Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

Detalhes bibliográficos
Autor(a) principal: de Rojas, Itziar
Data de Publicação: 2021
Outros Autores: Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel, Montrreal, Laura, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn, Tagliavini, Fabrizio, Küçükali, Fahri, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca, Jessen, Frank, Nicolas, Gaël, Antúnez, Carmen, Selbæk, Geir, Ortega, Gemma, Chêne, Geneviève, Hadjigeorgiou, Georgios, Rossi, Giacomina, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Antonell, Anna, Hampel, Harald, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild, Tankard, Rick M., Rainero, Innocenzo, Rosas Allende, Irene, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist, Kornhuber, Johannes, Bis, Joshua C., Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan, Popp, Julius, Deckert, Jürgen, Buerger, Katharina, Morgan, Kevin, Fließbach, Klaus, Sleegers, Kristel, Sims, Rebecca, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla, Tremolizzo, Lucio, Hausner, Lucrezia, Bellenguez, Céline, Benussi, Luisa, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M Candida, Tsolaki, Magda, Rosende-Roca, Maitée, Löwenmark, Malin, Hulsman, Marc, Spallazzi, Marco, Pericak-Vance, Margaret A., Quintela, Inés, Esiri, Margaret, Bernal Sánchez-Arjona, María, Dalmasso, Maria Carolina, Martínez-Larrad, María Teresa, Arcaro, Marina, Nöthen, Markus M., Fernández-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., González-Perez, Antonio, Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary, Schmid, Matthias, Ewers, Michael, Heneka, Michael T., Wagner, Michael, Scamosci, Michela, Kivipelto, Miia, Calero, Miguel, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M., Banaj, Nerisa, Armstrong, Nicola J., Scarmeas, Nikolaos, Franco-Macías, Emilio, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossù, Paola, Caffarra, Paolo, Dionigi Rossi, Paolo, Macías, Juan, Sakka, Paraskevi, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik, Blesa, Rafael, Cecchetti, Roberta, Ghidoni, Roberta, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hägg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Botne Sando, Sigrid, Kern, Silke, Archetti, Silvana, Cervera-Carles, Laura, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, Menéndez-González, Manuel, Del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina, Escott-Price, Valentina, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Frank-García, Ana, Jian, Xueqiu, Pijnenburg, Yolande A. L., Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sánchez-Juan, Pascual, Pastor, Pau, Pérez-Tur, Jordi, Piñol-Ripoll, Gerard, Lopez de Munain, Adolfo, García-Alberca, Jose María, Royo, Jose Luís, Bullido, María J., Álvarez, Victoria, Lleó, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquié, Marta, Sáez, María Eugenia, Moreno, Fermin, Carracedo, Ángel, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sánchez-Valle, Raquel, Serrano-Ríos, Manuel, Orellana, Adelina, Huerto Vilas, Raquel, Tárraga, Lluís, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A, Posthuma, Danielle, Clarimón, Jordi, Boada, Mercè, van der Flier, Wiesje M., Ramirez, Alfredo, Lambert, Jean-Charles, Baquero, Miquel, van der Lee, Sven J., Ruiz, Agustín, Diez-Fairen, Mónica, Lage, Carmen, García-Madrona, Sebastián, García-González, Pablo, Alarcón-Martín, Emilio, Valero, Sergi, Sotolongo-Grau, Oscar, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benaque, Alba, Pérez-Cordón, Alba, Benussi, Alberto, Rábano, Alberto, Padovani, Alessandro, Squassina, Alessio, De Mendonça, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Pastor, Ana Belén, Espinosa, Ana, Corma-Gómez, Anaïs, Martín Montes, Angel, Sanabria, Ángela, DeStefano, Anita L., Schneider, Anja, Haapasalo, Annakaisa, Kinhult Ståhlbom, Anne, Tybjærg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbatón-Anchuelo, Arturo, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta, Nordestgaard, Børge G., Kunkle, Brian W., Charbonnier, Camille, Abdelnour, Carla, Masullo, Carlo, Martínez Rodríguez, Carmen, Muñoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher, Pisanu, Claudia, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag, Rujescu, Dan, Alcolea, Daniel, Galimberti, Daniela, Wallon, David, Seripa, Davide, Grünblatt, Edna, Dardiotis, Efthimios, Düzel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/48526
