Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/158326 |
Resumo: | Funding Information: This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396; European Union's Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020. The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396 ; European Union’s Horizon 2020 ( European Research Council ) under grant agreement No ERC- 2016-CoG 725034 ; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020 . The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Publisher Copyright: © 2023 The Authors |
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Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxideAntibacterial activityKineticsLavandula stoechasOxygenated monoterpenesSupercritical COEnvironmental ChemistryPollutionPharmaceutical ScienceManagement, Monitoring, Policy and LawSDG 7 - Affordable and Clean EnergyFunding Information: This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396; European Union's Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020. The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396 ; European Union’s Horizon 2020 ( European Research Council ) under grant agreement No ERC- 2016-CoG 725034 ; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020 . The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Publisher Copyright: © 2023 The AuthorsThe goal of this study was to establish a green methodology for obtaining safe, high-quality, and potent antibacterial extracts of Lavandula stoechas flowers. Supercritical carbon dioxide (scCO2) at different conditions (pressure 100–300 bar, temperature 40 and 60 °C, and CO2 flow 10–30) was applied. Moreover, the impact of the parameters on the extraction yield, chemical profile of the extracts, and the activity against Gram-positive and Gram-negative bacteria was investigated. ScCO2 extraction kinetics was investigated by modelling the extraction curves using the models described by Brunner, Martinez, and their modifications. In vitro assays were applied to estimate the susceptibility of Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus to extracts. A pattern recognition approach was applied to explore the correlations between the employed scCO2 parameters, detected volatile compounds, and extracts’ antibacterial properties. The achieved yield ranged from 1.17 to 2.4% (w/w), with oxygenated monoterpenes fenchone (5.76–22.72%) and verbenone (8.04.-18.65%) as the most abundant ones. The most significant susceptibility of Gram-positive and Gram-negative bacteria was attributed to extracts obtained at 200 bar, with minimal inhibitory concentration in the range 2.71 ± 1.31–20.69 ± 0.91 mgmL−1 and 3.39 ± 0.48–34.28 ± 5.94 mgmL−1, respectively. The obtained extracts represent safe, viable, and promising alternatives for tackling antimicrobial resistance. Moreover, by varying process conditions, it is possible to adjust the chemical profile and the activity of the extracts according to the target purpose. Furthermore, the requirements of clean and sustainable technologies, such as environmental preservation, rational use of renewable resources, and provision of natural, safe, and high-quality extracts can be met.DQ - Departamento de QuímicaRUNVladić, JelenaJerković, IgorSvilović, SandraPavić, ValentinaPastor, KristianPaiva, AlexandreJokić, StelaRebocho, SilviaDuarte, Ana Rita2023-09-26T22:20:51Z2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/158326eng2352-5541PURE: 72434467https://doi.org/10.1016/j.scp.2023.101126info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:38Zoai:run.unl.pt:10362/158326Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:04.441728Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide |
title |
Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide |
spellingShingle |
Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide Vladić, Jelena Antibacterial activity Kinetics Lavandula stoechas Oxygenated monoterpenes Supercritical CO Environmental Chemistry Pollution Pharmaceutical Science Management, Monitoring, Policy and Law SDG 7 - Affordable and Clean Energy |
title_short |
Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide |
title_full |
Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide |
title_fullStr |
Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide |
title_full_unstemmed |
Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide |
title_sort |
Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide |
author |
Vladić, Jelena |
author_facet |
Vladić, Jelena Jerković, Igor Svilović, Sandra Pavić, Valentina Pastor, Kristian Paiva, Alexandre Jokić, Stela Rebocho, Silvia Duarte, Ana Rita |
author_role |
author |
author2 |
Jerković, Igor Svilović, Sandra Pavić, Valentina Pastor, Kristian Paiva, Alexandre Jokić, Stela Rebocho, Silvia Duarte, Ana Rita |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
DQ - Departamento de Química RUN |
dc.contributor.author.fl_str_mv |
Vladić, Jelena Jerković, Igor Svilović, Sandra Pavić, Valentina Pastor, Kristian Paiva, Alexandre Jokić, Stela Rebocho, Silvia Duarte, Ana Rita |
dc.subject.por.fl_str_mv |
Antibacterial activity Kinetics Lavandula stoechas Oxygenated monoterpenes Supercritical CO Environmental Chemistry Pollution Pharmaceutical Science Management, Monitoring, Policy and Law SDG 7 - Affordable and Clean Energy |
topic |
Antibacterial activity Kinetics Lavandula stoechas Oxygenated monoterpenes Supercritical CO Environmental Chemistry Pollution Pharmaceutical Science Management, Monitoring, Policy and Law SDG 7 - Affordable and Clean Energy |
description |
Funding Information: This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396; European Union's Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020. The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101003396 ; European Union’s Horizon 2020 ( European Research Council ) under grant agreement No ERC- 2016-CoG 725034 ; National funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDB/50006/2020 and UIDP/50006/2020 . The biological activity has been supported by research ID: 3105-12-21. The authors would like to thank Ana Jovanoski for her editorial support. Publisher Copyright: © 2023 The Authors |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-26T22:20:51Z 2023-06 2023-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/158326 |
url |
http://hdl.handle.net/10362/158326 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2352-5541 PURE: 72434467 https://doi.org/10.1016/j.scp.2023.101126 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
17 application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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