Potentiometric determination of captopril in pharmaceutical formulations

Detalhes bibliográficos
Autor(a) principal: Ribeiro, PRD
Data de Publicação: 2003
Outros Autores: Santini, A. O., Pezza, H. R., Pezza, L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/195747
Resumo: A simple, precise, rapid and low-cost potentiometric method for captopril determination in pure form and in pharmaceutical preparations is proposed. Captopril present in tablets containing known quantity of drug was potentiometrically titrated in aqueous solution with NaOH using a glass pH electrode, coupled to an autotitrator. No interferences were observed in the presence of common components of the tablets as lactose, microcrystalline cellulose, croscarmellose sodium, starch and magnesium stearate. The analytical results obtained by applying the proposed method compared very favorably with those obtained by the United States Pharmacopoeia Standard procedure. Recovery of captopril from various tablet dosage formulations range from 98.0 to 102.0%.
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spelling Potentiometric determination of captopril in pharmaceutical formulationspotentiometric determinationcaptoprilpharmaceutical formulationsA simple, precise, rapid and low-cost potentiometric method for captopril determination in pure form and in pharmaceutical preparations is proposed. Captopril present in tablets containing known quantity of drug was potentiometrically titrated in aqueous solution with NaOH using a glass pH electrode, coupled to an autotitrator. No interferences were observed in the presence of common components of the tablets as lactose, microcrystalline cellulose, croscarmellose sodium, starch and magnesium stearate. The analytical results obtained by applying the proposed method compared very favorably with those obtained by the United States Pharmacopoeia Standard procedure. Recovery of captopril from various tablet dosage formulations range from 98.0 to 102.0%.UNESP, Inst Quim, Dept Quim Analit, BR-14801970 Araraquara, SP, BrazilUNESP, Inst Quim, Dept Quim Organ, BR-14801970 Araraquara, SP, BrazilUNESP, Inst Quim, Dept Quim Analit, BR-14801970 Araraquara, SP, BrazilUNESP, Inst Quim, Dept Quim Organ, BR-14801970 Araraquara, SP, BrazilEditora UnespUniversidade Estadual Paulista (Unesp)Ribeiro, PRDSantini, A. O.Pezza, H. R.Pezza, L.2020-12-10T18:02:12Z2020-12-10T18:02:12Z2003-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article39-44Ecletica Quimica. Sao Paulo: Editora Unesp, v. 28, n. 1, p. 39-44, 2003.0100-4670http://hdl.handle.net/11449/195747WOS:000186315900005Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEcletica Quimicainfo:eu-repo/semantics/openAccess2021-10-23T11:43:35Zoai:repositorio.unesp.br:11449/195747Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:58:04.316139Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Potentiometric determination of captopril in pharmaceutical formulations
title Potentiometric determination of captopril in pharmaceutical formulations
spellingShingle Potentiometric determination of captopril in pharmaceutical formulations
Ribeiro, PRD
potentiometric determination
captopril
pharmaceutical formulations
title_short Potentiometric determination of captopril in pharmaceutical formulations
title_full Potentiometric determination of captopril in pharmaceutical formulations
title_fullStr Potentiometric determination of captopril in pharmaceutical formulations
title_full_unstemmed Potentiometric determination of captopril in pharmaceutical formulations
title_sort Potentiometric determination of captopril in pharmaceutical formulations
author Ribeiro, PRD
author_facet Ribeiro, PRD
Santini, A. O.
Pezza, H. R.
Pezza, L.
author_role author
author2 Santini, A. O.
Pezza, H. R.
Pezza, L.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ribeiro, PRD
Santini, A. O.
Pezza, H. R.
Pezza, L.
dc.subject.por.fl_str_mv potentiometric determination
captopril
pharmaceutical formulations
topic potentiometric determination
captopril
pharmaceutical formulations
description A simple, precise, rapid and low-cost potentiometric method for captopril determination in pure form and in pharmaceutical preparations is proposed. Captopril present in tablets containing known quantity of drug was potentiometrically titrated in aqueous solution with NaOH using a glass pH electrode, coupled to an autotitrator. No interferences were observed in the presence of common components of the tablets as lactose, microcrystalline cellulose, croscarmellose sodium, starch and magnesium stearate. The analytical results obtained by applying the proposed method compared very favorably with those obtained by the United States Pharmacopoeia Standard procedure. Recovery of captopril from various tablet dosage formulations range from 98.0 to 102.0%.
publishDate 2003
dc.date.none.fl_str_mv 2003-01-01
2020-12-10T18:02:12Z
2020-12-10T18:02:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Ecletica Quimica. Sao Paulo: Editora Unesp, v. 28, n. 1, p. 39-44, 2003.
0100-4670
http://hdl.handle.net/11449/195747
WOS:000186315900005
identifier_str_mv Ecletica Quimica. Sao Paulo: Editora Unesp, v. 28, n. 1, p. 39-44, 2003.
0100-4670
WOS:000186315900005
url http://hdl.handle.net/11449/195747
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ecletica Quimica
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 39-44
dc.publisher.none.fl_str_mv Editora Unesp
publisher.none.fl_str_mv Editora Unesp
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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