Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/48526 |
Resumo: | © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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Common variants in Alzheimer's disease and risk stratification by polygenic risk scores© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease.Repositório da Universidade de Lisboade Rojas, ItziarMoreno-Grau, SoniaTesi, NiccoloGrenier-Boley, BenjaminAndrade, VictorJansen, Iris E.Pedersen, Nancy L.Stringa, NajadaZettergren, AnnaHernández, IsabelMontrreal, LauraDuron, EmmanuelleBoerwinkle, EricFerri, EvelynTagliavini, FabrizioKüçükali, FahriPasquier, FlorenceSanchez-Garcia, FlorentinoMangialasche, FrancescaJessen, FrankNicolas, GaëlAntúnez, CarmenSelbæk, GeirOrtega, GemmaChêne, GenevièveHadjigeorgiou, GeorgiosRossi, GiacominaSpalletta, GianfrancoGiaccone, GiorgioGrande, GiuliaBinetti, GiulianoPapenberg, GoranAntonell, AnnaHampel, HaraldBailly, HenriZetterberg, HenrikSoininen, HilkkaKarlsson, Ida K.Alvarez, IgnacioAppollonio, IldebrandoGiegling, InaSkoog, IngmarSaltvedt, IngvildTankard, Rick M.Rainero, InnocenzoRosas Allende, IreneHort, JakubDiehl-Schmid, JanineVan Dongen, JasperVidal, Jean-SebastienLehtisalo, JenniWiltfang, JensThomassen, Jesper QvistKornhuber, JohannesBis, Joshua C.Haines, Jonathan L.Vogelgsang, JonathanPineda, Juan A.Fortea, JuanPopp, JuliusDeckert, JürgenBuerger, KatharinaMorgan, KevinFließbach, KlausSleegers, KristelSims, RebeccaMolina-Porcel, LauraKilander, LenaWeinhold, LeonieFarrer, Lindsay A.Wang, Li-SanKleineidam, LucaFarotti, LuciaParnetti, LucillaTremolizzo, LucioHausner, LucreziaBellenguez, CélineBenussi, LuisaFroelich, LutzIkram, M. ArfanDeniz-Naranjo, M CandidaTsolaki, MagdaRosende-Roca, MaitéeLöwenmark, MalinHulsman, MarcSpallazzi, MarcoPericak-Vance, Margaret A.Quintela, InésEsiri, MargaretBernal Sánchez-Arjona, MaríaDalmasso, Maria CarolinaMartínez-Larrad, María TeresaArcaro, MarinaNöthen, Markus M.Fernández-Fuertes, MartaDichgans, MartinIngelsson, MartinHerrmann, Martin J.González-Perez, AntonioScherer, MartinVyhnalek, MartinKosmidis, Mary H.Yannakoulia, MarySchmid, MatthiasEwers, MichaelHeneka, Michael T.Wagner, MichaelScamosci, MichelaKivipelto, MiiaCalero, MiguelHiltunen, MikkoZulaica, MirenAlegret, MontserratFornage, MyriamRoberto, Nataliavan Schoor, Natasja M.Seidu, Nazib M.Banaj, NerisaArmstrong, Nicola J.Scarmeas, NikolaosFranco-Macías, EmilioScherbaum, NorbertGoldhardt, OliverHanon, OliverPeters, OliverSkrobot, Olivia AnnaQuenez, OlivierLerch, OndrejBossù, PaolaCaffarra, PaoloDionigi Rossi, PaoloMacías, JuanSakka, ParaskeviHoffmann, PerHolmans, Peter A.Fischer, PeterRiederer, PeterYang, QiongMarshall, RachelKalaria, Rajesh N.Mayeux, RichardVandenberghe, RikBlesa, RafaelCecchetti, RobertaGhidoni, RobertaFrikke-Schmidt, RuthSorbi, SandroHägg, SaraEngelborghs, SebastiaanHelisalmi, SeppoBotne