimental studies, with no pre-clinical or clinical studies, making methodological qualification difficult; in some studies, with the biomolecule Evasin and Serpin, the need for elucidation of these biomolecules in question was suggested. Thus, we found evidence that the saliva of American hard ticks is the most studied for pharmacological applications of anti-inflammatory and immunomodulatory action.Sabiendo que las garrapatas tienen moléculas bioactivas en su saliva que modulan las actividades hemostáticas e inmunomoduladoras en humanos, llevamos a cabo una búsqueda sistemática de biomoléculas presentes en la saliva de las garrapatas con gran potencial farmacológico. Los estudios publicados en los últimos diez años. Siguiendo las recomendaciones de la herramienta Prisma, se seleccionaron estudios primarios y secundarios de carácter sistemático, sin restricción de idioma o país. Se excluyeron los estudios que incluyeron artrópodos distintos a las garrapatas y los estudios en los que el uso de saliva no tuvo aplicación farmacológica. Para las búsquedas utilizamos las bases de datos: MEDLINE®/PubMed®, Web of Science, LILACS, EMBASE, Cochrane y SCOPUS. La calidad metodológica se realizó utilizando las herramientas disponibles en Joanna Briggs. Los datos generados fueron tabulados y resumidos mediante análisis narrativo cualitativo. La metodología seleccionó 19 artículos que cumplían con los criterios de elegibilidad. La saliva de las garrapatas duras, es más prometedora cuando se usa en estudios experimentales con células humanas. La elucidación de las biomoléculas fue posible, siendo la evasina y la serpina las biomoléculas con el potencial farmacológico más evidente para la acción antiinflamatoria. En los estudios seleccionados, encontramos solo estudios experimentales, sin estudios preclínicos ni clínicos, lo que dificulta la calificación metodológica; en algunos estudios, con las biomoléculas Evasin y Serpin, se sugirió la necesidad de dilucidar estas biomoléculas en cuestión. Así, encontramos evidencia de que la saliva de la garrapata dura americana es la más estudiada para aplicaciones farmacológicas de acción antiinflamatoria e inmunomoduladora.Sabendo que os carrapatos possuem moléculas bioativas em sua saliva as quais modulam atividades hemostáticas e imunomoduladoras em humanos, realizamos uma busca sistemática de biomoléculas presentes na saliva do carrapato com grande potencial farmacológico. Avaliamos estudos publicados nos últimos dez anos. Seguindo as recomendações da ferramenta Prisma, foram selecionados estudos primários e secundários de caráter sistemático, não havendo restrição de idioma ou país. Foram excluídos estudos que incluíam artrópodes diferentes de carrapatos e estudos em que o uso de saliva não tinha aplicação farmacológica. Para as buscas, utilizamos as seguintes bases de dados: MEDLINE®/PubMed®, Web of Science, LILACS, EMBASE, Cochrane e SCOPUS. A qualidade metodológica foi realizada com as ferramentas disponíveis no Joanna Briggs, sempre com dois ou mais avaliadores independentes. Os dados gerados foram tabulados e resumidos por meio de análise narrativa qualitativa. A metodologia selecionou 19 artigos que atenderam aos critérios de elegibilidade. As salivas de carrapatos duros, encontrados nas Américas, são mais promissoras quando utilizadas em estudos experimentais com células humanas. A elucidação das biomoléculas foi possível, sendo a evasina e a serpina as biomoléculas com os potenciais farmacológicos mais evidentes para ação anti-inflamatória. Nos estudos selecionados encontramos apenas estudos experimentais, não havendo estudos pré-clínicos ou clínicos, dificultando a qualificação metodológica; em alguns estudos, com a biomolécula Evasin e Serpin, sugeriu-se a necessidade de elucidação dessas biomoléculas em questão. Assim, localizamos evidências que a saliva de carrapatos duros americanos é a mais estudada para aplicações farmacológicas de ação anti-inflamatória e imunomoduladora.Research, Society and Development2023-03-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4045310.33448/rsd-v12i3.40453Research, Society and Development; Vol. 12 No. 3; e16312340453Research, Society and Development; Vol. 12 Núm. 3; e16312340453Research, Society and Development; v. 12 n. 3; e163123404532525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/40453/33148Copyright (c) 2023 Yanne Oliveira Barbosa; Beatriz Rodrigues Martins; Cristhianne Molinero Andrade Ratkevicius; Wellington Francisco Rodrigues; Carlo José Freire Oliveira; Ana Paula Espindula ; Renata Pereira Alveshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBarbosa, Yanne Oliveira Martins, Beatriz Rodrigues Ratkevicius, Cristhianne Molinero Andrade Rodrigues, Wellington Francisco Oliveira, Carlo José Freire Espindula , Ana PaulaAlves, Renata Pereira 2023-03-23T08:33:38Zoai:ojs.pkp.sfu.ca:article/40453Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-03-23T08:33:38Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Biomolecules present in tick saliva with pharmacological potential: a systematic review Biomoléculas presentes en la saliva de garrapatas con potencial farmacológico: una revisión sistemática Biomoléculas presentes na saliva do carrapato com potencial farmacológico: uma revisão sistemática |
