Biomolecular information, brain activity and cognitive functions
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5016/1806-8774.2007v9p12 http://hdl.handle.net/11449/70112 |
Resumo: | Molecular neurobiology has provided an explanation of mechanisms supporting mental functions as learning, memory, emotion and consciousness. However, an explanatory gap remains between two levels of description: molecular mechanisms determining cellular and tissue functions, and cognitive functions. In this paper we review molecular and cellular mechanisms that determine brain activity, and then hypothetize about their relation with cognition and consciousness. The brain is conceived of as a dynamic system that exchanges information with the whole body and the environment. Three explanatory hypotheses are presented, stating that: a) brain tissue function is coordinated by macromolecules controlling ion movements, b) structured (amplitude, frequency and phase-modulated) local field potentials generated by organized ionic movement embody cognitive information patterns, and c) conscious episodes are constructed by a large-scale mechanism that uses oscillatory synchrony to integrate local field patterns. © by São Paulo State University. |
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Biomolecular information, brain activity and cognitive functionsBiomolecular informationBrain functionCognitionLocal field potentialsMolecular neurobiologydopamineserotoninAMPA receptorangiotensinbombesinbradykinincalcium ionchloride ioncholecystokinincorticotropincorticotropin releasing factordelta sleep inducing peptidedynorphinendorphinenkephalinG protein coupled receptorinsulinmetabotropic receptorn methyl dextro aspartic acid receptorneuropeptideneuropeptide Yneurotensinoxytocinpotassium ionprolactinprotirelinsodium ionsubstance Pvasopressinaction potentialcell cyclecognitionconsciousnesselectricityelectroencephalogramexcitatory postsynaptic potentialhumanhyperpolarizationinhibitory postsynaptic potentialmembrane depolarizationmolecular interactionneurotransmissionprotein bindingreviewbrain functionbrain tissuecell functionemotioninformation processingion transportlearningmacromoleculememoryneurobiologyoscillationMolecular neurobiology has provided an explanation of mechanisms supporting mental functions as learning, memory, emotion and consciousness. However, an explanatory gap remains between two levels of description: molecular mechanisms determining cellular and tissue functions, and cognitive functions. In this paper we review molecular and cellular mechanisms that determine brain activity, and then hypothetize about their relation with cognition and consciousness. The brain is conceived of as a dynamic system that exchanges information with the whole body and the environment. Three explanatory hypotheses are presented, stating that: a) brain tissue function is coordinated by macromolecules controlling ion movements, b) structured (amplitude, frequency and phase-modulated) local field potentials generated by organized ionic movement embody cognitive information patterns, and c) conscious episodes are constructed by a large-scale mechanism that uses oscillatory synchrony to integrate local field patterns. © by São Paulo State University.Department of Education Institute of Biosciences São Paulo State University (Unesp)Faculty of Medicine and Nursing University of MariliaDepartmento de Educação Instituto de Biociências Campus de Rubião Jr., CEP 18618-000, Botucatu, SPDepartment of Education Institute of Biosciences São Paulo State University (Unesp)Universidade Estadual Paulista (Unesp)Universidade de Marília (UNIMAR)Instituto de BiociênciasPereira Jr., Alfredo [UNESP]Furlan, Fábio Augusto2014-05-27T11:22:42Z2014-05-27T11:22:42Z2007-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12-29application/pdfhttp://dx.doi.org/10.5016/1806-8774.2007v9p12Annual Review of Biomedical Sciences, v. 9, p. 12-29.1806-8774http://hdl.handle.net/11449/7011210.5016/1806-8774.2007v9p122-s2.0-381491161132-s2.0-38149116113.pdf0000-0002-5960-041XScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnnual Review of Biomedical Sciencesinfo:eu-repo/semantics/openAccess2023-10-06T06:03:28Zoai:repositorio.unesp.br:11449/70112Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T11:37:50.930603Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Biomolecular information, brain activity and cognitive functions |
title |
Biomolecular information, brain activity and cognitive functions |
spellingShingle |
Biomolecular information, brain activity and cognitive functions Pereira Jr., Alfredo [UNESP] Biomolecular information Brain function Cognition Local field potentials Molecular neurobiology dopamine serotonin AMPA receptor angiotensin bombesin bradykinin calcium ion chloride ion cholecystokinin corticotropin corticotropin releasing factor delta sleep inducing peptide dynorphin endorphin enkephalin G protein coupled receptor insulin metabotropic receptor n methyl dextro aspartic acid receptor neuropeptide neuropeptide Y neurotensin oxytocin potassium ion prolactin protirelin sodium ion substance P vasopressin action potential cell cycle cognition consciousness electricity electroencephalogram excitatory postsynaptic potential human hyperpolarization inhibitory postsynaptic potential membrane depolarization molecular interaction neurotransmission protein binding review brain function brain tissue cell function emotion information processing ion transport learning macromolecule memory neurobiology oscillation |