Resumo: © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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spelling Common variants in Alzheimer's disease and risk stratification by polygenic risk scores© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease.Repositório da Universidade de Lisboade Rojas, ItziarMoreno-Grau, SoniaTesi, NiccoloGrenier-Boley, BenjaminAndrade, VictorJansen, Iris E.Pedersen, Nancy L.Stringa, NajadaZettergren, AnnaHernández, IsabelMontrreal, LauraDuron, EmmanuelleBoerwinkle, EricFerri, EvelynTagliavini, FabrizioKüçükali, FahriPasquier, FlorenceSanchez-Garcia, FlorentinoMangialasche, FrancescaJessen, FrankNicolas, GaëlAntúnez, CarmenSelbæk, GeirOrtega, GemmaChêne, GenevièveHadjigeorgiou, GeorgiosRossi, GiacominaSpalletta, GianfrancoGiaccone, GiorgioGrande, GiuliaBinetti, GiulianoPapenberg, GoranAntonell, AnnaHampel, HaraldBailly, HenriZetterberg, HenrikSoininen, HilkkaKarlsson, Ida K.Alvarez, IgnacioAppollonio, IldebrandoGiegling, InaSkoog, IngmarSaltvedt, IngvildTankard, Rick M.Rainero, InnocenzoRosas Allende, IreneHort, JakubDiehl-Schmid, JanineVan Dongen, JasperVidal, Jean-SebastienLehtisalo, JenniWiltfang, JensThomassen, Jesper QvistKornhuber, JohannesBis, Joshua C.Haines, Jonathan L.Vogelgsang, JonathanPineda, Juan A.Fortea, JuanPopp, JuliusDeckert, JürgenBuerger, KatharinaMorgan, KevinFließbach, KlausSleegers, KristelSims, RebeccaMolina-Porcel, LauraKilander, LenaWeinhold, LeonieFarrer, Lindsay A.Wang, Li-SanKleineidam, LucaFarotti, LuciaParnetti, LucillaTremolizzo, LucioHausner, LucreziaBellenguez, CélineBenussi, LuisaFroelich, LutzIkram, M. ArfanDeniz-Naranjo, M CandidaTsolaki, MagdaRosende-Roca, MaitéeLöwenmark, MalinHulsman, MarcSpallazzi, MarcoPericak-Vance, Margaret A.Quintela, InésEsiri, MargaretBernal Sánchez-Arjona, MaríaDalmasso, Maria CarolinaMartínez-Larrad, María TeresaArcaro, MarinaNöthen, Markus M.Fernández-Fuertes, MartaDichgans, MartinIngelsson, MartinHerrmann, Martin J.González-Perez, AntonioScherer, MartinVyhnalek, MartinKosmidis, Mary H.Yannakoulia, MarySchmid, MatthiasEwers, MichaelHeneka, Michael T.Wagner, MichaelScamosci, MichelaKivipelto, MiiaCalero, MiguelHiltunen, MikkoZulaica, MirenAlegret, MontserratFornage, MyriamRoberto, Nataliavan Schoor, Natasja M.Seidu, Nazib M.Banaj, NerisaArmstrong, Nicola J.Scarmeas, NikolaosFranco-Macías, EmilioScherbaum, NorbertGoldhardt, OliverHanon, OliverPeters, OliverSkrobot, Olivia AnnaQuenez, OlivierLerch, OndrejBossù, PaolaCaffarra, PaoloDionigi Rossi, PaoloMacías, JuanSakka, ParaskeviHoffmann, PerHolmans, Peter A.Fischer, PeterRiederer, PeterYang, QiongMarshall, RachelKalaria, Rajesh N.Mayeux, RichardVandenberghe, RikBlesa, RafaelCecchetti, RobertaGhidoni, RobertaFrikke-Schmidt, RuthSorbi, SandroHägg, SaraEngelborghs, SebastiaanHelisalmi, SeppoBotne Sando, SigridKern, SilkeArchetti, SilvanaCervera-Carles, LauraBoschi, SilviaFostinelli, SilviaGil, SilviaMendoza, SilviaMead, SimonCiccone, SimonaDjurovic, SrdjanHeilmann-Heimbach, StefanieRiedel-Heller, SteffiKuulasmaa, TeemuMenéndez-González, ManuelDel Ser, TeodoroLebouvier, ThibaudPolak, ThomasNgandu, TiiaGrimmer, TimoBessi, ValentinaEscott-Price, ValentinaGiedraitis, VilmantasDeramecourt, VincentMaier, WolfgangFrank-García, AnaJian, XueqiuPijnenburg, Yolande A. L.Kehoe, Patrick GavinGarcia-Ribas, GuillermoSánchez-Juan, PascualPastor, PauPérez-Tur, JordiPiñol-Ripoll, GerardLopez de Munain, AdolfoGarcía-Alberca, Jose MaríaRoyo, Jose LuísBullido, María J.