Jaboticaba (Myrciaria jaboticaba) Attenuates Ventricular Remodeling after Myocardial Infarction in Rats

Detalhes bibliográficos
Autor(a) principal: da Silva, Renata Candido [UNESP]
Data de Publicação: 2022
Outros Autores: Polegato, Bertha Furlan [UNESP], Azevedo, Paula Shmidt [UNESP], Fernandes, Ana Angélica [UNESP], Okoshi, Katashi [UNESP], de Paiva, Sergio Alberto Rupp [UNESP], Minicucci, Marcos Ferreira [UNESP], Zornoff, Leonardo Antônio Mamede [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/antiox11020249
http://hdl.handle.net/11449/230269
Resumo: The cardiac remodeling after myocardial infarction is characterized by inflammation and oxidative stress. Thus, this study aimed to test the hypothesis that jaboticaba, due to its anti‐inflammatory and antioxidants properties, attenuates cardiac remodeling after myocardial infarction. Wistar rats were submitted to myocardial infarction due to coronary artery occlusion, and divided into four experimental groups: C, sham control animals; I, animals submitted to myocardial infarction, received a standard diet; IJ2, animals submitted to myocardial infarction, received a standard diet plus 2% jaboticaba; and IJ4, animals submitted to myocardial infarction, received a standard diet plus 4% jaboticaba. After a three‐month follow‐up, echocardiography, histology, oxidative stress, and cardiac energy metabolism were analyzed. There was no difference in infarct size or mortality among the infarcted groups. The IJ4 group displayed improved diastolic function, as assessed by isovolumetric relaxation time normalized to the heart rate. As expected, the percentage of collagen was higher in all infarcted groups than in the C group. However, the IJ2 group had less collagen than groups I and IJ4. The IJ4 group presented lower PFK activity than I and IJ2, and lower pyruvate dehydrogenase activity than controls, whereas the IJ2 group showed no differences compared to the control group in both LDH and ATP synthase activity. The 2% and 4% doses attenuated lipid peroxidation and increased the activity of glutathione peroxidase compared with the I group. In conclusion, jaboticaba attenuated the remodeling process after myocardial infarction, which was associated with decreased oxidative stress and improved energy metabolism.
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spelling Jaboticaba (Myrciaria jaboticaba) Attenuates Ventricular Remodeling after Myocardial Infarction in RatsCardiac remodelingEnergy metabolismFibrosisJaboticabaOxidative stressThe cardiac remodeling after myocardial infarction is characterized by inflammation and oxidative stress. Thus, this study aimed to test the hypothesis that jaboticaba, due to its anti‐inflammatory and antioxidants properties, attenuates cardiac remodeling after myocardial infarction. Wistar rats were submitted to myocardial infarction due to coronary artery occlusion, and divided into four experimental groups: C, sham control animals; I, animals submitted to myocardial infarction, received a standard diet; IJ2, animals submitted to myocardial infarction, received a standard diet plus 2% jaboticaba; and IJ4, animals submitted to myocardial infarction, received a standard diet plus 4% jaboticaba. After a three‐month follow‐up, echocardiography, histology, oxidative stress, and cardiac energy metabolism were analyzed. There was no difference in infarct size or mortality among the infarcted groups. The IJ4 group displayed improved diastolic function, as assessed by isovolumetric relaxation time normalized to the heart rate. As expected, the percentage of collagen was higher in all infarcted groups than in the C group. However, the IJ2 group had less collagen than groups I and IJ4. The IJ4 group presented lower PFK activity than I and IJ2, and lower pyruvate dehydrogenase activity than controls, whereas the IJ2 group showed no differences compared to the control group in both LDH and ATP synthase activity. The 2% and 4% doses attenuated lipid peroxidation and increased the activity of glutathione peroxidase compared with the I group. In conclusion, jaboticaba attenuated the remodeling process after myocardial infarction, which was associated with decreased oxidative stress and improved energy metabolism.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Internal Medicine Department Botucatu Medical School São Paulo State University (UNESP)Chemistry and Biochemistry Department Institute of Biosciences of Botucatu São Paulo State University (UNESP)Internal Medicine Department Botucatu Medical School São Paulo State University (UNESP)Chemistry and Biochemistry Department Institute of Biosciences of Botucatu São Paulo State University (UNESP)FAPESP: 2018/20790‐0Universidade Estadual Paulista (UNESP)da Silva, Renata Candido [UNESP]Polegato, Bertha Furlan [UNESP]Azevedo, Paula Shmidt [UNESP]Fernandes, Ana Angélica [UNESP]Okoshi, Katashi [UNESP]de Paiva, Sergio Alberto Rupp [UNESP]Minicucci, Marcos Ferreira [UNESP]Zornoff, Leonardo Antônio Mamede [UNESP]2022-04-29T08:38:48Z2022-04-29T08:38:48Z2022-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/antiox11020249Antioxidants, v. 11, n. 2, 2022.2076-3921http://hdl.handle.net/11449/23026910.3390/antiox110202492-s2.0-85123406329Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAntioxidantsinfo:eu-repo/semantics/openAccess2024-08-14T17:37:05Zoai:repositorio.unesp.br:11449/230269Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:37:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Jaboticaba (Myrciaria jaboticaba) Attenuates Ventricular Remodeling after Myocardial Infarction in Rats
