Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17992 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil. |
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Bastos, Viviane A.Gomes Neto, FranciscoPerales, JonasFerreira, Ana Gisele C. NevesValente, Richard H.2017-03-09T16:04:50Z2017-03-09T16:04:50Z2016BASTOS, Viviane A. et al. Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges. Toxins, v.8, n.9, 250, 20p, 2016.2072-6651https://www.arca.fiocruz.br/handle/icict/1799210.3390/toxins8090250engMDPIModelagemEspectrometria de MassasImunidade naturalInibidor da metalloendopeptidaseResistência naturalveneno de cobracross-linking; hydrogen/deuterium exchangemass spectrometrymetalloendopeptidase inhibitormodelingnatural immunitynatural resistancesnake venomstructuretherapeutic applicationNatural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challengesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil.The research on natural snake venom metalloendopeptidase inhibitors (SVMPIs) began in the 18th century with the pioneering work of Fontana on the resistance that vipers exhibited to their own venom. During the past 40 years, SVMPIs have been isolated mainly from the sera of resistant animals, and characterized to different extents. They are acidic oligomeric glycoproteins that remain biologically active over a wide range of pH and temperature values. Based on primary structure determination, mammalian plasmatic SVMPIs are classified as members of the immunoglobulin (Ig) supergene protein family, while the one isolated from muscle belongs to the ficolin/opsonin P35 family. On the other hand, SVMPIs from snake plasma have been placed in the cystatin superfamily. These natural antitoxins constitute the first line of defense against snake venoms, inhibiting the catalytic activities of snake venom metalloendopeptidases through the establishment of high-affinity, non-covalent interactions. This review presents a historical account of the field of natural resistance, summarizing its main discoveries and current challenges, which are mostly related to the limitations that preclude three-dimensional structural determinations of these inhibitors using "gold-standard" methods; perspectives on how to circumvent such limitations are presented. Potential applications of these SVMPIs in medicine are also highlighted.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17992/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALviviane_bastos_etal_IOC_2016.pdfviviane_bastos_etal_IOC_2016.pdfapplication/pdf1536361https://www.arca.fiocruz.br/bitstream/icict/17992/2/viviane_bastos_etal_IOC_2016.pdfeff20fdf3b52fcd113aeebe9ad960cedMD52TEXTviviane_bastos_etal_IOC_2016.pdf.txtviviane_bastos_etal_IOC_2016.pdf.txtExtracted texttext/plain85568https://www.arca.fiocruz.br/bitstream/icict/17992/3/viviane_bastos_etal_IOC_2016.pdf.txt7fbd70282ab784cf6268595be7d72793MD53icict/179922018-08-15 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dc.title.pt_BR.fl_str_mv |
Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges |
title |
Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges |
spellingShingle |
Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges Bastos, Viviane A. Modelagem Espectrometria de Massas Imunidade natural Inibidor da metalloendopeptidase Resistência natural veneno de cobra cross-linking; hydrogen/deuterium exchange mass spectrometry metalloendopeptidase inhibitor modeling natural immunity natural resistance snake venom structure therapeutic application |
title_short |
Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges |
title_full |
Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges |
title_fullStr |
Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges |
title_full_unstemmed |
Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges |
title_sort |
Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges |
author |
Bastos, Viviane A. |
author_facet |
Bastos, Viviane A. Gomes Neto, Francisco Perales, Jonas Ferreira, Ana Gisele C. Neves Valente, Richard H. |
author_role |
author |
author2 |
Gomes Neto, Francisco Perales, Jonas Ferreira, Ana Gisele C. Neves Valente, Richard H. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Bastos, Viviane A. Gomes Neto, Francisco Perales, Jonas Ferreira, Ana Gisele C. Neves Valente, Richard H. |
dc.subject.other.pt_BR.fl_str_mv |
Modelagem Espectrometria de Massas Imunidade natural Inibidor da metalloendopeptidase Resistência natural veneno de cobra |
topic |
Modelagem Espectrometria de Massas Imunidade natural Inibidor da metalloendopeptidase Resistência natural veneno de cobra cross-linking; hydrogen/deuterium exchange mass spectrometry metalloendopeptidase inhibitor modeling natural immunity natural resistance snake venom structure therapeutic application |
dc.subject.en.pt_BR.fl_str_mv |
cross-linking; hydrogen/deuterium exchange mass spectrometry metalloendopeptidase inhibitor modeling natural immunity natural resistance snake venom structure therapeutic application |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Toxinas, CNPq. Brasília, DF, Brasil. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-03-09T16:04:50Z |
dc.date.available.fl_str_mv |
2017-03-09T16:04:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BASTOS, Viviane A. et al. Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges. Toxins, v.8, n.9, 250, 20p, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/17992 |
dc.identifier.issn.pt_BR.fl_str_mv |
2072-6651 |
dc.identifier.doi.none.fl_str_mv |
10.3390/toxins8090250 |
identifier_str_mv |
BASTOS, Viviane A. et al. Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges. Toxins, v.8, n.9, 250, 20p, 2016. 2072-6651 10.3390/toxins8090250 |
url |
https://www.arca.fiocruz.br/handle/icict/17992 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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MDPI |
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MDPI |
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