Sando, SigridKern, SilkeArchetti, SilvanaCervera-Carles, LauraBoschi, SilviaFostinelli, SilviaGil, SilviaMendoza, SilviaMead, SimonCiccone, SimonaDjurovic, SrdjanHeilmann-Heimbach, StefanieRiedel-Heller, SteffiKuulasmaa, TeemuMenéndez-González, ManuelDel Ser, TeodoroLebouvier, ThibaudPolak, ThomasNgandu, TiiaGrimmer, TimoBessi, ValentinaEscott-Price, ValentinaGiedraitis, VilmantasDeramecourt, VincentMaier, WolfgangFrank-García, AnaJian, XueqiuPijnenburg, Yolande A. L.Kehoe, Patrick GavinGarcia-Ribas, GuillermoSánchez-Juan, PascualPastor, PauPérez-Tur, JordiPiñol-Ripoll, GerardLopez de Munain, AdolfoGarcía-Alberca, Jose MaríaRoyo, Jose LuísBullido, María J.Álvarez, VictoriaLleó, AlbertoReal, Luis M.Mir, PabloMedina, MiguelScheltens, PhilipHolstege, HenneMarquié, MartaSáez, María EugeniaMoreno, FerminCarracedo, ÁngelAmouyel, PhilippeSchellenberg, Gerard D.Williams, JulieSeshadri, Sudhavan Duijn, Cornelia M.Mather, Karen A.Sánchez-Valle, RaquelSerrano-Ríos, ManuelOrellana, AdelinaHuerto Vilas, RaquelTárraga, LluísBlennow, KajHuisman, MartijnAndreassen, Ole APosthuma, DanielleClarimón, JordiBoada, Mercèvan der Flier, Wiesje M.Ramirez, AlfredoLambert, Jean-CharlesBaquero, Miquelvan der Lee, Sven J.Ruiz, AgustínDiez-Fairen, MónicaLage, CarmenGarcía-Madrona, SebastiánGarcía-González, PabloAlarcón-Martín, EmilioValero, SergiSotolongo-Grau, OscarUllgren, AbbeNaj, Adam C.Lemstra, Afina W.Benaque, AlbaPérez-Cordón, AlbaBenussi, AlbertoRábano, AlbertoPadovani, AlessandroSquassina, AlessioDe Mendonça, AlexandreArias Pastor, AlfonsoKok, Almar A. L.Meggy, AlunPastor, Ana BelénEspinosa, AnaCorma-Gómez, AnaïsMartín Montes, AngelSanabria, ÁngelaDeStefano, Anita L.Schneider, AnjaHaapasalo, AnnakaisaKinhult Ståhlbom, AnneTybjærg-Hansen, AnneHartmann, Annette M.Spottke, AnnikaCorbatón-Anchuelo, ArturoRongve, ArvidBorroni, BarbaraArosio, BeatriceNacmias, BenedettaNordestgaard, Børge G.Kunkle, Brian W.Charbonnier, CamilleAbdelnour, CarlaMasullo, CarloMartínez Rodríguez, CarmenMuñoz-Fernandez, CarmenDufouil, CaroleGraff, CarolineFerreira, Catarina B.Chillotti, CaterinaReynolds, Chandra A.Fenoglio, ChiaraVan Broeckhoven, ChristineClark, ChristopherPisanu, ClaudiaSatizabal, Claudia L.Holmes, CliveBuiza-Rueda, DoloresAarsland, DagRujescu, DanAlcolea, DanielGalimberti, DanielaWallon, DavidSeripa, DavideGrünblatt, EdnaDardiotis, EfthimiosDüzel, EmrahScarpini, ElioConti, ElisaRubino, ElisaGelpi, EllenRodriguez-Rodriguez, Eloy2021-06-14T14:40:24Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48526engNat Commun 12, 3417 (2021)10.1038/s41467-021-22491-82041-1723info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:07:25Zoai:repositorio.ul.pt:10451/48526Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:07:25Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores |
title |
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores |
spellingShingle |
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores de Rojas, Itziar |
title_short |
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores |
title_full |
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores |
title_fullStr |
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores |
title_full_unstemmed |
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores |
title_sort |
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores |
author |
de Rojas, Itziar |
author_facet |
de Rojas, Itziar Moreno-Grau, Sonia Tesi, Niccolo Grenier-Boley, Benjamin Andrade, Victor Jansen, Iris E. Pedersen, Nancy L. Stringa, Najada Zettergren, Anna Hernández, Isabel Montrreal, Laura Duron, Emmanuelle Boerwinkle, Eric Ferri, Evelyn Tagliavini, Fabrizio Küçükali, Fahri Pasquier, Florence Sanchez-Garcia, Florentino Mangialasche, Francesca Jessen, Frank Nicolas, Gaël Antúnez, Carmen Selbæk, Geir Ortega, Gemma Chêne, Geneviève Hadjigeorgiou, Georgios Rossi, Giacomina Spalletta, Gianfranco Giaccone, Giorgio Grande, Giulia Binetti, Giuliano Papenberg, Goran Antonell, Anna Hampel, Harald Bailly, Henri Zetterberg, Henrik Soininen, Hilkka Karlsson, Ida K. Alvarez, Ignacio Appollonio, Ildebrando Giegling, Ina Skoog, Ingmar Saltvedt, Ingvild Tankard, Rick M. Rainero, Innocenzo Rosas Allende, Irene Hort, Jakub Diehl-Schmid, Janine Van Dongen, Jasper Vidal, Jean-Sebastien Lehtisalo, Jenni Wiltfang, Jens Thomassen, Jesper Qvist Kornhuber, Johannes Bis, Joshua C. Haines, Jonathan L. Vogelgsang, Jonathan Pineda, Juan A. Fortea, Juan Popp, Julius Deckert, Jürgen Buerger, Katharina Morgan, Kevin Fließbach, Klaus Sleegers, Kristel Sims, Rebecca Molina-Porcel, Laura Kilander, Lena Weinhold, Leonie Farrer, Lindsay A. Wang, Li-San Kleineidam, Luca Farotti, Lucia Parnetti, Lucilla Tremolizzo, Lucio Hausner, Lucrezia Bellenguez, Céline Benussi, Luisa Froelich, Lutz Ikram, M. Arfan Deniz-Naranjo, M Candida Tsolaki, Magda Rosende-Roca, Maitée Löwenmark, Malin Hulsman, Marc Spallazzi, Marco Pericak-Vance, Margaret A. Quintela, Inés Esiri, Margaret Bernal Sánchez-Arjona, María Dalmasso, Maria Carolina Martínez-Larrad, María Teresa Arcaro, Marina Nöthen, Markus M. Fernández-Fuertes, Marta Dichgans, Martin Ingelsson, Martin Herrmann, Martin J. González-Perez, Antonio Scherer, Martin Vyhnalek, Martin Kosmidis, Mary H. Yannakoulia, Mary Schmid, Matthias Ewers, Michael Heneka, Michael T. Wagner, Michael Scamosci, Michela Kivipelto, Miia Calero, Miguel Hiltunen, Mikko Zulaica, Miren Alegret, Montserrat Fornage, Myriam Roberto, Natalia van Schoor, Natasja M. Seidu, Nazib M. Banaj, Nerisa Armstrong, Nicola J. Scarmeas, Nikolaos Franco-Macías, Emilio