Myofibroblasts in schistosomal portal fibrosis of man.

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 1999
Outros Autores: Guerret, Sylviane Stocker, Fernandes, André L. M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5653
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Zilton de AraújoGuerret, Sylviane StockerFernandes, André L. M2012-10-05T19:03:21Z2012-10-05T19:03:21Z1999ANDRADE, Z.A.; GUERRET, S.; FERNANDES, A.L. Myofibroblasts in schistosomal portal fibrosis of man. Memórias do Instituto Oswaldo Cruz, v. 94, n.1, p. 87-93, jan.-feb. 1999.0074-0276https://www.arca.fiocruz.br/handle/icict/5653engMyofibroblasts in schistosomal portal fibrosis of man.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilLaboratoire Marcel Merieux. Lyon, FranceFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilMyofibroblasts, cells with intermediate features between smooth muscle cells and fibroblasts, have been described as an important cellular component of schistosomal portal fibrosis. The origin, distribution and fate of myofibroblasts were investigated by means of light, fluorescent, immunoenzymatic and ultrastructural techniques in wedge liver biopsies from 68 patients with the hepatosplenic form of schistosomiasis. Results demonstrated that the presence of myofibroblasts varied considerably from case to case and was always related to smooth muscle cell dispersion, which occurred around medium-sized damaged portal vein branches. By sequential observation of several cases, it was evident that myofibroblasts derived by differentiation of vascular smooth muscle and gradually tended to disappear, some of them further differentiating into fibroblasts. Thus, in schistosomal pipestem fibrosis myofibroblasts appear as transient cells, focally accumulated around damaged portal vein branches, and do not seem to have by themselves any important participation in the pathogenesis of hepatosplenic schistosomiasis.MyofibroblastSchistosomiasisPipestem fibrosisLiverFibroblastos/patologiaMúsculo Liso/patologiaVeia Porta/patologiaAdolescenteAdultoBiópsiaFemininoFibroseHumanosHepatopatias/patologiaMasculinoMeia-IdadeEsplenopatias/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade ZA Myofibroblasts in schistosomal....pdfAndrade ZA Myofibroblasts in schistosomal....pdfapplication/pdf627926https://www.arca.fiocruz.br/bitstream/icict/5653/1/Andrade%20ZA%20Myofibroblasts%20in%20schistosomal....pdf1683eee117f56bc280b4e0fbbf335266MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5653/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade ZA Myofibroblasts in schistosomal....pdf.txtAndrade ZA Myofibroblasts in schistosomal....pdf.txtExtracted texttext/plain19107https://www.arca.fiocruz.br/bitstream/icict/5653/5/Andrade%20ZA%20Myofibroblasts%20in%20schistosomal....pdf.txt6132683a34776e0b8d246fc134fefbcfMD55THUMBNAILAndrade ZA Myofibroblasts in schistosomal....pdf.jpgAndrade ZA Myofibroblasts in schistosomal....pdf.jpgGenerated Thumbnailimage/jpeg2380https://www.arca.fiocruz.br/bitstream/icict/5653/4/Andrade%20ZA%20Myofibroblasts%20in%20schistosomal....pdf.jpg7dbee5517d0cc0d7528452e4277ae99aMD54icict/56532023-03-15 14:33:13.752oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:13Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Myofibroblasts in schistosomal portal fibrosis of man.
title Myofibroblasts in schistosomal portal fibrosis of man.
spellingShingle Myofibroblasts in schistosomal portal fibrosis of man.
Andrade, Zilton de Araújo
Myofibroblast
Schistosomiasis
Pipestem fibrosis
Liver
Fibroblastos/patologia
Músculo Liso/patologia
Veia Porta/patologia
Adolescente
Adulto
Biópsia
Feminino
Fibrose
Humanos
Hepatopatias/patologia
Masculino
Meia-Idade
Esplenopatias/patologia
title_short Myofibroblasts in schistosomal portal fibrosis of man.
title_full Myofibroblasts in schistosomal portal fibrosis of man.
title_fullStr Myofibroblasts in schistosomal portal fibrosis of man.
title_full_unstemmed Myofibroblasts in schistosomal portal fibrosis of man.
title_sort Myofibroblasts in schistosomal portal fibrosis of man.
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Guerret, Sylviane Stocker
Fernandes, André L. M
author_role author
author2 Guerret, Sylviane Stocker
Fernandes, André L. M
author2_role author
author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Guerret, Sylviane Stocker
Fernandes, André L. M
dc.subject.en.pt_BR.fl_str_mv Myofibroblast
Schistosomiasis
Pipestem fibrosis
Liver
topic Myofibroblast
Schistosomiasis
Pipestem fibrosis
Liver
Fibroblastos/patologia
Músculo Liso/patologia
Veia Porta/patologia
Adolescente
Adulto
Biópsia
Feminino
Fibrose
Humanos
Hepatopatias/patologia
Masculino
Meia-Idade
Esplenopatias/patologia
dc.subject.decs.pt_BR.fl_str_mv Fibroblastos/patologia
Músculo Liso/patologia
Veia Porta/patologia
Adolescente
Adulto
Biópsia
Feminino
Fibrose
Humanos
Hepatopatias/patologia
Masculino
Meia-Idade
Esplenopatias/patologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2012-10-05T19:03:21Z
dc.date.available.fl_str_mv 2012-10-05T19:03:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Z.A.; GUERRET, S.; FERNANDES, A.L. Myofibroblasts in schistosomal portal fibrosis of man. Memórias do Instituto Oswaldo Cruz, v. 94, n.1, p. 87-93, jan.-feb. 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5653
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv ANDRADE, Z.A.; GUERRET, S.; FERNANDES, A.L. Myofibroblasts in schistosomal portal fibrosis of man. Memórias do Instituto Oswaldo Cruz, v. 94, n.1, p. 87-93, jan.-feb. 1999.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5653
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