Biomolecules present in tick saliva with pharmacological potential: a systematic review

Detalhes bibliográficos
Autor(a) principal: Barbosa, Yanne Oliveira
Data de Publicação: 2023
Outros Autores: Martins, Beatriz Rodrigues, Ratkevicius, Cristhianne Molinero Andrade, Rodrigues, Wellington Francisco, Oliveira, Carlo José Freire, Espindula , Ana Paula, Alves, Renata Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/40453
Resumo: Knowing that ticks have bioactive molecules in their saliva which modulate hemostatic and immunomodulatory activities in humans, we carried out a systematic search for biomolecules present in tick saliva with great pharmacological potential. We evaluated studies published in the last ten years. Following the recommendations of the Prisma tool, primary and secondary studies of a systematic nature were selected, with no language or country restriction. Studies that included arthropods other than ticks and studies in which the use of saliva had no pharmacological application were excluded. For searches, we used the following databases: MEDLINE®/PubMed®, Web of Science, LILACS, EMBASE, Cochrane and SCOPUS. The methodological quality was performed using the tools available in Joanna Briggs, always with two or more independent evaluators. The generated data were tabulated and summarized through qualitative narrative analysis. The methodology selected 19 articles that met the eligibility criteria. The saliva of hard ticks, found in the Americas, is more promising when used in experimental studies with human cells. The elucidation of the biomolecules was possible, with evasin and serpine being the biomolecules with the most evident pharmacological potential for anti-inflammatory action. In the selected studies, we found only experimental studies, with no pre-clinical or clinical studies, making methodological qualification difficult; in some studies, with the biomolecule Evasin and Serpin, the need for elucidation of these biomolecules in question was suggested. Thus, we found evidence that the saliva of American hard ticks is the most studied for pharmacological applications of anti-inflammatory and immunomodulatory action.
id UNIFEI_f774d60a589ede9d51fb296fd65fbc65
oai_identifier_str oai:ojs.pkp.sfu.ca:article/40453
network_acronym_str UNIFEI
network_name_str Research, Society and Development
repository_id_str
spelling Biomolecules present in tick saliva with pharmacological potential: a systematic reviewBiomoléculas presentes en la saliva de garrapatas con potencial farmacológico: una revisión sistemáticaBiomoléculas presentes na saliva do carrapato com potencial farmacológico: uma revisão sistemáticaSalivaCarrapatoPotencial farmacológicoBiomoléculas salivares.SalivaGarrapataPotencial farmacológicoBiomoléculas salivales.SalivaTickPharmacological potentialSalivary biomolecules.Knowing that ticks have bioactive molecules in their saliva which modulate hemostatic and immunomodulatory activities in humans, we carried out a systematic search for biomolecules present in tick saliva with great pharmacological potential. We evaluated studies published in the last ten years. Following the recommendations of the Prisma tool, primary and secondary studies of a systematic nature were selected, with no language or country restriction. Studies that included arthropods other than ticks and studies in which the use of saliva had no pharmacological application were excluded. For searches, we used the following databases: MEDLINE®/PubMed®, Web of Science, LILACS, EMBASE, Cochrane and SCOPUS. The methodological quality was performed using the tools available in Joanna Briggs, always with two or more independent evaluators. The generated data were tabulated and summarized through qualitative narrative analysis. The methodology selected 19 articles that met the eligibility criteria. The saliva of hard ticks, found in the Americas, is more promising when used in experimental studies with human cells. The elucidation of the biomolecules was possible, with evasin and serpine being the biomolecules with the most evident pharmacological potential for anti-inflammatory action. In the selected studies, we found only experimental studies, with no pre-clinical or clinical studies, making methodological qualification difficult; in some studies, with the biomolecule Evasin and Serpin, the need for elucidation of these biomolecules in question was suggested. Thus, we found evidence that the saliva of American hard ticks is the most studied for pharmacological applications of anti-inflammatory and immunomodulatory action.Sabiendo que las garrapatas tienen moléculas bioactivas en su saliva que modulan las actividades hemostáticas e inmunomoduladoras en humanos, llevamos a cabo una búsqueda sistemática de biomoléculas presentes en la saliva de las garrapatas con gran potencial farmacológico. Los estudios