Scherbaum, Norbert Goldhardt, Oliver Hanon, Oliver Peters, Oliver Skrobot, Olivia Anna Quenez, Olivier Lerch, Ondrej Bossù, Paola Caffarra, Paolo Dionigi Rossi, Paolo Macías, Juan Sakka, Paraskevi Hoffmann, Per Holmans, Peter A. Fischer, Peter Riederer, Peter Yang, Qiong Marshall, Rachel Kalaria, Rajesh N. Mayeux, Richard Vandenberghe, Rik Blesa, Rafael Cecchetti, Roberta Ghidoni, Roberta Frikke-Schmidt, Ruth Sorbi, Sandro Hägg, Sara Engelborghs, Sebastiaan Helisalmi, Seppo Botne Sando, Sigrid Kern, Silke Archetti, Silvana Cervera-Carles, Laura Boschi, Silvia Fostinelli, Silvia Gil, Silvia Mendoza, Silvia Mead, Simon Ciccone, Simona Djurovic, Srdjan Heilmann-Heimbach, Stefanie Riedel-Heller, Steffi Kuulasmaa, Teemu Menéndez-González, Manuel Del Ser, Teodoro Lebouvier, Thibaud Polak, Thomas Ngandu, Tiia Grimmer, Timo Bessi, Valentina Escott-Price, Valentina Giedraitis, Vilmantas Deramecourt, Vincent Maier, Wolfgang Frank-García, Ana Jian, Xueqiu Pijnenburg, Yolande A. L. Kehoe, Patrick Gavin Garcia-Ribas, Guillermo Sánchez-Juan, Pascual Pastor, Pau Pérez-Tur, Jordi Piñol-Ripoll, Gerard Lopez de Munain, Adolfo García-Alberca, Jose María Royo, Jose Luís Bullido, María J. Álvarez, Victoria Lleó, Alberto Real, Luis M. Mir, Pablo Medina, Miguel Scheltens, Philip Holstege, Henne Marquié, Marta Sáez, María Eugenia Moreno, Fermin Carracedo, Ángel Amouyel, Philippe Schellenberg, Gerard D. Williams, Julie Seshadri, Sudha van Duijn, Cornelia M. Mather, Karen A. Sánchez-Valle, Raquel Serrano-Ríos, Manuel Orellana, Adelina Huerto Vilas, Raquel Tárraga, Lluís Blennow, Kaj Huisman, Martijn Andreassen, Ole A Posthuma, Danielle Clarimón, Jordi Boada, Mercè van der Flier, Wiesje M. Ramirez, Alfredo Lambert, Jean-Charles Baquero, Miquel van der Lee, Sven J. Ruiz, Agustín Diez-Fairen, Mónica Lage, Carmen García-Madrona, Sebastián García-González, Pablo Alarcón-Martín, Emilio Valero, Sergi Sotolongo-Grau, Oscar Ullgren, Abbe Naj, Adam C. Lemstra, Afina W. Benaque, Alba Pérez-Cordón, Alba Benussi, Alberto Rábano, Alberto Padovani, Alessandro Squassina, Alessio De Mendonça, Alexandre Arias Pastor, Alfonso Kok, Almar A. L. Meggy, Alun Pastor, Ana Belén Espinosa, Ana Corma-Gómez, Anaïs Martín Montes, Angel Sanabria, Ángela DeStefano, Anita L. Schneider, Anja Haapasalo, Annakaisa Kinhult Ståhlbom, Anne Tybjærg-Hansen, Anne Hartmann, Annette M. Spottke, Annika Corbatón-Anchuelo, Arturo Rongve, Arvid Borroni, Barbara Arosio, Beatrice Nacmias, Benedetta Nordestgaard, Børge G. Kunkle, Brian W. Charbonnier, Camille Abdelnour, Carla Masullo, Carlo Martínez Rodríguez, Carmen Muñoz-Fernandez, Carmen Dufouil, Carole Graff, Caroline Ferreira, Catarina B. Chillotti, Caterina Reynolds, Chandra A. Fenoglio, Chiara Van Broeckhoven, Christine Clark, Christopher Pisanu, Claudia Satizabal, Claudia L. Holmes, Clive Buiza-Rueda, Dolores Aarsland, Dag Rujescu, Dan Alcolea, Daniel Galimberti, Daniela Wallon, David Seripa, Davide Grünblatt, Edna Dardiotis, Efthimios Düzel, Emrah Scarpini, Elio Conti, Elisa Rubino, Elisa Gelpi, Ellen Rodriguez-Rodriguez, Eloy |
