Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59573 |
Resumo: | Fiocruz Rondônia. Laboratório de Entomologia. Plataforma de Produção e Infecção de Vetores da Malária. Porto Velho, RO, Brazil |
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Andrade, Alice O.Santos, Najara A. C.Bastos, Alessandra S.Pontual, José D. C.Araújo, Jéssica E.Silva, Alexia M. V.Martinez, Leandro N.Lima, Alzemar Alves deAguiar, Anna Caroline CamposTeles, Carolina Bioni GarciaMedeiros, Jansen Fernandes dePereira, Dhelio BatistaVinetz, Joseph M.Gazzinelli, Ricardo TostesAraújo, Maisa S.2023-07-13T19:15:10Z2023-07-13T19:15:10Z2023ANDRADE, Alice O. et al. Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. PLoS neglected tropical diseases, v. 17, n. 6, p. e0011425, 2023. doi.org/10.1371/journal.pntd.00114251935-2735https://www.arca.fiocruz.br/handle/icict/59573engPublic Library of ScienceTransmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingiinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFiocruz Rondônia. Laboratório de Entomologia. Plataforma de Produção e Infecção de Vetores da Malária. Porto Velho, RO, BrazilFiocruz Rondônia. Laboratório de Entomologia. Plataforma de Produção e Infecção de Vetores da Malária. Porto Velho, RO, Brazil/Fundação Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brazil/Fiocruz Rondônia. Porto Velho, RO, BrazilFiocruz Rondônia. Laboratório de Entomologia. Plataforma de Produção e Infecção de Vetores da Malária. Porto Velho, RO, BrazilFiocruz Rondônia. Laboratório de Entomologia. Plataforma de Produção e Infecção de Vetores da Malária. Porto Velho, RO, BrazilFiocruz Rondônia. Laboratório de Entomologia. Plataforma de Produção e Infecção de Vetores da Malária. Porto Velho, RO, Brazil/Fundação Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brazil/Fiocruz Rondônia. Porto Velho, RO, BrazilCentro de Pesquisa em Medicina Tropical. Ambulatório de Malária. Porto Velho, RO, BrazilFundação Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brazil/Fiocruz Rondônia. Porto Velho, RO, Brazil/Fiocruz Rondônia. Plataforma de Bioensaios de Malária e Leishmaniose da Fiocruz. Porto Velho, RO, BrazilCentro de Pesquisa em Medicina Tropical. Ambulatório de Malária. Porto Velho, RO, BrazilDepartamento de Biociência. Universidade Federal de São Paulo. Santos, SP, BrazilFundação Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brazil/Fiocruz Rondônia. Porto Velho, RO, Brazil/Fiocruz Rondônia. Plataforma de Bioensaios de Malária e Leishmaniose da Fiocruz. Porto Velho, RO, BrazilFiocruz Rondônia. Laboratório de Entomologia. Plataforma de Produção e Infecção de Vetores da Malária. Porto Velho, RO, Brazil/Fundação Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brazil/Fiocruz Rondônia. Porto Velho, RO, BrazilCentro de Pesquisa em Medicina Tropical. Ambulatório de Malária. Porto Velho, RO, BrazilSection of Infectious Diseases. Department of Internal Medicine. Yale School of Medicine. New Haven, CT, United States of AmericaFundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil/Department of Medicine. University of Massachusetts Medical School. Worcester, MA, United States of AmericaFundação Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brazil/Fiocruz Rondônia. Porto Velho, RO, BrazilMalaria is caused by parasite of the genus Plasmodium and is still one of the most important infectious diseases in the world. Several biological characteristics of Plasmodium vivax contribute to the resilience of this species, including early gametocyte production, both of which lead to efficient malaria transmission to mosquitoes. This study evaluated the impact of currently used drugs on the transmission of P. vivax. Participants received one of the following treatments for malaria: i) chloroquine [10 mg/kg on day 1 and 7.5 mg/kg on day 2 and 3] co-administered with Primaquine [0.5 mg/kg/day for 7 days]; ii) Chloroquine [10 mg/kg on day 1 and 7.5 mg/kg on day 2 and 3] co-administered with one-dose of Tafenoquine [300 mg on day 1]; and iii) Artesunate and Mefloquine [100 mg and 200 mg on day 1, 2 and 3] co-administered with Primaquine [0.5 mg/kg/day for 14 days]. Patient blood was collected before treatment and 4 h, 24 h, 48 h and 72 h after treatment. The blood was used to perform a direct membrane feeding assay (DMFA) using Anopheles darlingi mosquitoes. The results showed 100% inhibition of the mosquito infection