Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30640 |
Resumo: | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil. |
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Yahouédéhou, Sètondji Cocou Modeste AlexandreAdorno, Elisângela VitóriaGuarda, Caroline Conceição daNdidi, Uche SamuelCarvalho, Suellen PinheiroSantiago, Rayra PereiraAleluia, Milena MagalhãesOliveira, Rodrigo Mota deGonçalves, Marilda de Souza2018-12-17T17:49:24Z2018-12-17T17:49:24Z2018YAHOUÉDÉHOU, S. C. M. A. et al. Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism. Pharmacogenomics Journal, sep. 2018.1470-269Xhttps://www.arca.fiocruz.br/handle/icict/3064010.1038/s41397-018-0045-1engSpringer NatureDoença falciformeHidroxiureiaFatores socioeconômicosTratamentoMetabolismoAnemia, Sickle CellHydroxyureaSocioeconomic FactorsTherapyMetabolismHydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Hydroxyurea (HU) was approved to be used in the treatment of sickle cell disease (SCD) because of its anti-sickling potential. However, there is variability in HU response among SCD patients and this can be due to physiological, socioeconomic, environmental, metabolic and/or genetic factors. The present review focuses on the latter two. Three quantitative trait loci, HBG2, BCL11A and HMIP, have been suggested as important markers for HU response. Other genes (ASS1, KLF10, HAO2, MAP3K5, PDE7B, TOX, NOS1, NOS2A, FLT1, ARG1, ARG2, UGT1A1, OR51B5/6, SIN3A, SALL2, SAR1A, UTB, OCTN1, CYP2C9, AQP9, MPO, CYP2E1, and GSTT1) have also been considered. Studies implicate catalase, urease, horseradish peroxidase and enzymes of CYP450 family in HU metabolism. However, little is known about these enzymes. Therefore, further studies are needed to elucidate the metabolic pathway of HU, which will facilitate pharmacogenomic studies and help in identification of candidate genes for predicting HU response.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30640/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALYahouedehou SCMA Hydroxyurea in the....pdfYahouedehou SCMA Hydroxyurea in the....pdfapplication/pdf590783https://www.arca.fiocruz.br/bitstream/icict/30640/2/Yahouedehou%20SCMA%20Hydroxyurea%20in%20the....pdfbbd5c090cc7d875c0687cd3b8a0c0e4cMD52TEXTYahouedehou SCMA Hydroxyurea in the....pdf.txtYahouedehou SCMA Hydroxyurea in the....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism |
title |
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism |
spellingShingle |
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism Yahouédéhou, Sètondji Cocou Modeste Alexandre Doença falciforme Hidroxiureia Fatores socioeconômicos Tratamento Metabolismo Anemia, Sickle Cell Hydroxyurea Socioeconomic Factors Therapy Metabolism |
title_short |
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism |
title_full |
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism |
title_fullStr |
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism |
title_full_unstemmed |
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism |
title_sort |
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism |
author |
Yahouédéhou, Sètondji Cocou Modeste Alexandre |
author_facet |
Yahouédéhou, Sètondji Cocou Modeste Alexandre Adorno, Elisângela Vitória Guarda, Caroline Conceição da Ndidi, Uche Samuel Carvalho, Suellen Pinheiro Santiago, Rayra Pereira Aleluia, Milena Magalhães Oliveira, Rodrigo Mota de Gonçalves, Marilda de Souza |
author_role |
author |
author2 |
Adorno, Elisângela Vitória Guarda, Caroline Conceição da Ndidi, Uche Samuel Carvalho, Suellen Pinheiro Santiago, Rayra Pereira Aleluia, Milena Magalhães Oliveira, Rodrigo Mota de Gonçalves, Marilda de Souza |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Yahouédéhou, Sètondji Cocou Modeste Alexandre Adorno, Elisângela Vitória Guarda, Caroline Conceição da Ndidi, Uche Samuel Carvalho, Suellen Pinheiro Santiago, Rayra Pereira Aleluia, Milena Magalhães Oliveira, Rodrigo Mota de Gonçalves, Marilda de Souza |
dc.subject.other.pt_BR.fl_str_mv |
Doença falciforme Hidroxiureia Fatores socioeconômicos Tratamento Metabolismo |
topic |
Doença falciforme Hidroxiureia Fatores socioeconômicos Tratamento Metabolismo Anemia, Sickle Cell Hydroxyurea Socioeconomic Factors Therapy Metabolism |
dc.subject.en.pt_BR.fl_str_mv |
Anemia, Sickle Cell Hydroxyurea Socioeconomic Factors Therapy Metabolism |
description |
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-12-17T17:49:24Z |
dc.date.available.fl_str_mv |
2018-12-17T17:49:24Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
YAHOUÉDÉHOU, S. C. M. A. et al. Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism. Pharmacogenomics Journal, sep. 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/30640 |
dc.identifier.issn.pt_BR.fl_str_mv |
1470-269X |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41397-018-0045-1 |
identifier_str_mv |
YAHOUÉDÉHOU, S. C. M. A. et al. Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism. Pharmacogenomics Journal, sep. 2018. 1470-269X 10.1038/s41397-018-0045-1 |
url |
https://www.arca.fiocruz.br/handle/icict/30640 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
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