Álvarez, VictoriaLleó, AlbertoReal, Luis M.Mir, PabloMedina, MiguelScheltens, PhilipHolstege, HenneMarquié, MartaSáez, María EugeniaMoreno, FerminCarracedo, ÁngelAmouyel, PhilippeSchellenberg, Gerard D.Williams, JulieSeshadri, Sudhavan Duijn, Cornelia M.Mather, Karen A.Sánchez-Valle, RaquelSerrano-Ríos, ManuelOrellana, AdelinaHuerto Vilas, RaquelTárraga, LluísBlennow, KajHuisman, MartijnAndreassen, Ole APosthuma, DanielleClarimón, JordiBoada, Mercèvan der Flier, Wiesje M.Ramirez, AlfredoLambert, Jean-CharlesBaquero, Miquelvan der Lee, Sven J.Ruiz, AgustínDiez-Fairen, MónicaLage, CarmenGarcía-Madrona, SebastiánGarcía-González, PabloAlarcón-Martín, EmilioValero, SergiSotolongo-Grau, OscarUllgren, AbbeNaj, Adam C.Lemstra, Afina W.Benaque, AlbaPérez-Cordón, AlbaBenussi, AlbertoRábano, AlbertoPadovani, AlessandroSquassina, AlessioDe Mendonça, AlexandreArias Pastor, AlfonsoKok, Almar A. L.Meggy, AlunPastor, Ana BelénEspinosa, AnaCorma-Gómez, AnaïsMartín Montes, AngelSanabria, ÁngelaDeStefano, Anita L.Schneider, AnjaHaapasalo, AnnakaisaKinhult Ståhlbom, AnneTybjærg-Hansen, AnneHartmann, Annette M.Spottke, AnnikaCorbatón-Anchuelo, ArturoRongve, ArvidBorroni, BarbaraArosio, BeatriceNacmias, BenedettaNordestgaard, Børge G.Kunkle, Brian W.Charbonnier, CamilleAbdelnour, CarlaMasullo, CarloMartínez Rodríguez, CarmenMuñoz-Fernandez, CarmenDufouil, CaroleGraff, CarolineFerreira, Catarina B.Chillotti, CaterinaReynolds, Chandra A.Fenoglio, ChiaraVan Broeckhoven, ChristineClark, ChristopherPisanu, ClaudiaSatizabal, Claudia L.Holmes, CliveBuiza-Rueda, DoloresAarsland, DagRujescu, DanAlcolea, DanielGalimberti, DanielaWallon, DavidSeripa, DavideGrünblatt, EdnaDardiotis, EfthimiosDüzel, EmrahScarpini, ElioConti, ElisaRubino, ElisaGelpi, EllenRodriguez-Rodriguez, Eloy2021-06-14T14:40:24Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48526engNat Commun 12, 3417 (2021)10.1038/s41467-021-22491-82041-1723info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:51:54Zoai:repositorio.ul.pt:10451/48526Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:22.182060Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
title Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
spellingShingle Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
de Rojas, Itziar
title_short Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
title_full Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
title_fullStr Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
title_full_unstemmed Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
title_sort Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
author de Rojas, Itziar
author_facet de Rojas, Itziar
Moreno-Grau, Sonia
Tesi, Niccolo
Grenier-Boley, Benjamin
Andrade, Victor
Jansen, Iris E.
Pedersen, Nancy L.
Stringa, Najada
Zettergren, Anna
Hernández, Isabel
Montrreal, Laura
Duron, Emmanuelle
Boerwinkle, Eric
Ferri, Evelyn
Tagliavini, Fabrizio
Küçükali, Fahri
Pasquier, Florence
Sanchez-Garcia, Florentino
Mangialasche, Francesca
Jessen, Frank
Nicolas, Gaël
Antúnez, Carmen
Selbæk, Geir
Ortega, Gemma
Chêne, Geneviève
Hadjigeorgiou, Georgios
Rossi, Giacomina
Spalletta, Gianfranco
Giaccone, Giorgio
Grande, Giulia
Binetti, Giuliano
Papenberg, Goran
Antonell, Anna
Hampel, Harald
Bailly, Henri
Zetterberg, Henrik
Soininen, Hilkka
Karlsson, Ida K.
Alvarez, Ignacio
Appollonio, Ildebrando
Giegling, Ina
Skoog, Ingmar
Saltvedt, Ingvild
Tankard, Rick M.
Rainero, Innocenzo
Rosas Allende, Irene
Hort, Jakub
Diehl-Schmid, Janine
Van Dongen, Jasper
Vidal, Jean-Sebastien
Lehtisalo, Jenni
Wiltfang, Jens
Thomassen, Jesper Qvist
Kornhuber, Johannes
Bis, Joshua C.
Haines, Jonathan L.
Vogelgsang, Jonathan
Pineda, Juan A.
Fortea, Juan
Popp, Julius
Deckert, Jürgen
Buerger, Katharina
Morgan, Kevin
Fließbach, Klaus
Sleegers, Kristel
Sims, Rebecca
Molina-Porcel, Laura
Kilander, Lena
Weinhold, Leonie
Farrer, Lindsay A.
