Role of fat-storing cells in schistosomal hepatic fibrosis of mice

Detalhes bibliográficos
Autor(a) principal: Barbosa Junior, Aryon de Almeida
Data de Publicação: 1993
Outros Autores: Pfeifer, Ulrich, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26816
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Barbosa Junior, Aryon de AlmeidaPfeifer, UlrichAndrade, Zilton de Araújo2018-06-12T12:27:55Z2018-06-12T12:27:55Z1993BARBOSA JUNIOR, A. A.; PFEIFER, U.; ANDRADE, Z. A. Role of fat-storing cells in schistosomal hepatic fibrosis of mice. Virchows Archiv B Cell Pathology, v. 64, p. 91-96, 1993.0340-6075https://www.arca.fiocruz.br/handle/icict/26816engSpringer VerlagCélulas armazenadoras de gorduraSchistosoma mansoniFibrose hepáticaHipervitaminose AGranulomas esquistossomóticosFat-storing cellsSchistosoma mansoni-Liver fibrosisHypervitaminosis ASchistosomal granulomasRole of fat-storing cells in schistosomal hepatic fibrosis of miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Bonn. Department of Pathology. GermanyFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe involvement of fat-storing cells (FSC) in hepatic schistosomal granuloma was investigated in mice infected with Schistosoma mansoni cercariae. After infection, 24 animals were treated with s.c. injections of vitamin A in a total dose of 210,000 IU given twice a week for 3 weeks. Two other groups of 24 animals each were: a) non-infected vitamin A-treated animals and (b) untreated infected controls. Animals from all groups were killed at weekly intervals from the 5th through the 10th week following infection. Pieces of liver were examined by light microscopy and transmission electron microscopy. In all vitamin A-treated animals, FSC disclosed prominent cytoplasmic fat droplets, which permitted their prompt identification in the light and in the electron microscope. They were found in large numbers as a constituent of periovular granulomas. In infected controls, FSC were not identified in granulomas, possibly because lipid droplets disappeared during differentiation to the fibroblastic phenotype. FSC also appeared within areas of septal fibrosis. These data suggest that FSC play an important part in focal portohepatic fibrosis during granuloma formation around S. mansoni eggs in the liver of mice.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26816/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBarbosa JA Role of fat-storing cells in schistosomal....pdfBarbosa JA Role of fat-storing cells in schistosomal....pdfapplication/pdf2315360https://www.arca.fiocruz.br/bitstream/icict/26816/2/Barbosa%20JA%20Role%20of%20fat-storing%20cells%20in%20schistosomal....pdf857f71d921900b490a9f9fc807bf2bd2MD52TEXTBarbosa JA Role of fat-storing cells in schistosomal....pdf.txtBarbosa JA Role of fat-storing cells in schistosomal....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Role of fat-storing cells in schistosomal hepatic fibrosis of mice
title Role of fat-storing cells in schistosomal hepatic fibrosis of mice
spellingShingle Role of fat-storing cells in schistosomal hepatic fibrosis of mice
Barbosa Junior, Aryon de Almeida
Células armazenadoras de gordura
Schistosoma mansoni
Fibrose hepática
Hipervitaminose A
Granulomas esquistossomóticos
Fat-storing cells
Schistosoma mansoni-
Liver fibrosis
Hypervitaminosis A
Schistosomal granulomas
title_short Role of fat-storing cells in schistosomal hepatic fibrosis of mice
title_full Role of fat-storing cells in schistosomal hepatic fibrosis of mice
title_fullStr Role of fat-storing cells in schistosomal hepatic fibrosis of mice
title_full_unstemmed Role of fat-storing cells in schistosomal hepatic fibrosis of mice
title_sort Role of fat-storing cells in schistosomal hepatic fibrosis of mice
author Barbosa Junior, Aryon de Almeida
author_facet Barbosa Junior, Aryon de Almeida
Pfeifer, Ulrich
Andrade, Zilton de Araújo
author_role author
author2 Pfeifer, Ulrich
Andrade, Zilton de Araújo
author2_role author
author
dc.contributor.author.fl_str_mv Barbosa Junior, Aryon de Almeida
Pfeifer, Ulrich
Andrade, Zilton de Araújo
dc.subject.other.pt_BR.fl_str_mv Células armazenadoras de gordura
Schistosoma mansoni
Fibrose hepática
Hipervitaminose A
Granulomas esquistossomóticos
topic Células armazenadoras de gordura
Schistosoma mansoni
Fibrose hepática
Hipervitaminose A
Granulomas esquistossomóticos
Fat-storing cells
Schistosoma mansoni-
Liver fibrosis
Hypervitaminosis A
Schistosomal granulomas
dc.subject.en.pt_BR.fl_str_mv Fat-storing cells
Schistosoma mansoni-
Liver fibrosis
Hypervitaminosis A
Schistosomal granulomas
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1993
dc.date.issued.fl_str_mv 1993
dc.date.accessioned.fl_str_mv 2018-06-12T12:27:55Z
dc.date.available.fl_str_mv 2018-06-12T12:27:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARBOSA JUNIOR, A. A.; PFEIFER, U.; ANDRADE, Z. A. Role of fat-storing cells in schistosomal hepatic fibrosis of mice. Virchows Archiv B Cell Pathology, v. 64, p. 91-96, 1993.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26816
dc.identifier.issn.pt_BR.fl_str_mv 0340-6075
identifier_str_mv BARBOSA JUNIOR, A. A.; PFEIFER, U.; ANDRADE, Z. A. Role of fat-storing cells in schistosomal hepatic fibrosis of mice. Virchows Archiv B Cell Pathology, v. 64, p. 91-96, 1993.
0340-6075
url https://www.arca.fiocruz.br/handle/icict/26816
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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