The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ijbiomac.2020.08.078 http://hdl.handle.net/11449/200950 |
Resumo: | The use of controlled drug delivery systems represents an alternative and promising strategy for the use of antimicrobials in the oral cavity. Microparticles, films and oral tablets based on alginate and gellan gum were developed also as a strategy to overcome the low aqueous solubility of morin. The systems were characterized in terms of morphological characteristics, mucoadhesion and in vitro drug release. Antibiofilm activity was analyzed for acidogenicity, microbial viability and the composition of the extracellular matrix of single-species biofilms. Scanning Electron Microscopy demonstrated that the microparticles were spherical, rough and compact. The film and the tablet presented smooth and continuous surface and in the inner of the tablet was porous. These systems were more mucoadhesive compared to the microparticles. The in vitro morin release profiles in artificial saliva demonstrated that the microparticles controlled the release better (39.6%), followed by the film (41.1%) and the tablet (91.4%) after 20 h of testing. The morin released from the systems reduced the acidogenicity, microbial viability, concentration of insoluble extracellular polysaccharides and dry weight of biofilms, when compared to the control group. The findings of this study showed that the morin has antibiofilm activity against cariogenic microorganisms. |
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The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morinAlginateControlled drug deliveryDental plaqueGellan gumMorin hydratePolysaccharidesThe use of controlled drug delivery systems represents an alternative and promising strategy for the use of antimicrobials in the oral cavity. Microparticles, films and oral tablets based on alginate and gellan gum were developed also as a strategy to overcome the low aqueous solubility of morin. The systems were characterized in terms of morphological characteristics, mucoadhesion and in vitro drug release. Antibiofilm activity was analyzed for acidogenicity, microbial viability and the composition of the extracellular matrix of single-species biofilms. Scanning Electron Microscopy demonstrated that the microparticles were spherical, rough and compact. The film and the tablet presented smooth and continuous surface and in the inner of the tablet was porous. These systems were more mucoadhesive compared to the microparticles. The in vitro morin release profiles in artificial saliva demonstrated that the microparticles controlled the release better (39.6%), followed by the film (41.1%) and the tablet (91.4%) after 20 h of testing. The morin released from the systems reduced the acidogenicity, microbial viability, concentration of insoluble extracellular polysaccharides and dry weight of biofilms, when compared to the control group. The findings of this study showed that the morin has antibiofilm activity against cariogenic microorganisms.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Morphology Pediatric Dentistry and Orthodontics School of Dentistry São Paulo State University - UNESPDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University-UNESPBiopolymers and Biomaterials Laboratory (BioPolMat) University of Araraquara - UNIARADepartment of Morphology Pediatric Dentistry and Orthodontics School of Dentistry São Paulo State University - UNESPDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University-UNESPFAPESP: 2013/07276-1FAPESP: 2013/12326-8FAPESP: 2018/25512-8CNPq: 304383/20163CNPq: 407822/2018-6FAPESP: CEPID - 13/07276-1Universidade Estadual Paulista (Unesp)University of Araraquara - UNIARAde Farias, Aline Leite [UNESP]Meneguin, Andréia Bagliotti [UNESP]da Silva Barud, HernaneBrighenti, Fernanda Lourenção [UNESP]2020-12-12T02:20:21Z2020-12-12T02:20:21Z2020-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1944-1958http://dx.doi.org/10.1016/j.ijbiomac.2020.08.078International Journal of Biological Macromolecules, v. 162, p. 1944-1958.1879-00030141-8130http://hdl.handle.net/11449/20095010.1016/j.ijbiomac.2020.08.0782-s2.0-8508983939560656363677173820000-0002-4470-5171Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Biological Macromoleculesinfo:eu-repo/semantics/openAccess2024-06-24T13:45:38Zoai:repositorio.unesp.br:11449/200950Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-24T13:45:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin |
title |
The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin |
spellingShingle |
The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin de Farias, Aline Leite [UNESP] Alginate Controlled drug delivery Dental plaque Gellan gum Morin hydrate Polysaccharides |
title_short |
The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin |
title_full |
The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin |
title_fullStr |
The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin |
title_full_unstemmed |
The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin |
title_sort |
The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin |
author |
de Farias, Aline Leite [UNESP] |
author_facet |
de Farias, Aline Leite [UNESP] Meneguin, Andréia Bagliotti [UNESP] da Silva Barud, Hernane Brighenti, Fernanda Lourenção [UNESP] |
author_role |
author |
author2 |
Meneguin, Andréia Bagliotti [UNESP] da Silva Barud, Hernane Brighenti, Fernanda Lourenção [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Araraquara - UNIARA |
dc.contributor.author.fl_str_mv |
de Farias, Aline Leite [UNESP] Meneguin, Andréia Bagliotti [UNESP] da Silva Barud, Hernane Brighenti, Fernanda Lourenção [UNESP] |
dc.subject.por.fl_str_mv |
Alginate Controlled drug delivery Dental plaque Gellan gum Morin hydrate Polysaccharides |
topic |
Alginate Controlled drug delivery Dental plaque Gellan gum Morin hydrate Polysaccharides |
description |
The use of controlled drug delivery systems represents an alternative and promising strategy for the use of antimicrobials in the oral cavity. Microparticles, films and oral tablets based on alginate and gellan gum were developed also as a strategy to overcome the low aqueous solubility of morin. The systems were characterized in terms of morphological characteristics, mucoadhesion and in vitro drug release. Antibiofilm activity was analyzed for acidogenicity, microbial viability and the composition of the extracellular matrix of single-species biofilms. Scanning Electron Microscopy demonstrated that the microparticles were spherical, rough and compact. The film and the tablet presented smooth and continuous surface and in the inner of the tablet was porous. These systems were more mucoadhesive compared to the microparticles. The in vitro morin release profiles in artificial saliva demonstrated that the microparticles controlled the release better (39.6%), followed by the film (41.1%) and the tablet (91.4%) after 20 h of testing. The morin released from the systems reduced the acidogenicity, microbial viability, concentration of insoluble extracellular polysaccharides and dry weight of biofilms, when compared to the control group. The findings of this study showed that the morin has antibiofilm activity against cariogenic microorganisms. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:20:21Z 2020-12-12T02:20:21Z 2020-11-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ijbiomac.2020.08.078 International Journal of Biological Macromolecules, v. 162, p. 1944-1958. 1879-0003 0141-8130 http://hdl.handle.net/11449/200950 10.1016/j.ijbiomac.2020.08.078 2-s2.0-85089839395 6065636367717382 0000-0002-4470-5171 |
url |
http://dx.doi.org/10.1016/j.ijbiomac.2020.08.078 http://hdl.handle.net/11449/200950 |
identifier_str_mv |
International Journal of Biological Macromolecules, v. 162, p. 1944-1958. 1879-0003 0141-8130 10.1016/j.ijbiomac.2020.08.078 2-s2.0-85089839395 6065636367717382 0000-0002-4470-5171 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Biological Macromolecules |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1944-1958 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803045343363858432 |