Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.

Detalhes bibliográficos
Autor(a) principal: Freitas, Luiz Antonio Rodrigues de
Data de Publicação: 1999
Outros Autores: Mbow, M. Lamine, Estay, Monica, Bleyenberg, Julie A, Titus, Richard G
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7900
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Celular. Salvador, BA, Brasil
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spelling Freitas, Luiz Antonio Rodrigues deMbow, M. LamineEstay, MonicaBleyenberg, Julie ATitus, Richard G2014-07-10T12:30:06Z2014-07-10T12:30:06Z1999FREITAS, L. A. R. et al. Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. Parasite Immunology, v. 21, n. 5, p. 273-277, 1999.0141-9838https://www.arca.fiocruz.br/handle/icict/7900engBlackwell ScienceIndomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Celular. Salvador, BA, BrasilColorado State University. Department of Pathology. College of Veterinary Medicine and Biomedical Sciences. Fort Collins, USAColorado State University. Department of Pathology. College of Veterinary Medicine and Biomedical Sciences. Fort Collins, USAColorado State University. Department of Pathology. College of Veterinary Medicine and Biomedical Sciences. Fort Collins, USAColorado State University. Department of Pathology. College of Veterinary Medicine and Biomedical Sciences. Fort Collins, USAProstaglandins of the E series inhibit the development of Th1 responses. When infected with Leishmania major, BALB/c mice fail to develop a Th1 response, but instead mount a Th2 response and die of the disease. Therefore, we treated L. major-infected BALB/c mice with indomethacin, which inhibits prostaglandin production. Indomethacin lessened disease severity (parasite burden and pathology), and promoted a Th1 response, but the mice still succumbed to infection. The explanation for these observations may be two-fold: (1) the beneficial effects of indomethacin were predominantly observed later in infection (beyond two weeks), a time at which indomethacin was unable to sufficiently block the development of a Th2 response; (2) indomethacin was unable to induce a Th1 response in BALB/c mice that was of the same magnitude as the Th1 response observed in C57BL/6 mice infected with L. major.Leishmania majorLeishmaniasisProstaglandinsCytokinesNitric oxideAntiprotozoários/uso terapêuticoIndometacina/uso terapêuticoLeishmania majorLeishmaniose Cutânea/quimioterapiaCélulas Th1/imunologiaAnimaisInibidores de Ciclo-Oxigenase/uso terapêuticoProgressão da DoençaFemininoImunidade CelularLeishmaniose Cutânea/imunologiaCamundongosCamundongos Endogâmicos BALB CAntagonistas de Prostaglandina/uso terapêuticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFreitas LA Indomethacin treatment slows....pdfFreitas LA Indomethacin treatment slows....pdfapplication/pdf120581https://www.arca.fiocruz.br/bitstream/icict/7900/1/Freitas%20LA%20Indomethacin%20treatment%20slows....pdfc18d299d9b2068ca5c74e80986fe775aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7900/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTFreitas LA Indomethacin treatment slows....pdf.txtFreitas LA Indomethacin treatment slows....pdf.txtExtracted texttext/plain23317https://www.arca.fiocruz.br/bitstream/icict/7900/3/Freitas%20LA%20Indomethacin%20treatment%20slows....pdf.txt0fdeddb191687f2c27f27249befce0ccMD53icict/79002023-03-15 14:33:16.688oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
title Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
spellingShingle Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
Freitas, Luiz Antonio Rodrigues de
Leishmania major
Leishmaniasis
Prostaglandins
Cytokines
Nitric oxide
Antiprotozoários/uso terapêutico
Indometacina/uso terapêutico
Leishmania major
Leishmaniose Cutânea/quimioterapia
Células Th1/imunologia
Animais
Inibidores de Ciclo-Oxigenase/uso terapêutico
Progressão da Doença
Feminino
Imunidade Celular
Leishmaniose Cutânea/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Antagonistas de Prostaglandina/uso terapêutico
title_short Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
title_full Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
title_fullStr Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
title_full_unstemmed Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
title_sort Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
author Freitas, Luiz Antonio Rodrigues de
author_facet Freitas, Luiz Antonio Rodrigues de
Mbow, M. Lamine
Estay, Monica
Bleyenberg, Julie A
Titus, Richard G
author_role author
author2 Mbow, M. Lamine
Estay, Monica
Bleyenberg, Julie A
Titus, Richard G
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Luiz Antonio Rodrigues de
Mbow, M. Lamine
Estay, Monica
Bleyenberg, Julie A
Titus, Richard G
dc.subject.en.pt_BR.fl_str_mv Leishmania major
Leishmaniasis
Prostaglandins
Cytokines
Nitric oxide
topic Leishmania major
Leishmaniasis
Prostaglandins
Cytokines
Nitric oxide
Antiprotozoários/uso terapêutico
Indometacina/uso terapêutico
Leishmania major
Leishmaniose Cutânea/quimioterapia
Células Th1/imunologia
Animais
Inibidores de Ciclo-Oxigenase/uso terapêutico
Progressão da Doença
Feminino
Imunidade Celular
Leishmaniose Cutânea/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Antagonistas de Prostaglandina/uso terapêutico
dc.subject.decs.pt_BR.fl_str_mv Antiprotozoários/uso terapêutico
Indometacina/uso terapêutico
Leishmania major
Leishmaniose Cutânea/quimioterapia
Células Th1/imunologia
Animais
Inibidores de Ciclo-Oxigenase/uso terapêutico
Progressão da Doença
Feminino
Imunidade Celular
Leishmaniose Cutânea/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Antagonistas de Prostaglandina/uso terapêutico
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Celular. Salvador, BA, Brasil
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2014-07-10T12:30:06Z
dc.date.available.fl_str_mv 2014-07-10T12:30:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREITAS, L. A. R. et al. Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. Parasite Immunology, v. 21, n. 5, p. 273-277, 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7900
dc.identifier.issn.none.fl_str_mv 0141-9838
identifier_str_mv FREITAS, L. A. R. et al. Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. Parasite Immunology, v. 21, n. 5, p. 273-277, 1999.
0141-9838
url https://www.arca.fiocruz.br/handle/icict/7900
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Science
publisher.none.fl_str_mv Blackwell Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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