New antimicrobial therapies used against fungi present in subgingival sites-A brief review
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.archoralbio.2011.03.007 http://hdl.handle.net/11449/7384 |
Resumo: | Although the main reservoir of Candida spp. is believed to be the buccal mucosa, these microorganisms can coaggregate with bacteria in subgingival biofilm and adhere to epithelial cells. The treatment of periodontal disease includes scaling and root planning (SR?) associated with proper oral hygiene. However, some patients may have negative responses to different therapeutic procedures, with a continuous loss of insertion, so the use of antimicrobials is needed as an adjuvant to SRP treatment. The use of a broad-spectrum antibiotic, such as tetracycline and metronidazole, as an aid in periodontal treatment has also been a factor for the development of superinfections by resistant bacteria and Candida species, even in patients with HIV. In the dental practice, the most commonly used antifungals are nystatin and fluconazole. However, the introduction of new drugs like the next generation of azoles is essential before the onset of emergent species in periodontal disease. Plants are good options for obtaining a wide variety of drugs. This alternative could benefit a large population that uses plants as a first treatment option. Plants have been used in medicine for a long time and are extensively used in folk medicine, because they represent an economic alternative, are easily accessible and are applicable to various diseases. Herein, we briefly review the literature pertaining the presence of Candida sp. in periodontal pockets, the conventional antifungal resistance and new therapies that include natural antifungal agents are reviewed. (C) 2011 Elsevier Ltd. All rights reserved. |
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New antimicrobial therapies used against fungi present in subgingival sites-A brief reviewCandida sppFungiAntifungalPeriodontal diseaseNew antimicrobial therapiesAlthough the main reservoir of Candida spp. is believed to be the buccal mucosa, these microorganisms can coaggregate with bacteria in subgingival biofilm and adhere to epithelial cells. The treatment of periodontal disease includes scaling and root planning (SR?) associated with proper oral hygiene. However, some patients may have negative responses to different therapeutic procedures, with a continuous loss of insertion, so the use of antimicrobials is needed as an adjuvant to SRP treatment. The use of a broad-spectrum antibiotic, such as tetracycline and metronidazole, as an aid in periodontal treatment has also been a factor for the development of superinfections by resistant bacteria and Candida species, even in patients with HIV. In the dental practice, the most commonly used antifungals are nystatin and fluconazole. However, the introduction of new drugs like the next generation of azoles is essential before the onset of emergent species in periodontal disease. Plants are good options for obtaining a wide variety of drugs. This alternative could benefit a large population that uses plants as a first treatment option. Plants have been used in medicine for a long time and are extensively used in folk medicine, because they represent an economic alternative, are easily accessible and are applicable to various diseases. Herein, we briefly review the literature pertaining the presence of Candida sp. in periodontal pockets, the conventional antifungal resistance and new therapies that include natural antifungal agents are reviewed. (C) 2011 Elsevier Ltd. All rights reserved.Univ Estadual Paulista, UNESP, Fac Pharmaceut Sci Araraquara, Dept Clin Anal,Lab Clin Mycol, Araraquara, SP, BrazilUniv Estadual Paulista, UNESP, Fac Pharmaceut Sci Araraquara, Dept Clin Anal,Lab Clin Mycol, Araraquara, SP, BrazilPergamon-Elsevier B.V. LtdUniversidade Estadual Paulista (Unesp)Orlandi Sardi, Janaina Cassia [UNESP]Almeida, Ana Marisa Fusco [UNESP]Mendes-Giannini, Maria José Soares [UNESP]2014-05-20T13:24:04Z2014-05-20T13:24:04Z2011-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article951-959application/pdfhttp://dx.doi.org/10.1016/j.archoralbio.2011.03.007Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 56, n. 10, p. 951-959, 2011.0003-9969http://hdl.handle.net/11449/738410.1016/j.archoralbio.2011.03.007WOS:000296112200003WOS000296112200003.pdf0000-0002-8059-0826Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Oral Biology2.0500,752info:eu-repo/semantics/openAccess2023-10-26T06:06:01Zoai:repositorio.unesp.br:11449/7384Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-26T06:06:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