author_role |
author |
author2 |
Moreno-Grau, Sonia Tesi, Niccolo Grenier-Boley, Benjamin Andrade, Victor Jansen, Iris E. Pedersen, Nancy L. Stringa, Najada Zettergren, Anna Hernández, Isabel Montrreal, Laura Duron, Emmanuelle Boerwinkle, Eric Ferri, Evelyn Tagliavini, Fabrizio Küçükali, Fahri Pasquier, Florence Sanchez-Garcia, Florentino Mangialasche, Francesca Jessen, Frank Nicolas, Gaël Antúnez, Carmen Selbæk, Geir Ortega, Gemma Chêne, Geneviève Hadjigeorgiou, Georgios Rossi, Giacomina Spalletta, Gianfranco Giaccone, Giorgio Grande, Giulia Binetti, Giuliano Papenberg, Goran Antonell, Anna Hampel, Harald Bailly, Henri Zetterberg, Henrik Soininen, Hilkka Karlsson, Ida K. Alvarez, Ignacio Appollonio, Ildebrando Giegling, Ina Skoog, Ingmar Saltvedt, Ingvild Tankard, Rick M. Rainero, Innocenzo Rosas Allende, Irene Hort, Jakub Diehl-Schmid, Janine Van Dongen, Jasper Vidal, Jean-Sebastien Lehtisalo, Jenni Wiltfang, Jens Thomassen, Jesper Qvist Kornhuber, Johannes Bis, Joshua C. Haines, Jonathan L. Vogelgsang, Jonathan Pineda, Juan A. Fortea, Juan Popp, Julius Deckert, Jürgen Buerger, Katharina Morgan, Kevin Fließbach, Klaus Sleegers, Kristel Sims, Rebecca Molina-Porcel, Laura Kilander, Lena Weinhold, Leonie Farrer, Lindsay A. Wang, Li-San Kleineidam, Luca Farotti, Lucia Parnetti, Lucilla Tremolizzo, Lucio Hausner, Lucrezia Bellenguez, Céline Benussi, Luisa Froelich, Lutz Ikram, M. Arfan Deniz-Naranjo, M Candida Tsolaki, Magda Rosende-Roca, Maitée Löwenmark, Malin Hulsman, Marc Spallazzi, Marco Pericak-Vance, Margaret A. Quintela, Inés Esiri, Margaret Bernal Sánchez-Arjona, María Dalmasso, Maria Carolina Martínez-Larrad, María Teresa Arcaro, Marina Nöthen, Markus M. Fernández-Fuertes, Marta Dichgans, Martin Ingelsson, Martin Herrmann, Martin J. González-Perez, Antonio Scherer, Martin Vyhnalek, Martin Kosmidis, Mary H. Yannakoulia, Mary Schmid, Matthias Ewers, Michael Heneka, Michael T. Wagner, Michael Scamosci, Michela Kivipelto, Miia Calero, Miguel Hiltunen, Mikko Zulaica, Miren Alegret, Montserrat Fornage, Myriam Roberto, Natalia van Schoor, Natasja M. Seidu, Nazib M. Banaj, Nerisa Armstrong, Nicola J. Scarmeas, Nikolaos Franco-Macías, Emilio Scherbaum, Norbert Goldhardt, Oliver Hanon, Oliver Peters, Oliver Skrobot, Olivia Anna Quenez, Olivier Lerch, Ondrej Bossù, Paola Caffarra, Paolo Dionigi Rossi, Paolo Macías, Juan Sakka, Paraskevi Hoffmann, Per Holmans, Peter A. Fischer, Peter Riederer, Peter Yang, Qiong Marshall, Rachel Kalaria, Rajesh N. Mayeux, Richard Vandenberghe, Rik Blesa, Rafael