Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/203932 |
Resumo: | To evaluate the gastroprotective and antioxidant effects of pretreatment with water kefir on ulcers induced with HCl/ethanol. All pretreatments lasted 14 days. Male mice were separated into five groups: the control (C) group received vehicle without ulcer induction; the ulcerated (U) group received vehicle; the lansoprazole (L) group received 30 mg/kg/day lansoprazole; the water kefir (WK15 and WK30) groups received WK at a dose of 0.15 or 0.30 ml/kg/day, respectively. Gastroprotection was measured by ulcer area, ulcer index and ulcer reduction percentage. Antioxidant effects were quantified by measuring advanced oxidized protein products (AOPPs), superoxide dismutase (SOD), and catalase activity in the stomach. Pretreatment with WK at both doses promoted gastroprotection against HCl/ethanol-induced ulcers much like the pretreatment with lansoprazole. In addition, WK decreased protein oxidation while increasing SOD and catalase activity. We concluded that pretreatment with water kefir increases the activity of antioxidant enzymes, preventing gastric lesions induced by HCl/ethanol by maintaining the antioxidant performance in gastric tissue. |
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Brazilian Journal of Pharmaceutical Sciences |
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Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcersUlcer lesionAntioxidant activityNatural productsProbioticTo evaluate the gastroprotective and antioxidant effects of pretreatment with water kefir on ulcers induced with HCl/ethanol. All pretreatments lasted 14 days. Male mice were separated into five groups: the control (C) group received vehicle without ulcer induction; the ulcerated (U) group received vehicle; the lansoprazole (L) group received 30 mg/kg/day lansoprazole; the water kefir (WK15 and WK30) groups received WK at a dose of 0.15 or 0.30 ml/kg/day, respectively. Gastroprotection was measured by ulcer area, ulcer index and ulcer reduction percentage. Antioxidant effects were quantified by measuring advanced oxidized protein products (AOPPs), superoxide dismutase (SOD), and catalase activity in the stomach. Pretreatment with WK at both doses promoted gastroprotection against HCl/ethanol-induced ulcers much like the pretreatment with lansoprazole. In addition, WK decreased protein oxidation while increasing SOD and catalase activity. We concluded that pretreatment with water kefir increases the activity of antioxidant enzymes, preventing gastric lesions induced by HCl/ethanol by maintaining the antioxidant performance in gastric tissue.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2022-11-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20393210.1590/s2175-97902022e191046 Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/203932/194846Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Falsoni, Raiana Maria Prucoli Moraes, Flávia de Souza AndradeRezende, Mahira Sabino da Silva, Cristiane Lyriode Andrade, Tadeu Uggere Brasil, Girlandia AlexandreLima, Ewelyne Miranda de2023-08-22T17:58:03Zoai:revistas.usp.br:article/203932Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-08-22T17:58:03Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers |
title |
Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers |
spellingShingle |
Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers Falsoni, Raiana Maria Prucoli Ulcer lesion Antioxidant activity Natural products Probiotic |
title_short |
Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers |
title_full |
Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers |
title_fullStr |
Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers |
title_full_unstemmed |
Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers |
title_sort |
Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers |
author |
Falsoni, Raiana Maria Prucoli |
author_facet |
Falsoni, Raiana Maria Prucoli Moraes, Flávia de Souza Andrade Rezende, Mahira Sabino da Silva, Cristiane Lyrio de Andrade, Tadeu Uggere Brasil, Girlandia Alexandre Lima, Ewelyne Miranda de |
author_role |
author |
author2 |
Moraes, Flávia de Souza Andrade Rezende, Mahira Sabino da Silva, Cristiane Lyrio de Andrade, Tadeu Uggere Brasil, Girlandia Alexandre Lima, Ewelyne Miranda de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Falsoni, Raiana Maria Prucoli Moraes, Flávia de Souza Andrade Rezende, Mahira Sabino da Silva, Cristiane Lyrio de Andrade, Tadeu Uggere Brasil, Girlandia Alexandre Lima, Ewelyne Miranda de |
dc.subject.por.fl_str_mv |
Ulcer lesion Antioxidant activity Natural products Probiotic |
topic |
Ulcer lesion Antioxidant activity Natural products Probiotic |
description |
To evaluate the gastroprotective and antioxidant effects of pretreatment with water kefir on ulcers induced with HCl/ethanol. All pretreatments lasted 14 days. Male mice were separated into five groups: the control (C) group received vehicle without ulcer induction; the ulcerated (U) group received vehicle; the lansoprazole (L) group received 30 mg/kg/day lansoprazole; the water kefir (WK15 and WK30) groups received WK at a dose of 0.15 or 0.30 ml/kg/day, respectively. Gastroprotection was measured by ulcer area, ulcer index and ulcer reduction percentage. Antioxidant effects were quantified by measuring advanced oxidized protein products (AOPPs), superoxide dismutase (SOD), and catalase activity in the stomach. Pretreatment with WK at both doses promoted gastroprotection against HCl/ethanol-induced ulcers much like the pretreatment with lansoprazole. In addition, WK decreased protein oxidation while increasing SOD and catalase activity. We concluded that pretreatment with water kefir increases the activity of antioxidant enzymes, preventing gastric lesions induced by HCl/ethanol by maintaining the antioxidant performance in gastric tissue. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/203932 10.1590/s2175-97902022e191046 |
url |
https://www.revistas.usp.br/bjps/article/view/203932 |
identifier_str_mv |
10.1590/s2175-97902022e191046 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/203932/194846 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222915637018624 |