Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT

Detalhes bibliográficos
Autor(a) principal: Avelleira, João Carlos Regazzi
Data de Publicação: 2003
Outros Autores: Vianna, Francisco Reis, Boechat, Alfredo Marques, Alves, Larissa, Madeira, Suzana
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Hansenologia Internationalis (Online)
DOI: 10.47878/hi.2003.v28.35302
Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35302
Resumo: The present study evaluate the efficacy of twelve doses of multidrug therapy, as suggested by World Health Organization, in ten lepromatous leprosy patients with bacilloscopic index equal or higher than 4. The patients have taken the doses in twelve month-doses regularly. At the end of treatment a specimen was collected by punch biopsy and inoculated into mouse hind footpad according to Shepard´s technique. Persistence of viable bacilli was demonstrated in three patients. In spite of the small number of patients, same results have been found by other authors, showing that in highly bacilliferous leprosy patients, at the beginning of treatment more doses may be required to prevent relapses.
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spelling Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDTPersistência de bacilos viáveis em pacientes de hanseníase multibacilar altamente bacilíferos após doze doses do esquema poliquimioterápico (PQT/OMS)HanseníaseterapêuticainoculaçãoLeprosytherapeuticinoculationThe present study evaluate the efficacy of twelve doses of multidrug therapy, as suggested by World Health Organization, in ten lepromatous leprosy patients with bacilloscopic index equal or higher than 4. The patients have taken the doses in twelve month-doses regularly. At the end of treatment a specimen was collected by punch biopsy and inoculated into mouse hind footpad according to Shepard´s technique. Persistence of viable bacilli was demonstrated in three patients. In spite of the small number of patients, same results have been found by other authors, showing that in highly bacilliferous leprosy patients, at the beginning of treatment more doses may be required to prevent relapses.Trabalho de investigação, com o objetivo de avaliar a eficácia do tratamento de doze doses com o esquema poliquimioterápico proposto pela Organização Mundial de Saúde em 10 pacientes de hanseníase virchoviana com índice baciloscópico igual ou maior que 4. Os pacientes foram submetidos ao tratamento por 12 meses, regularmente. Após o final do tratamento, foi feita retirada de material e inoculação em coxim plantar de camundongos, conforme a técnica de Shepard. Os resultados mostraram persistência de bacilos viáveis em três pacientes. Os autores, apesar da amostra pequena, observam que os mesmos resultados têm sido encontrados por outros autores sugerindo que talvez seja necessário tratar os pacientes com altos índices baciloscópico no início do tratamento, por mais tempo, na tentativa de evitar possíveis recidivas.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo2003-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3530210.47878/hi.2003.v28.35302Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 28 No. 1 (2003); 44-48Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 28 n. 1 (2003); 44-481982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporenghttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35302/33750https://periodicos.saude.sp.gov.br/hansenologia/article/view/35302/33751Avelleira, João Carlos RegazziVianna, Francisco ReisBoechat, Alfredo MarquesAlves, LarissaMadeira, Suzanainfo:eu-repo/semantics/openAccess2021-05-19T21:13:19Zoai:ojs.periodicos.saude.sp.gov.br:article/35302Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2021-05-19T21:13:19Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false
dc.title.none.fl_str_mv Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
Persistência de bacilos viáveis em pacientes de hanseníase multibacilar altamente bacilíferos após doze doses do esquema poliquimioterápico (PQT/OMS)
title Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
spellingShingle Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
Avelleira, João Carlos Regazzi
Hanseníase
terapêutica
inoculação
Leprosy
therapeutic
inoculation
Avelleira, João Carlos Regazzi
Hanseníase
terapêutica
inoculação
Leprosy
therapeutic
inoculation
title_short Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
title_full Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
title_fullStr Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
title_full_unstemmed Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
title_sort Persistence of viable bacilli in highly bacilliferous multibacillary leprosy patients after the twelve doses of multidrug therapy WHO/MDT
author Avelleira, João Carlos Regazzi
author_facet Avelleira, João Carlos Regazzi
Avelleira, João Carlos Regazzi
Vianna, Francisco Reis
Boechat, Alfredo Marques
Alves, Larissa
Madeira, Suzana
Vianna, Francisco Reis
Boechat, Alfredo Marques
Alves, Larissa
Madeira, Suzana
author_role author
author2 Vianna, Francisco Reis
Boechat, Alfredo Marques
Alves, Larissa
Madeira, Suzana
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Avelleira, João Carlos Regazzi
Vianna, Francisco Reis
Boechat, Alfredo Marques
Alves, Larissa
Madeira, Suzana
dc.subject.por.fl_str_mv Hanseníase
terapêutica
inoculação
Leprosy
therapeutic
inoculation
topic Hanseníase
terapêutica
inoculação
Leprosy
therapeutic
inoculation
description The present study evaluate the efficacy of twelve doses of multidrug therapy, as suggested by World Health Organization, in ten lepromatous leprosy patients with bacilloscopic index equal or higher than 4. The patients have taken the doses in twelve month-doses regularly. At the end of treatment a specimen was collected by punch biopsy and inoculated into mouse hind footpad according to Shepard´s technique. Persistence of viable bacilli was demonstrated in three patients. In spite of the small number of patients, same results have been found by other authors, showing that in highly bacilliferous leprosy patients, at the beginning of treatment more doses may be required to prevent relapses.
publishDate 2003
dc.date.none.fl_str_mv 2003-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35302
10.47878/hi.2003.v28.35302
url https://periodicos.saude.sp.gov.br/hansenologia/article/view/35302
identifier_str_mv 10.47878/hi.2003.v28.35302
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35302/33750
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35302/33751
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
dc.source.none.fl_str_mv Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 28 No. 1 (2003); 44-48
Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 28 n. 1 (2003); 44-48
1982-5161
reponame:Hansenologia Internationalis (Online)
instname:Instituto Lauro de Souza Lima (ILSL)
instacron:ILSL
instname_str Instituto Lauro de Souza Lima (ILSL)
instacron_str ILSL
institution ILSL
reponame_str Hansenologia Internationalis (Online)
collection Hansenologia Internationalis (Online)
repository.name.fl_str_mv Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)
repository.mail.fl_str_mv hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br
_version_ 1822182094191722496
dc.identifier.doi.none.fl_str_mv 10.47878/hi.2003.v28.35302

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