Role of fat-storing cells in schistosomal hepatic fibrosis of mice
Autor(a) principal: | |
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Data de Publicação: | 1993 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26816 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Barbosa Junior, Aryon de AlmeidaPfeifer, UlrichAndrade, Zilton de Araújo2018-06-12T12:27:55Z2018-06-12T12:27:55Z1993BARBOSA JUNIOR, A. A.; PFEIFER, U.; ANDRADE, Z. A. Role of fat-storing cells in schistosomal hepatic fibrosis of mice. Virchows Archiv B Cell Pathology, v. 64, p. 91-96, 1993.0340-6075https://www.arca.fiocruz.br/handle/icict/26816engSpringer VerlagCélulas armazenadoras de gorduraSchistosoma mansoniFibrose hepáticaHipervitaminose AGranulomas esquistossomóticosFat-storing cellsSchistosoma mansoni-Liver fibrosisHypervitaminosis ASchistosomal granulomasRole of fat-storing cells in schistosomal hepatic fibrosis of miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Bonn. Department of Pathology. GermanyFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe involvement of fat-storing cells (FSC) in hepatic schistosomal granuloma was investigated in mice infected with Schistosoma mansoni cercariae. After infection, 24 animals were treated with s.c. injections of vitamin A in a total dose of 210,000 IU given twice a week for 3 weeks. Two other groups of 24 animals each were: a) non-infected vitamin A-treated animals and (b) untreated infected controls. Animals from all groups were killed at weekly intervals from the 5th through the 10th week following infection. Pieces of liver were examined by light microscopy and transmission electron microscopy. In all vitamin A-treated animals, FSC disclosed prominent cytoplasmic fat droplets, which permitted their prompt identification in the light and in the electron microscope. They were found in large numbers as a constituent of periovular granulomas. In infected controls, FSC were not identified in granulomas, possibly because lipid droplets disappeared during differentiation to the fibroblastic phenotype. FSC also appeared within areas of septal fibrosis. These data suggest that FSC play an important part in focal portohepatic fibrosis during granuloma formation around S. mansoni eggs in the liver of mice.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26816/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBarbosa JA Role of fat-storing cells in schistosomal....pdfBarbosa JA Role of fat-storing cells in schistosomal....pdfapplication/pdf2315360https://www.arca.fiocruz.br/bitstream/icict/26816/2/Barbosa%20JA%20Role%20of%20fat-storing%20cells%20in%20schistosomal....pdf857f71d921900b490a9f9fc807bf2bd2MD52TEXTBarbosa JA Role of fat-storing cells in schistosomal....pdf.txtBarbosa JA Role of fat-storing cells in schistosomal....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Role of fat-storing cells in schistosomal hepatic fibrosis of mice |
title |
Role of fat-storing cells in schistosomal hepatic fibrosis of mice |
spellingShingle |
Role of fat-storing cells in schistosomal hepatic fibrosis of mice Barbosa Junior, Aryon de Almeida Células armazenadoras de gordura Schistosoma mansoni Fibrose hepática Hipervitaminose A Granulomas esquistossomóticos Fat-storing cells Schistosoma mansoni- Liver fibrosis Hypervitaminosis A Schistosomal granulomas |
title_short |
Role of fat-storing cells in schistosomal hepatic fibrosis of mice |
title_full |
Role of fat-storing cells in schistosomal hepatic fibrosis of mice |
title_fullStr |
Role of fat-storing cells in schistosomal hepatic fibrosis of mice |
title_full_unstemmed |
Role of fat-storing cells in schistosomal hepatic fibrosis of mice |
title_sort |
Role of fat-storing cells in schistosomal hepatic fibrosis of mice |
author |
Barbosa Junior, Aryon de Almeida |
author_facet |
Barbosa Junior, Aryon de Almeida Pfeifer, Ulrich Andrade, Zilton de Araújo |
author_role |
author |
author2 |
Pfeifer, Ulrich Andrade, Zilton de Araújo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Barbosa Junior, Aryon de Almeida Pfeifer, Ulrich Andrade, Zilton de Araújo |
dc.subject.other.pt_BR.fl_str_mv |
Células armazenadoras de gordura Schistosoma mansoni Fibrose hepática Hipervitaminose A Granulomas esquistossomóticos |
topic |
Células armazenadoras de gordura Schistosoma mansoni Fibrose hepática Hipervitaminose A Granulomas esquistossomóticos Fat-storing cells Schistosoma mansoni- Liver fibrosis Hypervitaminosis A Schistosomal granulomas |
dc.subject.en.pt_BR.fl_str_mv |
Fat-storing cells Schistosoma mansoni- Liver fibrosis Hypervitaminosis A Schistosomal granulomas |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
publishDate |
1993 |
dc.date.issued.fl_str_mv |
1993 |
dc.date.accessioned.fl_str_mv |
2018-06-12T12:27:55Z |
dc.date.available.fl_str_mv |
2018-06-12T12:27:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BARBOSA JUNIOR, A. A.; PFEIFER, U.; ANDRADE, Z. A. Role of fat-storing cells in schistosomal hepatic fibrosis of mice. Virchows Archiv B Cell Pathology, v. 64, p. 91-96, 1993. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/26816 |
dc.identifier.issn.pt_BR.fl_str_mv |
0340-6075 |
identifier_str_mv |
BARBOSA JUNIOR, A. A.; PFEIFER, U.; ANDRADE, Z. A. Role of fat-storing cells in schistosomal hepatic fibrosis of mice. Virchows Archiv B Cell Pathology, v. 64, p. 91-96, 1993. 0340-6075 |
url |
https://www.arca.fiocruz.br/handle/icict/26816 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Verlag |
publisher.none.fl_str_mv |
Springer Verlag |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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