Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients

Detalhes bibliográficos
Autor(a) principal: Bafica, Aline Michelle Barbosa
Data de Publicação: 2012
Outros Autores: Cardoso, Luciana Santos, Oliveira, Sérgio Costa, Loukas, Alex, Góes, Alfredo, Oliveira, Ricardo Riccio, Carvalho Filho, Edgar Marcelino, Araujo, Maria Ilma
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27254
Resumo: Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Bafica, Aline Michelle BarbosaCardoso, Luciana SantosOliveira, Sérgio CostaLoukas, AlexGóes, AlfredoOliveira, Ricardo RiccioCarvalho Filho, Edgar MarcelinoAraujo, Maria Ilma2018-07-03T18:39:25Z2018-07-03T18:39:25Z2012BAFICA, A. M. B. et al. Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients. Journal of Parasitology Research, Article ID 520308, 2012.2090-0023https://www.arca.fiocruz.br/handle/icict/2725410.1155/2012/520308Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Brazilian National Research Council (CNPq) and by the NIH Grant no. NIH AI 088650.Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Instituto Nacional de Ciˆencia e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilJames Cook University. School of Public Health and Tropical Medicine. Queensland Tropical Health Alliance. Cairns, AustraliaUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilHigh levels of proinflammatory cytokines such as IFN-γ and TNF are associated with tissue lesions in cutaneous leishmaniasis (CL). We previously demonstrated that Schistosoma mansoni antigens downmodulate the in vitro cytokine response in CL. In the current study we evaluated whether S. mansoni antigens alter monocyte and T-lymphocyte phenotypes in leishmaniasis. Peripheral blood mononuclear cells of CL patients were cultured with L. braziliensis antigen in the presence or absence of the S. mansoni antigens rSm29, rSmTSP-2- and PIII. Cells were stained with fluorochrome conjugated antibodies and analyzed by flow cytometry. The addition of rSm29 to the cultures decreased the expression of HLA-DR in nonclassical (CD14(+)CD16(++)) monocytes, while the addition of PIII diminished the expression of this molecule in classical (CD14(++)CD16(-)) and intermediate (CD14(++)CD16(+)) monocytes. The addition of PIII and rSmTSP-2 resulted in downmodulation of CD80 expression in nonclassical and CD86 expression in intermediate monocytes, respectively. These two antigens increased the expression of CTLA-4 in CD4(+) T cells and they also expanded the frequency of CD4(+)CD25(high)Foxp3(+) T cells. Taken together, we show that S. mansoni antigens, mainly rSmTSP-2 and PIII, are able to decrease the activation status of monocytes and also to upregulate the expression of modulatory molecules in T lymphocytes.engHindawi Publishing CorporationSchistosoma mansoniLeishmaniose TegumentarCélulas TMonócitosLeishmaniose cutâneaAntígenosSchistosoma mansoniTegumentary leishmaniasisT-CellMonocyteCutaneous leishmaniasisAntigensChanges in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27254/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBafica AMB Changes in T-Cell and Monocyte Phenotypes.pdfBafica AMB Changes in T-Cell 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dc.title.pt_BR.fl_str_mv Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients
title Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients
spellingShingle Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients
Bafica, Aline Michelle Barbosa
Schistosoma mansoni
Leishmaniose Tegumentar
Células T
Monócitos
Leishmaniose cutânea
Antígenos
Schistosoma mansoni
Tegumentary leishmaniasis
T-Cell
Monocyte
Cutaneous leishmaniasis
Antigens
title_short Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients
title_full Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients
title_fullStr Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients
title_full_unstemmed Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients
title_sort Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients
author Bafica, Aline Michelle Barbosa
author_facet Bafica, Aline Michelle Barbosa
Cardoso, Luciana Santos
Oliveira, Sérgio Costa
Loukas, Alex
Góes, Alfredo
Oliveira, Ricardo Riccio
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma
author_role author
author2 Cardoso, Luciana Santos
Oliveira, Sérgio Costa
Loukas, Alex
Góes, Alfredo
Oliveira, Ricardo Riccio
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bafica, Aline Michelle Barbosa
Cardoso, Luciana Santos
Oliveira, Sérgio Costa
Loukas, Alex
Góes, Alfredo
Oliveira, Ricardo Riccio
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma
dc.subject.other.pt_BR.fl_str_mv Schistosoma mansoni
Leishmaniose Tegumentar
Células T
Monócitos
Leishmaniose cutânea
Antígenos
topic Schistosoma mansoni
Leishmaniose Tegumentar
Células T
Monócitos
Leishmaniose cutânea
Antígenos
Schistosoma mansoni
Tegumentary leishmaniasis
T-Cell
Monocyte
Cutaneous leishmaniasis
Antigens
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Tegumentary leishmaniasis
T-Cell
Monocyte
Cutaneous leishmaniasis
Antigens
description Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2018-07-03T18:39:25Z
dc.date.available.fl_str_mv 2018-07-03T18:39:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BAFICA, A. M. B. et al. Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients. Journal of Parasitology Research, Article ID 520308, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27254
dc.identifier.issn.pt_BR.fl_str_mv 2090-0023
dc.identifier.doi.none.fl_str_mv 10.1155/2012/520308
identifier_str_mv BAFICA, A. M. B. et al. Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients. Journal of Parasitology Research, Article ID 520308, 2012.
2090-0023
10.1155/2012/520308
url https://www.arca.fiocruz.br/handle/icict/27254
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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