Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections

Detalhes bibliográficos
Autor(a) principal: Liehl, Peter
Data de Publicação: 2015
Outros Autores: Meireles, Patricia, Albuquerque, Inês S., Pinkevych, Mykola, Baptista, Fernanda, Mota, Maria M., Davenport, Miles P., Prudêncio, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/53211
Resumo: © 2015 American Society for Microbiology. The authors have paid a fee to allow immediate free access to this article.
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spelling Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections© 2015 American Society for Microbiology. The authors have paid a fee to allow immediate free access to this article.Following transmission through a mosquito bite to the mammalian host, Plasmodium parasites first invade and replicate inside hepatocytes before infecting erythrocytes and causing malaria. The mechanisms limiting Plasmodium reinfections in humans living in regions of malaria endemicity have mainly been explored by studying the resistance induced by the blood stage of infection. However, epidemiologic studies have suggested that in high-transmission areas, preerythrocytic stages also activate host resistance to reinfection. This, along with the recent discovery that liver infections trigger a specific and effective type I interferon (IFN) response, prompted us to hypothesize that this pre-erythrocyte-stage-induced resistance is linked to liver innate immunity. Here, we combined experimental approaches and mathematical modeling to recapitulate field studies and understand the molecular basis behind such resistance. We present a newly established mouse reinfection model and demonstrate that rodent malaria liver-stage infection inhibits reinfection. This protection relies on the activation of innate immunity and involves the type I IFN response and the antimicrobial cytokine gamma IFN (IFN-γ). Importantly, mathematical simulations indicate that the predictions based on our experimental murine reinfection model fit available epidemiological data. Overall, our study revealed that liver-stage-induced innate immunity may contribute to the preerythrocytic resistance observed in humans in regions of malaria hyperendemicity.This work was supported by Fundação para a Ciência e Tecnologia (FCT, Portugal) grants PTDC-SAU-MIC-117060-2010 (to Miguel Prudêncio) and EXCL/IMI-MIC/0056/2012 (to M.M.M.). P.L. was supported by Fondation pour la Recherche Médicale and FCT (fellowship SFRH/BPD/41547/2007). P.M. was supported by FCT (fellowship SFRH/BD/71098/2010). Miguel Prudêncio and M.P.D. are supported by an Australian Research Council Discovery Grant (DP120100064). M.P.D. is an NHMRC Senior Research Fellow.ASM JournalsRepositório da Universidade de LisboaLiehl, PeterMeireles, PatriciaAlbuquerque, Inês S.Pinkevych, MykolaBaptista, FernandaMota, Maria M.Davenport, Miles P.Prudêncio, Miguel2022-05-27T15:51:32Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/53211engInfect Immun. 2015 Mar;83(3):1172-11800019-956710.1128/IAI.02796-141098-5522info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:14:41Zoai:repositorio.ul.pt:10451/53211Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:14:41Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections
title Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections
spellingShingle Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections
Liehl, Peter
title_short Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections
title_full Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections
title_fullStr Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections
title_full_unstemmed Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections
title_sort Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections
author Liehl, Peter
author_facet Liehl, Peter
Meireles, Patricia
Albuquerque, Inês S.
Pinkevych, Mykola
Baptista, Fernanda
Mota, Maria M.
Davenport, Miles P.
Prudêncio, Miguel
author_role author
author2 Meireles, Patricia
Albuquerque, Inês S.
Pinkevych, Mykola
Baptista, Fernanda
Mota, Maria M.
Davenport, Miles P.
Prudêncio, Miguel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Liehl, Peter
Meireles, Patricia
Albuquerque, Inês S.
Pinkevych, Mykola
Baptista, Fernanda
Mota, Maria M.
Davenport, Miles P.
Prudêncio, Miguel
description © 2015 American Society for Microbiology. The authors have paid a fee to allow immediate free access to this article.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2022-05-27T15:51:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/53211
url http://hdl.handle.net/10451/53211
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Infect Immun. 2015 Mar;83(3):1172-1180
0019-9567
10.1128/IAI.02796-14
1098-5522
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ASM Journals
publisher.none.fl_str_mv ASM Journals
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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