In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.surgicalcosmetic.org.br/detalhe-artigo/216/Avaliacao-in-vitro-do-perfil-de-seguranca-de-cosmeceuticos-contendo-fatores-de-crescimento-e-seus-analogos http://hdl.handle.net/11449/74031 |
Resumo: | Introduction: Aging skin is a condition that affects (or will affect) all people, and its treatment is considered a clinical challenge. Growth factors and their analogues are emerging as a promising therapeutic option. Objectives: To evaluate the safety profile of some dermocosmetic products with formulations based on growth factors - or their analogs intended for that purpose - using in vitro human skin cell culture models. Methods: Two types of cell cultures were studied, and the effects of the study products on the proliferation of melanoma cells and normal human fibroblasts were evaluated. Results: No significant morphological alterations were found in the cultured human melanoma, and no significant decrease in the number of healthy cells was verified in the normal fibroblasts culture. In some cases there was even a proliferation of those cells. Conclusions: These preliminary data demonstrate that cosmeceutical products containing growth factors as an active principle can be considered safe for topical application. |
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In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analoguesIntercellular signaling peptides and proteinsSkinSking agingIntroduction: Aging skin is a condition that affects (or will affect) all people, and its treatment is considered a clinical challenge. Growth factors and their analogues are emerging as a promising therapeutic option. Objectives: To evaluate the safety profile of some dermocosmetic products with formulations based on growth factors - or their analogs intended for that purpose - using in vitro human skin cell culture models. Methods: Two types of cell cultures were studied, and the effects of the study products on the proliferation of melanoma cells and normal human fibroblasts were evaluated. Results: No significant morphological alterations were found in the cultured human melanoma, and no significant decrease in the number of healthy cells was verified in the normal fibroblasts culture. In some cases there was even a proliferation of those cells. Conclusions: These preliminary data demonstrate that cosmeceutical products containing growth factors as an active principle can be considered safe for topical application.Pharmacologist and immunotoxicologist physician Chemyunion Química Ltda., Sorocaba (SP)Faculdade de Medicina Universidade de São Paulo (USP), São Paulo (SP)Universidade Federal de São Paulo Escola Paulista de Medicina (EPM/HSPA UNI), São Paulo (SP)Cosmiatry, Pregnancy Dermatology, Vitiligo and Clinical Research Dermatology Outpatient Clinic of the Dermatology Service Universidade Católica de Campinas (PUC-Campinas), Campinas (SP)Dermatologist physician; Member of the Brazilian Society of Dermatology Pediatrician physician; Member of the Brazilian Society of Pediatrics Specialization in Cosmetics Safety Evaluation from the Vrije Universiteit, BrusselMantecorp Indústria Química e Farmacêutica Ltda., São Paulo (SP)Universidade Estadual Paulista (UNESP), Botucatu (SP)R and D Department Chemyunion Química Ltda., Sorocaba (SP)Dermatology Clinical Research intern KOLderma Instituto de Pesquisa Clínica Ltda, Campinas (SP)Universidade Estadual Paulista (UNESP), Botucatu (SP)Chemyunion Química Ltda.Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)Specialization in Cosmetics Safety Evaluation from the Vrije UniversiteitMantecorp Indústria Química e Farmacêutica Ltda.Universidade Estadual Paulista (Unesp)KOLderma Instituto de Pesquisa Clínica LtdaDieamant, GustavoCosta, AdilsonBechelli, LilianaTibério, Juliana [UNESP]Pereira, Carolina2014-05-27T11:27:24Z2014-05-27T11:27:24Z2012-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article229-236application/pdfhttp://www.surgicalcosmetic.org.br/detalhe-artigo/216/Avaliacao-in-vitro-do-perfil-de-seguranca-de-cosmeceuticos-contendo-fatores-de-crescimento-e-seus-analogosSurgical and Cosmetic Dermatology, v. 4, n. 3, p. 229-236, 2012.1984-55101984-8773http://hdl.handle.net/11449/740312-s2.0-848728711562-s2.0-84872871156.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSurgical and Cosmetic Dermatology0,1410,141info:eu-repo/semantics/openAccess2023-10-29T06:08:17Zoai:repositorio.unesp.br:11449/74031Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-29T06:08:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues |
title |
In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues |
spellingShingle |
In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues Dieamant, Gustavo Intercellular signaling peptides and proteins Skin Sking aging |
title_short |
In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues |
title_full |
In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues |
title_fullStr |
In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues |
title_full_unstemmed |
In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues |
title_sort |
In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues |
author |
Dieamant, Gustavo |
author_facet |
Dieamant, Gustavo Costa, Adilson Bechelli, Liliana Tibério, Juliana [UNESP] Pereira, Carolina |
author_role |
author |
author2 |
Costa, Adilson Bechelli, Liliana Tibério, Juliana [UNESP] Pereira, Carolina |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Chemyunion Química Ltda. Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) Specialization in Cosmetics Safety Evaluation from the Vrije Universiteit Mantecorp Indústria Química e Farmacêutica Ltda. Universidade Estadual Paulista (Unesp) KOLderma Instituto de Pesquisa Clínica Ltda |
dc.contributor.author.fl_str_mv |
Dieamant, Gustavo Costa, Adilson Bechelli, Liliana Tibério, Juliana [UNESP] Pereira, Carolina |
dc.subject.por.fl_str_mv |
Intercellular signaling peptides and proteins Skin Sking aging |
topic |
Intercellular signaling peptides and proteins Skin Sking aging |
description |
Introduction: Aging skin is a condition that affects (or will affect) all people, and its treatment is considered a clinical challenge. Growth factors and their analogues are emerging as a promising therapeutic option. Objectives: To evaluate the safety profile of some dermocosmetic products with formulations based on growth factors - or their analogs intended for that purpose - using in vitro human skin cell culture models. Methods: Two types of cell cultures were studied, and the effects of the study products on the proliferation of melanoma cells and normal human fibroblasts were evaluated. Results: No significant morphological alterations were found in the cultured human melanoma, and no significant decrease in the number of healthy cells was verified in the normal fibroblasts culture. In some cases there was even a proliferation of those cells. Conclusions: These preliminary data demonstrate that cosmeceutical products containing growth factors as an active principle can be considered safe for topical application. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-12-01 2014-05-27T11:27:24Z 2014-05-27T11:27:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.surgicalcosmetic.org.br/detalhe-artigo/216/Avaliacao-in-vitro-do-perfil-de-seguranca-de-cosmeceuticos-contendo-fatores-de-crescimento-e-seus-analogos Surgical and Cosmetic Dermatology, v. 4, n. 3, p. 229-236, 2012. 1984-5510 1984-8773 http://hdl.handle.net/11449/74031 2-s2.0-84872871156 2-s2.0-84872871156.pdf |
url |
http://www.surgicalcosmetic.org.br/detalhe-artigo/216/Avaliacao-in-vitro-do-perfil-de-seguranca-de-cosmeceuticos-contendo-fatores-de-crescimento-e-seus-analogos http://hdl.handle.net/11449/74031 |
identifier_str_mv |
Surgical and Cosmetic Dermatology, v. 4, n. 3, p. 229-236, 2012. 1984-5510 1984-8773 2-s2.0-84872871156 2-s2.0-84872871156.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Surgical and Cosmetic Dermatology 0,141 0,141 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
229-236 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803649558605987840 |