Wang, Li-San
Kleineidam, Luca
Farotti, Lucia
Parnetti, Lucilla
Tremolizzo, Lucio
Hausner, Lucrezia
Bellenguez, Céline
Benussi, Luisa
Froelich, Lutz
Ikram, M. Arfan
Deniz-Naranjo, M Candida
Tsolaki, Magda
Rosende-Roca, Maitée
Löwenmark, Malin
Hulsman, Marc
Spallazzi, Marco
Pericak-Vance, Margaret A.
Quintela, Inés
Esiri, Margaret
Bernal Sánchez-Arjona, María
Dalmasso, Maria Carolina
Martínez-Larrad, María Teresa
Arcaro, Marina
Nöthen, Markus M.
Fernández-Fuertes, Marta
Dichgans, Martin
Ingelsson, Martin
Herrmann, Martin J.
González-Perez, Antonio
Scherer, Martin
Vyhnalek, Martin
Kosmidis, Mary H.
Yannakoulia, Mary
Schmid, Matthias
Ewers, Michael
Heneka, Michael T.
Wagner, Michael
Scamosci, Michela
Kivipelto, Miia
Calero, Miguel
Hiltunen, Mikko
Zulaica, Miren
Alegret, Montserrat
Fornage, Myriam
Roberto, Natalia
van Schoor, Natasja M.
Seidu, Nazib M.
Banaj, Nerisa
Armstrong, Nicola J.
Scarmeas, Nikolaos
Franco-Macías, Emilio
Scherbaum, Norbert
Goldhardt, Oliver
Hanon, Oliver
Peters, Oliver
Skrobot, Olivia Anna
Quenez, Olivier
Lerch, Ondrej
Bossù, Paola
Caffarra, Paolo
Dionigi Rossi, Paolo
Macías, Juan
Sakka, Paraskevi
Hoffmann, Per
Holmans, Peter A.
Fischer, Peter
Riederer, Peter
Yang, Qiong
Marshall, Rachel
Kalaria, Rajesh N.
Mayeux, Richard
Vandenberghe, Rik
Blesa, Rafael
Cecchetti, Roberta
Ghidoni, Roberta
Frikke-Schmidt, Ruth
Sorbi, Sandro
Hägg, Sara
Engelborghs, Sebastiaan
Helisalmi, Seppo
Botne Sando, Sigrid
Kern, Silke
Archetti, Silvana
Cervera-Carles, Laura
Boschi, Silvia
Fostinelli, Silvia
Gil, Silvia
Mendoza, Silvia
Mead, Simon
Ciccone, Simona
Djurovic, Srdjan
Heilmann-Heimbach, Stefanie
Riedel-Heller, Steffi
Kuulasmaa, Teemu
Menéndez-González, Manuel
Del Ser, Teodoro
Lebouvier, Thibaud
Polak, Thomas
Ngandu, Tiia
Grimmer, Timo
Bessi, Valentina
Escott-Price, Valentina
Giedraitis, Vilmantas
Deramecourt, Vincent
Maier, Wolfgang
Frank-García, Ana
Jian, Xueqiu
Pijnenburg, Yolande A. L.
Kehoe, Patrick Gavin
Garcia-Ribas, Guillermo
Sánchez-Juan, Pascual
Pastor, Pau
Pérez-Tur, Jordi
Piñol-Ripoll, Gerard
Lopez de Munain, Adolfo
García-Alberca, Jose María
Royo, Jose Luís
Bullido, María J.
Álvarez, Victoria
Lleó, Alberto
Real, Luis M.
Mir, Pablo
Medina, Miguel
Scheltens, Philip
Holstege, Henne
Marquié, Marta
Sáez, María Eugenia
Moreno, Fermin
Carracedo, Ángel
Amouyel, Philippe
Schellenberg, Gerard D.
Williams, Julie
Seshadri, Sudha
van Duijn, Cornelia M.
Mather, Karen A.
Sánchez-Valle, Raquel
Serrano-Ríos, Manuel
Orellana, Adelina
Huerto Vilas, Raquel
Tárraga, Lluís
Blennow, Kaj
Huisman, Martijn
Andreassen, Ole A
Posthuma, Danielle
Clarimón, Jordi
Boada, Mercè
van der Flier, Wiesje M.
Ramirez, Alfredo
Lambert, Jean-Charles
Baquero, Miquel
van der Lee, Sven J.
Ruiz, Agustín
Diez-Fairen, Mónica
Lage, Carmen
García-Madrona, Sebastián
García-González, Pablo
Alarcón-Martín, Emilio
Valero, Sergi
Sotolongo-Grau, Oscar
Ullgren, Abbe
Naj, Adam C.
