Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.

Detalhes bibliográficos
Autor(a) principal: Souza, Valderes Lemos de
Data de Publicação: 2000
Outros Autores: Souza, Juliana Ascenção, Silva, Tânia Maria Correia, Veras, Patrícia Sampaio Tavares, Freitas, Luiz Antonio Rodrigues de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5627
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Souza, Valderes Lemos deSouza, Juliana AscençãoSilva, Tânia Maria CorreiaVeras, Patrícia Sampaio TavaresFreitas, Luiz Antonio Rodrigues de2012-10-02T21:28:31Z2012-10-02T21:28:31Z2000LEMOS de SOUZA, V. et al. Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice. Microbes and Infection, v. 2, n. 15, p. 1807-15, dec. 2000.1286-4579https://www.arca.fiocruz.br/handle/icict/5627engDifferent Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilMost experimental studies on leishmaniasis compare two different inbred strains of mice that are resistant or susceptible to one species of Leishmania. In the present study we characterized some cytokines and nitric oxide production as well as histological changes related to resistance and susceptibility in isogenic CBA mice infected with Leishmania major or Leishmania amazonensis. CBA mice are capable of controlling infection with L. major, but they succumb to infection with L. amazonensis. Cells from susceptible L. amazonensis-infected CBA mice produced interleukin (IL)-4 and IL-10 but no interferon (IFN)-γ. On the other hand, resistant L. major-infected CBA mice produced IFN-γ and IL-10, but IL-4 was detected only in the first week of infection. Histopathological studies showed patterns of tissue responses at the site of the infection and in the draining lymph nodes that correlated with resistance or susceptibility. Resistant mice showed a mixed inflammatory cell infiltration and granulomas in the lesions, whereas in susceptible mice only heavily parasitized macrophages were seen. Our results indicate an important role of the parasite species in determining the pattern of immune response. L. amazonensis induces a Th2-type immune response, whereas L. major induces a Th1-type response. These factors must be identified and taken into account in the strategies for the development of vaccines against leishmaniasis. The model presented here will be useful for the study of such factors.CBALeishmaniasisHistopathologyImmunologyLeishmania amazonensisLeishmania majorLeishmania major/patogenicidadeLeishmania/patogenicidadeLeishmaniose Cutânea/imunologiaLeishmaniose Cutânea/patologiaAnimaisCélulas CultivadasCitocinas/biossínteseLeishmaniose Cutânea/parasitologiaLinfonodos/citologiaLinfonodos/imunologiaCamundongosCamundongos Endogâmicos BALB CCamundongos Endogâmicos CBAÓxido Nítrico/biossíntesePele/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLemos de Souza V Different Leishmania species ....pdfLemos de Souza V Different Leishmania species ....pdfapplication/pdf1728919https://www.arca.fiocruz.br/bitstream/icict/5627/1/Lemos%20de%20Souza%20V%20Different%20Leishmania%20species%20....pdfa7cec6a643500fdd07847eb76799775bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5627/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTLemos de Souza V Different Leishmania species ....pdf.txtLemos de Souza V Different Leishmania species ....pdf.txtExtracted texttext/plain37883https://www.arca.fiocruz.br/bitstream/icict/5627/5/Lemos%20de%20Souza%20V%20Different%20Leishmania%20species%20....pdf.txt40e48b2629097f0547a53b6238fefd8dMD55THUMBNAILLemos de Souza V Different Leishmania species ....pdf.jpgLemos de Souza V Different Leishmania species ....pdf.jpgGenerated Thumbnailimage/jpeg2033https://www.arca.fiocruz.br/bitstream/icict/5627/4/Lemos%20de%20Souza%20V%20Different%20Leishmania%20species%20....pdf.jpg51a0dd512213f0fb337d7e489d3d234dMD54icict/56272023-03-15 14:33:14.52oai:www.arca.fiocruz.br:icict/5627TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGFzc2luYXIgZSBlbnRyZWdhciBlc3RhIGxpY2Vuw6dhLCBvL2EgU3IuL1NyYS4gKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBkbyBhdXRvcik6CgpBbyBjb25jb3JkYXIgZSBhY2VpdGFyIGVzdGEgbGljZW7Dp2Egdm9jw6ogKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyk6CgphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8uCgpiKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGUgYWNlaXRhIGFzIERpcmV0cml6ZXMgcGFyYSBvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIEZ1bmRhw6fDo28gT3N3YWxkbyBDcnV6IChGSU9DUlVaKS4KCmMpIENvbmNlZGUgw6AgRklPQ1JVWiBvIGRpcmVpdG8gbsOjby1leGNsdXNpdm8gZGUgYXJxdWl2YXIsIHJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhIHNlZ3VpciksIGNvbXVuaWNhcgogCmUvb3UgZGlzdHJpYnVpciBubyBSZXBvc2l0w7NyaW8gZGEgRklPQ1JVWiwgbyBkb2N1bWVudG8gZW50cmVndWUgKGluY2x1aW5kbyBvIHJlc3Vtby9hYnN0cmFjdCkgZW0gZm9ybWF0byBkaWdpdGFsIG91IAoKcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