publicados en los últimos diez años. Siguiendo las recomendaciones de la herramienta Prisma, se seleccionaron estudios primarios y secundarios de carácter sistemático, sin restricción de idioma o país. Se excluyeron los estudios que incluyeron artrópodos distintos a las garrapatas y los estudios en los que el uso de saliva no tuvo aplicación farmacológica. Para las búsquedas utilizamos las bases de datos: MEDLINE®/PubMed®, Web of Science, LILACS, EMBASE, Cochrane y SCOPUS. La calidad metodológica se realizó utilizando las herramientas disponibles en Joanna Briggs. Los datos generados fueron tabulados y resumidos mediante análisis narrativo cualitativo. La metodología seleccionó 19 artículos que cumplían con los criterios de elegibilidad. La saliva de las garrapatas duras, es más prometedora cuando se usa en estudios experimentales con células humanas. La elucidación de las biomoléculas fue posible, siendo la evasina y la serpina las biomoléculas con el potencial farmacológico más evidente para la acción antiinflamatoria. En los estudios seleccionados, encontramos solo estudios experimentales, sin estudios preclínicos ni clínicos, lo que dificulta la calificación metodológica; en algunos estudios, con las biomoléculas Evasin y Serpin, se sugirió la necesidad de dilucidar estas biomoléculas en cuestión. Así, encontramos evidencia de que la saliva de la garrapata dura americana es la más estudiada para aplicaciones farmacológicas de acción antiinflamatoria e inmunomoduladora.Sabendo que os carrapatos possuem moléculas bioativas em sua saliva as quais modulam atividades hemostáticas e imunomoduladoras em humanos, realizamos uma busca sistemática de biomoléculas presentes na saliva do carrapato com grande potencial farmacológico. Avaliamos estudos publicados nos últimos dez anos. Seguindo as recomendações da ferramenta Prisma, foram selecionados estudos primários e secundários de caráter sistemático, não havendo restrição de idioma ou país. Foram excluídos estudos que incluíam artrópodes diferentes de carrapatos e estudos em que o uso de saliva não tinha aplicação farmacológica. Para as buscas, utilizamos as seguintes bases de dados: MEDLINE®/PubMed®, Web of Science, LILACS, EMBASE, Cochrane e SCOPUS. A qualidade metodológica foi realizada com as ferramentas disponíveis no Joanna Briggs, sempre com dois ou mais avaliadores independentes. Os dados gerados foram tabulados e resumidos por meio de análise narrativa qualitativa. A metodologia selecionou 19 artigos que atenderam aos critérios de elegibilidade. As salivas de carrapatos duros, encontrados nas Américas, são mais promissoras quando utilizadas em estudos experimentais com células humanas. A elucidação das biomoléculas foi possível, sendo a evasina e a serpina as biomoléculas com os potenciais farmacológicos mais evidentes para ação anti-inflamatória. Nos estudos selecionados encontramos apenas estudos experimentais, não havendo estudos pré-clínicos ou clínicos, dificultando a qualificação metodológica; em alguns estudos, com a biomolécula Evasin e Serpin, sugeriu-se a necessidade de elucidação dessas biomoléculas em questão. Assim, localizamos evidências que a saliva de carrapatos duros americanos é a mais estudada para aplicações farmacológicas de ação anti-inflamatória e imunomoduladora.Research, Society and Development2023-03-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4045310.33448/rsd-v12i3.40453Research, Society and Development; Vol. 12 No. 3; e16312340453Research, Society and Development; Vol. 12 Núm. 3; e16312340453Research, Society and Development; v. 12 n. 3; e163123404532525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/40453/33148Copyright (c) 2023 Yanne Oliveira Barbosa; Beatriz Rodrigues Martins; Cristhianne Molinero Andrade Ratkevicius; Wellington Francisco Rodrigues; Carlo José Freire Oliveira; Ana Paula Espindula ; Renata Pereira Alveshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBarbosa, Yanne Oliveira Martins, Beatriz Rodrigues Ratkevicius, Cristhianne Molinero Andrade Rodrigues, Wellington Francisco Oliveira, Carlo José Freire Espindula , Ana PaulaAlves, Renata Pereira 2023-03-23T08:33:38Zoai:ojs.pkp.sfu.ca:article/40453Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-03-23T08:33:38Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Biomolecules present in tick saliva with pharmacological potential: a systematic review
Biomoléculas presentes en la saliva de garrapatas con potencial farmacológico: una revisión sistemática
Biomoléculas presentes na saliva do carrapato com potencial farmacológico: uma revisão sistemática
title Biomolecules present in tick saliva with pharmacological potential: a systematic review
spellingShingle Biomolecules present in tick saliva with pharmacological potential: a systematic review
Barbosa, Yanne Oliveira
Saliva
Carrapato
Potencial farmacológico
Biomoléculas salivares.