Lemstra, Afina W.
Benaque, Alba
Pérez-Cordón, Alba
Benussi, Alberto
Rábano, Alberto
Padovani, Alessandro
Squassina, Alessio
De Mendonça, Alexandre
Arias Pastor, Alfonso
Kok, Almar A. L.
Meggy, Alun
Pastor, Ana Belén
Espinosa, Ana
Corma-Gómez, Anaïs
Martín Montes, Angel
Sanabria, Ángela
DeStefano, Anita L.
Schneider, Anja
Haapasalo, Annakaisa
Kinhult Ståhlbom, Anne
Tybjærg-Hansen, Anne
Hartmann, Annette M.
Spottke, Annika
Corbatón-Anchuelo, Arturo
Rongve, Arvid
Borroni, Barbara
Arosio, Beatrice
Nacmias, Benedetta
Nordestgaard, Børge G.
Kunkle, Brian W.
Charbonnier, Camille
Abdelnour, Carla
Masullo, Carlo
Martínez Rodríguez, Carmen
Muñoz-Fernandez, Carmen
Dufouil, Carole
Graff, Caroline
Ferreira, Catarina B.
Chillotti, Caterina
Reynolds, Chandra A.
Fenoglio, Chiara
Van Broeckhoven, Christine
Clark, Christopher
Pisanu, Claudia
Satizabal, Claudia L.
Holmes, Clive
Buiza-Rueda, Dolores
Aarsland, Dag
Rujescu, Dan
Alcolea, Daniel
Galimberti, Daniela
Wallon, David
Seripa, Davide
Grünblatt, Edna
Dardiotis, Efthimios
Düzel, Emrah
Scarpini, Elio
Conti, Elisa
Rubino, Elisa
Gelpi, Ellen
Rodriguez-Rodriguez, Eloy
author_role author
author2 Moreno-Grau, Sonia
Tesi, Niccolo
Grenier-Boley, Benjamin
Andrade, Victor
Jansen, Iris E.
Pedersen, Nancy L.
Stringa, Najada
Zettergren, Anna
Hernández, Isabel
Montrreal, Laura
Duron, Emmanuelle
Boerwinkle, Eric
Ferri, Evelyn
Tagliavini, Fabrizio
Küçükali, Fahri
Pasquier, Florence
Sanchez-Garcia, Florentino
Mangialasche, Francesca
Jessen, Frank
Nicolas, Gaël
Antúnez, Carmen
Selbæk, Geir
Ortega, Gemma
Chêne, Geneviève
Hadjigeorgiou, Georgios
Rossi, Giacomina
Spalletta, Gianfranco
Giaccone, Giorgio
Grande, Giulia
Binetti, Giuliano
Papenberg, Goran
Antonell, Anna
Hampel, Harald
Bailly, Henri
Zetterberg, Henrik
Soininen, Hilkka
Karlsson, Ida K.
Alvarez, Ignacio
Appollonio, Ildebrando
Giegling, Ina
Skoog, Ingmar
Saltvedt, Ingvild
Tankard, Rick M.
Rainero, Innocenzo
Rosas Allende, Irene
Hort, Jakub
Diehl-Schmid, Janine
Van Dongen, Jasper
Vidal, Jean-Sebastien
Lehtisalo, Jenni
Wiltfang, Jens
Thomassen, Jesper Qvist
Kornhuber, Johannes
Bis, Joshua C.
Haines, Jonathan L.
Vogelgsang, Jonathan
Pineda, Juan A.
Fortea, Juan
Popp, Julius
Deckert, Jürgen
Buerger, Katharina
Morgan, Kevin
Fließbach, Klaus
Sleegers, Kristel
Sims, Rebecca
Molina-Porcel, Laura
Kilander, Lena
Weinhold, Leonie
Farrer, Lindsay A.
Wang, Li-San
Kleineidam, Luca
Farotti, Lucia
Parnetti, Lucilla
Tremolizzo, Lucio
Hausner, Lucrezia
Bellenguez, Céline
Benussi, Luisa
Froelich, Lutz
Ikram, M. Arfan
Deniz-Naranjo, M Candida
Tsolaki, Magda
Rosende-Roca, Maitée
Löwenmark, Malin
Hulsman, Marc
Spallazzi, Marco
Pericak-Vance, Margaret A.
Quintela, Inés
Esiri, Margaret
Bernal Sánchez-Arjona, María
Dalmasso, Maria Carolina
Martínez-Larrad, María Teresa
Arcaro, Marina
Nöthen, Markus M.
Fernández-Fuertes, Marta
Dichgans, Martin
Ingelsson, Martin
Herrmann, Martin J.
González-Perez, Antonio
Scherer, Martin
Vyhnalek, Martin
Kosmidis, Mary H.