Cecchetti, Roberta Ghidoni, Roberta Frikke-Schmidt, Ruth Sorbi, Sandro Hägg, Sara Engelborghs, Sebastiaan Helisalmi, Seppo Botne Sando, Sigrid Kern, Silke Archetti, Silvana Cervera-Carles, Laura Boschi, Silvia Fostinelli, Silvia Gil, Silvia Mendoza, Silvia Mead, Simon Ciccone, Simona Djurovic, Srdjan Heilmann-Heimbach, Stefanie Riedel-Heller, Steffi Kuulasmaa, Teemu Menéndez-González, Manuel Del Ser, Teodoro Lebouvier, Thibaud Polak, Thomas Ngandu, Tiia Grimmer, Timo Bessi, Valentina Escott-Price, Valentina Giedraitis, Vilmantas Deramecourt, Vincent Maier, Wolfgang Frank-García, Ana Jian, Xueqiu Pijnenburg, Yolande A. L. Kehoe, Patrick Gavin Garcia-Ribas, Guillermo Sánchez-Juan, Pascual Pastor, Pau Pérez-Tur, Jordi Piñol-Ripoll, Gerard Lopez de Munain, Adolfo García-Alberca, Jose María Royo, Jose Luís Bullido, María J. Álvarez, Victoria Lleó, Alberto Real, Luis M. Mir, Pablo Medina, Miguel Scheltens, Philip Holstege, Henne Marquié, Marta Sáez, María Eugenia Moreno, Fermin Carracedo, Ángel Amouyel, Philippe Schellenberg, Gerard D. Williams, Julie Seshadri, Sudha van Duijn, Cornelia M. Mather, Karen A. Sánchez-Valle, Raquel Serrano-Ríos, Manuel Orellana, Adelina Huerto Vilas, Raquel Tárraga, Lluís Blennow, Kaj Huisman, Martijn Andreassen, Ole A Posthuma, Danielle Clarimón, Jordi Boada, Mercè van der Flier, Wiesje M. Ramirez, Alfredo Lambert, Jean-Charles Baquero, Miquel van der Lee, Sven J. Ruiz, Agustín Diez-Fairen, Mónica Lage, Carmen García-Madrona, Sebastián García-González, Pablo Alarcón-Martín, Emilio Valero, Sergi Sotolongo-Grau, Oscar Ullgren, Abbe Naj, Adam C. Lemstra, Afina W. Benaque, Alba Pérez-Cordón, Alba Benussi, Alberto Rábano, Alberto Padovani, Alessandro Squassina, Alessio De Mendonça, Alexandre Arias Pastor, Alfonso Kok, Almar A. L. Meggy, Alun Pastor, Ana Belén Espinosa, Ana Corma-Gómez, Anaïs Martín Montes, Angel Sanabria, Ángela DeStefano, Anita L. Schneider, Anja Haapasalo, Annakaisa Kinhult Ståhlbom, Anne Tybjærg-Hansen, Anne Hartmann, Annette M. Spottke, Annika Corbatón-Anchuelo, Arturo Rongve, Arvid Borroni, Barbara Arosio, Beatrice Nacmias, Benedetta Nordestgaard, Børge G. Kunkle, Brian W. Charbonnier, Camille Abdelnour, Carla Masullo, Carlo Martínez Rodríguez, Carmen Muñoz-Fernandez, Carmen Dufouil, Carole Graff, Caroline Ferreira, Catarina B. Chillotti, Caterina Reynolds, Chandra A. Fenoglio, Chiara Van Broeckhoven, Christine Clark, Christopher Pisanu, Claudia Satizabal, Claudia L. Holmes, Clive Buiza-Rueda, Dolores Aarsland, Dag Rujescu, Dan Alcolea, Daniel Galimberti, Daniela Wallon, David Seripa, Davide Grünblatt, Edna Dardiotis, Efthimios Düzel, Emrah Scarpini, Elio Conti, Elisa Rubino, Elisa Gelpi, Ellen Rodriguez-Rodriguez, Eloy |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