title |
Biomolecules present in tick saliva with pharmacological potential: a systematic review |
spellingShingle |
Biomolecules present in tick saliva with pharmacological potential: a systematic review Barbosa, Yanne Oliveira Saliva Carrapato Potencial farmacológico Biomoléculas salivares. Saliva Garrapata Potencial farmacológico Biomoléculas salivales. Saliva Tick Pharmacological potential Salivary biomolecules. |
title_short |
Biomolecules present in tick saliva with pharmacological potential: a systematic review |
title_full |
Biomolecules present in tick saliva with pharmacological potential: a systematic review |
title_fullStr |
Biomolecules present in tick saliva with pharmacological potential: a systematic review |
title_full_unstemmed |
Biomolecules present in tick saliva with pharmacological potential: a systematic review |
title_sort |
Biomolecules present in tick saliva with pharmacological potential: a systematic review |
author |
Barbosa, Yanne Oliveira |
author_facet |
Barbosa, Yanne Oliveira Martins, Beatriz Rodrigues Ratkevicius, Cristhianne Molinero Andrade Rodrigues, Wellington Francisco Oliveira, Carlo José Freire Espindula , Ana Paula Alves, Renata Pereira |
author_role |
author |
author2 |
Martins, Beatriz Rodrigues Ratkevicius, Cristhianne Molinero Andrade Rodrigues, Wellington Francisco Oliveira, Carlo José Freire Espindula , Ana Paula Alves, Renata Pereira |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Barbosa, Yanne Oliveira Martins, Beatriz Rodrigues Ratkevicius, Cristhianne Molinero Andrade Rodrigues, Wellington Francisco Oliveira, Carlo José Freire Espindula , Ana Paula Alves, Renata Pereira |
dc.subject.por.fl_str_mv |
Saliva Carrapato Potencial farmacológico Biomoléculas salivares. Saliva Garrapata Potencial farmacológico Biomoléculas salivales. Saliva Tick Pharmacological potential Salivary biomolecules. |
topic |
Saliva Carrapato Potencial farmacológico Biomoléculas salivares. Saliva Garrapata Potencial farmacológico Biomoléculas salivales. Saliva Tick Pharmacological potential Salivary biomolecules. |
description |
Knowing that ticks have bioactive molecules in their saliva which modulate hemostatic and immunomodulatory activities in humans, we carried out a systematic search for biomolecules present in tick saliva with great pharmacological potential. We evaluated studies published in the last ten years. Following the recommendations of the Prisma tool, primary and secondary studies of a systematic nature were selected, with no language or country restriction. Studies that included arthropods other than ticks and studies in which the use of saliva had no pharmacological application were excluded. For searches, we used the following databases: MEDLINE®/PubMed®, Web of Science, LILACS, EMBASE, Cochrane and SCOPUS. The methodological quality was performed using the tools available in Joanna Briggs, always with two or more independent evaluators. The generated data were tabulated and summarized through qualitative narrative analysis. The methodology selected 19 articles that met the eligibility criteria. The saliva of hard ticks, found in the Americas, is more promising when used in experimental studies with human cells. The elucidation of the biomolecules was possible, with evasin and serpine being the biomolecules with the most evident pharmacological potential for anti-inflammatory action. In the selected studies, we found only experimental studies, with no pre-clinical or clinical studies, making methodological qualification difficult; in some studies, with the biomolecule Evasin and Serpin, the need for elucidation of these biomolecules in question was suggested. Thus, we found evidence that the saliva of American hard ticks is the most studied for pharmacological applications of anti-inflammatory and immunomodulatory action. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40453 10.33448/rsd-v12i3.40453 |
url |
https://rsdjournal.org/index.php/rsd/article/view/40453 |
identifier_str_mv |
10.33448/rsd-v12i3.40453 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40453/33148 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 3; e16312340453 Research, Society and Development; Vol. 12 Núm. 3; e16312340453 Research, Society and Development; v. 12 n. 3; e16312340453 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052619163697152 |