after 4 h using ASMQ+PQ, after 24 h for the combination of CQ+PQ and 48 h using CQ+TQ. The density of gametocytes declined over time in all treatment groups, although the decline was more rapid in the ASMQ+PQ group. In conclusion, it was possible to demonstrate the transmission-blocking efficacy of the malaria vivax treatment and that ASMQ+PQ acts faster than the two other treatments.MalariaMosquitoesPlasmodiumGametocytesOocystsAntimalarialsParasitic diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59573/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTransmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi.pdfTransmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi.pdfapplication/pdf1865802https://www.arca.fiocruz.br/bitstream/icict/59573/2/Transmission-blocking%20activity%20of%20antimalarials%20for%20Plasmodium%20vivax%20malaria%20in%20Anopheles%20darlingi.pdf1f45acfaf6da617f8a203d14b6acee1fMD52icict/595732023-07-13 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dc.title.en_US.fl_str_mv |
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi |
title |
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi |
spellingShingle |
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi Andrade, Alice O. Malaria Mosquitoes Plasmodium Gametocytes Oocysts Antimalarials Parasitic diseases |
title_short |
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi |
title_full |
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi |
title_fullStr |
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi |
title_full_unstemmed |
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi |
title_sort |
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi |
author |
Andrade, Alice O. |
author_facet |
Andrade, Alice O. Santos, Najara A. C. Bastos, Alessandra S. Pontual, José D. C. Araújo, Jéssica E. Silva, Alexia M. V. Martinez, Leandro N. Lima, Alzemar Alves de Aguiar, Anna Caroline Campos Teles, Carolina Bioni Garcia Medeiros, Jansen Fernandes de Pereira, Dhelio Batista Vinetz, Joseph M. Gazzinelli, Ricardo Tostes Araújo, Maisa S. |
author_role |
author |
author2 |
Santos, Najara A. C. Bastos, Alessandra S. Pontual, José D. C. Araújo, Jéssica E. Silva, Alexia M. V. Martinez, Leandro N. Lima, Alzemar Alves de Aguiar, Anna Caroline Campos Teles, Carolina Bioni Garcia Medeiros, Jansen Fernandes de Pereira, Dhelio Batista Vinetz, Joseph M. Gazzinelli, Ricardo Tostes Araújo, Maisa S. |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade, Alice O. Santos, Najara A. C. Bastos, Alessandra S. Pontual, José D. C. Araújo, Jéssica E. Silva, Alexia M. V. Martinez, Leandro N. Lima, Alzemar Alves de Aguiar, Anna Caroline Campos Teles, Carolina Bioni Garcia Medeiros, Jansen Fernandes de Pereira, Dhelio Batista Vinetz, Joseph M. Gazzinelli, Ricardo Tostes Araújo, Maisa S. |
dc.subject.en.en_US.fl_str_mv |
Malaria Mosquitoes Plasmodium Gametocytes Oocysts Antimalarials Parasitic diseases |
topic |
Malaria Mosquitoes Plasmodium Gametocytes Oocysts Antimalarials Parasitic diseases |
description |
Fiocruz Rondônia. Laboratório de Entomologia. Plataforma de Produção e Infecção de Vetores da Malária. Porto Velho, RO, Brazil |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-07-13T19:15:10Z |
dc.date.available.fl_str_mv |
2023-07-13T19:15:10Z |
dc.date.issued.fl_str_mv |
2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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dc.identifier.citation.fl_str_mv |
ANDRADE, Alice O. et al. Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. PLoS neglected tropical diseases, v. 17, n. 6, p. e0011425, 2023. doi.org/10.1371/journal.pntd.0011425 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/59573 |
dc.identifier.issn.en_US.fl_str_mv |
1935-2735 |
identifier_str_mv |
ANDRADE, Alice O. et al. Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. PLoS neglected tropical diseases, v. 17, n. 6, p. e0011425, 2023. doi.org/10.1371/journal.pntd.0011425 1935-2735 |
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https://www.arca.fiocruz.br/handle/icict/59573 |
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eng |
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eng |
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Public Library of Science |
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Public Library of Science |
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