de Rojas, Itziar Moreno-Grau, Sonia Tesi, Niccolo Grenier-Boley, Benjamin Andrade, Victor Jansen, Iris E. Pedersen, Nancy L. Stringa, Najada Zettergren, Anna Hernández, Isabel Montrreal, Laura Duron, Emmanuelle Boerwinkle, Eric Ferri, Evelyn Tagliavini, Fabrizio Küçükali, Fahri Pasquier, Florence Sanchez-Garcia, Florentino Mangialasche, Francesca Jessen, Frank Nicolas, Gaël Antúnez, Carmen Selbæk, Geir Ortega, Gemma Chêne, Geneviève Hadjigeorgiou, Georgios Rossi, Giacomina Spalletta, Gianfranco Giaccone, Giorgio Grande, Giulia Binetti, Giuliano Papenberg, Goran Antonell, Anna Hampel, Harald Bailly, Henri Zetterberg, Henrik Soininen, Hilkka Karlsson, Ida K. Alvarez, Ignacio Appollonio, Ildebrando Giegling, Ina Skoog, Ingmar Saltvedt, Ingvild Tankard, Rick M. Rainero, Innocenzo Rosas Allende, Irene Hort, Jakub Diehl-Schmid, Janine Van Dongen, Jasper Vidal, Jean-Sebastien Lehtisalo, Jenni Wiltfang, Jens Thomassen, Jesper Qvist Kornhuber, Johannes Bis, Joshua C. Haines, Jonathan L. Vogelgsang, Jonathan Pineda, Juan A. Fortea, Juan Popp, Julius Deckert, Jürgen Buerger, Katharina Morgan, Kevin Fließbach, Klaus Sleegers, Kristel Sims, Rebecca Molina-Porcel, Laura Kilander, Lena Weinhold, Leonie Farrer, Lindsay A. Wang, Li-San Kleineidam, Luca Farotti, Lucia Parnetti, Lucilla Tremolizzo, Lucio Hausner, Lucrezia Bellenguez, Céline Benussi, Luisa Froelich, Lutz Ikram, M. Arfan Deniz-Naranjo, M Candida Tsolaki, Magda Rosende-Roca, Maitée Löwenmark, Malin Hulsman, Marc Spallazzi, Marco Pericak-Vance, Margaret A. Quintela, Inés Esiri, Margaret Bernal Sánchez-Arjona, María Dalmasso, Maria Carolina Martínez-Larrad, María Teresa Arcaro, Marina Nöthen, Markus M. Fernández-Fuertes, Marta Dichgans, Martin Ingelsson, Martin Herrmann, Martin J. González-Perez, Antonio Scherer, Martin Vyhnalek, Martin Kosmidis, Mary H. Yannakoulia, Mary Schmid, Matthias Ewers, Michael Heneka, Michael T. Wagner, Michael Scamosci, Michela Kivipelto, Miia Calero, Miguel Hiltunen, Mikko Zulaica, Miren Alegret, Montserrat Fornage, Myriam Roberto, Natalia van Schoor, Natasja M. Seidu, Nazib M. Banaj, Nerisa Armstrong, Nicola J. Scarmeas, Nikolaos Franco-Macías, Emilio Scherbaum, Norbert Goldhardt, Oliver Hanon, Oliver Peters, Oliver Skrobot, Olivia Anna Quenez, Olivier Lerch, Ondrej Bossù, Paola Caffarra, Paolo Dionigi Rossi, Paolo Macías, Juan Sakka, Paraskevi Hoffmann, Per Holmans, Peter A. Fischer, Peter Riederer, Peter Yang, Qiong Marshall, Rachel Kalaria, Rajesh N. Mayeux, Richard Vandenberghe, Rik Blesa, Rafael Cecchetti, Roberta Ghidoni, Roberta Frikke-Schmidt, Ruth Sorbi, Sandro Hägg, Sara Engelborghs, Sebastiaan Helisalmi, Seppo Botne Sando, Sigrid Kern, Silke Archetti, Silvana Cervera-Carles, Laura Boschi, Silvia Fostinelli, Silvia Gil, Silvia Mendoza, Silvia Mead, Simon Ciccone, Simona Djurovic, Srdjan Heilmann-Heimbach, Stefanie