Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test

Detalhes bibliográficos
Autor(a) principal: de Morandim-Giannetti, Andreia A. [UNESP]
Data de Publicação: 2011
Outros Autores: Cotinguiba, Fernando [UNESP], Regasini, Luis O. [UNESP], Frigieri, Mariana C. [UNESP], Varanda, Eliana A. [UNESP], Coqueiro, Aline [UNESP], Kato, Massuo J., Bolzani, Vanderlan S. [UNESP], Furlan, Maysa [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/226393
Resumo: Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (Z)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound. © 2011 Academic Journals.
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spelling Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test(z)-piplartineAmes testMutagenic activatedPiper tuberculatumPiperaceaePhytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (Z)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound. © 2011 Academic Journals.Departamento de Química Orgânica Instituto de Química Universidade Estadual de São Paulo, Rua Francisco Degni, s/n, 14800-900 Araraquara-SPDepartamento de Engenharia Química Centro Universitário da FEI, Av. Humberto de Alencar Castelo Branco, 3972, 09850-901 São Bernardo do Campo-SPDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Rodovia Araraquara/Jaú Km 1, 14801-902 Araraquara-SPDepartamento de Química Fundamental Instituto de Química Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, 05508-000, São Paulo-SPDepartamento de Química Orgânica Instituto de Química Universidade Estadual de São Paulo, Rua Francisco Degni, s/n, 14800-900 Araraquara-SPDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Rodovia Araraquara/Jaú Km 1, 14801-902 Araraquara-SPUniversidade Estadual Paulista (UNESP)Centro Universitário da FEIUniversidade de São Paulo (USP)de Morandim-Giannetti, Andreia A. [UNESP]Cotinguiba, Fernando [UNESP]Regasini, Luis O. [UNESP]Frigieri, Mariana C. [UNESP]Varanda, Eliana A. [UNESP]Coqueiro, Aline [UNESP]Kato, Massuo J.Bolzani, Vanderlan S. [UNESP]Furlan, Maysa [UNESP]2022-04-28T22:48:46Z2022-04-28T22:48:46Z2011-06-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5398-5401African Journal of Biotechnology, v. 10, n. 27, p. 5398-5401, 2011.1684-5315http://hdl.handle.net/11449/2263932-s2.0-79959357732Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAfrican Journal of Biotechnologyinfo:eu-repo/semantics/openAccess2024-06-24T13:08:01Zoai:repositorio.unesp.br:11449/226393Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:41:45.271398Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test
title Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test
spellingShingle Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test
de Morandim-Giannetti, Andreia A. [UNESP]
(z)-piplartine
Ames test
Mutagenic activated
Piper tuberculatum
Piperaceae
title_short Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test
title_full Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test
title_fullStr Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test
title_full_unstemmed Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test
title_sort Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test
author de Morandim-Giannetti, Andreia A. [UNESP]
author_facet de Morandim-Giannetti, Andreia A. [UNESP]
Cotinguiba, Fernando [UNESP]
Regasini, Luis O. [UNESP]
Frigieri, Mariana C. [UNESP]
Varanda, Eliana A. [UNESP]
Coqueiro, Aline [UNESP]
Kato, Massuo J.
Bolzani, Vanderlan S. [UNESP]
Furlan, Maysa [UNESP]
author_role author
author2 Cotinguiba, Fernando [UNESP]
Regasini, Luis O. [UNESP]
Frigieri, Mariana C. [UNESP]
Varanda, Eliana A. [UNESP]
Coqueiro, Aline [UNESP]
Kato, Massuo J.
Bolzani, Vanderlan S. [UNESP]
Furlan, Maysa [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Centro Universitário da FEI
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv de Morandim-Giannetti, Andreia A. [UNESP]
Cotinguiba, Fernando [UNESP]
Regasini, Luis O. [UNESP]
Frigieri, Mariana C. [UNESP]
Varanda, Eliana A. [UNESP]
Coqueiro, Aline [UNESP]
Kato, Massuo J.
Bolzani, Vanderlan S. [UNESP]
Furlan, Maysa [UNESP]
dc.subject.por.fl_str_mv (z)-piplartine
Ames test
Mutagenic activated
Piper tuberculatum
Piperaceae
topic (z)-piplartine
Ames test
Mutagenic activated
Piper tuberculatum
Piperaceae
description Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (Z)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound. © 2011 Academic Journals.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-15
2022-04-28T22:48:46Z
2022-04-28T22:48:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv African Journal of Biotechnology, v. 10, n. 27, p. 5398-5401, 2011.
1684-5315
http://hdl.handle.net/11449/226393
2-s2.0-79959357732
identifier_str_mv African Journal of Biotechnology, v. 10, n. 27, p. 5398-5401, 2011.
1684-5315
2-s2.0-79959357732
url http://hdl.handle.net/11449/226393
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv African Journal of Biotechnology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5398-5401
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129234716065792

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