Yannakoulia, Mary
Schmid, Matthias
Ewers, Michael
Heneka, Michael T.
Wagner, Michael
Scamosci, Michela
Kivipelto, Miia
Calero, Miguel
Hiltunen, Mikko
Zulaica, Miren
Alegret, Montserrat
Fornage, Myriam
Roberto, Natalia
van Schoor, Natasja M.
Seidu, Nazib M.
Banaj, Nerisa
Armstrong, Nicola J.
Scarmeas, Nikolaos
Franco-Macías, Emilio
Scherbaum, Norbert
Goldhardt, Oliver
Hanon, Oliver
Peters, Oliver
Skrobot, Olivia Anna
Quenez, Olivier
Lerch, Ondrej
Bossù, Paola
Caffarra, Paolo
Dionigi Rossi, Paolo
Macías, Juan
Sakka, Paraskevi
Hoffmann, Per
Holmans, Peter A.
Fischer, Peter
Riederer, Peter
Yang, Qiong
Marshall, Rachel
Kalaria, Rajesh N.
Mayeux, Richard
Vandenberghe, Rik
Blesa, Rafael
Cecchetti, Roberta
Ghidoni, Roberta
Frikke-Schmidt, Ruth
Sorbi, Sandro
Hägg, Sara
Engelborghs, Sebastiaan
Helisalmi, Seppo
Botne Sando, Sigrid
Kern, Silke
Archetti, Silvana
Cervera-Carles, Laura
Boschi, Silvia
Fostinelli, Silvia
Gil, Silvia
Mendoza, Silvia
Mead, Simon
Ciccone, Simona
Djurovic, Srdjan
Heilmann-Heimbach, Stefanie
Riedel-Heller, Steffi
Kuulasmaa, Teemu
Menéndez-González, Manuel
Del Ser, Teodoro
Lebouvier, Thibaud
Polak, Thomas
Ngandu, Tiia
Grimmer, Timo
Bessi, Valentina
Escott-Price, Valentina
Giedraitis, Vilmantas
Deramecourt, Vincent
Maier, Wolfgang
Frank-García, Ana
Jian, Xueqiu
Pijnenburg, Yolande A. L.
Kehoe, Patrick Gavin
Garcia-Ribas, Guillermo
Sánchez-Juan, Pascual
Pastor, Pau
Pérez-Tur, Jordi
Piñol-Ripoll, Gerard
Lopez de Munain, Adolfo
García-Alberca, Jose María
Royo, Jose Luís
Bullido, María J.
Álvarez, Victoria
Lleó, Alberto
Real, Luis M.
Mir, Pablo
Medina, Miguel
Scheltens, Philip
Holstege, Henne
Marquié, Marta
Sáez, María Eugenia
Moreno, Fermin
Carracedo, Ángel
Amouyel, Philippe
Schellenberg, Gerard D.
Williams, Julie
Seshadri, Sudha
van Duijn, Cornelia M.
Mather, Karen A.
Sánchez-Valle, Raquel
Serrano-Ríos, Manuel
Orellana, Adelina
Huerto Vilas, Raquel
Tárraga, Lluís
Blennow, Kaj
Huisman, Martijn
Andreassen, Ole A
Posthuma, Danielle
Clarimón, Jordi
Boada, Mercè
van der Flier, Wiesje M.
Ramirez, Alfredo
Lambert, Jean-Charles
Baquero, Miquel
van der Lee, Sven J.
Ruiz, Agustín
Diez-Fairen, Mónica
Lage, Carmen
García-Madrona, Sebastián
García-González, Pablo
Alarcón-Martín, Emilio
Valero, Sergi
Sotolongo-Grau, Oscar
Ullgren, Abbe
Naj, Adam C.
Lemstra, Afina W.
Benaque, Alba
Pérez-Cordón, Alba
Benussi, Alberto
Rábano, Alberto
Padovani, Alessandro
Squassina, Alessio
De Mendonça, Alexandre
Arias Pastor, Alfonso
Kok, Almar A. L.
Meggy, Alun
Pastor, Ana Belén
Espinosa, Ana
Corma-Gómez, Anaïs
Martín Montes, Angel
Sanabria, Ángela
DeStefano, Anita L.
Schneider, Anja
Haapasalo, Annakaisa
Kinhult Ståhlbom, Anne
Tybjærg-Hansen, Anne
Hartmann, Annette M.
Spottke, Annika
Corbatón-Anchuelo, Arturo
Rongve, Arvid
Borroni, Barbara
Arosio, Beatrice
Nacmias, Benedetta
Nordestgaard, Børge G.
Kunkle, Brian W.
