Association of homocysteine and inflammatory related molecules in sickle cell anemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14119 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Vilas-Boas, WendellCerqueira, Bruno Antonio VelosoFigueiredo, Camylla Vilas BoasSantiago, Rayra PereiraGuarda, Caroline Conceição daPitanga, Thassila NogueiraSantana, Sanzio SilvaZanette, Angela Maria DiasGoncalves, Marilda de Souza2016-05-06T19:27:47Z2016-05-06T19:27:47Z2015VILAS-BOAS, W. et al. Association of homocysteine and inflammatory related molecules in sickle cell anemia. Hepatology, 20151024-5332https://www.arca.fiocruz.br/handle/icict/14119engManey PublishingAssociation of homocysteine and inflammatory related molecules in sickle cell anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação de Hematologia e Hemoterapia da Bahia–Hemoba. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilObjective: Investigate the role of homocysteine (Hcy), Th17-related cytokines, and adhesion molecules in the inflammatory state seen in the sickle cell anemia (SCA). Methods: We studied the Hcy, interleukin (IL)-17, and transforming growth factor β (TGF-β) cytokine levels of 62 SCA patients, as well as the expression levels of inflammatory and endothelial activation markers. Results: We found significant associations between Hcy levels and increased expression of IL-17 and TGF-β among SCA patients, and a positive significant correlation between Hcy and soluble vascular cellular adhesion molecules (sVCAM). SCA individuals had raised IL-17 levels when compared with controls. Discussion: These results suggest a possible role of Hyc in the induction of TGF-β and IL-17. Other authors proposed that Hcy may contribute to the initiation and progression of vascular disease by monocyte activation, resulting in the secretion of cytokines that amplify the inflammatory response. The role of Hcy in cytokine production and oxidative stress in the endothelium may explain the increase of sVCAM expression and, the vascular activation currently described among the SCA individuals with the highest Hcy serum levels. The chronic inflammation was observed in hyperhomocysteinemic mice, with an increased expression of VCAM-1 and plasma levels of tumor necrosis factor-alpha, showing an association of this inflammatory molecule and vascular changes. Conclusion: Our findings suggest that the increased levels of IL-17,Hcy and sVCAM contributes contributes to the vascular inflammation and activation presented by SCA patients, which probably have an important role in vaso-occlusion. On the basis of the presented data, IL-17 and Hcy might be considered as important components in the pathogenesis of SCA.Sickle cell anemiaCytokinesSoluble adhesion moleculesHomocysteineIL-17info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14119/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVilas-Boas W Association of....pdfVilas-Boas W Association of....pdfapplication/pdf614959https://www.arca.fiocruz.br/bitstream/icict/14119/2/Vilas-Boas%20W%20Association%20of....pdfe67cd48c7a295b7265ee44271b784686MD52TEXTVilas-Boas W Association of....pdf.txtVilas-Boas W Association of....pdf.txtExtracted texttext/plain28873https://www.arca.fiocruz.br/bitstream/icict/14119/3/Vilas-Boas%20W%20Association%20of....pdf.txt201eba5c66842fc29e71259d575a9d89MD53icict/141192023-03-15 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| dc.title.pt_BR.fl_str_mv |
Association of homocysteine and inflammatory related molecules in sickle cell anemia |
| title |
Association of homocysteine and inflammatory related molecules in sickle cell anemia |
| spellingShingle |
Association of homocysteine and inflammatory related molecules in sickle cell anemia Vilas-Boas, Wendell Sickle cell anemia Cytokines Soluble adhesion molecules Homocysteine IL-17 |
| title_short |
Association of homocysteine and inflammatory related molecules in sickle cell anemia |
| title_full |
Association of homocysteine and inflammatory related molecules in sickle cell anemia |
| title_fullStr |
Association of homocysteine and inflammatory related molecules in sickle cell anemia |
| title_full_unstemmed |
Association of homocysteine and inflammatory related molecules in sickle cell anemia |
| title_sort |
Association of homocysteine and inflammatory related molecules in sickle cell anemia |
| author |
Vilas-Boas, Wendell |
| author_facet |
Vilas-Boas, Wendell Cerqueira, Bruno Antonio Veloso Figueiredo, Camylla Vilas Boas Santiago, Rayra Pereira Guarda, Caroline Conceição da Pitanga, Thassila Nogueira Santana, Sanzio Silva Zanette, Angela Maria Dias Goncalves, Marilda de Souza |
| author_role |
author |
| author2 |
Cerqueira, Bruno Antonio Veloso Figueiredo, Camylla Vilas Boas Santiago, Rayra Pereira Guarda, Caroline Conceição da Pitanga, Thassila Nogueira Santana, Sanzio Silva Zanette, Angela Maria Dias Goncalves, Marilda de Souza |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vilas-Boas, Wendell Cerqueira, Bruno Antonio Veloso Figueiredo, Camylla Vilas Boas Santiago, Rayra Pereira Guarda, Caroline Conceição da Pitanga, Thassila Nogueira Santana, Sanzio Silva Zanette, Angela Maria Dias Goncalves, Marilda de Souza |
| dc.subject.en.pt_BR.fl_str_mv |
Sickle cell anemia Cytokines Soluble adhesion molecules Homocysteine IL-17 |
| topic |
Sickle cell anemia Cytokines Soluble adhesion molecules Homocysteine IL-17 |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
| publishDate |
2015 |
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2015 |
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2016-05-06T19:27:47Z |
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2016-05-06T19:27:47Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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VILAS-BOAS, W. et al. Association of homocysteine and inflammatory related molecules in sickle cell anemia. Hepatology, 2015 |
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https://www.arca.fiocruz.br/handle/icict/14119 |
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1024-5332 |
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VILAS-BOAS, W. et al. Association of homocysteine and inflammatory related molecules in sickle cell anemia. Hepatology, 2015 1024-5332 |
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https://www.arca.fiocruz.br/handle/icict/14119 |
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Maney Publishing |
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Maney Publishing |
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