Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://hdl.handle.net/11449/226126 |
Resumo: | With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance. Copyright © 2010 The International Society for Fluoride Research Inc. |
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Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluorideFluorideInsulin receptor substrateInsulin sensitivityInsulin signalRats and insulinWith half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance. Copyright © 2010 The International Society for Fluoride Research Inc.Dental School of Araçatuba UNESP - Univ Estadual Paulista, R. José Bonifácio, 1193, CEP: 16015-050, Araçatuba-SPDepartment of Child and Social Dentistry Dental School of Araçatuba UNESP - Univ Estadual PaulistaDental School of Araçatuba UNESP - Univ Estadual Paulista, R. José Bonifácio, 1193, CEP: 16015-050, Araçatuba-SPDepartment of Child and Social Dentistry Dental School of Araçatuba UNESP - Univ Estadual PaulistaUniversidade Estadual Paulista (UNESP)Chiba, Fernando Yamamoto [UNESP]Colombo, Natália Helena [UNESP]Shirakashi, Daisy Jaqueline [UNESP]Gomes, Wendrew Douglas De Souza [UNESP]Moimaz, Suzely Adas Saliba [UNESP]Garbin, Cléa Adas Saliba [UNESP]Silva, Cristina Antoniali [UNESP]Sumida, Doris Hissako [UNESP]2022-04-28T21:25:51Z2022-04-28T21:25:51Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article25-30Fluoride, v. 43, n. 1, p. 25-30, 2010.0015-4725http://hdl.handle.net/11449/2261262-s2.0-78449305397Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFluorideinfo:eu-repo/semantics/openAccess2024-09-19T17:55:47Zoai:repositorio.unesp.br:11449/226126Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T17:55:47Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride |
| title |
Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride |
| spellingShingle |
Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride Chiba, Fernando Yamamoto [UNESP] Fluoride Insulin receptor substrate Insulin sensitivity Insulin signal Rats and insulin |
| title_short |
Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride |
| title_full |
Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride |
| title_fullStr |
Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride |
| title_full_unstemmed |
Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride |
| title_sort |
Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride |
| author |
Chiba, Fernando Yamamoto [UNESP] |
| author_facet |
Chiba, Fernando Yamamoto [UNESP] Colombo, Natália Helena [UNESP] Shirakashi, Daisy Jaqueline [UNESP] Gomes, Wendrew Douglas De Souza [UNESP] Moimaz, Suzely Adas Saliba [UNESP] Garbin, Cléa Adas Saliba [UNESP] Silva, Cristina Antoniali [UNESP] Sumida, Doris Hissako [UNESP] |
| author_role |
author |
| author2 |
Colombo, Natália Helena [UNESP] Shirakashi, Daisy Jaqueline [UNESP] Gomes, Wendrew Douglas De Souza [UNESP] Moimaz, Suzely Adas Saliba [UNESP] Garbin, Cléa Adas Saliba [UNESP] Silva, Cristina Antoniali [UNESP] Sumida, Doris Hissako [UNESP] |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
| dc.contributor.author.fl_str_mv |
Chiba, Fernando Yamamoto [UNESP] Colombo, Natália Helena [UNESP] Shirakashi, Daisy Jaqueline [UNESP] Gomes, Wendrew Douglas De Souza [UNESP] Moimaz, Suzely Adas Saliba [UNESP] Garbin, Cléa Adas Saliba [UNESP] Silva, Cristina Antoniali [UNESP] Sumida, Doris Hissako [UNESP] |
| dc.subject.por.fl_str_mv |
Fluoride Insulin receptor substrate Insulin sensitivity Insulin signal Rats and insulin |
| topic |
Fluoride Insulin receptor substrate Insulin sensitivity Insulin signal Rats and insulin |
| description |
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance. Copyright © 2010 The International Society for Fluoride Research Inc. |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010-01-01 2022-04-28T21:25:51Z 2022-04-28T21:25:51Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
Fluoride, v. 43, n. 1, p. 25-30, 2010. 0015-4725 http://hdl.handle.net/11449/226126 2-s2.0-78449305397 |
| identifier_str_mv |
Fluoride, v. 43, n. 1, p. 25-30, 2010. 0015-4725 2-s2.0-78449305397 |
| url |
http://hdl.handle.net/11449/226126 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Fluoride |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
25-30 |
| dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| instname_str |
Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
| institution |
UNESP |
| reponame_str |
Repositório Institucional da UNESP |
| collection |
Repositório Institucional da UNESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
| repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
| _version_ |
1813546379639783424 |