Human immune response to sand fly salivary gland antigens: a useful epidemiological marker?
| Main Author: | |
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| Publication Date: | 2000 |
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| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/5624 |
Summary: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Barral, Aldina Maria PradoHonda, EduardoCaldas, Arlene de Jesus MendesCosta, Jackson Mauricio LopesVinhas, VeraRowton, Edgar DValenzuela, Jesus GCharlab, RosaneBarral Netto, ManoelRibeiro, José Marcos Chaves2012-10-02T20:35:03Z2012-10-02T20:35:03Z2000BARRAL, A. et al. Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? American Journal of Tropical Medicine and Hygiene, v. 62, n. 6, p. 740-5, jun. 2000.0002-9637https://www.arca.fiocruz.br/handle/icict/5624engHuman immune response to sand fly salivary gland antigens: a useful epidemiological marker?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário. Salvador, BA, BrasilUniversidade Federal do Maranhão. São Luiz, MA, BrasilWalter Reed Army Institute of Research. Department of Entomology. Washington, District of ColumbiaNational Institutes of Allergy and Infectious Diseases. Bethesda, MarylandFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAntibody (IgG) responses to salivary gland homogenate and to a recombinant salivary protein from the sand fly Lutzomyia longipalpis were investigated using sera from children living in an endemic area of visceral leishmaniasis in Brazil. We classified children into four groups according to their responses to Leishmania antigen: (Group I) positive serology and positive delayed type hypersensitivity (DTH), (Group II) positive serology and negative DTH, (Group III) negative serology and positive DTH, and (Group IV) negative serology and negative DTH. A highly significant correlation was found between anti-salivary gland IgG levels and DTH responses. An L. longipalpis salivary recombinant protein used as an antigen in an enzyme-linked immuno sorbent assay (ELISA) gave a significant but different result. A positive correlation was found between anti-Leishmania IgG and anti-recombinant protein IgG titers. The results indicate that sand fly salivary proteins may be of relevance to the study the epidemiology of leishmaniasis.Anticorpos/sangueAntígenos/imunologiaLeishmaniose Visceral/epidemiologiaPsychodidae/imunologiaProteínas e Peptídeos Salivares/imunologiaAnimaisAnticorpos/imunologiaWestern BlottingCriançaEnsaio de Imunoadsorção Enzimática/métodosHumanosHipersensibilidade TardiaImunoglobulina G/sangueImunoglobulina G/imunologiaLeishmaniose Visceral/imunologiaProteínas de Protozoários/imunologiaProteínas Recombinantes/imunologiaGlândulas Salivares/imunologiaProteínas e Peptídeos Salivares/genéticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarral A Human immune response ....pdfBarral A Human immune response ....pdfapplication/pdf73439https://www.arca.fiocruz.br/bitstream/icict/5624/1/Barral%20A%20Human%20immune%20response%20....pdf5354b8fbac841b0e77b6db52195eea1bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5624/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTBarral A Human immune response ....pdf.txtBarral A Human immune response ....pdf.txtExtracted texttext/plain34228https://www.arca.fiocruz.br/bitstream/icict/5624/5/Barral%20A%20Human%20immune%20response%20....pdf.txta0d1f7dc78e7192ac6b17e68ed659792MD55THUMBNAILBarral A Human immune response ....pdf.jpgBarral A Human immune response ....pdf.jpgGenerated Thumbnailimage/jpeg1873https://www.arca.fiocruz.br/bitstream/icict/5624/4/Barral%20A%20Human%20immune%20response%20....pdf.jpg89c4f36f2c3adcfbd9446c70f0bc88d4MD54icict/56242023-03-15 14:33:10.255oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? |
| title |
Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? |
| spellingShingle |
Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? Barral, Aldina Maria Prado Anticorpos/sangue Antígenos/imunologia Leishmaniose Visceral/epidemiologia Psychodidae/imunologia Proteínas e Peptídeos Salivares/imunologia Animais Anticorpos/imunologia Western Blotting Criança Ensaio de Imunoadsorção Enzimática/métodos Humanos Hipersensibilidade Tardia Imunoglobulina G/sangue Imunoglobulina G/imunologia Leishmaniose Visceral/imunologia Proteínas de Protozoários/imunologia Proteínas Recombinantes/imunologia Glândulas Salivares/imunologia Proteínas e Peptídeos Salivares/genética |
| title_short |
Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? |
| title_full |
Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? |
| title_fullStr |
Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? |
| title_full_unstemmed |
Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? |
| title_sort |
Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? |
| author |
Barral, Aldina Maria Prado |
| author_facet |
Barral, Aldina Maria Prado Honda, Eduardo Caldas, Arlene de Jesus Mendes Costa, Jackson Mauricio Lopes Vinhas, Vera Rowton, Edgar D Valenzuela, Jesus G Charlab, Rosane Barral Netto, Manoel Ribeiro, José Marcos Chaves |
| author_role |
author |
| author2 |
Honda, Eduardo Caldas, Arlene de Jesus Mendes Costa, Jackson Mauricio Lopes Vinhas, Vera Rowton, Edgar D Valenzuela, Jesus G Charlab, Rosane Barral Netto, Manoel Ribeiro, José Marcos Chaves |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barral, Aldina Maria Prado Honda, Eduardo Caldas, Arlene de Jesus Mendes Costa, Jackson Mauricio Lopes Vinhas, Vera Rowton, Edgar D Valenzuela, Jesus G Charlab, Rosane Barral Netto, Manoel Ribeiro, José Marcos Chaves |
| dc.subject.decs.pt_BR.fl_str_mv |
Anticorpos/sangue Antígenos/imunologia Leishmaniose Visceral/epidemiologia Psychodidae/imunologia Proteínas e Peptídeos Salivares/imunologia Animais Anticorpos/imunologia Western Blotting Criança Ensaio de Imunoadsorção Enzimática/métodos Humanos Hipersensibilidade Tardia Imunoglobulina G/sangue Imunoglobulina G/imunologia Leishmaniose Visceral/imunologia Proteínas de Protozoários/imunologia Proteínas Recombinantes/imunologia Glândulas Salivares/imunologia Proteínas e Peptídeos Salivares/genética |
| topic |
Anticorpos/sangue Antígenos/imunologia Leishmaniose Visceral/epidemiologia Psychodidae/imunologia Proteínas e Peptídeos Salivares/imunologia Animais Anticorpos/imunologia Western Blotting Criança Ensaio de Imunoadsorção Enzimática/métodos Humanos Hipersensibilidade Tardia Imunoglobulina G/sangue Imunoglobulina G/imunologia Leishmaniose Visceral/imunologia Proteínas de Protozoários/imunologia Proteínas Recombinantes/imunologia Glândulas Salivares/imunologia Proteínas e Peptídeos Salivares/genética |
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Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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2000 |
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2000 |
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2012-10-02T20:35:03Z |
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2012-10-02T20:35:03Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
BARRAL, A. et al. Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? American Journal of Tropical Medicine and Hygiene, v. 62, n. 6, p. 740-5, jun. 2000. |
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https://www.arca.fiocruz.br/handle/icict/5624 |
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0002-9637 |
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BARRAL, A. et al. Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? American Journal of Tropical Medicine and Hygiene, v. 62, n. 6, p. 740-5, jun. 2000. 0002-9637 |
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