Saliva
Garrapata
Potencial farmacológico
Biomoléculas salivales.
Saliva
Tick
Pharmacological potential
Salivary biomolecules.
title_short Biomolecules present in tick saliva with pharmacological potential: a systematic review
title_full Biomolecules present in tick saliva with pharmacological potential: a systematic review
title_fullStr Biomolecules present in tick saliva with pharmacological potential: a systematic review
title_full_unstemmed Biomolecules present in tick saliva with pharmacological potential: a systematic review
title_sort Biomolecules present in tick saliva with pharmacological potential: a systematic review
author Barbosa, Yanne Oliveira
author_facet Barbosa, Yanne Oliveira
Martins, Beatriz Rodrigues
Ratkevicius, Cristhianne Molinero Andrade
Rodrigues, Wellington Francisco
Oliveira, Carlo José Freire
Espindula , Ana Paula
Alves, Renata Pereira
author_role author
author2 Martins, Beatriz Rodrigues
Ratkevicius, Cristhianne Molinero Andrade
Rodrigues, Wellington Francisco
Oliveira, Carlo José Freire
Espindula , Ana Paula
Alves, Renata Pereira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa, Yanne Oliveira
Martins, Beatriz Rodrigues
Ratkevicius, Cristhianne Molinero Andrade
Rodrigues, Wellington Francisco
Oliveira, Carlo José Freire
Espindula , Ana Paula
Alves, Renata Pereira
dc.subject.por.fl_str_mv Saliva
Carrapato
Potencial farmacológico
Biomoléculas salivares.
Saliva
Garrapata
Potencial farmacológico
Biomoléculas salivales.
Saliva
Tick
Pharmacological potential
Salivary biomolecules.
topic Saliva
Carrapato
Potencial farmacológico
Biomoléculas salivares.
Saliva
Garrapata
Potencial farmacológico
Biomoléculas salivales.
Saliva
Tick
Pharmacological potential
Salivary biomolecules.
description Knowing that ticks have bioactive molecules in their saliva which modulate hemostatic and immunomodulatory activities in humans, we carried out a systematic search for biomolecules present in tick saliva with great pharmacological potential. We evaluated studies published in the last ten years. Following the recommendations of the Prisma tool, primary and secondary studies of a systematic nature were selected, with no language or country restriction. Studies that included arthropods other than ticks and studies in which the use of saliva had no pharmacological application were excluded. For searches, we used the following databases: MEDLINE®/PubMed®, Web of Science, LILACS, EMBASE, Cochrane and SCOPUS. The methodological quality was performed using the tools available in Joanna Briggs, always with two or more independent evaluators. The generated data were tabulated and summarized through qualitative narrative analysis. The methodology selected 19 articles that met the eligibility criteria. The saliva of hard ticks, found in the Americas, is more promising when used in experimental studies with human cells. The elucidation of the biomolecules was possible, with evasin and serpine being the biomolecules with the most evident pharmacological potential for anti-inflammatory action. In the selected studies, we found only experimental studies, with no pre-clinical or clinical studies, making methodological qualification difficult; in some studies, with the biomolecule Evasin and Serpin, the need for elucidation of these biomolecules in question was suggested. Thus, we found evidence that the saliva of American hard ticks is the most studied for pharmacological applications of anti-inflammatory and immunomodulatory action.
publishDate 2023
dc.date.none.fl_str_mv 2023-03-05
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/40453
10.33448/rsd-v12i3.40453
url https://rsdjournal.org/index.php/rsd/article/view/40453
identifier_str_mv 10.33448/rsd-v12i3.40453
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/40453/33148
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 12 No. 3; e16312340453
Research, Society and Development; Vol. 12 Núm. 3; e16312340453
Research, Society and Development; v. 12 n. 3; e16312340453
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052619163697152