uCgpkKSBEZWNsYXJhIHF1ZSBhdXRvcml6YSBhIEZJT0NSVVogYSBhcnF1aXZhciBtYWlzIGRlIHVtYSBjw7NwaWEgZGVzdGUgZG9jdW1lbnRvIGUgY29udmVydMOqLWxvLCBzZW0gYWx0ZXJhciBvIHNldSBjb250ZcO6ZG8sIAoKcGFyYSBxdWFscXVlciBmb3JtYXRvIGRlIGFycXVpdm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uCgplKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBzdWJtZXRpZG8gw6kgbyBzZXUgdHJhYmFsaG8gb3JpZ2luYWwsIGUgcXVlIGRldMOpbSBvIGRpcmVpdG8gZGUgY29uY2VkZXIgYSB0ZXJjZWlyb3Mgb3MgZGlyZWl0b3MgCgpjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2Ugb3MgZGlyZWl0b3MgZGUgcXVhbHF1ZXIgb3V0cmEgcGVzc29hIG91IGVudGlkYWRlLgoKZikgRGVjbGFyYSBxdWUsIG5vIGNhc28gZG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyBjb250ZXIgbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgb2J0ZXZlIGEgYXV0b3JpemHDp8OjbyAKCmlycmVzdHJpdGEgZG8gcmVzcGVjdGl2byBkZXRlbnRvciBkZXNzZXMgZGlyZWl0b3MsIHBhcmEgY2VkZXIgYSBGSU9DUlVaIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgTGljZW7Dp2EgZSBhdXRvcml6YXIgYSAKCnV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyAKCm5vIHRleHRvIG91IGNvbnRlw7pkbyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpnKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSDDiSBCQVNFQURPIEVNIFRSQUJBTEhPIEZJTkFOQ0lBRE8gT1UgQVBPSUFETyBQT1IgT1VUUkEgSU5TVElUVUnDh8ODTyBRVUUgTsODTyBBIEZJT0NSVVosIERFQ0xBUkEgUVVFIENVTVBSSVUgCgpRVUFJU1FVRVIgT0JSSUdBw4fDlUVTIEVYSUdJREFTIFBFTE8gUkVTUEVDVElWTyBDT05UUkFUTyBPVSBBQ09SRE8uIEEgRklPQ1JVWiBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgCgpkaXJlaXRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUgZSBuw6NvIGZhcsOhIHF1YWxxdWVyIGFsdGVyYcOnw6NvLCBwYXJhIGFsw6ltIGRvIHByZXZpc3RvIG5hIGFsw61uZWEgYykuCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.
title Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.
spellingShingle Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.
Souza, Valderes Lemos de
CBA
Leishmaniasis
Histopathology
Immunology
Leishmania amazonensis
Leishmania major
Leishmania major/patogenicidade
Leishmania/patogenicidade
Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/patologia
Animais
Células Cultivadas
Citocinas/biossíntese
Leishmaniose Cutânea/parasitologia
Linfonodos/citologia
Linfonodos/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos CBA
Óxido Nítrico/biossíntese
Pele/patologia
title_short Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.
title_full Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.
title_fullStr Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.
title_full_unstemmed Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.
title_sort Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.
author Souza, Valderes Lemos de
author_facet Souza, Valderes Lemos de
Souza, Juliana Ascenção
Silva, Tânia Maria Correia
Veras, Patrícia Sampaio Tavares
Freitas, Luiz Antonio Rodrigues de
author_role author
author2 Souza, Juliana Ascenção
Silva, Tânia Maria Correia
Veras, Patrícia Sampaio Tavares
Freitas, Luiz Antonio Rodrigues de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Souza, Valderes Lemos de
Souza, Juliana Ascenção
Silva, Tânia Maria Correia
Veras, Patrícia Sampaio Tavares
Freitas, Luiz Antonio Rodrigues de
dc.subject.en.pt_BR.fl_str_mv CBA
Leishmaniasis
Histopathology
Immunology
Leishmania amazonensis
Leishmania major
topic CBA
Leishmaniasis
Histopathology
Immunology
Leishmania amazonensis
Leishmania major
Leishmania major/patogenicidade
Leishmania/patogenicidade
Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/patologia
Animais
Células Cultivadas
Citocinas/biossíntese
Leishmaniose Cutânea/parasitologia
Linfonodos/citologia
Linfonodos/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos CBA
Óxido Nítrico/biossíntese
Pele/patologia
dc.subject.decs.pt_BR.fl_str_mv Leishmania major/patogenicidade
Leishmania/patogenicidade
Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/patologia
Animais
Células Cultivadas
Citocinas/biossíntese
Leishmaniose Cutânea/parasitologia
Linfonodos/citologia
Linfonodos/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos CBA
Óxido Nítrico/biossíntese
Pele/patologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2012-10-02T21:28:31Z
dc.date.available.fl_str_mv 2012-10-02T21:28:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEMOS de SOUZA, V. et al. Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice. Microbes and Infection, v. 2, n. 15, p. 1807-15, dec. 2000.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5627
dc.identifier.issn.none.fl_str_mv 1286-4579
identifier_str_mv LEMOS de SOUZA, V. et al. Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice. Microbes and Infection, v. 2, n. 15, p. 1807-15, dec. 2000.
1286-4579
url https://www.arca.fiocruz.br/handle/icict/5627
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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