New antimicrobial therapies used against fungi present in subgingival sites-A brief review |
title |
New antimicrobial therapies used against fungi present in subgingival sites-A brief review |
spellingShingle |
New antimicrobial therapies used against fungi present in subgingival sites-A brief review Orlandi Sardi, Janaina Cassia [UNESP] Candida spp Fungi Antifungal Periodontal disease New antimicrobial therapies |
title_short |
New antimicrobial therapies used against fungi present in subgingival sites-A brief review |
title_full |
New antimicrobial therapies used against fungi present in subgingival sites-A brief review |
title_fullStr |
New antimicrobial therapies used against fungi present in subgingival sites-A brief review |
title_full_unstemmed |
New antimicrobial therapies used against fungi present in subgingival sites-A brief review |
title_sort |
New antimicrobial therapies used against fungi present in subgingival sites-A brief review |
author |
Orlandi Sardi, Janaina Cassia [UNESP] |
author_facet |
Orlandi Sardi, Janaina Cassia [UNESP] Almeida, Ana Marisa Fusco [UNESP] Mendes-Giannini, Maria José Soares [UNESP] |
author_role |
author |
author2 |
Almeida, Ana Marisa Fusco [UNESP] Mendes-Giannini, Maria José Soares [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Orlandi Sardi, Janaina Cassia [UNESP] Almeida, Ana Marisa Fusco [UNESP] Mendes-Giannini, Maria José Soares [UNESP] |
dc.subject.por.fl_str_mv |
Candida spp Fungi Antifungal Periodontal disease New antimicrobial therapies |
topic |
Candida spp Fungi Antifungal Periodontal disease New antimicrobial therapies |
description |
Although the main reservoir of Candida spp. is believed to be the buccal mucosa, these microorganisms can coaggregate with bacteria in subgingival biofilm and adhere to epithelial cells. The treatment of periodontal disease includes scaling and root planning (SR?) associated with proper oral hygiene. However, some patients may have negative responses to different therapeutic procedures, with a continuous loss of insertion, so the use of antimicrobials is needed as an adjuvant to SRP treatment. The use of a broad-spectrum antibiotic, such as tetracycline and metronidazole, as an aid in periodontal treatment has also been a factor for the development of superinfections by resistant bacteria and Candida species, even in patients with HIV. In the dental practice, the most commonly used antifungals are nystatin and fluconazole. However, the introduction of new drugs like the next generation of azoles is essential before the onset of emergent species in periodontal disease. Plants are good options for obtaining a wide variety of drugs. This alternative could benefit a large population that uses plants as a first treatment option. Plants have been used in medicine for a long time and are extensively used in folk medicine, because they represent an economic alternative, are easily accessible and are applicable to various diseases. Herein, we briefly review the literature pertaining the presence of Candida sp. in periodontal pockets, the conventional antifungal resistance and new therapies that include natural antifungal agents are reviewed. (C) 2011 Elsevier Ltd. All rights reserved. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-10-01 2014-05-20T13:24:04Z 2014-05-20T13:24:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.archoralbio.2011.03.007 Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 56, n. 10, p. 951-959, 2011. 0003-9969 http://hdl.handle.net/11449/7384 10.1016/j.archoralbio.2011.03.007 WOS:000296112200003 WOS000296112200003.pdf 0000-0002-8059-0826 |
url |
http://dx.doi.org/10.1016/j.archoralbio.2011.03.007 http://hdl.handle.net/11449/7384 |
identifier_str_mv |
Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 56, n. 10, p. 951-959, 2011. 0003-9969 10.1016/j.archoralbio.2011.03.007 WOS:000296112200003 WOS000296112200003.pdf 0000-0002-8059-0826 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of Oral Biology 2.050 0,752 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
951-959 application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier B.V. Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier B.V. Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799964702861688832 |