Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticles

Detalhes bibliográficos
Autor(a) principal: Prospero, Andre Gonçalves [UNESP]
Data de Publicação: 2021
Outros Autores: Buranello, Lais Pereira [UNESP], Fernandes, Carlos Ah [UNESP], Dos Santos, Lucilene Delazari [UNESP], Soares, Guilherme [UNESP], C Rossini, Bruno [UNESP], Zufelato, Nícholas, Bakuzis, Andris Figueiroa, De Mattos Fontes, Marcos R [UNESP], De Arruda Miranda, José R [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2217/nnm-2021-0195
http://hdl.handle.net/11449/229666
Resumo: Background: We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and in vivo circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-coated and bovine serum albumin-coated MNPs. Methods: We employed the ACB system, gel electrophoresis and mass spectrometry analysis. Results: Higher CP formation led to a greater reduction in the in vitro ACB signal intensity and circulation time. We found fewer proteins forming the CP for the bovine serum albumin-coated MNPs, which presented the highest circulation time in vivo among the MNPs studied. Conclusion: These data showed better biocompatibility, stability and magnetic signal uniformity in biological media for bovine serum albumin-coated MNPs than for citrate-coated MNPs and bare MNPs.
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spelling Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticlesalternating current biosusceptometrybiomedical engineeringcorona proteinmagnetic nanoparticlesmass spectrometryBackground: We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and in vivo circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-coated and bovine serum albumin-coated MNPs. Methods: We employed the ACB system, gel electrophoresis and mass spectrometry analysis. Results: Higher CP formation led to a greater reduction in the in vitro ACB signal intensity and circulation time. We found fewer proteins forming the CP for the bovine serum albumin-coated MNPs, which presented the highest circulation time in vivo among the MNPs studied. Conclusion: These data showed better biocompatibility, stability and magnetic signal uniformity in biological media for bovine serum albumin-coated MNPs than for citrate-coated MNPs and bare MNPs.Department of Biophysics and Pharmacology São Paulo State University, São PauloMuseum National d'Histoire Naturelle Institut de Minéralogie Physique des Matériaux et Cosmochimie IMPMC Sorbonne Université UMR 7590 CNRSGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP), São PauloBiotechnology Institute São Paulo State University, São PauloInstitute of Physics and CNanoMed Federal University of GoiásDepartment of Biophysics and Pharmacology São Paulo State University, São PauloGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP), São PauloBiotechnology Institute São Paulo State University, São PauloUniversidade Estadual Paulista (UNESP)CNRSUniversidade Federal de Goiás (UFG)Prospero, Andre Gonçalves [UNESP]Buranello, Lais Pereira [UNESP]Fernandes, Carlos Ah [UNESP]Dos Santos, Lucilene Delazari [UNESP]Soares, Guilherme [UNESP]C Rossini, Bruno [UNESP]Zufelato, NícholasBakuzis, Andris FigueiroaDe Mattos Fontes, Marcos R [UNESP]De Arruda Miranda, José R [UNESP]2022-04-29T08:35:01Z2022-04-29T08:35:01Z2021-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2189-2206http://dx.doi.org/10.2217/nnm-2021-0195Nanomedicine, v. 16, n. 24, p. 2189-2206, 2021.1748-69631743-5889http://hdl.handle.net/11449/22966610.2217/nnm-2021-01952-s2.0-85116635426Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNanomedicineinfo:eu-repo/semantics/openAccess2024-08-15T15:22:26Zoai:repositorio.unesp.br:11449/229666Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:22:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticles
title Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticles
spellingShingle Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticles
Prospero, Andre Gonçalves [UNESP]
alternating current biosusceptometry
biomedical engineering
corona protein
magnetic nanoparticles
mass spectrometry
title_short Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticles
title_full Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticles
title_fullStr Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticles
title_full_unstemmed Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticles
title_sort Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4nanoparticles
author Prospero, Andre Gonçalves [UNESP]
author_facet Prospero, Andre Gonçalves [UNESP]
Buranello, Lais Pereira [UNESP]
Fernandes, Carlos Ah [UNESP]
Dos Santos, Lucilene Delazari [UNESP]
Soares, Guilherme [UNESP]
C Rossini, Bruno [UNESP]
Zufelato, Nícholas
Bakuzis, Andris Figueiroa
De Mattos Fontes, Marcos R [UNESP]
De Arruda Miranda, José R [UNESP]
author_role author
author2 Buranello, Lais Pereira [UNESP]
Fernandes, Carlos Ah [UNESP]
Dos Santos, Lucilene Delazari [UNESP]
Soares, Guilherme [UNESP]
C Rossini, Bruno [UNESP]
Zufelato, Nícholas
Bakuzis, Andris Figueiroa
De Mattos Fontes, Marcos R [UNESP]
De Arruda Miranda, José R [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
CNRS
Universidade Federal de Goiás (UFG)
dc.contributor.author.fl_str_mv Prospero, Andre Gonçalves [UNESP]
Buranello, Lais Pereira [UNESP]
Fernandes, Carlos Ah [UNESP]
Dos Santos, Lucilene Delazari [UNESP]
Soares, Guilherme [UNESP]
C Rossini, Bruno [UNESP]
Zufelato, Nícholas
Bakuzis, Andris Figueiroa
De Mattos Fontes, Marcos R [UNESP]
De Arruda Miranda, José R [UNESP]
dc.subject.por.fl_str_mv alternating current biosusceptometry
biomedical engineering
corona protein
magnetic nanoparticles
mass spectrometry
topic alternating current biosusceptometry
biomedical engineering
corona protein
magnetic nanoparticles
mass spectrometry
description Background: We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and in vivo circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-coated and bovine serum albumin-coated MNPs. Methods: We employed the ACB system, gel electrophoresis and mass spectrometry analysis. Results: Higher CP formation led to a greater reduction in the in vitro ACB signal intensity and circulation time. We found fewer proteins forming the CP for the bovine serum albumin-coated MNPs, which presented the highest circulation time in vivo among the MNPs studied. Conclusion: These data showed better biocompatibility, stability and magnetic signal uniformity in biological media for bovine serum albumin-coated MNPs than for citrate-coated MNPs and bare MNPs.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-01
2022-04-29T08:35:01Z
2022-04-29T08:35:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2217/nnm-2021-0195
Nanomedicine, v. 16, n. 24, p. 2189-2206, 2021.
1748-6963
1743-5889
http://hdl.handle.net/11449/229666
10.2217/nnm-2021-0195
2-s2.0-85116635426
url http://dx.doi.org/10.2217/nnm-2021-0195
http://hdl.handle.net/11449/229666
identifier_str_mv Nanomedicine, v. 16, n. 24, p. 2189-2206, 2021.
1748-6963
1743-5889
10.2217/nnm-2021-0195
2-s2.0-85116635426
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nanomedicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2189-2206
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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