Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory

Detalhes bibliográficos
Autor(a) principal: Barbosa, Mayra M. Ferrari
Data de Publicação: 2021
Outros Autores: Kanno, Alex Issamu, Farias, Leonardo Paiva, Madej, Mariusz, Sipos, Gergö, Sbrana, Silverio, Romani, Luigina, Boraschi, Diana, Leite, Luciana C. C., Italiani, Paola
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47835
Resumo: European Commission FP7 project HUMUNITY (GA 316383)
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spelling Barbosa, Mayra M. FerrariKanno, Alex IssamuFarias, Leonardo PaivaMadej, MariuszSipos, GergöSbrana, SilverioRomani, LuiginaBoraschi, DianaLeite, Luciana C. C.Italiani, Paola2021-06-22T14:14:34Z2021-06-22T14:14:34Z2021BARBOSA, Mayra M. Ferrari et al. Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory. Nanomaterials, v. 11, n. 4, p. 1-16, 6 Apr. 2021.2079-4991https://www.arca.fiocruz.br/handle/icict/4783510.3390/nano11040931European Commission FP7 project HUMUNITY (GA 316383)Horizon 2020 projects PANDORA (GA 671881)ENDONANO (GA 812661)Italian MIUR Flagship InterOmics project MEMORATPRIN project 20173ZECCMCNR Italy-Brazil Joint Laboratory initiativeFAPESP grant 2017/24632-6 (to L.C.C.L.)Fundação ButantanM.M.F.B. received a CAPES fellowshipInstituto Butantan. Laboratório de Desenvolvimento de Vacinas. São Paulo, SP, Brasil.Instituto Butantan. Laboratório de Desenvolvimento de Vacinas. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.Istituto di Biochimica e Biologia Cellulare. Consiglio Nazionale delle Ricerche. Napoli, Italia.Istituto di Biochimica e Biologia Cellulare. Consiglio Nazionale delle Ricerche. Napoli, Italia.Istituto di Fisiologia Clinica. Consiglio Nazionale delle Ricerche. Massa, Italia.University of Perugia. Dipartimento di Medicina e Chirurgia. Perugia, Italia.Istituto di Biochimica e Biologia Cellulare. Consiglio Nazionale delle Ricerche. Napoli, Italia / Stazione Zoologica Anton Dohrn. Napoli, Italia.Instituto Butantan. Laboratório de Desenvolvimento de Vacinas. São Paulo, SP, Brasil.Istituto di Biochimica e Biologia Cellulare. Consiglio Nazionale delle Ricerche. Napoli, Italia / Stazione Zoologica Anton Dohrn. Napoli, Italia.Innate immune cells such as monocytes and macrophages are activated in response to microbial and other challenges and mount an inflammatory defensive response. Exposed cells develop the so-called innate memory, which allows them to react differently to a subsequent challenge, aiming at better protection. In this study, using human primary monocytes in vitro, we have assessed the memory-inducing capacity of two antigenic molecules of Schistosoma mansoni in soluble form compared to the same molecules coupled to outer membrane vesicles of Neisseria lactamica. The results show that particulate challenges are much more efficient than soluble molecules in inducing innate memory, which is measured as the production of inflammatory and anti-inflammatory cytokines (TNFα, IL-6, IL-10). Controls run with LPS from Klebsiella pneumoniae compared to the whole bacteria show that while LPS alone has strong memory-inducing capacity, the entire bacteria are more efficient. These data suggest that microbial antigens that are unable to induce innate immune activation can nevertheless participate in innate activation and memory when in a particulate form, which is a notion that supports the use of nanoparticulate antigens in vaccination strategies for achieving adjuvant-like effects of innate activation as well as priming for improved reactivity to future challenges.engMDPIImunidadeMemóriaSchistosoma mansoniMonócitosMacrófagosVacinaçãoInnate immunityInnate memorySchistosoma mansoniMonocytesMacrophagesVaccinationPrimary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memoryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/47835/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALBarbosa, Mayra M Ferrari Primary and....pdfBarbosa, Mayra M Ferrari Primary and....pdfapplication/pdf2075791https://www.arca.fiocruz.br/bitstream/icict/47835/2/Barbosa%2c%20Mayra%20M%20Ferrari%20Primary%20and....pdfdd3803640e1d4778a7608e2341472b02MD52TEXTBarbosa, Mayra M Ferrari Primary and....pdf.txtBarbosa, Mayra M Ferrari Primary and....pdf.txtExtracted texttext/plain71757https://www.arca.fiocruz.br/bitstream/icict/47835/3/Barbosa%2c%20Mayra%20M%20Ferrari%20Primary%20and....pdf.txtfb9bc2680a83508c6ba0dce60060e038MD53icict/478352023-03-15 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dc.title.en.fl_str_mv Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory
title Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory
spellingShingle Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory
Barbosa, Mayra M. Ferrari
Imunidade
Memória
Schistosoma mansoni
Monócitos
Macrófagos
Vacinação
Innate immunity
Innate memory
Schistosoma mansoni
Monocytes
Macrophages
Vaccination
title_short Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory
title_full Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory
title_fullStr Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory
title_full_unstemmed Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory
title_sort Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory
author Barbosa, Mayra M. Ferrari
author_facet Barbosa, Mayra M. Ferrari
Kanno, Alex Issamu
Farias, Leonardo Paiva
Madej, Mariusz
Sipos, Gergö
Sbrana, Silverio
Romani, Luigina
Boraschi, Diana
Leite, Luciana C. C.
Italiani, Paola
author_role author
author2 Kanno, Alex Issamu
Farias, Leonardo Paiva
Madej, Mariusz
Sipos, Gergö
Sbrana, Silverio
Romani, Luigina
Boraschi, Diana
Leite, Luciana C. C.
Italiani, Paola
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa, Mayra M. Ferrari
Kanno, Alex Issamu
Farias, Leonardo Paiva
Madej, Mariusz
Sipos, Gergö
Sbrana, Silverio
Romani, Luigina
Boraschi, Diana
Leite, Luciana C. C.
Italiani, Paola
dc.subject.other.pt_BR.fl_str_mv Imunidade
Memória
Schistosoma mansoni
Monócitos
Macrófagos
Vacinação
topic Imunidade
Memória
Schistosoma mansoni
Monócitos
Macrófagos
Vacinação
Innate immunity
Innate memory
Schistosoma mansoni
Monocytes
Macrophages
Vaccination
dc.subject.en.en.fl_str_mv Innate immunity
Innate memory
Schistosoma mansoni
Monocytes
Macrophages
Vaccination
description European Commission FP7 project HUMUNITY (GA 316383)
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-22T14:14:34Z
dc.date.available.fl_str_mv 2021-06-22T14:14:34Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARBOSA, Mayra M. Ferrari et al. Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory. Nanomaterials, v. 11, n. 4, p. 1-16, 6 Apr. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47835
dc.identifier.issn.pt_BR.fl_str_mv 2079-4991
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/nano11040931
identifier_str_mv BARBOSA, Mayra M. Ferrari et al. Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory. Nanomaterials, v. 11, n. 4, p. 1-16, 6 Apr. 2021.
2079-4991
10.3390/nano11040931
url https://www.arca.fiocruz.br/handle/icict/47835
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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