Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/158489 |
Resumo: | This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through the FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R. Gavinho and A. Sofia Pádua acknowledge the FCT—Portuguese Foundation for Science and Technology for the Ph.D. grant ( UI/DB/151287/2021). Publisher Copyright: © 2023 by the authors. |
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7160 |
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Bioactive Glass Modified with Zirconium Incorporation for Dental Implant ApplicationsFabrication, Structural, Electrical, and Biological Analysisantibacterial propertiesbioactivityBioglassdielectric propertiesimplant coatingosseointegrationzirconiumCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistryThis research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through the FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R. Gavinho and A. Sofia Pádua acknowledge the FCT—Portuguese Foundation for Science and Technology for the Ph.D. grant ( UI/DB/151287/2021). Publisher Copyright: © 2023 by the authors.Implantology is crucial for restoring aesthetics and masticatory function in oral rehabilitation. Despite its advantages, certain issues, such as bacterial infection, may still arise that hinder osseointegration and result in implant rejection. This work aims to address these challenges by developing a biomaterial for dental implant coating based on 45S5 Bioglass® modified by zirconium insertion. The structural characterization of the glasses, by XRD, showed that the introduction of zirconium in the Bioglass network at a concentration higher than 2 mol% promotes phase separation, with crystal phase formation. Impedance spectroscopy was used, in the frequency range of 102–106 Hz and the temperature range of 200–400 K, to investigate the electrical properties of these Bioglasses, due to their ability to store electrical charges and therefore enhance the osseointegration capacity. The electrical study showed that the presence of crystal phases, in the glass ceramic with 8 mol% of zirconium, led to a significant increase in conductivity. In terms of biological properties, the Bioglasses exhibited an antibacterial effect against Gram-positive and Gram-negative bacteria and did not show cytotoxicity for the Saos-2 cell line at extract concentrations up to 25 mg/mL. Furthermore, the results of the bioactivity test revealed that within 24 h, a CaP-rich layer began to form on the surface of all the samples. According to our results, the incorporation of 2 mol% of ZrO2 into the Bioglass significantly improves its potential as a coating material for dental implants, enhancing both its antibacterial and osteointegration properties.DF – Departamento de FísicaCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaDCM - Departamento de Ciência dos MateriaisRUNHammami, ImenGavinho, Sílvia RodriguesPádua, Ana SofiaSá-Nogueira, IsabelSilva, Jorge CarvalhoBorges, João PauloValente, Manuel AlmeidaGraça, Manuel Pedro Fernandes2023-09-29T22:22:32Z2023-06-242023-06-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/158489eng1661-6596PURE: 72784442https://doi.org/10.3390/ijms241310571info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:54Zoai:run.unl.pt:10362/158489Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:10.279758Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications Fabrication, Structural, Electrical, and Biological Analysis |
title |
Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications |
spellingShingle |
Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications Hammami, Imen antibacterial properties bioactivity Bioglass dielectric properties implant coating osseointegration zirconium Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
title_short |
Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications |
title_full |
Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications |
title_fullStr |
Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications |
title_full_unstemmed |
Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications |
title_sort |
Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications |
author |
Hammami, Imen |
author_facet |
Hammami, Imen Gavinho, Sílvia Rodrigues Pádua, Ana Sofia Sá-Nogueira, Isabel Silva, Jorge Carvalho Borges, João Paulo Valente, Manuel Almeida Graça, Manuel Pedro Fernandes |
author_role |
author |
author2 |
Gavinho, Sílvia Rodrigues Pádua, Ana Sofia Sá-Nogueira, Isabel Silva, Jorge Carvalho Borges, João Paulo Valente, Manuel Almeida Graça, Manuel Pedro Fernandes |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
DF – Departamento de Física CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) UCIBIO - Applied Molecular Biosciences Unit DCV - Departamento de Ciências da Vida DCM - Departamento de Ciência dos Materiais RUN |
dc.contributor.author.fl_str_mv |
Hammami, Imen Gavinho, Sílvia Rodrigues Pádua, Ana Sofia Sá-Nogueira, Isabel Silva, Jorge Carvalho Borges, João Paulo Valente, Manuel Almeida Graça, Manuel Pedro Fernandes |
dc.subject.por.fl_str_mv |
antibacterial properties bioactivity Bioglass dielectric properties implant coating osseointegration zirconium Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
topic |
antibacterial properties bioactivity Bioglass dielectric properties implant coating osseointegration zirconium Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
description |
This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through the FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R. Gavinho and A. Sofia Pádua acknowledge the FCT—Portuguese Foundation for Science and Technology for the Ph.D. grant ( UI/DB/151287/2021). Publisher Copyright: © 2023 by the authors. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-29T22:22:32Z 2023-06-24 2023-06-24T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/158489 |
url |
http://hdl.handle.net/10362/158489 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1661-6596 PURE: 72784442 https://doi.org/10.3390/ijms241310571 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
17 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138155106926592 |