Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00784-017-2249-1 http://hdl.handle.net/11449/177050 |
Resumo: | Objectives: The objective of this study was to investigate the effects of mate tea (MT) [Ilex paraguariensis] on alveolar socket healing after tooth extraction. Materials and methods: Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum. Results: Histometry evidenced an increase in bone area (P < 0.0001) and osteocyte density (P < 0.0001). MT increased immunolabeling of MnSOD (P < 0.001), OCN (P < 0.0001), RANKL (P < 0.001), OPG (P < 0.0001), and TRAP (P < 0.001). Calcium and phosphorus concentrations did not differ between the groups. In addition, MT enhanced ALP (P < 0.05) and TRAP (P < 0.0001) activities. MT increased the TAC (P < 0.001), whereas it reduced MDA concentrations (P < 0.0001). Conclusions: MT increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction. Clinical relevance: Regular MT ingestion improves the antioxidant defenses and bone formation, which is beneficial for alveolar socket bone healing after tooth extraction. |
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Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in ratsAntioxidantIlex paraguariensisTooth extractionWound healingObjectives: The objective of this study was to investigate the effects of mate tea (MT) [Ilex paraguariensis] on alveolar socket healing after tooth extraction. Materials and methods: Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum. Results: Histometry evidenced an increase in bone area (P < 0.0001) and osteocyte density (P < 0.0001). MT increased immunolabeling of MnSOD (P < 0.001), OCN (P < 0.0001), RANKL (P < 0.001), OPG (P < 0.0001), and TRAP (P < 0.001). Calcium and phosphorus concentrations did not differ between the groups. In addition, MT enhanced ALP (P < 0.05) and TRAP (P < 0.0001) activities. MT increased the TAC (P < 0.001), whereas it reduced MDA concentrations (P < 0.0001). Conclusions: MT increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction. Clinical relevance: Regular MT ingestion improves the antioxidant defenses and bone formation, which is beneficial for alveolar socket bone healing after tooth extraction.Department of Basic Sciences School of Dentistry São Paulo State University (Unesp), Rodovia Marechal Rondon km 527, CEPPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicas – SBFis School of Dentistry São Paulo State University (Unesp)Department of Clinical Toxicological and Bromatological Analysis Faculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP)Department of Pathology and Clinical Propaedeutic School of Dentistry São Paulo State University (Unesp)Department of Basic Sciences School of Dentistry São Paulo State University (Unesp), Rodovia Marechal Rondon km 527, CEPPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicas – SBFis School of Dentistry São Paulo State University (Unesp)Department of Pathology and Clinical Propaedeutic School of Dentistry São Paulo State University (Unesp)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Brasilino, Matheus da Silva [UNESP]Stringhetta-Garcia, Camila Tami [UNESP]Pereira, Camila Scacco [UNESP]Pereira, Ariana Aparecida Ferreira [UNESP]Stringhetta, KarinaLeopoldino, Andréia MachadoCrivelini, Marcelo Macedo [UNESP]Ervolino, Edilson [UNESP]Dornelles, Rita Cássia Menegati [UNESP]de Melo Stevanato Nakamune, Ana Cláudia [UNESP]Chaves-Neto, Antonio Hernandes [UNESP]2018-12-11T17:23:39Z2018-12-11T17:23:39Z2018-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1449-1461application/pdfhttp://dx.doi.org/10.1007/s00784-017-2249-1Clinical Oral Investigations, v. 22, n. 3, p. 1449-1461, 2018.1436-37711432-6981http://hdl.handle.net/11449/17705010.1007/s00784-017-2249-12-s2.0-850314061592-s2.0-850314061594408095517346846954425748251267154359024227848890000-0003-4859-05830000-0003-0783-6612Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Oral Investigations0,9860,986info:eu-repo/semantics/openAccess2024-06-24T14:52:03Zoai:repositorio.unesp.br:11449/177050Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:00:03.858103Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats |
title |
Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats |
spellingShingle |
Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats Brasilino, Matheus da Silva [UNESP] Antioxidant Ilex paraguariensis Tooth extraction Wound healing |
title_short |
Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats |
title_full |
Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats |
title_fullStr |
Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats |
title_full_unstemmed |
Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats |
title_sort |
Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats |
author |
Brasilino, Matheus da Silva [UNESP] |
author_facet |
Brasilino, Matheus da Silva [UNESP] Stringhetta-Garcia, Camila Tami [UNESP] Pereira, Camila Scacco [UNESP] Pereira, Ariana Aparecida Ferreira [UNESP] Stringhetta, Karina Leopoldino, Andréia Machado Crivelini, Marcelo Macedo [UNESP] Ervolino, Edilson [UNESP] Dornelles, Rita Cássia Menegati [UNESP] de Melo Stevanato Nakamune, Ana Cláudia [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] |
author_role |
author |
author2 |
Stringhetta-Garcia, Camila Tami [UNESP] Pereira, Camila Scacco [UNESP] Pereira, Ariana Aparecida Ferreira [UNESP] Stringhetta, Karina Leopoldino, Andréia Machado Crivelini, Marcelo Macedo [UNESP] Ervolino, Edilson [UNESP] Dornelles, Rita Cássia Menegati [UNESP] de Melo Stevanato Nakamune, Ana Cláudia [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Brasilino, Matheus da Silva [UNESP] Stringhetta-Garcia, Camila Tami [UNESP] Pereira, Camila Scacco [UNESP] Pereira, Ariana Aparecida Ferreira [UNESP] Stringhetta, Karina Leopoldino, Andréia Machado Crivelini, Marcelo Macedo [UNESP] Ervolino, Edilson [UNESP] Dornelles, Rita Cássia Menegati [UNESP] de Melo Stevanato Nakamune, Ana Cláudia [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] |
dc.subject.por.fl_str_mv |
Antioxidant Ilex paraguariensis Tooth extraction Wound healing |
topic |
Antioxidant Ilex paraguariensis Tooth extraction Wound healing |
description |
Objectives: The objective of this study was to investigate the effects of mate tea (MT) [Ilex paraguariensis] on alveolar socket healing after tooth extraction. Materials and methods: Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum. Results: Histometry evidenced an increase in bone area (P < 0.0001) and osteocyte density (P < 0.0001). MT increased immunolabeling of MnSOD (P < 0.001), OCN (P < 0.0001), RANKL (P < 0.001), OPG (P < 0.0001), and TRAP (P < 0.001). Calcium and phosphorus concentrations did not differ between the groups. In addition, MT enhanced ALP (P < 0.05) and TRAP (P < 0.0001) activities. MT increased the TAC (P < 0.001), whereas it reduced MDA concentrations (P < 0.0001). Conclusions: MT increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction. Clinical relevance: Regular MT ingestion improves the antioxidant defenses and bone formation, which is beneficial for alveolar socket bone healing after tooth extraction. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:23:39Z 2018-12-11T17:23:39Z 2018-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00784-017-2249-1 Clinical Oral Investigations, v. 22, n. 3, p. 1449-1461, 2018. 1436-3771 1432-6981 http://hdl.handle.net/11449/177050 10.1007/s00784-017-2249-1 2-s2.0-85031406159 2-s2.0-85031406159 4408095517346846 9544257482512671 5435902422784889 0000-0003-4859-0583 0000-0003-0783-6612 |
url |
http://dx.doi.org/10.1007/s00784-017-2249-1 http://hdl.handle.net/11449/177050 |
identifier_str_mv |
Clinical Oral Investigations, v. 22, n. 3, p. 1449-1461, 2018. 1436-3771 1432-6981 10.1007/s00784-017-2249-1 2-s2.0-85031406159 4408095517346846 9544257482512671 5435902422784889 0000-0003-4859-0583 0000-0003-0783-6612 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Oral Investigations 0,986 0,986 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1449-1461 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129570965028864 |