Effects of fluoride intake on insulin sensitivity and insulin signal transduction

Detalhes bibliográficos
Autor(a) principal: Chehoud, Keila Aziz [UNESP]
Data de Publicação: 2008
Outros Autores: Chiba, Fernando Yamamoto [UNESP], Sassaki, Kikue Takebayashi [UNESP], Garbin, Cléa Adas Saliba [UNESP], Sumida, Doris Hissako [UNESP]
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/225400
Resumo: Forty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues. Copyright © 2008 The International Society for Fluoride Research Inc.
id UNSP_d109ebaaf0081db7698af43041909495
oai_identifier_str oai:repositorio.unesp.br:11449/225400
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Effects of fluoride intake on insulin sensitivity and insulin signal transductionInsulin receptor substrateInsulin sensitivityInsulin signalPlasma fluorideRats and insulinForty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues. Copyright © 2008 The International Society for Fluoride Research Inc.Department of Basic Sciences Dental School of Araçatuba São Paulo State University - UNESP, AraçatubaDepartment of Child and Social Dentistry Dental School of Araçatuba São Paulo State University - UNESP, AraçatubaDental School of Araçatuba São Paulo State University - UNESP, R. José Bonifácio, 1193, CEP: 16015-050, Araçatuba-SPDepartment of Basic Sciences Dental School of Araçatuba São Paulo State University - UNESP, AraçatubaDepartment of Child and Social Dentistry Dental School of Araçatuba São Paulo State University - UNESP, AraçatubaDental School of Araçatuba São Paulo State University - UNESP, R. José Bonifácio, 1193, CEP: 16015-050, Araçatuba-SPUniversidade Estadual Paulista (UNESP)Chehoud, Keila Aziz [UNESP]Chiba, Fernando Yamamoto [UNESP]Sassaki, Kikue Takebayashi [UNESP]Garbin, Cléa Adas Saliba [UNESP]Sumida, Doris Hissako [UNESP]2022-04-28T20:48:16Z2022-04-28T20:48:16Z2008-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject270-275Fluoride, v. 41, n. 4, p. 270-275, 2008.0015-4725http://hdl.handle.net/11449/2254002-s2.0-58849133027Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFluorideinfo:eu-repo/semantics/openAccess2024-09-19T17:57:44Zoai:repositorio.unesp.br:11449/225400Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T17:57:44Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of fluoride intake on insulin sensitivity and insulin signal transduction
title Effects of fluoride intake on insulin sensitivity and insulin signal transduction
spellingShingle Effects of fluoride intake on insulin sensitivity and insulin signal transduction
Chehoud, Keila Aziz [UNESP]
Insulin receptor substrate
Insulin sensitivity
Insulin signal
Plasma fluoride
Rats and insulin
title_short Effects of fluoride intake on insulin sensitivity and insulin signal transduction
title_full Effects of fluoride intake on insulin sensitivity and insulin signal transduction
title_fullStr Effects of fluoride intake on insulin sensitivity and insulin signal transduction
title_full_unstemmed Effects of fluoride intake on insulin sensitivity and insulin signal transduction
title_sort Effects of fluoride intake on insulin sensitivity and insulin signal transduction
author Chehoud, Keila Aziz [UNESP]
author_facet Chehoud, Keila Aziz [UNESP]
Chiba, Fernando Yamamoto [UNESP]
Sassaki, Kikue Takebayashi [UNESP]
Garbin, Cléa Adas Saliba [UNESP]
Sumida, Doris Hissako [UNESP]
author_role author
author2 Chiba, Fernando Yamamoto [UNESP]
Sassaki, Kikue Takebayashi [UNESP]
Garbin, Cléa Adas Saliba [UNESP]
Sumida, Doris Hissako [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Chehoud, Keila Aziz [UNESP]
Chiba, Fernando Yamamoto [UNESP]
Sassaki, Kikue Takebayashi [UNESP]
Garbin, Cléa Adas Saliba [UNESP]
Sumida, Doris Hissako [UNESP]
dc.subject.por.fl_str_mv Insulin receptor substrate
Insulin sensitivity
Insulin signal
Plasma fluoride
Rats and insulin
topic Insulin receptor substrate
Insulin sensitivity
Insulin signal
Plasma fluoride
Rats and insulin
description Forty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues. Copyright © 2008 The International Society for Fluoride Research Inc.
publishDate 2008
dc.date.none.fl_str_mv 2008-10-01
2022-04-28T20:48:16Z
2022-04-28T20:48:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv Fluoride, v. 41, n. 4, p. 270-275, 2008.
0015-4725
http://hdl.handle.net/11449/225400
2-s2.0-58849133027
identifier_str_mv Fluoride, v. 41, n. 4, p. 270-275, 2008.
0015-4725
2-s2.0-58849133027
url http://hdl.handle.net/11449/225400
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fluoride
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 270-275
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1813546460273180672

Registros relacionados