Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/159630 |
Resumo: | Funding Information: This work is funded by National Funds through the FCT-Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. P.S. acknowledges the individual contract CEECIND.03189.2020. Publisher Copyright: © 2023 by the authors. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Gellan Gum/Alginate Microparticles as Drug Delivery VehiclesDOE Production Optimization and Drug Deliveryalginatecoaxial airflowdesign of experimentsgellan gummicroparticlesMolecular MedicinePharmaceutical ScienceDrug DiscoveryFunding Information: This work is funded by National Funds through the FCT-Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. P.S. acknowledges the individual contract CEECIND.03189.2020. Publisher Copyright: © 2023 by the authors.Gellan gum is a biocompatible and easily accessible polysaccharide with excellent properties to produce microparticles as drug delivery systems. However, the production methods often fail in reproducibility, compromising the translational potential of such systems. In this work, the production of gellan gum-based microparticles was optimized using the coaxial air flow method, and an inexpensive and reproducible production method. A design of experiments was used to identify the main parameters that affect microparticle production and optimization, focusing on diameter and dispersibility. Airflow was the most significant factor for both parameters. Pump flow affected the diameter, while the gellan gum/alginate ratio affected dispersibility. Microparticles were revealed to be sensitive to pH with swelling, degradation, and encapsulation efficiency affected by pH. Using methylene blue as a model drug, higher encapsulation, and swelling indexes were obtained at pH 7.4, while a more pronounced release occurred at pH 6.5. Within PBs solutions, the microparticles endured up to two months. The microparticle release profiles were studied using well-known models, showing a Fickian-type release, but with no alteration by pH. The developed microparticles showed promising results as drug-delivery vehicles sensitive to pH.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisRUNCarrêlo, HenriqueCidade, Maria TeresaBorges, João PauloSoares, Paula2023-11-06T22:10:42Z2023-07-192023-07-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article22application/pdfhttp://hdl.handle.net/10362/159630eng1424-8247PURE: 75516526https://doi.org/10.3390/ph16071029info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:42:02Zoai:run.unl.pt:10362/159630Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:37.765272Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles DOE Production Optimization and Drug Delivery |
title |
Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles |
spellingShingle |
Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles Carrêlo, Henrique alginate coaxial airflow design of experiments gellan gum microparticles Molecular Medicine Pharmaceutical Science Drug Discovery |
title_short |
Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles |
title_full |
Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles |
title_fullStr |
Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles |
title_full_unstemmed |
Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles |
title_sort |
Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles |
author |
Carrêlo, Henrique |
author_facet |
Carrêlo, Henrique Cidade, Maria Teresa Borges, João Paulo Soares, Paula |
author_role |
author |
author2 |
Cidade, Maria Teresa Borges, João Paulo Soares, Paula |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DCM - Departamento de Ciência dos Materiais RUN |
dc.contributor.author.fl_str_mv |
Carrêlo, Henrique Cidade, Maria Teresa Borges, João Paulo Soares, Paula |
dc.subject.por.fl_str_mv |
alginate coaxial airflow design of experiments gellan gum microparticles Molecular Medicine Pharmaceutical Science Drug Discovery |
topic |
alginate coaxial airflow design of experiments gellan gum microparticles Molecular Medicine Pharmaceutical Science Drug Discovery |
description |
Funding Information: This work is funded by National Funds through the FCT-Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. P.S. acknowledges the individual contract CEECIND.03189.2020. Publisher Copyright: © 2023 by the authors. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-06T22:10:42Z 2023-07-19 2023-07-19T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/159630 |
url |
http://hdl.handle.net/10362/159630 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1424-8247 PURE: 75516526 https://doi.org/10.3390/ph16071029 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
22 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138158764359680 |