Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongos

Detalhes bibliográficos
Autor(a) principal: de Almeida, Eduardo Tonon [UNESP]
Data de Publicação: 2005
Outros Autores: Mauro, Antonio Eduardo [UNESP], Santana, Anderson Martinez [UNESP], Godoy Netto, Adelino Vieira de [UNESP], Carlos, Iracilda Zeppone [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0100-40422005000300008
http://hdl.handle.net/11449/26005
Resumo: The immune responses are mediated by a variety of cells that, when activated, produce a number of molecules. Macrophages are the first cells to take part in the immune response releasing many compounds in the extracellular environment such as H2O2. Taking into account this aspect we evaluated the activation of an immunological system, in vitro, by determining the H2O2 released in cultures of peritoneal macrophage cells from Swiss mice in the presence of organopalladated compounds of the type [Pd(dmba)(X)(dppp)], dmba = N,N-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphine)propane, X = Cl, N3, NCO, NCS. An excellent activation of macrophages by the [Pd(dmba)(X)(dppp)] compounds was observed and the influence of the X ligand on the immune response could be verified.
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spelling Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongosActivation of mice peritoneal macrophages by palladium(II) organometallic mononuclear compoundspalladium(II) complexesmacrophageshydrogen peroxideThe immune responses are mediated by a variety of cells that, when activated, produce a number of molecules. Macrophages are the first cells to take part in the immune response releasing many compounds in the extracellular environment such as H2O2. Taking into account this aspect we evaluated the activation of an immunological system, in vitro, by determining the H2O2 released in cultures of peritoneal macrophage cells from Swiss mice in the presence of organopalladated compounds of the type [Pd(dmba)(X)(dppp)], dmba = N,N-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphine)propane, X = Cl, N3, NCO, NCS. An excellent activation of macrophages by the [Pd(dmba)(X)(dppp)] compounds was observed and the influence of the X ligand on the immune response could be verified.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista Instituto de Química de Araraquara Departamento de Química Geral e InorgânicaUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas de Araraquara Departamento de Análises ClínicasUniversidade Estadual Paulista Instituto de Química de Araraquara Departamento de Química Geral e InorgânicaUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas de Araraquara Departamento de Análises ClínicasSociedade Brasileira de QuímicaUniversidade Estadual Paulista (Unesp)de Almeida, Eduardo Tonon [UNESP]Mauro, Antonio Eduardo [UNESP]Santana, Anderson Martinez [UNESP]Godoy Netto, Adelino Vieira de [UNESP]Carlos, Iracilda Zeppone [UNESP]2014-05-20T14:20:00Z2014-05-20T14:20:00Z2005-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article405-408application/pdfhttp://dx.doi.org/10.1590/S0100-40422005000300008Química Nova. Sociedade Brasileira de Química, v. 28, n. 3, p. 405-408, 2005.0100-4042http://hdl.handle.net/11449/2600510.1590/S0100-40422005000300008S0100-40422005000300008S0100-40422005000300008.pdf3300223970814448SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporQuímica Nova0.6460,255info:eu-repo/semantics/openAccess2024-06-21T15:18:34Zoai:repositorio.unesp.br:11449/26005Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:02:03.724846Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongos
Activation of mice peritoneal macrophages by palladium(II) organometallic mononuclear compounds
title Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongos
spellingShingle Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongos
de Almeida, Eduardo Tonon [UNESP]
palladium(II) complexes
macrophages
hydrogen peroxide
title_short Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongos
title_full Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongos
title_fullStr Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongos
title_full_unstemmed Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongos
title_sort Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongos
author de Almeida, Eduardo Tonon [UNESP]
author_facet de Almeida, Eduardo Tonon [UNESP]
Mauro, Antonio Eduardo [UNESP]
Santana, Anderson Martinez [UNESP]
Godoy Netto, Adelino Vieira de [UNESP]
Carlos, Iracilda Zeppone [UNESP]
author_role author
author2 Mauro, Antonio Eduardo [UNESP]
Santana, Anderson Martinez [UNESP]
Godoy Netto, Adelino Vieira de [UNESP]
Carlos, Iracilda Zeppone [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv de Almeida, Eduardo Tonon [UNESP]
Mauro, Antonio Eduardo [UNESP]
Santana, Anderson Martinez [UNESP]
Godoy Netto, Adelino Vieira de [UNESP]
Carlos, Iracilda Zeppone [UNESP]
dc.subject.por.fl_str_mv palladium(II) complexes
macrophages
hydrogen peroxide
topic palladium(II) complexes
macrophages
hydrogen peroxide
description The immune responses are mediated by a variety of cells that, when activated, produce a number of molecules. Macrophages are the first cells to take part in the immune response releasing many compounds in the extracellular environment such as H2O2. Taking into account this aspect we evaluated the activation of an immunological system, in vitro, by determining the H2O2 released in cultures of peritoneal macrophage cells from Swiss mice in the presence of organopalladated compounds of the type [Pd(dmba)(X)(dppp)], dmba = N,N-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphine)propane, X = Cl, N3, NCO, NCS. An excellent activation of macrophages by the [Pd(dmba)(X)(dppp)] compounds was observed and the influence of the X ligand on the immune response could be verified.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
2014-05-20T14:20:00Z
2014-05-20T14:20:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-40422005000300008
Química Nova. Sociedade Brasileira de Química, v. 28, n. 3, p. 405-408, 2005.
0100-4042
http://hdl.handle.net/11449/26005
10.1590/S0100-40422005000300008
S0100-40422005000300008
S0100-40422005000300008.pdf
3300223970814448
url http://dx.doi.org/10.1590/S0100-40422005000300008
http://hdl.handle.net/11449/26005
identifier_str_mv Química Nova. Sociedade Brasileira de Química, v. 28, n. 3, p. 405-408, 2005.
0100-4042
10.1590/S0100-40422005000300008
S0100-40422005000300008
S0100-40422005000300008.pdf
3300223970814448
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Química Nova
0.646
0,255
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 405-408
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128596234993664

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