Regeneration of critical bone defects with anionic collagen matrix as scaffolds.
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7796 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil |
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Miguel, Fúlvio BorgesBarbosa Junior, Aryon de AlmeidaPaula, Fabiana Lopes deBarreto, Isabela CerqueiraGoissis, GilbertoRosa, Fabiana Paim2014-06-04T19:41:27Z2014-06-04T19:41:27Z2013MIGUEL, F. B. et al. Regeneration of critical bone defects with anionic collagen matrix as scaffolds. Journal of Materials Science: Materials in Medicine, v. 24, n. 11, p. 2567-275, 2013.1573-4838https://www.arca.fiocruz.br/handle/icict/779610.1007/s10856-013-4980-8engSpringer VerlagRegeneration of critical bone defects with anionic collagen matrix as scaffolds.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHealth Sciences Center of Federal University of the Recôncavo of Bahia. Santo Antônio de Jesus, BA, BrasilHealth Sciences Institute of Federal University of Bahia. Salvador, BA, BrasilBiotech Biomédica. São Carlos, SP, BrasilHealth Sciences Institute of Federal University of Bahia. Salvador, BA, BrasilThe aim of this study was to make a histomorphometric evaluation of the osteogenic potential of anionic collagen matrix as scaffolds; either crosslinked in glutaraldehyde or not cross-linked and, implanted in critical bone defects in rat calvaria. Seventy-two rats were randomly distributed in three groups: anionic collagen scaffolds treated for 24 h of selective hydrolysis (ACSH); anionic collagen scaffolds treated for 24 h of selective hydrolysis and 5 min of crosslinking in glutaraldehyde 0.05% (ACSHGA); empty bone defect (Control), evaluated at the biological points of 15, 45, 90 and 120 days. The results showed that the biomaterials implanted were biocompatible and showed a high osteogenic potential. These biomaterials presented a speed of biodegradation compatible with bone neoformation, which was shown to be associated with angiogenesis inside the scaffolds at all biological points. The percentage of mineralization of ACSH (87%) differed statistically from that found in ACSHGA (66%). It was concluded that the regeneration of critical bone defect was more evident in anionic collagen without crosslinking (ACSH).ColágenoOssosAnimaisRatosImplanteBiomateriaisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMiguel FB Regeneration of....pdfMiguel FB Regeneration of....pdfapplication/pdf646690https://www.arca.fiocruz.br/bitstream/icict/7796/1/Miguel%20FB%20Regeneration%20of....pdf8ce2b1adb50829fc2682b9c4b430159eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7796/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMiguel FB Regeneration of....pdf.txtMiguel FB Regeneration of....pdf.txtExtracted texttext/plain34206https://www.arca.fiocruz.br/bitstream/icict/7796/5/Miguel%20FB%20Regeneration%20of....pdf.txtbdbd845ecfd18dff157b8a760283bd3dMD55THUMBNAILMiguel FB Regeneration of....pdf.jpgMiguel FB Regeneration of....pdf.jpgGenerated Thumbnailimage/jpeg2078https://www.arca.fiocruz.br/bitstream/icict/7796/4/Miguel%20FB%20Regeneration%20of....pdf.jpg7e10cad5876c357d0051ef238a925af2MD54icict/77962023-03-15 14:33:19.483oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Regeneration of critical bone defects with anionic collagen matrix as scaffolds. |
title |
Regeneration of critical bone defects with anionic collagen matrix as scaffolds. |
spellingShingle |
Regeneration of critical bone defects with anionic collagen matrix as scaffolds. Miguel, Fúlvio Borges Colágeno Ossos Animais Ratos Implante Biomateriais |
title_short |
Regeneration of critical bone defects with anionic collagen matrix as scaffolds. |
title_full |
Regeneration of critical bone defects with anionic collagen matrix as scaffolds. |
title_fullStr |
Regeneration of critical bone defects with anionic collagen matrix as scaffolds. |
title_full_unstemmed |
Regeneration of critical bone defects with anionic collagen matrix as scaffolds. |
title_sort |
Regeneration of critical bone defects with anionic collagen matrix as scaffolds. |
author |
Miguel, Fúlvio Borges |
author_facet |
Miguel, Fúlvio Borges Barbosa Junior, Aryon de Almeida Paula, Fabiana Lopes de Barreto, Isabela Cerqueira Goissis, Gilberto Rosa, Fabiana Paim |
author_role |
author |
author2 |
Barbosa Junior, Aryon de Almeida Paula, Fabiana Lopes de Barreto, Isabela Cerqueira Goissis, Gilberto Rosa, Fabiana Paim |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Miguel, Fúlvio Borges Barbosa Junior, Aryon de Almeida Paula, Fabiana Lopes de Barreto, Isabela Cerqueira Goissis, Gilberto Rosa, Fabiana Paim |
dc.subject.decs.pt_BR.fl_str_mv |
Colágeno Ossos Animais Ratos Implante Biomateriais |
topic |
Colágeno Ossos Animais Ratos Implante Biomateriais |
description |
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2014-06-04T19:41:27Z |
dc.date.available.fl_str_mv |
2014-06-04T19:41:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MIGUEL, F. B. et al. Regeneration of critical bone defects with anionic collagen matrix as scaffolds. Journal of Materials Science: Materials in Medicine, v. 24, n. 11, p. 2567-275, 2013. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7796 |
dc.identifier.issn.none.fl_str_mv |
1573-4838 |
dc.identifier.doi.none.fl_str_mv |
10.1007/s10856-013-4980-8 |
identifier_str_mv |
MIGUEL, F. B. et al. Regeneration of critical bone defects with anionic collagen matrix as scaffolds. Journal of Materials Science: Materials in Medicine, v. 24, n. 11, p. 2567-275, 2013. 1573-4838 10.1007/s10856-013-4980-8 |
url |
https://www.arca.fiocruz.br/handle/icict/7796 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Springer Verlag |
publisher.none.fl_str_mv |
Springer Verlag |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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