Effects of fluoride intake on insulin sensitivity and insulin signal transduction

Detalhes bibliográficos
Autor(a) principal: Chehoud, Keila Aziz [UNESP]
Data de Publicação: 2008
Outros Autores: Chiba, Fernando Yamamoto [UNESP], Sassaki, Kikue Takebayashi [UNESP], Garbin, Clea Adas Saliba [UNESP], Sumida, Doris Hissako [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.fluorideresearch.org/414/files/FJ2008_v41_n4_p00i-0iv.pdf
http://hdl.handle.net/11449/14977
Resumo: Forty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues.
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spelling Effects of fluoride intake on insulin sensitivity and insulin signal transductionInsulin receptor substrateInsulin sensitivityInsulin signalPlasma fluorideRats and insulinForty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State Univ UNESP, Dent Sch Aracatuba, Dept Basic Sci, BR-16015050 Aracatuba, SP, BrazilSão Paulo State Univ UNESP, Dent Sch Aracatuba, Dept Child & Social Dent, BR-16015050 Aracatuba, SP, BrazilSão Paulo State Univ UNESP, Dent Sch Aracatuba, Dept Basic Sci, BR-16015050 Aracatuba, SP, BrazilSão Paulo State Univ UNESP, Dent Sch Aracatuba, Dept Child & Social Dent, BR-16015050 Aracatuba, SP, BrazilFAPESP: 05/53301-1Int Soc Fluoride ResearchUniversidade Estadual Paulista (Unesp)Chehoud, Keila Aziz [UNESP]Chiba, Fernando Yamamoto [UNESP]Sassaki, Kikue Takebayashi [UNESP]Garbin, Clea Adas Saliba [UNESP]Sumida, Doris Hissako [UNESP]2013-09-30T18:29:13Z2014-05-20T13:43:02Z2013-09-30T18:29:13Z2014-05-20T13:43:02Z2008-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article270-275http://www.fluorideresearch.org/414/files/FJ2008_v41_n4_p00i-0iv.pdfFluoride. Ocean View: Int Soc Fluoride Research, v. 41, n. 4, p. 270-275, 2008.0015-4725http://hdl.handle.net/11449/14977WOS:0002639019000037239471016654133827540168870234344191585257096860000-0001-5069-8812Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFluoride1.4380,429info:eu-repo/semantics/openAccess2024-09-19T17:56:24Zoai:repositorio.unesp.br:11449/14977Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T17:56:24Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of fluoride intake on insulin sensitivity and insulin signal transduction
title Effects of fluoride intake on insulin sensitivity and insulin signal transduction
spellingShingle Effects of fluoride intake on insulin sensitivity and insulin signal transduction
Chehoud, Keila Aziz [UNESP]
Insulin receptor substrate
Insulin sensitivity
Insulin signal
Plasma fluoride
Rats and insulin
title_short Effects of fluoride intake on insulin sensitivity and insulin signal transduction
title_full Effects of fluoride intake on insulin sensitivity and insulin signal transduction
title_fullStr Effects of fluoride intake on insulin sensitivity and insulin signal transduction
title_full_unstemmed Effects of fluoride intake on insulin sensitivity and insulin signal transduction
title_sort Effects of fluoride intake on insulin sensitivity and insulin signal transduction
author Chehoud, Keila Aziz [UNESP]
author_facet Chehoud, Keila Aziz [UNESP]
Chiba, Fernando Yamamoto [UNESP]
Sassaki, Kikue Takebayashi [UNESP]
Garbin, Clea Adas Saliba [UNESP]
Sumida, Doris Hissako [UNESP]
author_role author
author2 Chiba, Fernando Yamamoto [UNESP]
Sassaki, Kikue Takebayashi [UNESP]
Garbin, Clea Adas Saliba [UNESP]
Sumida, Doris Hissako [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Chehoud, Keila Aziz [UNESP]
Chiba, Fernando Yamamoto [UNESP]
Sassaki, Kikue Takebayashi [UNESP]
Garbin, Clea Adas Saliba [UNESP]
Sumida, Doris Hissako [UNESP]
dc.subject.por.fl_str_mv Insulin receptor substrate
Insulin sensitivity
Insulin signal
Plasma fluoride
Rats and insulin
topic Insulin receptor substrate
Insulin sensitivity
Insulin signal
Plasma fluoride
Rats and insulin
description Forty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues.
publishDate 2008
dc.date.none.fl_str_mv 2008-10-01
2013-09-30T18:29:13Z
2013-09-30T18:29:13Z
2014-05-20T13:43:02Z
2014-05-20T13:43:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.fluorideresearch.org/414/files/FJ2008_v41_n4_p00i-0iv.pdf
Fluoride. Ocean View: Int Soc Fluoride Research, v. 41, n. 4, p. 270-275, 2008.
0015-4725
http://hdl.handle.net/11449/14977
WOS:000263901900003
7239471016654133
8275401688702343
4419158525709686
0000-0001-5069-8812
url http://www.fluorideresearch.org/414/files/FJ2008_v41_n4_p00i-0iv.pdf
http://hdl.handle.net/11449/14977
identifier_str_mv Fluoride. Ocean View: Int Soc Fluoride Research, v. 41, n. 4, p. 270-275, 2008.
0015-4725
WOS:000263901900003
7239471016654133
8275401688702343
4419158525709686
0000-0001-5069-8812
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fluoride
1.438
0,429
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 270-275
dc.publisher.none.fl_str_mv Int Soc Fluoride Research
publisher.none.fl_str_mv Int Soc Fluoride Research
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1813546416910368768

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