title_short |
Biomolecular information, brain activity and cognitive functions |
title_full |
Biomolecular information, brain activity and cognitive functions |
title_fullStr |
Biomolecular information, brain activity and cognitive functions |
title_full_unstemmed |
Biomolecular information, brain activity and cognitive functions |
title_sort |
Biomolecular information, brain activity and cognitive functions |
author |
Pereira Jr., Alfredo [UNESP] |
author_facet |
Pereira Jr., Alfredo [UNESP] Furlan, Fábio Augusto |
author_role |
author |
author2 |
Furlan, Fábio Augusto |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de Marília (UNIMAR) Instituto de Biociências |
dc.contributor.author.fl_str_mv |
Pereira Jr., Alfredo [UNESP] Furlan, Fábio Augusto |
dc.subject.por.fl_str_mv |
Biomolecular information Brain function Cognition Local field potentials Molecular neurobiology dopamine serotonin AMPA receptor angiotensin bombesin bradykinin calcium ion chloride ion cholecystokinin corticotropin corticotropin releasing factor delta sleep inducing peptide dynorphin endorphin enkephalin G protein coupled receptor insulin metabotropic receptor n methyl dextro aspartic acid receptor neuropeptide neuropeptide Y neurotensin oxytocin potassium ion prolactin protirelin sodium ion substance P vasopressin action potential cell cycle cognition consciousness electricity electroencephalogram excitatory postsynaptic potential human hyperpolarization inhibitory postsynaptic potential membrane depolarization molecular interaction neurotransmission protein binding review brain function brain tissue cell function emotion information processing ion transport learning macromolecule memory neurobiology oscillation |
topic |
Biomolecular information Brain function Cognition Local field potentials Molecular neurobiology dopamine serotonin AMPA receptor angiotensin bombesin bradykinin calcium ion chloride ion cholecystokinin corticotropin corticotropin releasing factor delta sleep inducing peptide dynorphin endorphin enkephalin G protein coupled receptor insulin metabotropic receptor n methyl dextro aspartic acid receptor neuropeptide neuropeptide Y neurotensin oxytocin potassium ion prolactin protirelin sodium ion substance P vasopressin action potential cell cycle cognition consciousness electricity electroencephalogram excitatory postsynaptic potential human hyperpolarization inhibitory postsynaptic potential membrane depolarization molecular interaction neurotransmission protein binding review brain function brain tissue cell function emotion information processing ion transport learning macromolecule memory neurobiology oscillation |
description |
Molecular neurobiology has provided an explanation of mechanisms supporting mental functions as learning, memory, emotion and consciousness. However, an explanatory gap remains between two levels of description: molecular mechanisms determining cellular and tissue functions, and cognitive functions. In this paper we review molecular and cellular mechanisms that determine brain activity, and then hypothetize about their relation with cognition and consciousness. The brain is conceived of as a dynamic system that exchanges information with the whole body and the environment. Three explanatory hypotheses are presented, stating that: a) brain tissue function is coordinated by macromolecules controlling ion movements, b) structured (amplitude, frequency and phase-modulated) local field potentials generated by organized ionic movement embody cognitive information patterns, and c) conscious episodes are constructed by a large-scale mechanism that uses oscillatory synchrony to integrate local field patterns. © by São Paulo State University. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 2014-05-27T11:22:42Z 2014-05-27T11:22:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5016/1806-8774.2007v9p12 Annual Review of Biomedical Sciences, v. 9, p. 12-29. 1806-8774 http://hdl.handle.net/11449/70112 10.5016/1806-8774.2007v9p12 2-s2.0-38149116113 2-s2.0-38149116113.pdf 0000-0002-5960-041X |
url |
http://dx.doi.org/10.5016/1806-8774.2007v9p12 http://hdl.handle.net/11449/70112 |
identifier_str_mv |
Annual Review of Biomedical Sciences, v. 9, p. 12-29. 1806-8774 10.5016/1806-8774.2007v9p12 2-s2.0-38149116113 2-s2.0-38149116113.pdf 0000-0002-5960-041X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Annual Review of Biomedical Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12-29 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803045855474745344 |