C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0274510 http://hdl.handle.net/11449/247638 |
Resumo: | In chronic kidney disease dogs, the inflammatory process increases C-reactive protein concentrations. This study aimed to determine C-reactive protein serum concentrations in stage IV chronic kidney disease dogs treated with intermittent hemodialysis. A prospective cohort study was conducted with 23 dogs allocated into three groups: control group (CG, n = 7), intermittent hemodialysis group (IHG, n = 8) and clinical treatment group (CTG, n = 8), both comprised of stage IV chronic kidney disease dogs. One blood sample from CG (initial evaluation) and two samples from IHG and CTG (first- and last-moment) were obtained to determine C-reactive protein concentration, total leukocytes, platelets, erythrocytes, total plasma protein, serum albumin, urea, creatinine, and phosphorus. C-reactive protein was higher in IHG compared to CG in the first- and last-moments (p <0.001) and compared to CTG in the first-moment (p = 0.0406). C-reactive protein presented moderate positive correlation with leukocytes (r = 0.5479; p = 0.01), and moderate negative correlation with albumin (r = - 0.5974; p = 0.006) and red blood cells (r = - 0.5878, p = 0.01). A high correlation coefficient was observed in the tests' evaluation (CI = 0.59-0.78; r = 0.70; P<0.0001). In conclusion, both assays used in this study to measure C-reactive protein have provided safe and reliable quantification of the results. Additionally, despite IHG dogs presented an active inflammatory profile, intermittent hemodialysis has proven to be beneficial, leading to a clinical improvement in life quality of patients, and thus being recommended for stage IV CKD dogs when performed by trained professionals. |
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C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysisIn chronic kidney disease dogs, the inflammatory process increases C-reactive protein concentrations. This study aimed to determine C-reactive protein serum concentrations in stage IV chronic kidney disease dogs treated with intermittent hemodialysis. A prospective cohort study was conducted with 23 dogs allocated into three groups: control group (CG, n = 7), intermittent hemodialysis group (IHG, n = 8) and clinical treatment group (CTG, n = 8), both comprised of stage IV chronic kidney disease dogs. One blood sample from CG (initial evaluation) and two samples from IHG and CTG (first- and last-moment) were obtained to determine C-reactive protein concentration, total leukocytes, platelets, erythrocytes, total plasma protein, serum albumin, urea, creatinine, and phosphorus. C-reactive protein was higher in IHG compared to CG in the first- and last-moments (p <0.001) and compared to CTG in the first-moment (p = 0.0406). C-reactive protein presented moderate positive correlation with leukocytes (r = 0.5479; p = 0.01), and moderate negative correlation with albumin (r = - 0.5974; p = 0.006) and red blood cells (r = - 0.5878, p = 0.01). A high correlation coefficient was observed in the tests' evaluation (CI = 0.59-0.78; r = 0.70; P<0.0001). In conclusion, both assays used in this study to measure C-reactive protein have provided safe and reliable quantification of the results. Additionally, despite IHG dogs presented an active inflammatory profile, intermittent hemodialysis has proven to be beneficial, leading to a clinical improvement in life quality of patients, and thus being recommended for stage IV CKD dogs when performed by trained professionals.Department of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)Pet Care Veterinary Hospital Pacaembu UnitDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)Department of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)Universidade Estadual Paulista (UNESP)Pet Care Veterinary Hospital Pacaembu UnitPicelli de Azevedo, Maria Gabriela [UNESP]Salgueiro Geraldes, Silvano [UNESP]Bilbau Sant'Anna, PaulaPoloni Batista, BeatrizRodrigues Maia, Suellen [UNESP]Silveira de Moraes, Reiner [UNESP]Moreira Dos Santos Schmidt, Elizabeth [UNESP]Ferreira de Souza, Fabiana [UNESP]Melchert, Alessandra [UNESP]Pinheiro Ferreira, João Carlos [UNESP]Rezende Dadalto, Carmel [UNESP]Mogollón García, Henry David [UNESP]Chalfun Guimarães-Okamoto, Priscylla Tatiana [UNESP]2023-07-29T13:21:39Z2023-07-29T13:21:39Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlee0274510http://dx.doi.org/10.1371/journal.pone.0274510PloS one, v. 17, n. 9, p. e0274510-, 2022.1932-6203http://hdl.handle.net/11449/24763810.1371/journal.pone.02745102-s2.0-85138416135Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPloS oneinfo:eu-repo/semantics/openAccess2024-09-09T14:01:21Zoai:repositorio.unesp.br:11449/247638Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:01:21Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis |
title |
C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis |
spellingShingle |
C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis Picelli de Azevedo, Maria Gabriela [UNESP] |
title_short |
C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis |
title_full |
C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis |
title_fullStr |
C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis |
title_full_unstemmed |
C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis |
title_sort |
C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis |
author |
Picelli de Azevedo, Maria Gabriela [UNESP] |
author_facet |
Picelli de Azevedo, Maria Gabriela [UNESP] Salgueiro Geraldes, Silvano [UNESP] Bilbau Sant'Anna, Paula Poloni Batista, Beatriz Rodrigues Maia, Suellen [UNESP] Silveira de Moraes, Reiner [UNESP] Moreira Dos Santos Schmidt, Elizabeth [UNESP] Ferreira de Souza, Fabiana [UNESP] Melchert, Alessandra [UNESP] Pinheiro Ferreira, João Carlos [UNESP] Rezende Dadalto, Carmel [UNESP] Mogollón García, Henry David [UNESP] Chalfun Guimarães-Okamoto, Priscylla Tatiana [UNESP] |
author_role |
author |
author2 |
Salgueiro Geraldes, Silvano [UNESP] Bilbau Sant'Anna, Paula Poloni Batista, Beatriz Rodrigues Maia, Suellen [UNESP] Silveira de Moraes, Reiner [UNESP] Moreira Dos Santos Schmidt, Elizabeth [UNESP] Ferreira de Souza, Fabiana [UNESP] Melchert, Alessandra [UNESP] Pinheiro Ferreira, João Carlos [UNESP] Rezende Dadalto, Carmel [UNESP] Mogollón García, Henry David [UNESP] Chalfun Guimarães-Okamoto, Priscylla Tatiana [UNESP] |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Pet Care Veterinary Hospital Pacaembu Unit |
dc.contributor.author.fl_str_mv |
Picelli de Azevedo, Maria Gabriela [UNESP] Salgueiro Geraldes, Silvano [UNESP] Bilbau Sant'Anna, Paula Poloni Batista, Beatriz Rodrigues Maia, Suellen [UNESP] Silveira de Moraes, Reiner [UNESP] Moreira Dos Santos Schmidt, Elizabeth [UNESP] Ferreira de Souza, Fabiana [UNESP] Melchert, Alessandra [UNESP] Pinheiro Ferreira, João Carlos [UNESP] Rezende Dadalto, Carmel [UNESP] Mogollón García, Henry David [UNESP] Chalfun Guimarães-Okamoto, Priscylla Tatiana [UNESP] |
description |
In chronic kidney disease dogs, the inflammatory process increases C-reactive protein concentrations. This study aimed to determine C-reactive protein serum concentrations in stage IV chronic kidney disease dogs treated with intermittent hemodialysis. A prospective cohort study was conducted with 23 dogs allocated into three groups: control group (CG, n = 7), intermittent hemodialysis group (IHG, n = 8) and clinical treatment group (CTG, n = 8), both comprised of stage IV chronic kidney disease dogs. One blood sample from CG (initial evaluation) and two samples from IHG and CTG (first- and last-moment) were obtained to determine C-reactive protein concentration, total leukocytes, platelets, erythrocytes, total plasma protein, serum albumin, urea, creatinine, and phosphorus. C-reactive protein was higher in IHG compared to CG in the first- and last-moments (p <0.001) and compared to CTG in the first-moment (p = 0.0406). C-reactive protein presented moderate positive correlation with leukocytes (r = 0.5479; p = 0.01), and moderate negative correlation with albumin (r = - 0.5974; p = 0.006) and red blood cells (r = - 0.5878, p = 0.01). A high correlation coefficient was observed in the tests' evaluation (CI = 0.59-0.78; r = 0.70; P<0.0001). In conclusion, both assays used in this study to measure C-reactive protein have provided safe and reliable quantification of the results. Additionally, despite IHG dogs presented an active inflammatory profile, intermittent hemodialysis has proven to be beneficial, leading to a clinical improvement in life quality of patients, and thus being recommended for stage IV CKD dogs when performed by trained professionals. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-07-29T13:21:39Z 2023-07-29T13:21:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0274510 PloS one, v. 17, n. 9, p. e0274510-, 2022. 1932-6203 http://hdl.handle.net/11449/247638 10.1371/journal.pone.0274510 2-s2.0-85138416135 |
url |
http://dx.doi.org/10.1371/journal.pone.0274510 http://hdl.handle.net/11449/247638 |
identifier_str_mv |
PloS one, v. 17, n. 9, p. e0274510-, 2022. 1932-6203 10.1371/journal.pone.0274510 2-s2.0-85138416135 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PloS one |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
e0274510 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
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UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1810021327284731904 |