Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/s13036-022-00305-9 http://hdl.handle.net/11449/246056 |
Resumo: | Background: Non-invasive magnetic imaging techniques are necessary to assist magnetic nanoparticles in biomedical applications, mainly detecting their distribution inside the body. In Alternating Current Biosusceptometry (ACB), the magnetic nanoparticle's magnetization response under an oscillating magnetic field, which is applied through an excitation coil, is detected with a balanced detection coil system. Results: We built a Multi-Channel ACB system (MC-ACB) containing nineteen pick-up coils and obtained 2D quantitative images of magnetic nanoparticle distributions by solving an inverse problem. We reconstructed the magnetic nanoparticles spatial distributions in a field of view of 14 × 14 cm2 with a spatial resolution of 2.0 cm and sensitivity in the milligram scale. A correlation coefficient between quantitative reconstructed and nominal magnetic nanoparticle distributions above 0.6 was found for all measurements. Conclusion: Besides other interesting features such as sufficient large field of view dimension for mice and rat studies, portability, and the ability to assess the quantitative magnetic nanoparticles distributions in real-time, the MC-ACB system is a promising tool for quantitative imaging of magnetic nanoparticles distributions in real-time, offering an affordable setup for easy access in clinical or laboratory environments. |
id |
UNSP_d1961a5f095cddda850fbc607e5ca0f1 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/246056 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility arrayAlternate current biosusceptometryInverse problemMagnetic nanoparticlesQuantitative imagingBackground: Non-invasive magnetic imaging techniques are necessary to assist magnetic nanoparticles in biomedical applications, mainly detecting their distribution inside the body. In Alternating Current Biosusceptometry (ACB), the magnetic nanoparticle's magnetization response under an oscillating magnetic field, which is applied through an excitation coil, is detected with a balanced detection coil system. Results: We built a Multi-Channel ACB system (MC-ACB) containing nineteen pick-up coils and obtained 2D quantitative images of magnetic nanoparticle distributions by solving an inverse problem. We reconstructed the magnetic nanoparticles spatial distributions in a field of view of 14 × 14 cm2 with a spatial resolution of 2.0 cm and sensitivity in the milligram scale. A correlation coefficient between quantitative reconstructed and nominal magnetic nanoparticle distributions above 0.6 was found for all measurements. Conclusion: Besides other interesting features such as sufficient large field of view dimension for mice and rat studies, portability, and the ability to assess the quantitative magnetic nanoparticles distributions in real-time, the MC-ACB system is a promising tool for quantitative imaging of magnetic nanoparticles distributions in real-time, offering an affordable setup for easy access in clinical or laboratory environments.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Physikalisch-Technische Bundesanstalt, Abbestraße 2–12Biosciences Institute of Botucatu São Paulo State University, BotucatuInstitute of Physics Federal University of GoiásFaculty of Philosophy Sciences and Letters at Ribeirão Preto University of São Paulo, Ribeirão Preto, Sao PauloBiosciences Institute of Botucatu São Paulo State University, BotucatuFAPESP: 2021/09829-4CNPq: 311074/2018-9Physikalisch-Technische BundesanstaltUniversidade Estadual Paulista (UNESP)Universidade Federal de Goiás (UFG)Universidade de São Paulo (USP)Soares, Guilherme [UNESP]Pinto, Leonardo [UNESP]Liebl, MaikBiasotti, Gabriel [UNESP]Prospero, Andre [UNESP]Stoppa, Erick [UNESP]Bakuzis, AndrisBaffa, OswaldoWiekhorst, FrankMiranda, José Ricardo Arruda [UNESP]2023-07-29T12:30:31Z2023-07-29T12:30:31Z2022-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s13036-022-00305-9Journal of Biological Engineering, v. 16, n. 1, 2022.1754-1611http://hdl.handle.net/11449/24605610.1186/s13036-022-00305-92-s2.0-85139705503Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Biological Engineeringinfo:eu-repo/semantics/openAccess2023-07-29T12:30:31Zoai:repositorio.unesp.br:11449/246056Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T12:30:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array |
title |
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array |
spellingShingle |
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array Soares, Guilherme [UNESP] Alternate current biosusceptometry Inverse problem Magnetic nanoparticles Quantitative imaging |
title_short |
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array |
title_full |
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array |
title_fullStr |
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array |
title_full_unstemmed |
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array |
title_sort |
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array |
author |
Soares, Guilherme [UNESP] |
author_facet |
Soares, Guilherme [UNESP] Pinto, Leonardo [UNESP] Liebl, Maik Biasotti, Gabriel [UNESP] Prospero, Andre [UNESP] Stoppa, Erick [UNESP] Bakuzis, Andris Baffa, Oswaldo Wiekhorst, Frank Miranda, José Ricardo Arruda [UNESP] |
author_role |
author |
author2 |
Pinto, Leonardo [UNESP] Liebl, Maik Biasotti, Gabriel [UNESP] Prospero, Andre [UNESP] Stoppa, Erick [UNESP] Bakuzis, Andris Baffa, Oswaldo Wiekhorst, Frank Miranda, José Ricardo Arruda [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Physikalisch-Technische Bundesanstalt Universidade Estadual Paulista (UNESP) Universidade Federal de Goiás (UFG) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Soares, Guilherme [UNESP] Pinto, Leonardo [UNESP] Liebl, Maik Biasotti, Gabriel [UNESP] Prospero, Andre [UNESP] Stoppa, Erick [UNESP] Bakuzis, Andris Baffa, Oswaldo Wiekhorst, Frank Miranda, José Ricardo Arruda [UNESP] |
dc.subject.por.fl_str_mv |
Alternate current biosusceptometry Inverse problem Magnetic nanoparticles Quantitative imaging |
topic |
Alternate current biosusceptometry Inverse problem Magnetic nanoparticles Quantitative imaging |
description |
Background: Non-invasive magnetic imaging techniques are necessary to assist magnetic nanoparticles in biomedical applications, mainly detecting their distribution inside the body. In Alternating Current Biosusceptometry (ACB), the magnetic nanoparticle's magnetization response under an oscillating magnetic field, which is applied through an excitation coil, is detected with a balanced detection coil system. Results: We built a Multi-Channel ACB system (MC-ACB) containing nineteen pick-up coils and obtained 2D quantitative images of magnetic nanoparticle distributions by solving an inverse problem. We reconstructed the magnetic nanoparticles spatial distributions in a field of view of 14 × 14 cm2 with a spatial resolution of 2.0 cm and sensitivity in the milligram scale. A correlation coefficient between quantitative reconstructed and nominal magnetic nanoparticle distributions above 0.6 was found for all measurements. Conclusion: Besides other interesting features such as sufficient large field of view dimension for mice and rat studies, portability, and the ability to assess the quantitative magnetic nanoparticles distributions in real-time, the MC-ACB system is a promising tool for quantitative imaging of magnetic nanoparticles distributions in real-time, offering an affordable setup for easy access in clinical or laboratory environments. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-01 2023-07-29T12:30:31Z 2023-07-29T12:30:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s13036-022-00305-9 Journal of Biological Engineering, v. 16, n. 1, 2022. 1754-1611 http://hdl.handle.net/11449/246056 10.1186/s13036-022-00305-9 2-s2.0-85139705503 |
url |
http://dx.doi.org/10.1186/s13036-022-00305-9 http://hdl.handle.net/11449/246056 |
identifier_str_mv |
Journal of Biological Engineering, v. 16, n. 1, 2022. 1754-1611 10.1186/s13036-022-00305-9 2-s2.0-85139705503 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Biological Engineering |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803045949859168256 |