Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0264854 http://hdl.handle.net/11449/230511 |
Resumo: | Myocardial infarction has a high mortality rate worldwide. Therefore, clinical intervention in cardiac remodeling after myocardial infarction is essential. Ac¸ai pulp is a natural product and has been considered a functional food because of its antioxidant/anti-inflammatory properties. The aim of the present study was to analyze the effect of ac¸ai pulp supplementation on cardiac remodeling after myocardial infarction in rats. After 7 days of surgery, male Wistar rats were assigned to six groups: sham animals fed standard chow (SA0, n = 14), fed standard chow with 2% ac¸ai pulp (SA2, n = 12) and fed standard chow with 5% ac¸ai pulp (SA5, n = 14), infarcted animals fed standard chow (IA0, n = 12), fed standard chow with 2% ac¸ai pulp (IA2, n = 12), and fed standard chow with 5% ac¸ai pulp (IA5, n = 12). After 3 months of supplementation, echocardiography and euthanasia were performed. Ac¸ai pulp supplementation, after myocardial infarction, improved energy metabolism, attenuated oxidative stress (lower concentration of malondialdehyde, P = 0.023; dose-dependent effect), modulated the inflammatory process (lower concentration of interleukin-10, P0.001; dose-dependent effect) and decreased the deposit of collagen (lower percentage of interstitial collagen fraction, P0.001; dose-dependent effect). In conclusion, ac¸ai pulp supplementation attenuated cardiac remodeling after myocardial infarction in rats. Also, different doses of ac¸ai pulp supplementation have dose-dependent effects on cardiac remodeling. |
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Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathwaysMyocardial infarction has a high mortality rate worldwide. Therefore, clinical intervention in cardiac remodeling after myocardial infarction is essential. Ac¸ai pulp is a natural product and has been considered a functional food because of its antioxidant/anti-inflammatory properties. The aim of the present study was to analyze the effect of ac¸ai pulp supplementation on cardiac remodeling after myocardial infarction in rats. After 7 days of surgery, male Wistar rats were assigned to six groups: sham animals fed standard chow (SA0, n = 14), fed standard chow with 2% ac¸ai pulp (SA2, n = 12) and fed standard chow with 5% ac¸ai pulp (SA5, n = 14), infarcted animals fed standard chow (IA0, n = 12), fed standard chow with 2% ac¸ai pulp (IA2, n = 12), and fed standard chow with 5% ac¸ai pulp (IA5, n = 12). After 3 months of supplementation, echocardiography and euthanasia were performed. Ac¸ai pulp supplementation, after myocardial infarction, improved energy metabolism, attenuated oxidative stress (lower concentration of malondialdehyde, P = 0.023; dose-dependent effect), modulated the inflammatory process (lower concentration of interleukin-10, P0.001; dose-dependent effect) and decreased the deposit of collagen (lower percentage of interstitial collagen fraction, P0.001; dose-dependent effect). In conclusion, ac¸ai pulp supplementation attenuated cardiac remodeling after myocardial infarction in rats. Also, different doses of ac¸ai pulp supplementation have dose-dependent effects on cardiac remodeling.Internal Medicine Department Botucatu Medical School Universidade Estadual Paulista (UNESP), São PauloChemistry and Biochemistry Department Institute of Biosciences Universidade Estadual Paulista (UNESP), São PauloInternal Medicine Department Botucatu Medical School Universidade Estadual Paulista (UNESP), São PauloChemistry and Biochemistry Department Institute of Biosciences Universidade Estadual Paulista (UNESP), São PauloUniversidade Estadual Paulista (UNESP)Figueiredo, Amanda Menezes [UNESP]Cardoso, Ana Carolina [UNESP]Buzati Pereira, Bruna Leticia [UNESP]Candido Silva, Renata Aparecida [UNESP]Goncalves Della Ripa, Andrea Freitas [UNESP]Bachiega Pinelli, Tatiana Fernanda [UNESP]Oliveira, Bruna Camargo [UNESP]Murino Rafacho, Bruna Paola [UNESP]Watanabe Ishikawa, Larissa Lumi [UNESP]Azevedo, Paula Schmidt [UNESP]Okoshi, Katashi [UNESP]Henrique Fernandes, Ana Angelica [UNESP]Mamede Zornoff, Leonardo Antonio [UNESP]Minicucci, Marcos Ferreira [UNESP]Polegato, Bertha Furlan [UNESP]Rupp Paiva, Sergio Alberto [UNESP]2022-04-29T08:40:33Z2022-04-29T08:40:33Z2022-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pone.0264854PLoS ONE, v. 17, n. 3 March, 2022.1932-6203http://hdl.handle.net/11449/23051110.1371/journal.pone.02648542-s2.0-85125785929Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPLoS ONEinfo:eu-repo/semantics/openAccess2022-04-29T08:40:34Zoai:repositorio.unesp.br:11449/230511Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:40:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways |
title |
Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways |
spellingShingle |
Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways Figueiredo, Amanda Menezes [UNESP] |
title_short |
Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways |
title_full |
Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways |
title_fullStr |
Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways |
title_full_unstemmed |
Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways |
title_sort |
Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways |
author |
Figueiredo, Amanda Menezes [UNESP] |
author_facet |
Figueiredo, Amanda Menezes [UNESP] Cardoso, Ana Carolina [UNESP] Buzati Pereira, Bruna Leticia [UNESP] Candido Silva, Renata Aparecida [UNESP] Goncalves Della Ripa, Andrea Freitas [UNESP] Bachiega Pinelli, Tatiana Fernanda [UNESP] Oliveira, Bruna Camargo [UNESP] Murino Rafacho, Bruna Paola [UNESP] Watanabe Ishikawa, Larissa Lumi [UNESP] Azevedo, Paula Schmidt [UNESP] Okoshi, Katashi [UNESP] Henrique Fernandes, Ana Angelica [UNESP] Mamede Zornoff, Leonardo Antonio [UNESP] Minicucci, Marcos Ferreira [UNESP] Polegato, Bertha Furlan [UNESP] Rupp Paiva, Sergio Alberto [UNESP] |
author_role |
author |
author2 |
Cardoso, Ana Carolina [UNESP] Buzati Pereira, Bruna Leticia [UNESP] Candido Silva, Renata Aparecida [UNESP] Goncalves Della Ripa, Andrea Freitas [UNESP] Bachiega Pinelli, Tatiana Fernanda [UNESP] Oliveira, Bruna Camargo [UNESP] Murino Rafacho, Bruna Paola [UNESP] Watanabe Ishikawa, Larissa Lumi [UNESP] Azevedo, Paula Schmidt [UNESP] Okoshi, Katashi [UNESP] Henrique Fernandes, Ana Angelica [UNESP] Mamede Zornoff, Leonardo Antonio [UNESP] Minicucci, Marcos Ferreira [UNESP] Polegato, Bertha Furlan [UNESP] Rupp Paiva, Sergio Alberto [UNESP] |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Figueiredo, Amanda Menezes [UNESP] Cardoso, Ana Carolina [UNESP] Buzati Pereira, Bruna Leticia [UNESP] Candido Silva, Renata Aparecida [UNESP] Goncalves Della Ripa, Andrea Freitas [UNESP] Bachiega Pinelli, Tatiana Fernanda [UNESP] Oliveira, Bruna Camargo [UNESP] Murino Rafacho, Bruna Paola [UNESP] Watanabe Ishikawa, Larissa Lumi [UNESP] Azevedo, Paula Schmidt [UNESP] Okoshi, Katashi [UNESP] Henrique Fernandes, Ana Angelica [UNESP] Mamede Zornoff, Leonardo Antonio [UNESP] Minicucci, Marcos Ferreira [UNESP] Polegato, Bertha Furlan [UNESP] Rupp Paiva, Sergio Alberto [UNESP] |
description |
Myocardial infarction has a high mortality rate worldwide. Therefore, clinical intervention in cardiac remodeling after myocardial infarction is essential. Ac¸ai pulp is a natural product and has been considered a functional food because of its antioxidant/anti-inflammatory properties. The aim of the present study was to analyze the effect of ac¸ai pulp supplementation on cardiac remodeling after myocardial infarction in rats. After 7 days of surgery, male Wistar rats were assigned to six groups: sham animals fed standard chow (SA0, n = 14), fed standard chow with 2% ac¸ai pulp (SA2, n = 12) and fed standard chow with 5% ac¸ai pulp (SA5, n = 14), infarcted animals fed standard chow (IA0, n = 12), fed standard chow with 2% ac¸ai pulp (IA2, n = 12), and fed standard chow with 5% ac¸ai pulp (IA5, n = 12). After 3 months of supplementation, echocardiography and euthanasia were performed. Ac¸ai pulp supplementation, after myocardial infarction, improved energy metabolism, attenuated oxidative stress (lower concentration of malondialdehyde, P = 0.023; dose-dependent effect), modulated the inflammatory process (lower concentration of interleukin-10, P0.001; dose-dependent effect) and decreased the deposit of collagen (lower percentage of interstitial collagen fraction, P0.001; dose-dependent effect). In conclusion, ac¸ai pulp supplementation attenuated cardiac remodeling after myocardial infarction in rats. Also, different doses of ac¸ai pulp supplementation have dose-dependent effects on cardiac remodeling. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:40:33Z 2022-04-29T08:40:33Z 2022-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0264854 PLoS ONE, v. 17, n. 3 March, 2022. 1932-6203 http://hdl.handle.net/11449/230511 10.1371/journal.pone.0264854 2-s2.0-85125785929 |
url |
http://dx.doi.org/10.1371/journal.pone.0264854 http://hdl.handle.net/11449/230511 |
identifier_str_mv |
PLoS ONE, v. 17, n. 3 March, 2022. 1932-6203 10.1371/journal.pone.0264854 2-s2.0-85125785929 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PLoS ONE |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799964736313360384 |