Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges

Detalhes bibliográficos
Autor(a) principal: Bastos, Viviane A.
Data de Publicação: 2016
Outros Autores: Gomes Neto, Francisco, Perales, Jonas, Ferreira, Ana Gisele C. Neves, Valente, Richard H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17992
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.
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spelling Bastos, Viviane A.Gomes Neto, FranciscoPerales, JonasFerreira, Ana Gisele C. NevesValente, Richard H.2017-03-09T16:04:50Z2017-03-09T16:04:50Z2016BASTOS, Viviane A. et al. Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges. Toxins, v.8, n.9, 250, 20p, 2016.2072-6651https://www.arca.fiocruz.br/handle/icict/1799210.3390/toxins8090250engMDPIModelagemEspectrometria de MassasImunidade naturalInibidor da metalloendopeptidaseResistência naturalveneno de cobracross-linking; hydrogen/deuterium exchangemass spectrometrymetalloendopeptidase inhibitormodelingnatural immunitynatural resistancesnake venomstructuretherapeutic applicationNatural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challengesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.The research on natural snake venom metalloendopeptidase inhibitors (SVMPIs) began in the 18th century with the pioneering work of Fontana on the resistance that vipers exhibited to their own venom. During the past 40 years, SVMPIs have been isolated mainly from the sera of resistant animals, and characterized to different extents. They are acidic oligomeric glycoproteins that remain biologically active over a wide range of pH and temperature values. Based on primary structure determination, mammalian plasmatic SVMPIs are classified as members of the immunoglobulin (Ig) supergene protein family, while the one isolated from muscle belongs to the ficolin/opsonin P35 family. On the other hand, SVMPIs from snake plasma have been placed in the cystatin superfamily. These natural antitoxins constitute the first line of defense against snake venoms, inhibiting the catalytic activities of snake venom metalloendopeptidases through the establishment of high-affinity, non-covalent interactions. This review presents a historical account of the field of natural resistance, summarizing its main discoveries and current challenges, which are mostly related to the limitations that preclude three-dimensional structural determinations of these inhibitors using "gold-standard" methods; perspectives on how to circumvent such limitations are presented. Potential applications of these SVMPIs in medicine are also highlighted.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17992/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALviviane_bastos_etal_IOC_2016.pdfviviane_bastos_etal_IOC_2016.pdfapplication/pdf1536361https://www.arca.fiocruz.br/bitstream/icict/17992/2/viviane_bastos_etal_IOC_2016.pdfeff20fdf3b52fcd113aeebe9ad960cedMD52TEXTviviane_bastos_etal_IOC_2016.pdf.txtviviane_bastos_etal_IOC_2016.pdf.txtExtracted texttext/plain85568https://www.arca.fiocruz.br/bitstream/icict/17992/3/viviane_bastos_etal_IOC_2016.pdf.txt7fbd70282ab784cf6268595be7d72793MD53icict/179922018-08-15 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dc.title.pt_BR.fl_str_mv Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
title Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
spellingShingle Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
Bastos, Viviane A.
Modelagem
Espectrometria de Massas
Imunidade natural
Inibidor da metalloendopeptidase
Resistência natural
veneno de cobra
cross-linking; hydrogen/deuterium exchange
mass spectrometry
metalloendopeptidase inhibitor
modeling
natural immunity
natural resistance
snake venom
structure
therapeutic application
title_short Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
title_full Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
title_fullStr Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
title_full_unstemmed Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
title_sort Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
author Bastos, Viviane A.
author_facet Bastos, Viviane A.
Gomes Neto, Francisco
Perales, Jonas
Ferreira, Ana Gisele C. Neves
Valente, Richard H.
author_role author
author2 Gomes Neto, Francisco
Perales, Jonas
Ferreira, Ana Gisele C. Neves
Valente, Richard H.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bastos, Viviane A.
Gomes Neto, Francisco
Perales, Jonas
Ferreira, Ana Gisele C. Neves
Valente, Richard H.
dc.subject.other.pt_BR.fl_str_mv Modelagem
Espectrometria de Massas
Imunidade natural
Inibidor da metalloendopeptidase
Resistência natural
veneno de cobra
topic Modelagem
Espectrometria de Massas
Imunidade natural
Inibidor da metalloendopeptidase
Resistência natural
veneno de cobra
cross-linking; hydrogen/deuterium exchange
mass spectrometry
metalloendopeptidase inhibitor
modeling
natural immunity
natural resistance
snake venom
structure
therapeutic application
dc.subject.en.pt_BR.fl_str_mv cross-linking; hydrogen/deuterium exchange
mass spectrometry
metalloendopeptidase inhibitor
modeling
natural immunity
natural resistance
snake venom
structure
therapeutic application
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-09T16:04:50Z
dc.date.available.fl_str_mv 2017-03-09T16:04:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BASTOS, Viviane A. et al. Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges. Toxins, v.8, n.9, 250, 20p, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17992
dc.identifier.issn.pt_BR.fl_str_mv 2072-6651
dc.identifier.doi.none.fl_str_mv 10.3390/toxins8090250
identifier_str_mv BASTOS, Viviane A. et al. Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges. Toxins, v.8, n.9, 250, 20p, 2016.
2072-6651
10.3390/toxins8090250
url https://www.arca.fiocruz.br/handle/icict/17992
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/17992/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/17992/2/viviane_bastos_etal_IOC_2016.pdf
https://www.arca.fiocruz.br/bitstream/icict/17992/3/viviane_bastos_etal_IOC_2016.pdf.txt
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