Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways

• Autor(a) principal: Figueiredo, Amanda Menezes [UNESP]
• Data de Publicação: 2022
• Outros Autores: Cardoso, Ana Carolina [UNESP], Buzati Pereira, Bruna Leticia [UNESP], Candido Silva, Renata Aparecida [UNESP], Goncalves Della Ripa, Andrea Freitas [UNESP], Bachiega Pinelli, Tatiana Fernanda [UNESP], Oliveira, Bruna Camargo [UNESP], Murino Rafacho, Bruna Paola [UNESP], Watanabe Ishikawa, Larissa Lumi [UNESP], Azevedo, Paula Schmidt [UNESP], Okoshi, Katashi [UNESP], Henrique Fernandes, Ana Angelica [UNESP], Mamede Zornoff, Leonardo Antonio [UNESP], Minicucci, Marcos Ferreira [UNESP], Polegato, Bertha Furlan [UNESP], Rupp Paiva, Sergio Alberto [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1371/journal.pone.0264854; http://hdl.handle.net/11449/230511

Myocardial infarction has a high mortality rate worldwide. Therefore, clinical intervention in cardiac remodeling after myocardial infarction is essential. Ac¸ai pulp is a natural product and has been considered a functional food because of its antioxidant/anti-inflammatory properties. The aim of the present study was to analyze the effect of ac¸ai pulp supplementation on cardiac remodeling after myocardial infarction in rats. After 7 days of surgery, male Wistar rats were assigned to six groups: sham animals fed standard chow (SA0, n = 14), fed standard chow with 2% ac¸ai pulp (SA2, n = 12) and fed standard chow with 5% ac¸ai pulp (SA5, n = 14), infarcted animals fed standard chow (IA0, n = 12), fed standard chow with 2% ac¸ai pulp (IA2, n = 12), and fed standard chow with 5% ac¸ai pulp (IA5, n = 12). After 3 months of supplementation, echocardiography and euthanasia were performed. Ac¸ai pulp supplementation, after myocardial infarction, improved energy metabolism, attenuated oxidative stress (lower concentration of malondialdehyde, P = 0.023; dose-dependent effect), modulated the inflammatory process (lower concentration of interleukin-10, P0.001; dose-dependent effect) and decreased the deposit of collagen (lower percentage of interstitial collagen fraction, P0.001; dose-dependent effect). In conclusion, ac¸ai pulp supplementation attenuated cardiac remodeling after myocardial infarction in rats. Also, different doses of ac¸ai pulp supplementation have dose-dependent effects on cardiac remodeling.