T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26380 |
Resumo: | Barral Netto, Manoel. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Pompeu, MargaridaFreitas, A. LReis, G. A. dosBarral Netto, Manoel2018-05-10T14:25:32Z2018-05-10T14:25:32Z1992POMPEU, M. et al. T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice. Parasitology Research, v. 78, p. 16-22, 1992.0932-0113https://www.arca.fiocruz.br/handle/icict/26380Barral Netto, Manoel. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.US-PHS (grant AI 16-282-11), the Brazilian National Research Council (CNPq) and the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, BrasilUniversidade Feederal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, BrasilAbstract. Highly susceptible naive BALB/c mice or mice that had previously been immunized i.v. with solubilized homologous antigen (partially resistant) were infected with Leishmania amazonensis. Histologically, the main differences between the two groups were lymphocytic infiltration and macrophage activation. Assays of T-cell function at 3 and 10 weeks after infection revealed that purified T-cells did not proliferate following treatment with leishmania antigen. A mitogenic anti-CD3 monoclonal antibody (mAb) failed to activate T-cells after 3 weeks of infection as judged by proliferation and IL-2 secretion assays. After 10 weeks of infection, anti-CD3 mAb fully activated T-cells to proliferation and IL-2 secretion. On the other hand, T-cells released IL-3 in response to leishmania antigen, anti-CD3 mAb and anti- Thyl mAb at 3 and 10 weeks post-infection. Surprisingly, a mitogenic anti-Thy 1 mAb (G7) fully activated Tcells even at 3 weeks of infection as judged by proliferative and IL-2 secretion assays. No significant differences were found in the proliferative or interleukin secretory responses of T-cells from animals that had been infected in either the presence or the absence of prior immunization. Since the Thyl triggering pathway has different accessory cell and cytokine requirements than does the CD3 : TCR lymphocyte activation pathway, it is possible that immunization was more effective in changing the cellular interactions of the T-lymphocyte than in altering its intrinsic capabilities.engSpringer VerlagLeishmania amazonensisLinfócitos TInfecçãoAnimaisCamundongosLeishmania amazonensisT-lymphocytesInfectionAnimalsMiceT-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26380/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPompeu ML T-lymphocytes in experimental Leishmania amazonensis.pdfPompeu ML 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dc.title.pt_BR.fl_str_mv |
T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice |
title |
T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice |
spellingShingle |
T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice Pompeu, Margarida Leishmania amazonensis Linfócitos T Infecção Animais Camundongos Leishmania amazonensis T-lymphocytes Infection Animals Mice |
title_short |
T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice |
title_full |
T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice |
title_fullStr |
T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice |
title_full_unstemmed |
T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice |
title_sort |
T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice |
author |
Pompeu, Margarida |
author_facet |
Pompeu, Margarida Freitas, A. L Reis, G. A. dos Barral Netto, Manoel |
author_role |
author |
author2 |
Freitas, A. L Reis, G. A. dos Barral Netto, Manoel |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Pompeu, Margarida Freitas, A. L Reis, G. A. dos Barral Netto, Manoel |
dc.subject.other.pt_BR.fl_str_mv |
Leishmania amazonensis Linfócitos T Infecção Animais Camundongos |
topic |
Leishmania amazonensis Linfócitos T Infecção Animais Camundongos Leishmania amazonensis T-lymphocytes Infection Animals Mice |
dc.subject.en.pt_BR.fl_str_mv |
Leishmania amazonensis T-lymphocytes Infection Animals Mice |
description |
Barral Netto, Manoel. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
publishDate |
1992 |
dc.date.issued.fl_str_mv |
1992 |
dc.date.accessioned.fl_str_mv |
2018-05-10T14:25:32Z |
dc.date.available.fl_str_mv |
2018-05-10T14:25:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
POMPEU, M. et al. T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice. Parasitology Research, v. 78, p. 16-22, 1992. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/26380 |
dc.identifier.issn.pt_BR.fl_str_mv |
0932-0113 |
identifier_str_mv |
POMPEU, M. et al. T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice. Parasitology Research, v. 78, p. 16-22, 1992. 0932-0113 |
url |
https://www.arca.fiocruz.br/handle/icict/26380 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Springer Verlag |
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Springer Verlag |
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Repositório Institucional da FIOCRUZ (ARCA) |
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