Riedel-Heller, Steffi Kuulasmaa, Teemu Menéndez-González, Manuel Del Ser, Teodoro Lebouvier, Thibaud Polak, Thomas Ngandu, Tiia Grimmer, Timo Bessi, Valentina Escott-Price, Valentina Giedraitis, Vilmantas Deramecourt, Vincent Maier, Wolfgang Frank-García, Ana Jian, Xueqiu Pijnenburg, Yolande A. L. Kehoe, Patrick Gavin Garcia-Ribas, Guillermo Sánchez-Juan, Pascual Pastor, Pau Pérez-Tur, Jordi Piñol-Ripoll, Gerard Lopez de Munain, Adolfo García-Alberca, Jose María Royo, Jose Luís Bullido, María J. Álvarez, Victoria Lleó, Alberto Real, Luis M. Mir, Pablo Medina, Miguel Scheltens, Philip Holstege, Henne Marquié, Marta Sáez, María Eugenia Moreno, Fermin Carracedo, Ángel Amouyel, Philippe Schellenberg, Gerard D. Williams, Julie Seshadri, Sudha van Duijn, Cornelia M. Mather, Karen A. Sánchez-Valle, Raquel Serrano-Ríos, Manuel Orellana, Adelina Huerto Vilas, Raquel Tárraga, Lluís Blennow, Kaj Huisman, Martijn Andreassen, Ole A Posthuma, Danielle Clarimón, Jordi Boada, Mercè van der Flier, Wiesje M. Ramirez, Alfredo Lambert, Jean-Charles Baquero, Miquel van der Lee, Sven J. Ruiz, Agustín Diez-Fairen, Mónica Lage, Carmen García-Madrona, Sebastián García-González, Pablo Alarcón-Martín, Emilio Valero, Sergi Sotolongo-Grau, Oscar Ullgren, Abbe Naj, Adam C. Lemstra, Afina W. Benaque, Alba Pérez-Cordón, Alba Benussi, Alberto Rábano, Alberto Padovani, Alessandro Squassina, Alessio De Mendonça, Alexandre Arias Pastor, Alfonso Kok, Almar A. L. Meggy, Alun Pastor, Ana Belén Espinosa, Ana Corma-Gómez, Anaïs Martín Montes, Angel Sanabria, Ángela DeStefano, Anita L. Schneider, Anja Haapasalo, Annakaisa Kinhult Ståhlbom, Anne Tybjærg-Hansen, Anne Hartmann, Annette M. Spottke, Annika Corbatón-Anchuelo, Arturo Rongve, Arvid Borroni, Barbara Arosio, Beatrice Nacmias, Benedetta Nordestgaard, Børge G. Kunkle, Brian W. Charbonnier, Camille Abdelnour, Carla Masullo, Carlo Martínez Rodríguez, Carmen Muñoz-Fernandez, Carmen Dufouil, Carole Graff, Caroline Ferreira, Catarina B. Chillotti, Caterina Reynolds, Chandra A. Fenoglio, Chiara Van Broeckhoven, Christine Clark, Christopher Pisanu, Claudia Satizabal, Claudia L. Holmes, Clive Buiza-Rueda, Dolores Aarsland, Dag Rujescu, Dan Alcolea, Daniel Galimberti, Daniela Wallon, David Seripa, Davide Grünblatt, Edna Dardiotis, Efthimios Düzel, Emrah Scarpini, Elio Conti, Elisa Rubino, Elisa Gelpi, Ellen Rodriguez-Rodriguez, Eloy |
description |
© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-14T14:40:24Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/48526 |
url |
http://hdl.handle.net/10451/48526 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nat Commun 12, 3417 (2021) 10.1038/s41467-021-22491-8 2041-1723 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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