Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide

Detalhes bibliográficos
Autor(a) principal: Vladić, Jelena
Data de Publicação: 2023
Outros Autores: Jerković, Igor, Svilović, Sandra, Pavić, Valentina, Pastor, Kristian, Paiva, Alexandre, Jokić, Stela, Rebocho, Silvia, Duarte, Ana Rita
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158326
Resumo: Funding Information: This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396; European Union's Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020. The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396 ; European Union’s Horizon 2020 ( European Research Council ) under grant agreement No ERC- 2016-CoG 725034 ; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020 . The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Publisher Copyright: © 2023 The Authors
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spelling Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxideAntibacterial activityKineticsLavandula stoechasOxygenated monoterpenesSupercritical COEnvironmental ChemistryPollutionPharmaceutical ScienceManagement, Monitoring, Policy and LawSDG 7 - Affordable and Clean EnergyFunding Information: This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396; European Union's Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020. The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396 ; European Union’s Horizon 2020 ( European Research Council ) under grant agreement No ERC- 2016-CoG 725034 ; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020 . The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Publisher Copyright: © 2023 The AuthorsThe goal of this study was to establish a green methodology for obtaining safe, high-quality, and potent antibacterial extracts of Lavandula stoechas flowers. Supercritical carbon dioxide (scCO2) at different conditions (pressure 100–300 bar, temperature 40 and 60 °C, and CO2 flow 10–30) was applied. Moreover, the impact of the parameters on the extraction yield, chemical profile of the extracts, and the activity against Gram-positive and Gram-negative bacteria was investigated. ScCO2 extraction kinetics was investigated by modelling the extraction curves using the models described by Brunner, Martinez, and their modifications. In vitro assays were applied to estimate the susceptibility of Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus to extracts. A pattern recognition approach was applied to explore the correlations between the employed scCO2 parameters, detected volatile compounds, and extracts’ antibacterial properties. The achieved yield ranged from 1.17 to 2.4% (w/w), with oxygenated monoterpenes fenchone (5.76–22.72%) and verbenone (8.04.-18.65%) as the most abundant ones. The most significant susceptibility of Gram-positive and Gram-negative bacteria was attributed to extracts obtained at 200 bar, with minimal inhibitory concentration in the range 2.71 ± 1.31–20.69 ± 0.91 mgmL−1 and 3.39 ± 0.48–34.28 ± 5.94 mgmL−1, respectively. The obtained extracts represent safe, viable, and promising alternatives for tackling antimicrobial resistance. Moreover, by varying process conditions, it is possible to adjust the chemical profile and the activity of the extracts according to the target purpose. Furthermore, the requirements of clean and sustainable technologies, such as environmental preservation, rational use of renewable resources, and provision of natural, safe, and high-quality extracts can be met.DQ - Departamento de QuímicaRUNVladić, JelenaJerković, IgorSvilović, SandraPavić, ValentinaPastor, KristianPaiva, AlexandreJokić, StelaRebocho, SilviaDuarte, Ana Rita2023-09-26T22:20:51Z2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/158326eng2352-5541PURE: 72434467https://doi.org/10.1016/j.scp.2023.101126info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:38Zoai:run.unl.pt:10362/158326Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:04.441728Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide
title Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide
spellingShingle Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide
Vladić, Jelena
Antibacterial activity
Kinetics
Lavandula stoechas
Oxygenated monoterpenes
Supercritical CO
Environmental Chemistry
Pollution
Pharmaceutical Science
Management, Monitoring, Policy and Law
SDG 7 - Affordable and Clean Energy
title_short Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide
title_full Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide
title_fullStr Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide
title_full_unstemmed Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide
title_sort Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide
author Vladić, Jelena
author_facet Vladić, Jelena
Jerković, Igor
Svilović, Sandra
Pavić, Valentina
Pastor, Kristian
Paiva, Alexandre
Jokić, Stela
Rebocho, Silvia
Duarte, Ana Rita
author_role author
author2 Jerković, Igor
Svilović, Sandra
Pavić, Valentina
Pastor, Kristian
Paiva, Alexandre
Jokić, Stela
Rebocho, Silvia
Duarte, Ana Rita
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Vladić, Jelena
Jerković, Igor
Svilović, Sandra
Pavić, Valentina
Pastor, Kristian
Paiva, Alexandre
Jokić, Stela
Rebocho, Silvia
Duarte, Ana Rita
dc.subject.por.fl_str_mv Antibacterial activity
Kinetics
Lavandula stoechas
Oxygenated monoterpenes
Supercritical CO
Environmental Chemistry
Pollution
Pharmaceutical Science
Management, Monitoring, Policy and Law
SDG 7 - Affordable and Clean Energy
topic Antibacterial activity
Kinetics
Lavandula stoechas
Oxygenated monoterpenes
Supercritical CO
Environmental Chemistry
Pollution
Pharmaceutical Science
Management, Monitoring, Policy and Law
SDG 7 - Affordable and Clean Energy
description Funding Information: This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396; European Union's Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020. The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396 ; European Union’s Horizon 2020 ( European Research Council ) under grant agreement No ERC- 2016-CoG 725034 ; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020 . The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Publisher Copyright: © 2023 The Authors
publishDate 2023
dc.date.none.fl_str_mv 2023-09-26T22:20:51Z
2023-06
2023-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158326
url http://hdl.handle.net/10362/158326
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2352-5541
PURE: 72434467
https://doi.org/10.1016/j.scp.2023.101126
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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