Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats

Detalhes bibliográficos
Autor(a) principal: Brasilino, Matheus da Silva [UNESP]
Data de Publicação: 2018
Outros Autores: Stringhetta-Garcia, Camila Tami [UNESP], Pereira, Camila Scacco [UNESP], Pereira, Ariana Aparecida Ferreira [UNESP], Stringhetta, Karina, Leopoldino, Andréia Machado, Crivelini, Marcelo Macedo [UNESP], Ervolino, Edilson [UNESP], Dornelles, Rita Cássia Menegati [UNESP], de Melo Stevanato Nakamune, Ana Cláudia [UNESP], Chaves-Neto, Antonio Hernandes [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s00784-017-2249-1
http://hdl.handle.net/11449/177050
Resumo: Objectives: The objective of this study was to investigate the effects of mate tea (MT) [Ilex paraguariensis] on alveolar socket healing after tooth extraction. Materials and methods: Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum. Results: Histometry evidenced an increase in bone area (P < 0.0001) and osteocyte density (P < 0.0001). MT increased immunolabeling of MnSOD (P < 0.001), OCN (P < 0.0001), RANKL (P < 0.001), OPG (P < 0.0001), and TRAP (P < 0.001). Calcium and phosphorus concentrations did not differ between the groups. In addition, MT enhanced ALP (P < 0.05) and TRAP (P < 0.0001) activities. MT increased the TAC (P < 0.001), whereas it reduced MDA concentrations (P < 0.0001). Conclusions: MT increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction. Clinical relevance: Regular MT ingestion improves the antioxidant defenses and bone formation, which is beneficial for alveolar socket bone healing after tooth extraction.
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spelling Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in ratsAntioxidantIlex paraguariensisTooth extractionWound healingObjectives: The objective of this study was to investigate the effects of mate tea (MT) [Ilex paraguariensis] on alveolar socket healing after tooth extraction. Materials and methods: Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum. Results: Histometry evidenced an increase in bone area (P < 0.0001) and osteocyte density (P < 0.0001). MT increased immunolabeling of MnSOD (P < 0.001), OCN (P < 0.0001), RANKL (P < 0.001), OPG (P < 0.0001), and TRAP (P < 0.001). Calcium and phosphorus concentrations did not differ between the groups. In addition, MT enhanced ALP (P < 0.05) and TRAP (P < 0.0001) activities. MT increased the TAC (P < 0.001), whereas it reduced MDA concentrations (P < 0.0001). Conclusions: MT increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction. Clinical relevance: Regular MT ingestion improves the antioxidant defenses and bone formation, which is beneficial for alveolar socket bone healing after tooth extraction.Department of Basic Sciences School of Dentistry São Paulo State University (Unesp), Rodovia Marechal Rondon km 527, CEPPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicas – SBFis School of Dentistry São Paulo State University (Unesp)Department of Clinical Toxicological and Bromatological Analysis Faculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP)Department of Pathology and Clinical Propaedeutic School of Dentistry São Paulo State University (Unesp)Department of Basic Sciences School of Dentistry São Paulo State University (Unesp), Rodovia Marechal Rondon km 527, CEPPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicas – SBFis School of Dentistry São Paulo State University (Unesp)Department of Pathology and Clinical Propaedeutic School of Dentistry São Paulo State University (Unesp)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Brasilino, Matheus da Silva [UNESP]Stringhetta-Garcia, Camila Tami [UNESP]Pereira, Camila Scacco [UNESP]Pereira, Ariana Aparecida Ferreira [UNESP]Stringhetta, KarinaLeopoldino, Andréia MachadoCrivelini, Marcelo Macedo [UNESP]Ervolino, Edilson [UNESP]Dornelles, Rita Cássia Menegati [UNESP]de Melo Stevanato Nakamune, Ana Cláudia [UNESP]Chaves-Neto, Antonio Hernandes [UNESP]2018-12-11T17:23:39Z2018-12-11T17:23:39Z2018-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1449-1461application/pdfhttp://dx.doi.org/10.1007/s00784-017-2249-1Clinical Oral Investigations, v. 22, n. 3, p. 1449-1461, 2018.1436-37711432-6981http://hdl.handle.net/11449/17705010.1007/s00784-017-2249-12-s2.0-850314061592-s2.0-850314061594408095517346846954425748251267154359024227848890000-0003-4859-05830000-0003-0783-6612Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Oral Investigations0,9860,986info:eu-repo/semantics/openAccess2024-06-24T14:52:03Zoai:repositorio.unesp.br:11449/177050Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:00:03.858103Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats
title Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats
spellingShingle Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats
Brasilino, Matheus da Silva [UNESP]
Antioxidant
Ilex paraguariensis
Tooth extraction
Wound healing
title_short Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats
title_full Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats
title_fullStr Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats
title_full_unstemmed Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats
title_sort Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats
author Brasilino, Matheus da Silva [UNESP]
author_facet Brasilino, Matheus da Silva [UNESP]
Stringhetta-Garcia, Camila Tami [UNESP]
Pereira, Camila Scacco [UNESP]
Pereira, Ariana Aparecida Ferreira [UNESP]
Stringhetta, Karina
Leopoldino, Andréia Machado
Crivelini, Marcelo Macedo [UNESP]
Ervolino, Edilson [UNESP]
Dornelles, Rita Cássia Menegati [UNESP]
de Melo Stevanato Nakamune, Ana Cláudia [UNESP]
Chaves-Neto, Antonio Hernandes [UNESP]
author_role author
author2 Stringhetta-Garcia, Camila Tami [UNESP]
Pereira, Camila Scacco [UNESP]
Pereira, Ariana Aparecida Ferreira [UNESP]
Stringhetta, Karina
Leopoldino, Andréia Machado
Crivelini, Marcelo Macedo [UNESP]
Ervolino, Edilson [UNESP]
Dornelles, Rita Cássia Menegati [UNESP]
de Melo Stevanato Nakamune, Ana Cláudia [UNESP]
Chaves-Neto, Antonio Hernandes [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Brasilino, Matheus da Silva [UNESP]
Stringhetta-Garcia, Camila Tami [UNESP]
Pereira, Camila Scacco [UNESP]
Pereira, Ariana Aparecida Ferreira [UNESP]
Stringhetta, Karina
Leopoldino, Andréia Machado
Crivelini, Marcelo Macedo [UNESP]
Ervolino, Edilson [UNESP]
Dornelles, Rita Cássia Menegati [UNESP]
de Melo Stevanato Nakamune, Ana Cláudia [UNESP]
Chaves-Neto, Antonio Hernandes [UNESP]
dc.subject.por.fl_str_mv Antioxidant
Ilex paraguariensis
Tooth extraction
Wound healing
topic Antioxidant
Ilex paraguariensis
Tooth extraction
Wound healing
description Objectives: The objective of this study was to investigate the effects of mate tea (MT) [Ilex paraguariensis] on alveolar socket healing after tooth extraction. Materials and methods: Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum. Results: Histometry evidenced an increase in bone area (P < 0.0001) and osteocyte density (P < 0.0001). MT increased immunolabeling of MnSOD (P < 0.001), OCN (P < 0.0001), RANKL (P < 0.001), OPG (P < 0.0001), and TRAP (P < 0.001). Calcium and phosphorus concentrations did not differ between the groups. In addition, MT enhanced ALP (P < 0.05) and TRAP (P < 0.0001) activities. MT increased the TAC (P < 0.001), whereas it reduced MDA concentrations (P < 0.0001). Conclusions: MT increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction. Clinical relevance: Regular MT ingestion improves the antioxidant defenses and bone formation, which is beneficial for alveolar socket bone healing after tooth extraction.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:23:39Z
2018-12-11T17:23:39Z
2018-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s00784-017-2249-1
Clinical Oral Investigations, v. 22, n. 3, p. 1449-1461, 2018.
1436-3771
1432-6981
http://hdl.handle.net/11449/177050
10.1007/s00784-017-2249-1
2-s2.0-85031406159
2-s2.0-85031406159
4408095517346846
9544257482512671
5435902422784889
0000-0003-4859-0583
0000-0003-0783-6612
url http://dx.doi.org/10.1007/s00784-017-2249-1
http://hdl.handle.net/11449/177050
identifier_str_mv Clinical Oral Investigations, v. 22, n. 3, p. 1449-1461, 2018.
1436-3771
1432-6981
10.1007/s00784-017-2249-1
2-s2.0-85031406159
4408095517346846
9544257482512671
5435902422784889
0000-0003-4859-0583
0000-0003-0783-6612
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Oral Investigations
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dc.format.none.fl_str_mv 1449-1461
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dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
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