title Jaboticaba (Myrciaria jaboticaba) Attenuates Ventricular Remodeling after Myocardial Infarction in Rats
spellingShingle Jaboticaba (Myrciaria jaboticaba) Attenuates Ventricular Remodeling after Myocardial Infarction in Rats
da Silva, Renata Candido [UNESP]
Cardiac remodeling
Energy metabolism
Fibrosis
Jaboticaba
Oxidative stress
title_short Jaboticaba (Myrciaria jaboticaba) Attenuates Ventricular Remodeling after Myocardial Infarction in Rats
title_full Jaboticaba (Myrciaria jaboticaba) Attenuates Ventricular Remodeling after Myocardial Infarction in Rats
title_fullStr Jaboticaba (Myrciaria jaboticaba) Attenuates Ventricular Remodeling after Myocardial Infarction in Rats
title_full_unstemmed Jaboticaba (Myrciaria jaboticaba) Attenuates Ventricular Remodeling after Myocardial Infarction in Rats
title_sort Jaboticaba (Myrciaria jaboticaba) Attenuates Ventricular Remodeling after Myocardial Infarction in Rats
author da Silva, Renata Candido [UNESP]
author_facet da Silva, Renata Candido [UNESP]
Polegato, Bertha Furlan [UNESP]
Azevedo, Paula Shmidt [UNESP]
Fernandes, Ana Angélica [UNESP]
Okoshi, Katashi [UNESP]
de Paiva, Sergio Alberto Rupp [UNESP]
Minicucci, Marcos Ferreira [UNESP]
Zornoff, Leonardo Antônio Mamede [UNESP]
author_role author
author2 Polegato, Bertha Furlan [UNESP]
Azevedo, Paula Shmidt [UNESP]
Fernandes, Ana Angélica [UNESP]
Okoshi, Katashi [UNESP]
de Paiva, Sergio Alberto Rupp [UNESP]
Minicucci, Marcos Ferreira [UNESP]
Zornoff, Leonardo Antônio Mamede [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv da Silva, Renata Candido [UNESP]
Polegato, Bertha Furlan [UNESP]
Azevedo, Paula Shmidt [UNESP]
Fernandes, Ana Angélica [UNESP]
Okoshi, Katashi [UNESP]
de Paiva, Sergio Alberto Rupp [UNESP]
Minicucci, Marcos Ferreira [UNESP]
Zornoff, Leonardo Antônio Mamede [UNESP]
dc.subject.por.fl_str_mv Cardiac remodeling
Energy metabolism
Fibrosis
Jaboticaba
Oxidative stress
topic Cardiac remodeling
Energy metabolism
Fibrosis
Jaboticaba
Oxidative stress
description The cardiac remodeling after myocardial infarction is characterized by inflammation and oxidative stress. Thus, this study aimed to test the hypothesis that jaboticaba, due to its anti‐inflammatory and antioxidants properties, attenuates cardiac remodeling after myocardial infarction. Wistar rats were submitted to myocardial infarction due to coronary artery occlusion, and divided into four experimental groups: C, sham control animals; I, animals submitted to myocardial infarction, received a standard diet; IJ2, animals submitted to myocardial infarction, received a standard diet plus 2% jaboticaba; and IJ4, animals submitted to myocardial infarction, received a standard diet plus 4% jaboticaba. After a three‐month follow‐up, echocardiography, histology, oxidative stress, and cardiac energy metabolism were analyzed. There was no difference in infarct size or mortality among the infarcted groups. The IJ4 group displayed improved diastolic function, as assessed by isovolumetric relaxation time normalized to the heart rate. As expected, the percentage of collagen was higher in all infarcted groups than in the C group. However, the IJ2 group had less collagen than groups I and IJ4. The IJ4 group presented lower PFK activity than I and IJ2, and lower pyruvate dehydrogenase activity than controls, whereas the IJ2 group showed no differences compared to the control group in both LDH and ATP synthase activity. The 2% and 4% doses attenuated lipid peroxidation and increased the activity of glutathione peroxidase compared with the I group. In conclusion, jaboticaba attenuated the remodeling process after myocardial infarction, which was associated with decreased oxidative stress and improved energy metabolism.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-29T08:38:48Z
2022-04-29T08:38:48Z
2022-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/antiox11020249
Antioxidants, v. 11, n. 2, 2022.
2076-3921
http://hdl.handle.net/11449/230269
10.3390/antiox11020249
2-s2.0-85123406329
url http://dx.doi.org/10.3390/antiox11020249
http://hdl.handle.net/11449/230269
identifier_str_mv Antioxidants, v. 11, n. 2, 2022.
2076-3921
10.3390/antiox11020249
2-s2.0-85123406329
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antioxidants
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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