Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1476-511X-10-165 http://hdl.handle.net/11449/7207 |
Resumo: | Background: This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin), in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals.Methods: Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9): 1) standard (STD): fed on casein as protein source; 2) hypercholesterolemic (HC): STD plus 1% cholesterol and 0.5% cholic acid; 3) HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day); 4) HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day); 5) HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3) and (4). The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain.Results: A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet.Conclusion: Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin) and the protein (glycinin) were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism. |
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Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic ratscholesterolsoybean glycininrosuvastatinexperimental modelhypercholesterolemiaBackground: This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin), in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals.Methods: Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9): 1) standard (STD): fed on casein as protein source; 2) hypercholesterolemic (HC): STD plus 1% cholesterol and 0.5% cholic acid; 3) HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day); 4) HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day); 5) HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3) and (4). The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain.Results: A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet.Conclusion: Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin) and the protein (glycinin) were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism.Scientific Development Faculty of Pharmaceutical Sciences - PADC - UNESPSão Paulo State Univ UNESP, Dept Food & Nutr, Fac Pharmaceut Sci, Araraquara, SP, BrazilEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA), Ctr Appl Biol, Sete Lagoas, MG, BrazilSão Paulo State Univ UNESP, Dept Food & Nutr, Fac Pharmaceut Sci, Araraquara, SP, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Fassini, Priscila G. [UNESP]Noda, Roberto W.Ferreira, Ederlan S. [UNESP]Silva, Maraiza A. [UNESP]Neves, Valdir Augusto [UNESP]Demonte, Aureluce [UNESP]2014-05-20T13:23:43Z2014-05-20T13:23:43Z2011-09-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1186/1476-511X-10-165Lipids In Health and Disease. London: Biomed Central Ltd., v. 10, p. 7, 2011.1476-511Xhttp://hdl.handle.net/11449/720710.1186/1476-511X-10-165WOS:000295826700001WOS000295826700001.pdf40313195199104195269969767845353Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLipids in Health and Disease2.663info:eu-repo/semantics/openAccess2024-06-21T12:47:12Zoai:repositorio.unesp.br:11449/7207Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-21T12:47:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats |
title |
Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats |
spellingShingle |
Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats Fassini, Priscila G. [UNESP] cholesterol soybean glycinin rosuvastatin experimental model hypercholesterolemia |
title_short |
Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats |
title_full |
Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats |
title_fullStr |
Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats |
title_full_unstemmed |
Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats |
title_sort |
Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats |
author |
Fassini, Priscila G. [UNESP] |
author_facet |
Fassini, Priscila G. [UNESP] Noda, Roberto W. Ferreira, Ederlan S. [UNESP] Silva, Maraiza A. [UNESP] Neves, Valdir Augusto [UNESP] Demonte, Aureluce [UNESP] |
author_role |
author |
author2 |
Noda, Roberto W. Ferreira, Ederlan S. [UNESP] Silva, Maraiza A. [UNESP] Neves, Valdir Augusto [UNESP] Demonte, Aureluce [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) |
dc.contributor.author.fl_str_mv |
Fassini, Priscila G. [UNESP] Noda, Roberto W. Ferreira, Ederlan S. [UNESP] Silva, Maraiza A. [UNESP] Neves, Valdir Augusto [UNESP] Demonte, Aureluce [UNESP] |
dc.subject.por.fl_str_mv |
cholesterol soybean glycinin rosuvastatin experimental model hypercholesterolemia |
topic |
cholesterol soybean glycinin rosuvastatin experimental model hypercholesterolemia |
description |
Background: This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin), in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals.Methods: Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9): 1) standard (STD): fed on casein as protein source; 2) hypercholesterolemic (HC): STD plus 1% cholesterol and 0.5% cholic acid; 3) HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day); 4) HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day); 5) HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3) and (4). The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain.Results: A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet.Conclusion: Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin) and the protein (glycinin) were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09-21 2014-05-20T13:23:43Z 2014-05-20T13:23:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1476-511X-10-165 Lipids In Health and Disease. London: Biomed Central Ltd., v. 10, p. 7, 2011. 1476-511X http://hdl.handle.net/11449/7207 10.1186/1476-511X-10-165 WOS:000295826700001 WOS000295826700001.pdf 4031319519910419 5269969767845353 |
url |
http://dx.doi.org/10.1186/1476-511X-10-165 http://hdl.handle.net/11449/7207 |
identifier_str_mv |
Lipids In Health and Disease. London: Biomed Central Ltd., v. 10, p. 7, 2011. 1476-511X 10.1186/1476-511X-10-165 WOS:000295826700001 WOS000295826700001.pdf 4031319519910419 5269969767845353 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lipids in Health and Disease 2.663 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803045525085224960 |