Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba

Detalhes bibliográficos
Autor(a) principal: Espósito, Mariana Araújo
Data de Publicação: 2023
Outros Autores: Trento, Marcus Vinicius Cardoso, Braga, Mariana Aparecida, Marcussi, Silvana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/207291
Resumo: The composition and pharmacological properties of Lippia alba (Mill.) (L. alba) (Verbenaceae) flower and leaf essential oils (EO) were determined in this study. The major constituents in the flower EO were geranial (49.83%) and neral (32.75%), and in the leaf EO were geranial (38.06%), neral (31.02%), and limonene (18.03%). Flower EO inhibited thrombolysis induced by Bothrops moojeni (B. moojeni) and Lachesis muta muta (L. muta muta) venoms (0.05-1.2 µL mL-1). When tested against L. muta muta venom, the protective effect was smaller in both EO. The EOs prolonged the clotting time induced by L. muta muta venom and a procoagulant effect was observed on B. moojeni. In the comet assay, the flower EO presented anti-genotoxic action (damage frequency of only 11.6 - 34.9%) against the L. muta muta venom. The positive control (Doxorubicin) and the venom alone presented a damage frequency of 80.3% and 70.7%, respectively. The flower EO protected DNA from damage induced by L. muta muta venom. L. alba leaf and flower EOs presented anti-genotoxic action
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spelling Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia albaNatural ProductsHemostasisSnake Venoms as toolsComet AssayEnzyme InhibitorsThe composition and pharmacological properties of Lippia alba (Mill.) (L. alba) (Verbenaceae) flower and leaf essential oils (EO) were determined in this study. The major constituents in the flower EO were geranial (49.83%) and neral (32.75%), and in the leaf EO were geranial (38.06%), neral (31.02%), and limonene (18.03%). Flower EO inhibited thrombolysis induced by Bothrops moojeni (B. moojeni) and Lachesis muta muta (L. muta muta) venoms (0.05-1.2 µL mL-1). When tested against L. muta muta venom, the protective effect was smaller in both EO. The EOs prolonged the clotting time induced by L. muta muta venom and a procoagulant effect was observed on B. moojeni. In the comet assay, the flower EO presented anti-genotoxic action (damage frequency of only 11.6 - 34.9%) against the L. muta muta venom. The positive control (Doxorubicin) and the venom alone presented a damage frequency of 80.3% and 70.7%, respectively. The flower EO protected DNA from damage induced by L. muta muta venom. L. alba leaf and flower EOs presented anti-genotoxic actionUniversidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-01-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20729110.1590/s2175-97902022000X2e20575Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/207291/197609Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessEspósito, Mariana AraújoTrento, Marcus Vinicius CardosoBraga, Mariana AparecidaMarcussi, Silvana2023-08-30T15:53:57Zoai:revistas.usp.br:article/207291Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-08-30T15:53:57Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba
title Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba
spellingShingle Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba
Espósito, Mariana Araújo
Natural Products
Hemostasis
Snake Venoms as tools
Comet Assay
Enzyme Inhibitors
title_short Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba
title_full Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba
title_fullStr Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba
title_full_unstemmed Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba
title_sort Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba
author Espósito, Mariana Araújo
author_facet Espósito, Mariana Araújo
Trento, Marcus Vinicius Cardoso
Braga, Mariana Aparecida
Marcussi, Silvana
author_role author
author2 Trento, Marcus Vinicius Cardoso
Braga, Mariana Aparecida
Marcussi, Silvana
author2_role author
author
author
dc.contributor.author.fl_str_mv Espósito, Mariana Araújo
Trento, Marcus Vinicius Cardoso
Braga, Mariana Aparecida
Marcussi, Silvana
dc.subject.por.fl_str_mv Natural Products
Hemostasis
Snake Venoms as tools
Comet Assay
Enzyme Inhibitors
topic Natural Products
Hemostasis
Snake Venoms as tools
Comet Assay
Enzyme Inhibitors
description The composition and pharmacological properties of Lippia alba (Mill.) (L. alba) (Verbenaceae) flower and leaf essential oils (EO) were determined in this study. The major constituents in the flower EO were geranial (49.83%) and neral (32.75%), and in the leaf EO were geranial (38.06%), neral (31.02%), and limonene (18.03%). Flower EO inhibited thrombolysis induced by Bothrops moojeni (B. moojeni) and Lachesis muta muta (L. muta muta) venoms (0.05-1.2 µL mL-1). When tested against L. muta muta venom, the protective effect was smaller in both EO. The EOs prolonged the clotting time induced by L. muta muta venom and a procoagulant effect was observed on B. moojeni. In the comet assay, the flower EO presented anti-genotoxic action (damage frequency of only 11.6 - 34.9%) against the L. muta muta venom. The positive control (Doxorubicin) and the venom alone presented a damage frequency of 80.3% and 70.7%, respectively. The flower EO protected DNA from damage induced by L. muta muta venom. L. alba leaf and flower EOs presented anti-genotoxic action
publishDate 2023
dc.date.none.fl_str_mv 2023-01-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/207291
10.1590/s2175-97902022000X2e20575
url https://www.revistas.usp.br/bjps/article/view/207291
identifier_str_mv 10.1590/s2175-97902022000X2e20575
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/207291/197609
dc.rights.driver.fl_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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