Charbonnier, Camille
Abdelnour, Carla
Masullo, Carlo
Martínez Rodríguez, Carmen
Muñoz-Fernandez, Carmen
Dufouil, Carole
Graff, Caroline
Ferreira, Catarina B.
Chillotti, Caterina
Reynolds, Chandra A.
Fenoglio, Chiara
Van Broeckhoven, Christine
Clark, Christopher
Pisanu, Claudia
Satizabal, Claudia L.
Holmes, Clive
Buiza-Rueda, Dolores
Aarsland, Dag
Rujescu, Dan
Alcolea, Daniel
Galimberti, Daniela
Wallon, David
Seripa, Davide
Grünblatt, Edna
Dardiotis, Efthimios
Düzel, Emrah
Scarpini, Elio
Conti, Elisa
Rubino, Elisa
Gelpi, Ellen
Rodriguez-Rodriguez, Eloy
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv de Rojas, Itziar
Moreno-Grau, Sonia
Tesi, Niccolo
Grenier-Boley, Benjamin
Andrade, Victor
Jansen, Iris E.
Pedersen, Nancy L.
Stringa, Najada
Zettergren, Anna
Hernández, Isabel
Montrreal, Laura
Duron, Emmanuelle
Boerwinkle, Eric
Ferri, Evelyn
Tagliavini, Fabrizio
Küçükali, Fahri
Pasquier, Florence
Sanchez-Garcia, Florentino
Mangialasche, Francesca
Jessen, Frank
Nicolas, Gaël
Antúnez, Carmen
Selbæk, Geir
Ortega, Gemma
Chêne, Geneviève
Hadjigeorgiou, Georgios
Rossi, Giacomina
Spalletta, Gianfranco
Giaccone, Giorgio
Grande, Giulia
Binetti, Giuliano
Papenberg, Goran
Antonell, Anna
Hampel, Harald
Bailly, Henri
Zetterberg, Henrik
Soininen, Hilkka
Karlsson, Ida K.
Alvarez, Ignacio
Appollonio, Ildebrando
Giegling, Ina
Skoog, Ingmar
Saltvedt, Ingvild
Tankard, Rick M.
Rainero, Innocenzo
Rosas Allende, Irene
Hort, Jakub
Diehl-Schmid, Janine
Van Dongen, Jasper
Vidal, Jean-Sebastien
Lehtisalo, Jenni
Wiltfang, Jens
Thomassen, Jesper Qvist
Kornhuber, Johannes
Bis, Joshua C.
Haines, Jonathan L.
Vogelgsang, Jonathan
Pineda, Juan A.
Fortea, Juan
Popp, Julius
Deckert, Jürgen
Buerger, Katharina
Morgan, Kevin
Fließbach, Klaus
Sleegers, Kristel
Sims, Rebecca
Molina-Porcel, Laura
Kilander, Lena
Weinhold, Leonie
Farrer, Lindsay A.
Wang, Li-San
Kleineidam, Luca
Farotti, Lucia
Parnetti, Lucilla
Tremolizzo, Lucio
Hausner, Lucrezia
Bellenguez, Céline
Benussi, Luisa
Froelich, Lutz
Ikram, M. Arfan
Deniz-Naranjo, M Candida
Tsolaki, Magda
Rosende-Roca, Maitée
Löwenmark, Malin
Hulsman, Marc
Spallazzi, Marco
Pericak-Vance, Margaret A.
Quintela, Inés
Esiri, Margaret
Bernal Sánchez-Arjona, María
Dalmasso, Maria Carolina
Martínez-Larrad, María Teresa
Arcaro, Marina
Nöthen, Markus M.
Fernández-Fuertes, Marta
Dichgans, Martin
Ingelsson, Martin
Herrmann, Martin J.
González-Perez, Antonio
Scherer, Martin
Vyhnalek, Martin
Kosmidis, Mary H.
Yannakoulia, Mary
Schmid, Matthias
Ewers, Michael
Heneka, Michael T.
Wagner, Michael
Scamosci, Michela
Kivipelto, Miia
Calero, Miguel
Hiltunen, Mikko
Zulaica, Miren
Alegret, Montserrat
Fornage, Myriam
Roberto, Natalia
van Schoor, Natasja M.
Seidu, Nazib M.
Banaj, Nerisa
Armstrong, Nicola J.
Scarmeas, Nikolaos
Franco-Macías, Emilio
Scherbaum, Norbert
Goldhardt, Oliver
Hanon, Oliver
Peters, Oliver
Skrobot, Olivia Anna
Quenez, Olivier
Lerch, Ondrej
Bossù, Paola
Caffarra, Paolo
Dionigi Rossi, Paolo
Macías, Juan
Sakka, Paraskevi
Hoffmann, Per
Holmans, Peter A.
