HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005

• Autor(a) principal: Félix, A.
• Data de Publicação: 2016
• Outros Autores: Alemany, L., Tous, S., de Sanjosé, S., Bosch, F.X.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.1016/j.pvr.2016.02.003
• topic: HPV; Invasive cervical carcinoma; Portugal; Retrospective study; adult; aged; Article; cohort analysis; controlled study; female; genotype; human; Human papillomavirus type 11; Human papillomavirus type 16; Human papillomavirus type 18; Human papillomavirus type 30; Human papillomavirus type 31; Human papillomavirus type 33; Human papillomavirus type 35; Human papillomavirus type 39; Human papillomavirus type 42; Human papillomavirus type 45; Human papillomavirus type 51; Human papillomavirus type 52; Human papillomavirus type 53; Human papillomavirus type 56; Human papillomavirus type 58; Human papillomavirus type 59; Human papillomavirus type 66; Human papillomavirus type 67; Human papillomavirus type 68; Human papillomavirus type 69; Human papillomavirus type 70; Human papillomavirus type 73; Human papillomavirus type 91; major clinical study; nonhuman; priority journal; retrospective study; uterine cervix cancer; virus detection; Wart virus; SDG 3 - Good Health and Well-being

Objectives To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. Methods Cases diagnosed at the Instituto Português de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 system. Results Of the 1214 samples that were considered appropriate for HPV detection, 714 (58.8%; 95% CI: 56.0–61.6%) were positive for HPV DNA. This detection rate varied being lower in the first 3 decades (31.3%; 50.1%; 46.5%) and higher in the last decades (77.4–95.1%). This difference was due probably to the fixative used in the first three decades. The five most common types identified among HPV positive cases were HPV16 (58.2%), HPV18 (9.2%), HPV33 (6.2%), HPV45 (4.7%) and HPV31 (4.4%). Multiple infections were detected in 2.8% of the cases. HPV16 and 18 accounted for 67.4% of infections. There were no statistically significant changes of these types over the studied period. An increase at patient׳s age at diagnosis was observed in the last decades (p