Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatment

Detalhes bibliográficos
Autor(a) principal: Barros, Natan Roberto de [UNESP]
Data de Publicação: 2017
Outros Autores: Romeiro Miranda, Matheus Carlos [UNESP], Borges, Felipe Azevedo [UNESP], Padua Gemeinder, Jose Lucio [UNESP], Mendonca, Ricardo Jose de, Cilli, Eduardo Maffud [UNESP], Herculano, Rondinelli Donizetti [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/00914037.2017.1280795
http://hdl.handle.net/11449/165901
Resumo: Enuresis affects up to 20% of children of 5 years old, enuretic children present arginine vasopressin secretion deficiency, compared to normal children. To keep the level of antidiuretic hormone in the body, the aim of this work was to develop natural rubber latex membranes loaded with desmopressin peptide and characterize its in vitro release. Results demonstrated that 60% of desmopressin incorporated in natural latex was released up to 96 h. Furthermore, hemolysis tests showed no detectable disturbance of the red blood cell membranes. Based on the results, it was possible to conclude that natural latex membranes are able to load desmopressin.
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spelling Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatmentBiomaterialdesmopressinenuresisnatural rubber latexsustained releaseEnuresis affects up to 20% of children of 5 years old, enuretic children present arginine vasopressin secretion deficiency, compared to normal children. To keep the level of antidiuretic hormone in the body, the aim of this work was to develop natural rubber latex membranes loaded with desmopressin peptide and characterize its in vitro release. Results demonstrated that 60% of desmopressin incorporated in natural latex was released up to 96 h. Furthermore, hemolysis tests showed no detectable disturbance of the red blood cell membranes. Based on the results, it was possible to conclude that natural latex membranes are able to load desmopressin.Sao Paulo State Univ, Chem Inst, 55 Prof Francisco Degni St, BR-14800060 Araraquara, SP, BrazilSao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, BrazilUFTM ICBN, Biochem Sect, Uberaba, BrazilSao Paulo State Univ, Chem Inst, 55 Prof Francisco Degni St, BR-14800060 Araraquara, SP, BrazilSao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, BrazilTaylor & Francis AsUniversidade Estadual Paulista (Unesp)UFTM ICBNBarros, Natan Roberto de [UNESP]Romeiro Miranda, Matheus Carlos [UNESP]Borges, Felipe Azevedo [UNESP]Padua Gemeinder, Jose Lucio [UNESP]Mendonca, Ricardo Jose deCilli, Eduardo Maffud [UNESP]Herculano, Rondinelli Donizetti [UNESP]2018-11-29T03:50:30Z2018-11-29T03:50:30Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article871-876application/pdfhttp://dx.doi.org/10.1080/00914037.2017.1280795International Journal Of Polymeric Materials And Polymeric Biomaterials. Oslo: Taylor & Francis As, v. 66, n. 17, p. 871-876, 2017.0091-4037http://hdl.handle.net/11449/16590110.1080/00914037.2017.1280795WOS:000416503400002WOS000416503400002.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal Of Polymeric Materials And Polymeric Biomaterials0,489info:eu-repo/semantics/openAccess2024-06-13T17:38:42Zoai:repositorio.unesp.br:11449/165901Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:48:58.934805Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatment
title Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatment
spellingShingle Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatment
Barros, Natan Roberto de [UNESP]
Biomaterial
desmopressin
enuresis
natural rubber latex
sustained release
title_short Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatment
title_full Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatment
title_fullStr Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatment
title_full_unstemmed Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatment
title_sort Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatment
author Barros, Natan Roberto de [UNESP]
author_facet Barros, Natan Roberto de [UNESP]
Romeiro Miranda, Matheus Carlos [UNESP]
Borges, Felipe Azevedo [UNESP]
Padua Gemeinder, Jose Lucio [UNESP]
Mendonca, Ricardo Jose de
Cilli, Eduardo Maffud [UNESP]
Herculano, Rondinelli Donizetti [UNESP]
author_role author
author2 Romeiro Miranda, Matheus Carlos [UNESP]
Borges, Felipe Azevedo [UNESP]
Padua Gemeinder, Jose Lucio [UNESP]
Mendonca, Ricardo Jose de
Cilli, Eduardo Maffud [UNESP]
Herculano, Rondinelli Donizetti [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
UFTM ICBN
dc.contributor.author.fl_str_mv Barros, Natan Roberto de [UNESP]
Romeiro Miranda, Matheus Carlos [UNESP]
Borges, Felipe Azevedo [UNESP]
Padua Gemeinder, Jose Lucio [UNESP]
Mendonca, Ricardo Jose de
Cilli, Eduardo Maffud [UNESP]
Herculano, Rondinelli Donizetti [UNESP]
dc.subject.por.fl_str_mv Biomaterial
desmopressin
enuresis
natural rubber latex
sustained release
topic Biomaterial
desmopressin
enuresis
natural rubber latex
sustained release
description Enuresis affects up to 20% of children of 5 years old, enuretic children present arginine vasopressin secretion deficiency, compared to normal children. To keep the level of antidiuretic hormone in the body, the aim of this work was to develop natural rubber latex membranes loaded with desmopressin peptide and characterize its in vitro release. Results demonstrated that 60% of desmopressin incorporated in natural latex was released up to 96 h. Furthermore, hemolysis tests showed no detectable disturbance of the red blood cell membranes. Based on the results, it was possible to conclude that natural latex membranes are able to load desmopressin.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
2018-11-29T03:50:30Z
2018-11-29T03:50:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/00914037.2017.1280795
International Journal Of Polymeric Materials And Polymeric Biomaterials. Oslo: Taylor & Francis As, v. 66, n. 17, p. 871-876, 2017.
0091-4037
http://hdl.handle.net/11449/165901
10.1080/00914037.2017.1280795
WOS:000416503400002
WOS000416503400002.pdf
url http://dx.doi.org/10.1080/00914037.2017.1280795
http://hdl.handle.net/11449/165901
identifier_str_mv International Journal Of Polymeric Materials And Polymeric Biomaterials. Oslo: Taylor & Francis As, v. 66, n. 17, p. 871-876, 2017.
0091-4037
10.1080/00914037.2017.1280795
WOS:000416503400002
WOS000416503400002.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal Of Polymeric Materials And Polymeric Biomaterials
0,489
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 871-876
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis As
publisher.none.fl_str_mv Taylor & Francis As
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129251926343680

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