Fischer, Peter
Riederer, Peter
Yang, Qiong
Marshall, Rachel
Kalaria, Rajesh N.
Mayeux, Richard
Vandenberghe, Rik
Blesa, Rafael
Cecchetti, Roberta
Ghidoni, Roberta
Frikke-Schmidt, Ruth
Sorbi, Sandro
Hägg, Sara
Engelborghs, Sebastiaan
Helisalmi, Seppo
Botne Sando, Sigrid
Kern, Silke
Archetti, Silvana
Cervera-Carles, Laura
Boschi, Silvia
Fostinelli, Silvia
Gil, Silvia
Mendoza, Silvia
Mead, Simon
Ciccone, Simona
Djurovic, Srdjan
Heilmann-Heimbach, Stefanie
Riedel-Heller, Steffi
Kuulasmaa, Teemu
Menéndez-González, Manuel
Del Ser, Teodoro
Lebouvier, Thibaud
Polak, Thomas
Ngandu, Tiia
Grimmer, Timo
Bessi, Valentina
Escott-Price, Valentina
Giedraitis, Vilmantas
Deramecourt, Vincent
Maier, Wolfgang
Frank-García, Ana
Jian, Xueqiu
Pijnenburg, Yolande A. L.
Kehoe, Patrick Gavin
Garcia-Ribas, Guillermo
Sánchez-Juan, Pascual
Pastor, Pau
Pérez-Tur, Jordi
Piñol-Ripoll, Gerard
Lopez de Munain, Adolfo
García-Alberca, Jose María
Royo, Jose Luís
Bullido, María J.
Álvarez, Victoria
Lleó, Alberto
Real, Luis M.
Mir, Pablo
Medina, Miguel
Scheltens, Philip
Holstege, Henne
Marquié, Marta
Sáez, María Eugenia
Moreno, Fermin
Carracedo, Ángel
Amouyel, Philippe
Schellenberg, Gerard D.
Williams, Julie
Seshadri, Sudha
van Duijn, Cornelia M.
Mather, Karen A.
Sánchez-Valle, Raquel
Serrano-Ríos, Manuel
Orellana, Adelina
Huerto Vilas, Raquel
Tárraga, Lluís
Blennow, Kaj
Huisman, Martijn
Andreassen, Ole A
Posthuma, Danielle
Clarimón, Jordi
Boada, Mercè
van der Flier, Wiesje M.
Ramirez, Alfredo
Lambert, Jean-Charles
Baquero, Miquel
van der Lee, Sven J.
Ruiz, Agustín
Diez-Fairen, Mónica
Lage, Carmen
García-Madrona, Sebastián
García-González, Pablo
Alarcón-Martín, Emilio
Valero, Sergi
Sotolongo-Grau, Oscar
Ullgren, Abbe
Naj, Adam C.
Lemstra, Afina W.
Benaque, Alba
Pérez-Cordón, Alba
Benussi, Alberto
Rábano, Alberto
Padovani, Alessandro
Squassina, Alessio
De Mendonça, Alexandre
Arias Pastor, Alfonso
Kok, Almar A. L.
Meggy, Alun
Pastor, Ana Belén
Espinosa, Ana
Corma-Gómez, Anaïs
Martín Montes, Angel
Sanabria, Ángela
DeStefano, Anita L.
Schneider, Anja
Haapasalo, Annakaisa
Kinhult Ståhlbom, Anne
Tybjærg-Hansen, Anne
Hartmann, Annette M.
Spottke, Annika
Corbatón-Anchuelo, Arturo
Rongve, Arvid
Borroni, Barbara
Arosio, Beatrice
Nacmias, Benedetta
Nordestgaard, Børge G.
Kunkle, Brian W.
Charbonnier, Camille
Abdelnour, Carla
Masullo, Carlo
Martínez Rodríguez, Carmen
Muñoz-Fernandez, Carmen
Dufouil, Carole
Graff, Caroline
Ferreira, Catarina B.
Chillotti, Caterina
Reynolds, Chandra A.
Fenoglio, Chiara
Van Broeckhoven, Christine
Clark, Christopher
Pisanu, Claudia
Satizabal, Claudia L.
Holmes, Clive
Buiza-Rueda, Dolores
Aarsland, Dag
Rujescu, Dan
Alcolea, Daniel
Galimberti, Daniela
Wallon, David
Seripa, Davide
Grünblatt, Edna
Dardiotis, Efthimios
Düzel, Emrah
Scarpini, Elio
Conti, Elisa
Rubino, Elisa
Gelpi, Ellen
Rodriguez-Rodriguez, Eloy
description © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-14T14:40:24Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/48526
url http://hdl.handle.net/10451/48526
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nat Commun 12, 3417 (2021)
10.1038/s41467-021-22491-8
2041-1723
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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