Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.

Detalhes bibliográficos
Autor(a) principal: Freitas, Luiz Antonio Rodrigues de
Data de Publicação: 1999
Outros Autores: Mbow, M. Lamine, Estay, Monica, Bleyenberg, Julie A., Titus, Richard G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5651
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
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spelling Freitas, Luiz Antonio Rodrigues deMbow, M. LamineEstay, MonicaBleyenberg, Julie A.Titus, Richard G.2012-10-05T17:53:04Z2012-10-05T17:53:04Z1999FREITAS, Luiz Antonio Rodrigues de et al. Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. Parasite Immunology, v. 21, n. 5, p. 273-7, May 1999.0141-9838https://www.arca.fiocruz.br/handle/icict/5651engIndomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilCollege of Veterinary Medicine and Biomedical Sciences. Colorado State University. Fort Collins USACollege of Veterinary Medicine and Biomedical Sciences. Colorado State University. Fort Collins USACollege of Veterinary Medicine and Biomedical Sciences. Colorado State University. Fort Collins USACollege of Veterinary Medicine and Biomedical Sciences. Colorado State University. Fort Collins USAProstaglandins of the E series inhibit the development of Th1 responses. When infected with Leishmania major, BALB/c mice fail to develop a Th1 response, but instead mount a Th2 response and die of the disease. Therefore, we treated L. major-infected BALB/c mice with indomethacin, which inhibits prostaglandin production. Indomethacin lessened disease severity (parasite burden and pathology), and promoted a Th1 response, but the mice still succumbed to infection. The explanation for these observations may be two-fold: (1) the beneficial effects of indomethacin were predominantly observed later in infection (beyond two weeks), a time at which indomethacin was unable to sufficiently block the development of a Th2 response; (2) indomethacin was unable to induce a Th1 response in BALB/c mice that was of the same magnitude as the Th1 response observed in C57BL/6 mice infected with L. major.Leishmania MajorLeishmaniasisProstaglandinsCytokinesNitric OxideAntiprotozoários/uso terapêuticoIndometacina/uso terapêuticoLeishmania majorLeishmaniose Cutânea/quimioterapiaCélulas Th1/imunologiaAnimaisInibidores de Ciclooxigenase/uso terapêuticoProgressão da DoençaFemininoImunidade CelularLeishmaniose Cutânea/imunologiaCamundongosCamundongos Endogâmicos BALB CCamundongos Endogâmicos C57BLAntagonistas de Prostaglandina/uso terapêuticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALdE Freitas LA Indomethacin treatment slows....pdfdE Freitas LA Indomethacin treatment slows....pdfapplication/pdf120581https://www.arca.fiocruz.br/bitstream/icict/5651/1/dE%20Freitas%20LA%20Indomethacin%20treatment%20slows....pdfc18d299d9b2068ca5c74e80986fe775aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5651/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTdE Freitas LA Indomethacin treatment slows....pdf.txtdE Freitas LA Indomethacin treatment slows....pdf.txtExtracted texttext/plain23317https://www.arca.fiocruz.br/bitstream/icict/5651/5/dE%20Freitas%20LA%20Indomethacin%20treatment%20slows....pdf.txt0fdeddb191687f2c27f27249befce0ccMD55THUMBNAILdE Freitas LA Indomethacin treatment slows....pdf.jpgdE Freitas LA Indomethacin treatment slows....pdf.jpgGenerated Thumbnailimage/jpeg1885https://www.arca.fiocruz.br/bitstream/icict/5651/4/dE%20Freitas%20LA%20Indomethacin%20treatment%20slows....pdf.jpgd704a521e81a23d7752477586e3f753cMD54icict/56512023-03-15 14:33:10.571oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
title Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
spellingShingle Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
Freitas, Luiz Antonio Rodrigues de
Leishmania Major
Leishmaniasis
Prostaglandins
Cytokines
Nitric Oxide
Antiprotozoários/uso terapêutico
Indometacina/uso terapêutico
Leishmania major
Leishmaniose Cutânea/quimioterapia
Células Th1/imunologia
Animais
Inibidores de Ciclooxigenase/uso terapêutico
Progressão da Doença
Feminino
Imunidade Celular
Leishmaniose Cutânea/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Antagonistas de Prostaglandina/uso terapêutico
title_short Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
title_full Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
title_fullStr Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
title_full_unstemmed Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
title_sort Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
author Freitas, Luiz Antonio Rodrigues de
author_facet Freitas, Luiz Antonio Rodrigues de
Mbow, M. Lamine
Estay, Monica
Bleyenberg, Julie A.
Titus, Richard G.
author_role author
author2 Mbow, M. Lamine
Estay, Monica
Bleyenberg, Julie A.
Titus, Richard G.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Luiz Antonio Rodrigues de
Mbow, M. Lamine
Estay, Monica
Bleyenberg, Julie A.
Titus, Richard G.
dc.subject.en.pt_BR.fl_str_mv Leishmania Major
Leishmaniasis
Prostaglandins
Cytokines
Nitric Oxide
topic Leishmania Major
Leishmaniasis
Prostaglandins
Cytokines
Nitric Oxide
Antiprotozoários/uso terapêutico
Indometacina/uso terapêutico
Leishmania major
Leishmaniose Cutânea/quimioterapia
Células Th1/imunologia
Animais
Inibidores de Ciclooxigenase/uso terapêutico
Progressão da Doença
Feminino
Imunidade Celular
Leishmaniose Cutânea/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Antagonistas de Prostaglandina/uso terapêutico
dc.subject.decs.pt_BR.fl_str_mv Antiprotozoários/uso terapêutico
Indometacina/uso terapêutico
Leishmania major
Leishmaniose Cutânea/quimioterapia
Células Th1/imunologia
Animais
Inibidores de Ciclooxigenase/uso terapêutico
Progressão da Doença
Feminino
Imunidade Celular
Leishmaniose Cutânea/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Antagonistas de Prostaglandina/uso terapêutico
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2012-10-05T17:53:04Z
dc.date.available.fl_str_mv 2012-10-05T17:53:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv FREITAS, Luiz Antonio Rodrigues de et al. Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. Parasite Immunology, v. 21, n. 5, p. 273-7, May 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5651
dc.identifier.issn.none.fl_str_mv 0141-9838
identifier_str_mv FREITAS, Luiz Antonio Rodrigues de et al. Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. Parasite Immunology, v. 21, n. 5, p. 273-7, May 1999.
0141-9838
url https://www.arca.fiocruz.br/handle/icict/5651
dc.language.iso.fl_str_mv eng
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